Deletions of chromosome 3p are frequent in many different types of cancer. Researchers in Tokyo (Daigo, 1999) isolated a novel gene by large-scale sequencing of genomic DNA at 3p21.3. Using RT-PCR they found non-functional RNA transcripts in 11/30
primary non-small cell lung cancers, 3/10 primary esophageal squamous cell carcinomas, 4/14 esophageal cancer cell lines and 2/2 renal cancer cell lines. However, no alterations of the gene itself were identified. They originally designated this candidate
tumour supressor gene DLC1 (NOTE: the symbol DLC1 was later assigned to the gene Deleted in Liver Cancer 1 at 8p22)
Daigo Y, et al. Molecular cloning of a candidate tumor suppressor gene, DLC1, from chromosome 3p21.3 Cancer Res 1999; 59:1966-72 Related articles (PubMed)
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DLEC1; Deleted in lung and esophageal cancer 1 (3p22-p21.3)
