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  Breast Cancer

Mutated Genes and Abnormal Protein Expression (82)
Recurrent Chromosome Abnormalities (1)
Overview of the Molecular Biology of Breast Cancer
Hereditary Breast and Ovarian Cancer
Genetic Polymorphisms and Breast Cancer Risk
Anti-estrogen resistance in Breast Cancer
del(1p32-pter) in Breast Cancer
Breast Cancer: Clinical and Epidemiological Resources
  Mutated Genes and Abnormal Protein Expression
GeneLocationTopics
HSPCA ( HSP90A , HSPC1 ) -HSPCA and Breast Cancer
BCAR2 -BCAR2 and Breast Cancer
BCAR3 ( NSP2 ) -BCAR3 and Breast Cancer
GSTM1 ( GST1 , MU ) 1p13.3 -GSTM1 and Breast Cancer
ARHC ( RhoC ) 1p21-p13 -RhoC Overexpression in Inflammatory Breast Cancer
MUC1 ( PUM , PEM ) 1q21 -MUC1 and Breast Cancer
S100A4 ( MTS1 , P9KA , metastasin ) 1q21 -S100A4 and Breast Cancer
KISS1 ( KiSS-1 ) 1q32 -KISS1 and Breast Cancer
CYP1B1 ( GLC3A ) 2p22-p21 -CYP1B1 Polymorphisms in Breast Cancer
SRD5A22p23 -SRD5A2 and Breast Cancer
BIN1 ( AMPHL , SH3P9 ) 2q14 -BIN1 and Breast Cancer
BARD12q34-q35  
ARHA ( ARH12 , RhoA ) 3p21.3 -RhoA Overexpression in Breast Cancer
TGFBR23p22 -TGFBR2 in EHLA and Risk of Breast Cancer
RARB ( NR1B2 , HAP ) 3p24 -RARB Expression in Breast Cancer
EIF4E ( EIF-4E ) 4q21-q25 -EIF4E in Breast Cancer
HSPCB ( HSP90B , HSPC2 ) 6p12 -HSPCB and Breast Cancer
TFAP2B ( AP2B ) 6p12 -TFAP2B Expression in Breast cancer
NOTCH4 ( INT3 , NOTCH3 ) 6p21.3 -NOTCH4 and Breast Cancer
TFAP2A ( AP2 , AP2TF ) 6p24 -TFAP2A Expression in Breast Cancer
LIBC6q22  
TPD52L1 ( D53 , hD53 ) 6q22-q23  
ESR1 ( ESRA ) 6q25.1 -ESR1 and Breast Cancer
AMPH7p14-p13 -AMPH Expression in Breast Cancer
IL6 ( IFNB2 ) 7p21 -IL-6 Expression in Breast Cancer
HSPB1 ( HSP27 ) 7q -HSP27 and Breast Cancer
TPD52 ( D52 ) 8q21  
EIF3S6 ( INT6 ) 8q22-q23  
MYC ( CMYC , C-MYC ) 8q24.12-q24.13 -MYC and Breast Cancer
BAG19p12 -BAG1 and Breast Cancer
CDKN2A ( P16 , INK4A , MTS1 ) 9p21 -CDKN2A Mutation and Breast Cancer
COT ( MAP3K8 , TPL-2 , EST ) 10p11.2 -COT Over Expression and Amplification in Breast Cancer
SNCG ( BCSG1 ) 10q23.2-q23.3  
FGF8 ( AIGF ) 10q24 -FGF8 Over-Expression in Breast Cancer
PLAU ( uPA , URK ) 10q24 -uPA Expression and Breast Cancer Prognosis
CYP1710q24.3 -CYP17 and Breast Cancer
MKI67 ( Ki-67 ) 10q25-qter -Ki-67 and Breast Cancer Proliferation (MIB-1 assay)
STIP1 ( HSP70 ) 11? -HSP70 and Breast Cancer
TSG10111p15.2-p15.1  
HRAS11p15.5 -HRAS Minisatellite Alleles and Breast Cancer Risk
IGF211p15.5 -IGF2 and Breast Cancer
CTSD ( CPSD ) 11p15.5 -Cathepsin D Expression in Breast Cancer
