Summary Information - COT Gene Database Entries for COT Other COT Related Resources COT and Cancer COT Over Expression and Amplification in Breast Cancer Feedback / suggest a new topic for COT
COT; COT (cancer Osaka thyroid) oncogene Location: 10p11.2 Aliases: MAP3K8, TPL-2 Return to COT Contents
Location: 10p11.2
Aliases: MAP3K8, TPL-2
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OMIM GeneCard (Weizmann Institute) Swiss-Prot Locus Link UniGene GenAtlas GDB Nomenclature (search for COT) Return to COT Contents
Search Medline for related articles (PubMed) Medline Search: cancer AND gene AND (COT[TI] OR MAP3K8[TI] OR TPL-2[TI]) (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Return to COT Contents
Chan AM, et al. Expression cDNA cloning of a serine kinase transforming gene. Oncogene 1993;8(5):1329-33 Related articles (PubMed) Tsatsanis C, Spandidos DA The role of oncogenic kinases in human cancer. [Review] Int J Mol Med 2000;5(6):583-90 Related articles (PubMed) Tsatsanis C, et al. Tpl-2 induces IL-2 expression in T-cell lines by triggering multiple signaling pathways that activate NFAT and NF-kappaB. Oncogene 1998 Nov 19;17(20):2609-18 Related articles (PubMed) Ohara R, et al. Identification of the cells expressing cot proto-oncogene mRNA. J Cell Sci 1995;108 ( Pt 1):97-103 Related articles (PubMed) Return to COT Contents
Sourvinos G, et al. Overexpression of the Tpl-2/Cot oncogene in human breast cancer. Oncogene 1999 Sep 2;18(35):4968-73 Related articles (PubMed) Medline Search: breast cancer AND (cot OR tpl-2) (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Related Resources Breast Cancer Genetics Breast Cancer : Clinical and Epidemiological Information Return to COT Contents