 Summary Information
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Location: 11p13
Overview:
The Wilms' tumour suppressor gene (WT1) gene was first cloned in 1989. The protein it produces is thought to have an important role in normal kidney and gonad development. Mutations in this gene are found in children with familial (inherited) Wilms' tumour
and in children with WAGR genitourinary malformations. However, only about 10% of sporadic (non-familial) Wilms' tumours contain a WT1 mutation. The gene may also have a role in other cancers including leukaemia.
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| Gene Database Entries for WT1
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OMIM
GeneCard (Weizmann Institute)
Human Gene Mutation Database (Cardiff, UK)
Tumor Gene Database
Swiss-Prot
Locus Link
UniGene
GenAtlas
GDB
Nomenclature (search for WT1)
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| Other Related Resources
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WT1 Mutation Database (Universal Mutation Database, France)
 Wilms' Tumour Resources
Medline Search: WT1 AND WILMS TUMOR (PubMed)
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Medline Search: WT1 and Leukemia (PubMed)
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- Medline Search: cancer AND gene AND WT1[TI] (PubMed)
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| WT1 and Wilms' Tumour
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Rahman N, et al. Confirmation of FWT1 as a Wilms' tumour susceptibility gene and phenotypic characteristics of Wilms' tumour attributable to FWT1. Hum Genet. 1998;103(5):547-56. Related articles (PubMed)
Huff V. Genotype/phenotype correlations in Wilms' tumor. Med Pediatr Oncol. 1996;27(5):408-14. Related articles (PubMed)
Coppes MJ, et al. Genetics of Wilms' tumor. Semin Urol Oncol. 1999;17(1):2-10. Review. Related articles (PubMed)
Medline Search: WT1 AND Wilms tumor (PubMed)
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- Related Resources
Wilms' Tumour Genetics
Wilms' Tumour : Clinical and Epidemiological Information
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| WT1 and Leukaemia
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Gaiger A, et al. Detection of the WT1 transcript by RT-PCR in complete remission has no prognostic relevance in de novo acute myeloid leukemia. Leukemia 1998; 12(12):1886-94 Related articles (PubMed)
Sugiyama H. Wilms tumor gene (WT1) as a new marker for the detection of minimal residual disease in leukemia. [Review] Leuk Lymphoma 1998; 30(1-2):55-61 Related articles (PubMed)
Menssen HD, et al. Presence of Wilms' tumor gene (wt1) transcripts and the WT1 nuclear protein in the majority of human acute leukemias. Leukemia 1995; 9(6):1060-7 Related articles (PubMed)
Medline Search: WT1 AND leukemia (PubMed)
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Leukaemia Genetics
Leukaemia : Clinical and Epidemiological Information
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| WT1 and Childhood Leukaemia
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Niegemann E, et. al. WT1 Gene Expression in Childhood Leukemias. Acta Haematol 1999; 102(2):72-76 Related articles (PubMed)
Miyagawa K,et al. Mutations of the WT1 gene in childhood nonlymphoid hematological malignancies. Genes Chromosomes Cancer 1999; 25(2):176-83 Related articles (PubMed)
Medline Search: WT1 AND childhood leukemia (PubMed)
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Childhood Leukaemia Genetics
Childhood Leukaemia : Clinical and Epidemiological Information
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| WT1 and Myelodysplastic Syndromes
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Tamaki H, et al. The Wilms' tumor gene WT1 is a good marker for diagnosis of disease progression of myelodysplastic syndromes. Leukemia 1999;13(3):393-9 Related articles (PubMed)
Patmasiriwat P, et al. WT1 and GATA1 expression in myelodysplastic syndrome and acute leukemia. Leukemia 1999; 13(6):891-900 Related articles (PubMed)
Hosoya N, et al. Mutation analysis of the WT1 gene in myelodysplastic syndromes. Jpn J Cancer Res 1998; 89(8):821-4 Related articles (PubMed)
Medline Search: WT1 AND myelodysplastic syndromes (PubMed)
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Myelodysplastic Syndromes : Clinical and Epidemiological Information
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| t(17;22)(q12;q12) EWS-E1AF Translocation in Ewing's Sarcoma
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Ishida S, et al. The genomic breakpoint and chimeric transcripts in the EWSR1-ETV4/E1AF gene fusion in Ewing sarcoma. Cytogenet Cell Genet. 1998;82(3-4):278-83. Related articles (PubMed)
Urano F, et al. Molecular analysis of Ewing's sarcoma: another fusion gene, EWS-E1AF, available for diagnosis. Jpn J Cancer Res 1998 Jul;89(7):703-11 Related articles (PubMed)
Kaneko Y, et al. Fusion of an ETS-family gene, EIAF, to EWS by t(17;22)(q12;q12) chromosome translocation in an undifferentiated sarcoma of infancy. Genes Chromosomes Cancer 1996 Feb;15(2):115-21 Related articles (PubMed)
- Related Resources
Ewing's Sarcoma Genetics
Ewing's Sarcoma : Clinical and Epidemiological Information
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| WT1 and Mesothelioma
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Kumar-Singh S, et al. Syndecan-1 expression in malignant mesothelioma: correlation with cell differentiation, WT1 expression, and clinical outcome. J Pathol 1998; 186(3):300-5 Related articles (PubMed)
Kumar-Singh S, et al. WT1 mutation in malignant mesothelioma and WT1 immunoreactivity in relation to p53 and growth factor receptor expression, cell-type transition, and prognosis. J Pathol. 1997; 181(1):67-74 Related articles (PubMed)
Amin KM, et al. Wilms' tumor 1 susceptibility (WT1) gene products are selectively expressed in malignant mesothelioma. Am J Pathol. 1995; 146(2):344-56 Related articles (PubMed)
Park S, et al. The Wilms tumour gene WT1 is expressed in murine mesoderm-derived tissues and mutated in a human mesothelioma. Nat Genet. 1993; 4(4):415-20 Related articles (PubMed)
Medline Search: WT1 AND mesothelioma (PubMed)
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- Mesothelioma Resources
Mesothelioma Genetics
Mesothelioma : Clinical and Epidemiological Information
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[Home] This page created: 09/10/1999 Last revised: 29/04/2003 © Copyright 1999-
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