-Cathepsin D Expression in Breast Cancer
-Cathepsin D and Prognosis in Breast Cancer
SLC22A1L ( BWSCR1A , ORCTL2 , IMPT1 ) 11p15.5 -SLC22A1L and Breast Cancer ?
CD44 ( MDU3 , HA , MDU2 ) 11pter-p13 -CD44 and Breast Cancer
EMS111q13 -EMS1 and Breast Cancer
CCND1 ( D11S287E , Cyclin D , PRAD1 ) 11q13 -CCND1 and Breast Cancer
GSTP1 ( FAEES3 , GST3 , PI ) 11q13 -GSTP1 Polymorphisms and Breast Cancer
ATM ( ATA , ATC ) 11q22.3 -Ataxia-telangiectasia and Risk of Breast Cancer
CDKN1B ( KIP1 , P27 ) 12p13 -CDKN1B and Breast Cancer
CD9 ( p24 , MIC3 , BA2 ) 12p13 -CD9 and Breast Cancer
ERBB3 ( HER3 ) 12q13  
IGF112q22-q24.1 -IGF1 Expression in Breast Cancer
BRCA213q12.3 -BRCA2 and Breast Cancer
-BRCA2 in Familial Breast Cancer
-BRCA2 and Outcome in Breast Cancer
-BRCA2 and Breast Cancer During Pregnancy
RB1 ( Rb ) 13q14.2 -RB1 and Breast Cancer
EFNB2 ( EPLG5 , LERK5 , ephrin-B2 ) 13q33 -EFNB2 Expression and Breast Cancer
ING113q34 -ING1 Supression in Breast Cancer
ESR2 ( ESRB , ERBeta ) 14q -ESR2 and Breast Cancer
CYP1915q21.1 -CYP19 Polymorphisms and Breast Cancer Risk
CYP1A1 ( CYP1 ) 15q22-q24 -CYP1A1 and Breast Cancer
CSK ( c-src ) 15q23-q25 -CSK and Breast Cancer
IGF1R ( JTK13 ) 15q25-q26 -IGF1R and Breast Cancer
MMP2 ( CLG4A , CLG4 , GELA ) 16q13 -MMP2 and Breast Cancer
BCAR116q23.1 -BCAR1 Expression and Breast Cancer
-BCAR1 and Tamoxifen Resistance in Breast Cancer
-BCAR1 Expression and Prognosis in Breast Cancer
MAP2K4 ( MKK4 , SEK1 , JNKK1 ) 17p11.2 -MAP2K4 Mutations in Breast Cancer
TP53 ( p53 , P53 ) 17p13.1 -TP53 and Breast Cancer
LASP1 ( MLN50 ) 17q11-q21.3 -LASP1 Expression in Breast Cancer
ERBB2 ( HER2 , NEU ) 17q11.2-q12 -ERBB2 and Breast Cancer
-anti-HER2 Monoclonal Antibody in Breast Cancer Treatment
-ERBB2 and Benign Breast Lesions
-ERBB2 and Mammary Paget's disease
BRCA117q21 -BRCA1 Screening
-BRCA1 and Breast Cancer
TIMP217q25 -TIMP2 and Breast Cancer
BIRC5 ( survivin , SVV , API4 ) 17q25(?) -Survivin Expression in Breast Cancer
PI5 ( maspin ) 18q21.3 -Maspin and Breast Cancer
STK11 ( LKB1 , PJS ) 19p13.3  
KLK3 ( PSA , APS ) 19q13 -Prostate Specific Antigen and Breast Cancer
PCNA20p12 -PCNA and Breast Cancer
TFAP2C20q13.2 -TFAP2C Expression in Breast Cancer
BCAS1 ( NABC1 , AIBC1 ) 20q13.2-q13.3  
TFF1 ( D21S21 , BCEI ) 21q22.3  
PSEN2 ( D21S21 , HPS2 , BCEI ) 21q22.3 -PSEN2 Expression in Breast Cancer
COMT22q11.2 -COMT Polymorphisms and Breast Cancer
MMP11 ( STMY3 , STR3 ) 22q11.2 -MMP11 Expression in Breast Cancer
GSTT122q11.23 ? -GSTT1 Polymorphisms and Breast Cancer
CHEK2 ( CHK2 , RAD53 , CDS1 ) 22q12.1 -CHEK2 mutations in Breast Cancer

