 Summary Information
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Location: 2p24.1
Aliases: NMYC, N-MYC
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| Gene Database Entries for MYCN
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OMIM
GeneCard (Weizmann Institute)
Atlas of Genetics and Cytogenetics in Oncology and Haematology
Tumor Gene Database
Swiss-Prot
Locus Link
UniGene
GenAtlas
GDB
Nomenclature (search for MYCN)
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| Other Related Resources
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MYCN Amplification in Neuroblastoma - Recent Publications (Neuroblastoma Online Researcher's Forum)
MYCN (SwissProt)
 1p Deletions in Neuroblastoma
Neuroblastoma Resources
Gain of 17q in Neuroblastoma
Medline Search: MYCN (PubMed)
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| MYCN Amplification in Neuroblastoma
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Amplification (duplicate copies) of the MYCN gene (also referred to as N-MYC) is established as an adverse prognostic factor in neuroblastoma. The amplicon (material co-amplified with MYCN) varies between patients, but can include the DDX1 gene. MYCN amplification is also correlates with 1p36 deletion and gain of chromosome 17q. MYCN amplified cell lines also overexpress ID2.
Godfried MB, et al. The N-myc and c-myc downstream pathways include the chromosome 17q genes nm23-H1 and nm23-H2. Oncogene 2002; 21(13):2097-101 Related articles (PubMed)
Slamon DJ, et al Identification and characterization of the protein encoded by the human N-myc oncogene. Science. 1986 May 9;232(4751):768-72 Related articles (PubMed)
Ibson JM, et al. Sequence of a germ-line N-myc gene and amplification as a mechanism of activation. Oncogene. 1988;2(4):399-402 Related articles (PubMed)
Brodeur GM Molecular basis for heterogeneity in human neuroblastomas. (Review) Eur J Cancer 1995;31A:505-10 Related articles (PubMed)
Medline Search: (MYCN OR NMYC OR N-MYC) AND neuroblastoma (PubMed)
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| MYCN Amplification in Infants with Neuroblastoma
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Schmidt ML, et al. Biologic Factors Determine Prognosis in Infants With Stage IV Neuroblastoma: A Prospective Children's Cancer Group Study. J Clin Oncol 2000;18(6):1260-1268 Related articles (PubMed)
Katzenstein HM, et al. Prognostic significance of age, MYCN oncogene amplification, tumor cell ploidy, and histology in 110 infants with stage D(S) neuroblastoma: the pediatric oncology group experience--a pediatric oncology group study. J Clin Oncol 1998;16(6):2007-17 Related articles (PubMed)
Medline Search: (MYCN OR NMYC OR N-MYC) AND neuroblastoma AND (infant[TI] OR infants[TI]) (PubMed)
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| MYCN in Localised Neuroblastoma
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Perez CA, et al. Biologic variables in the outcome of stages I and II neuroblastoma treated with surgery as primary therapy: a children's cancer group study. J Clin Oncol 2000;18(1):18-26 Related articles (PubMed)
Rubie H, et al. N-Myc gene amplification is a major prognostic factor in localized neuroblastoma: results of the French NBL 90 study. Neuroblastoma Study Group of the Societe Francaise d'Oncologie Pediatrique. J Clin Oncol 1997;15(3):1171-82 Related articles (PubMed)
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| MYCN Protein Expression in Neuroblastoma
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Sarkar AK, Nuchtern JG Lysis of MYCN-amplified neuroblastoma cells by MYCN peptide-specific cytotoxic T lymphocytes. Cancer Res. 2000 Apr 1;60(7):1908-13. Related articles (PubMed)
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Neuroblastoma : Clinical and Epidemiological Information
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| MYCN Amplification in Lung Cancer
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Nau MM, et al. Human small-cell lung cancers show amplification and expression of the N-myc gene. Proc Natl Acad Sci USA. 1986; 83(4):1092-6 Related articles (PubMed)
Mizushima Y, et al. Effect of cisplatin exposure on the degree of N-myc amplification in small cell lung carcinoma cell lines with N-myc amplification. Oncology. 1996; 53(5):417-21 Related articles (PubMed)
Medline Search: (MYCN OR NMYC OR N-MYC) AND lung cancer (PubMed)
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Lung Cancer Genetics
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| MYCN Amplification in Osteosarcoma
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Pompetti F, et al. Oncogene alterations in primary, recurrent, and metastatic J Cell Biochem 1996; 63(1):37-50 Related articles (PubMed)
Judware R, et al. N-myc over-expression downregulates alpha3beta1 integrin expression in human Saos-2 osteosarcoma cells. Clin Exp Metastasis. 1997; 15(3):228-38 Related articles (PubMed)
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Osteosarcoma Genetics
Osteosarcoma : Clinical and Epidemiological Information
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| MYCN Amplification in Rhabdomyosarcoma
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MYCN gene amplification occurs in a subset patients with rhabdomyosarcoma. It has been reported in 40-60% of patients with alveolar rhabdomyosarcoma, but infrequently occurs in patients with embyronal rhabdomyosarcoma.
Some studies suggest that MYCN amplification in may be associated with a worse prognosis in rhabdomyosarcoma, however, findings have generally been based on small numbers.
Hachitanda Y, et al. N-myc gene amplification in rhabdomyosarcoma detected by fluorescence in situ hybridization: its correlation with histologic features Mod Pathol. 1998; 11(12):1222-7 Related articles (PubMed)
Dias P, et al. N-myc gene is amplified in alveolar rhabdomyosarcomas (RMS) but not in embryonal RMS. Int J Cancer. 1990; 45(4):593-6 Related articles (PubMed)
Driman D, et al. MYCN gene amplification in rhabdomyosarcoma. Cancer. 1994; 73(8):2231-7 Related articles (PubMed)
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Childhood Soft Tissue Sarcoma Genetics
Childhood Soft Tissue Sarcoma : Clinical and Epidemiological Information
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| MYCN Amplification in Retinoblastoma
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There have been a number of reports of MYCN amplification in retinoblastoma cell lines and primary tumours. Doz et al. (1996) found only 1 of 45 primary retinoblastomas studies exhibited MYCN amplification while Kim et al. (1999) found 6 of 33 primary
tumours were amplified. The latter study also suggested that MYCN amplified tumours have higher proliferation levels than non-amplified tumours.
Kim CJ, et al. Proliferation not apoptosis as a prognostic indicator in retinoblastoma. Virchows Arch 1999;434(4):301-5 Related articles (PubMed)
Doz F, et al. N-MYC amplification, loss of heterozygosity on the short arm of chromosome 1 and DNA ploidy in retinoblastoma. Eur J Cancer 1996;32A(4):645-9 Related articles (PubMed)
Yokoyama T, et al. The N-myc gene product in primary retinoblastomas. Cancer 1989 Jun 1;63(11):2134-8 Related articles (PubMed)
Lee WH, et al. Expression and amplification of the N-myc gene in primary retinoblastoma. Nature 1984 May 31-Jun 6;309(5967):458-60 Related articles (PubMed)
Medline Search: retinoblastoma AND (mycn OR n-myc) (PubMed)
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Retinoblastoma Genetics
Retinoblastoma : Clinical and Epidemiological Information
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[Home] This page created: 09/10/1999 Last revised: 29/04/2003 © Copyright 1999-
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