 Summary Information
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Location: 11q13
Aliases: D11S287E, Cyclin D
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| Gene Database Entries for CCND1
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OMIM
GeneCard (Weizmann Institute)
Tumor Gene Database
Genbank
Swiss-Prot
Locus Link
UniGene
GenAtlas
GDB
Nomenclature (search for CCND1)
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| Other Related Resources
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- Search Medline for related articles (PubMed)
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- Medline Search: cancer AND gene AND (CCND1[TI] OR D11S287E[TI] OR Cyclin D[TI]) (PubMed)
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| CCND1 Overexpression in Mantle Cell Lymphoma
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Mantle cell lymphoma (MCL) is characterised by a t(11;14)(q13;q32) translocation. This juxtaposes the bcl-1 locus to the
immunoglobulin (Ig) gene sequences and leads to deregulation of cyclin D1.
Espinet B, et al. Translocation (11;14)(q13;q32) and preferential involvement of chromosomes 1, 2, 9, 13, and 17 in mantle cell lymphoma. Cancer Genet Cytogenet. 1999; 111(1):92-8 Related articles (PubMed)
Stamatopoulos K, et al. Molecular analysis of bcl-1/IgH junctional sequences in mantle cell lymphoma: potential mechanism of the t(11;14) chromosomal translocation. Br J Haematol. 1999;105(1):190-7. Related articles (PubMed)
Medline Search: mantle cell lymphoma and (cyclin D1 OR CCND1) (PubMed)
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- Related Resources
 BCL1 gene- CCND1 gene
Mantle Cell Lymphoma Genetics
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| CCND1 and Breast Cancer
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Fredersdorf S, et al. High level expression of p27(kip1) and cyclin D1 in some human breast cancer cells: inverse correlation between the expression of p27(kip1) and degree of malignancy in human breast and colorectal cancers. Proc Natl Acad Sci U S A. 1997; 94(12):6380-5 Related articles (PubMed)
Medline Search: breast cancer AND cyclin D (PubMed)
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Breast Cancer Genetics
Breast Cancer : Clinical and Epidemiological Information
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| CCND1 and Head and Neck Cancers
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Matthias C, et al. Cyclin D1, glutathione S-transferase, and cytochrome P450 genotypes and outcome in patients with upper aerodigestive tract cancers: assessment of the importance of individual genes using multivariate analysis Cancer Epidemiol Biomarkers Prev 1999 Sep;8(9):815-23 Related articles (PubMed)
Matthias C, et al. Polymorphism within the cyclin D1 gene is associated with prognosis in patients with squamous cell carcinoma of the head and neck. Clin Cancer Res 1998;4(10):2411-8 Related articles (PubMed)
Kyomoto R, et al. Cyclin-D1-gene amplification is a more potent prognostic factor than its protein over-expression in human head-and-neck squamous-cell carcinoma. Int J Cancer 1997 Dec 19;74(6):576-81 Related articles (PubMed)
Medline Search: head and neck cancer AND cyclin D (PubMed)
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Head and Neck Cancer Genetics
Head and Neck Cancer : Clinical and Epidemiological Information
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| CCND1 and Laryngeal Carcinoma
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Bellacosa A, et al. Cyclin D1 gene amplification in human laryngeal squamous cell carcinomas: prognostic significance and clinical implications. Clin Cancer Res 1996;2(1):175-80 Related articles (PubMed)
Medline Search: laryngeal cancer AND cyclin D (PubMed)
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Larynx, hypopharynx, oropharynx Ca. Genetics
Larynx, hypopharynx, oropharynx Ca. : Clinical and Epidemiological Information
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| CCND1 Amplification and Overexpression in Multiple Myeloma
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Hoechtlen-Vollmar W, et al. Amplification of cyclin D1 gene in multiple myeloma: clinical and prognostic relevance. Br J Haematol 2000 Apr;109(1):30-8 Related articles (PubMed)
Pruneri G, et al. Immunohistochemical analysis of cyclin D1 shows deregulated expression in multiple myeloma with the t(11;14). Am J Pathol 2000 May;156(5):1505-13 Related articles (PubMed)
Janssen JW, et al. Concurrent activation of a novel putative transforming gene, myeov, and cyclin D1 in a subset of multiple myeloma cell lines with t(11;14)(q13;q32). Blood 2000 Apr 15;95(8):2691-8 Related articles (PubMed)
Medline Search: multiple myeloma AND cyclin D1 (PubMed)
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- Related Resources
- t(11;14)(q13;q32) in Multiple myeloma
Multiple Myeloma Genetics
Multiple Myeloma : Clinical and Epidemiological Information
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