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RASSF1; RAS association domain family protein 1

Location: 3p21.3

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Dammann and colleagues (2000) cloned RASSF1 mapped to the 3p21.3 region of minimal homozygous deletion in lung cancer. They identified three transcripts, A, B and C, derived from alternative splicing. Transcripts A and C were expressed in all normal tissues but transcript A was missing in SCLC cell lines. Loss of expression was associated with methylation of the RASSF1A CpG-island promoter sequence (24/60 primary lung tumours were highly methylated and 4/41 had missense mutations). They suggest that RASSF1A is a candidate lung tumour suppressor gene.

Dammann R, et al. Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3. Nat Genet. 2000; 25: 315-319

Medline Search: lung cancer AND RAS association domain family protein (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

Related Resources
Lung Cancer Genetics
Lung Cancer : Clinical and Epidemiological Information

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