 

  Recurrent Chromosome Abnormalities

del(1p32-pter) in Breast Cancer
  Overview of the Molecular Biology of Breast Cancer

  • Ingvarsson S Molecular genetics of breast cancer progression. [Review] Semin Cancer Biol 1999; 9(4):277-88    Related articles (PubMed)

  • Schorr K, et al. Bcl-2 gene family and related proteins in mammary gland involution and breast cancer. J Mammary Gland Biol Neoplasia 1999; 4(2):153-64    Related articles (PubMed)

  • Medline Search: breast cancer AND genetics (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Breast Cancer Genetics
    Breast Cancer : Clinical and Epidemiological Information

     

  •   Hereditary Breast and Ovarian Cancer

  • Tonin PN Genes implicated in hereditary breast cancer syndromes. [Review] Semin Surg Oncol 2000 Jun;18(4):281-6    Related articles (PubMed)

  • Eisen A, et al. Prophylactic Surgery in Women With a Hereditary Predisposition to Breast and Ovarian Cancer. [Review] J Clin Oncol 2000 May 9;18(9):1980-1995    Related articles (PubMed)

  • Saunders C, et al. Setting up a breast cancer family history clinic. [Review] Ann R Coll Surg Engl 1999 Nov;81(6):393-8    Related articles (PubMed)

  • Rosenthal TC, Puck SM Screening for genetic risk of breast cancer. [Review] Am Fam Physician 1999 Jan 1;59(1):99-104, 106    Related articles (PubMed)

  • Medline Search: familial breast cancer (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
  • Hereditary Breast Cancer Web Resources
  •  

  •   Genetic Polymorphisms and Breast Cancer Risk

  • Dunning AM, et al. A systematic review of genetic polymorphisms and breast cancer risk. Cancer Epidemiol Biomarkers Prev 1999; 8(10):843-54    Related articles (PubMed)

  • Curran JE, et al. Polymorphisms of glutathione S-transferase genes (GSTM1, GSTP1 and GSTT1) and breast cancer susceptibility. Cancer Lett 2000 May 29;153(1-2):113-20    Related articles (PubMed)

  • Medline Search: breast cancer AND polymorphism[TI] (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Breast Cancer Genetics
    Breast Cancer : Clinical and Epidemiological Information

     

  •   Anti-estrogen resistance in Breast Cancer

    Breast tumours are initially dependent on estrogens for growth and progression. Anti-estrogens, particularly tamoxifen can inhibit breast cancer growth. However, breast cancers frequently develop anti-estrogen resistance. Genes implicated in breast cancer anti-estrogen resistance include BCAR1, BCAR2 and BCAR3.

    Breast Cancer Genetics
    Breast Cancer : Clinical and Epidemiological Information

     

      del(1p32-pter) in Breast Cancer

  • el-Rifai W, et al. DNA copy number losses at 1p32-pter in monozygotic twins concordant for breast cancer. Cancer Genet Cytogenet 1999 Jul 15;112(2):169-72    Related articles (PubMed)

  • Bieche I. et al. Deletion mapping of chromosomal region 1p32-pter in primary breast cancer. Genes Chromosomes Cancer 1999; 24:255-63    Related articles (PubMed)

  • Medline Search: breast cancer AND chromosome 1 (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Breast Cancer Genetics
    Breast Cancer : Clinical and Epidemiological Information
    Chromosme 1

     

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