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  Chromosome 21

Genes Linked with Cancer (24)

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 21; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
TPTE 21p11 CT44, PTEN2-Bladder Cancer
-Eye Cancer
-Skin Cancer
-Soft Tissue Sarcoma
-Uterine Sarcoma
BAGE 21p11.1 BAGE1, CT2.1-Breast Cancer
-Liver Cancer
-Lung Cancer
-Melanoma
-Multiple Myeloma
-Ovarian Cancer
CXADR 21q21.1 CAR, HCAR, CAR4/6-Stomach Cancer
ADAMTS1 21q21.2 C3-C5, METH1-Bone Cancer (primary)
-Cancer Screening
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Pancreatic Cancer
-Prostate Cancer
DONSON 21q22.1 B17, C21orf60-Astrocytoma, Childhood
-Brain Tumours, Childhood
-Brain, Ependymoma, Childhood
-Medulloblastoma
-Rhabdoid Tumours
TIAM1 21q22.11 -Breast Cancer
-Colorectal Cancer
OLIG2 21q22.11 BHLHB1, OLIGO2, RACK17, PRKCBP2, bHLHe19Somatic-Astrocytoma, Childhood
-Brain and CNS Tumours
-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Childhood Cancers
SOD1 21q22.11 ALS, SOD, ALS1, IPOA, hSod1, HEL-S-44, homodimer-Breast Cancer
-Neuroblastoma
-Prostate Cancer
BACH1 21q22.11 BACH-1, BTBD24-Breast Cancer
-Fanconi Anaemia
-Ovarian Cancer
ETS2 21q22.2 ETS2IT1-Acute Myeloid Leukaemia
-Breast Cancer
-Cervical Cancer
-Leukaemia
-Lung Cancer
-Prostate Cancer
TFF2 21q22.3 SP, SML1-Bile Duct Cancer
-Stomach Cancer
CSTB 21q22.3 PME, ULD, CST6, EPM1, STFB, EPM1A-Brain Tumours, Childhood
-Esophageal Cancer
-Skin Cancer
ITGB2 21q22.3 LAD, CD18, MF17, MFI7, LCAMB, LFA-1, MAC-1-Breast Cancer
-Leukaemia
-Skin Cancer
TFF3 21q22.3 ITF, P1B, TFI-Breast Cancer
-Prostate Cancer
TRPM2 21q22.3 KNP3, EREG1, TRPC7, LTRPC2, NUDT9H, NUDT9L1-Breast Cancer
-Ovarian Cancer
-Prostate Cancer
RUNX1 21q22.3 AML1, CBFA2, EVI-1, AMLCR1, PEBP2aB, AML1-EVI-1Somatic
Translocation
-Acute Lymphocytic Leukaemia (ALL)
-Acute Lymphocytic Leukemia (ALL), child
-Acute Myeloid Leukaemia
-Leukaemia
TMPRSS2 21q22.3 PP9284, PRSS10Somatic
Intronic Deletion or Translocation
-Prostate Cancer
U2AF1 21q22.3 RN, FP793, U2AF35, U2AFBP, RNU2AF1Somatic-Acute Myeloid Leukaemia
-Haematological Malignancies
-Lung Cancer
-Myelodysplastic Syndromes
S100B 21q22.3 NEF, S100, S100-B, S100beta-Bladder Cancer
-Melanoma
TFF1 21q22.3 pS2, BCEI, HPS2, HP1.A, pNR-2, D21S21-Breast Cancer
-Stomach Cancer
MX1 21q22.3 MX, MxA, IFI78, IFI-78K-Acute Myeloid Leukaemia
-Prostate Cancer
COL18A1 21q22.3 KS, KNO, KNO1-Bladder Cancer
-Lung Cancer
-Nasopharyngeal Cancer
-Ovarian Cancer
-Prostate Cancer
-Skin Cancer
SLC19A1 21q22.3 CHMD, FOLT, IFC1, REFC, RFC1-Acute Lymphocytic Leukaemia (ALL)
-Lung Cancer
-Rectal Cancer
ERG 21q22.3 p55, erg-3Somatic
Translocation
Intronic Deletion or Translocation
-Acute Myeloid Leukaemia
-Ewing's Sarcoma
-Prostate Cancer

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 21:

Abnormality Type Gene(s)
ERG-TMPRSS2 Fusion in Prostate CancerIntronic Deletion or TranslocationERG (21q22.3)TMPRSS2 (21q22.3)
t(8;21)(q22;q22) in Acute Myeloid LeukemiaTranslocationRUNX1 (21q22.3)RUNX1T1 (8q22)
t(12;21) in Adult Lyphocytic LeukaemiaTranslocationRUNX1 (21q22.3)ETV6 (12p13)
t(16;21)(p11;q22) in Leukemia (ANLL)TranslocationERG (21q22.3)FUS (16p11.2)
ETV1 translocations in Prostate CancerTranslocationTMPRSS2 (21q22.3)ETV1 (7p21.3)
t(12;21) in Childhood Acute Lymphoblastic LeukaemiaTranslocationRUNX1 (21q22.3)ETV6 (12p13)
t(3;21)(q26;q22) in Secondary Leukaemia / MDSTranslocationRUNX1 (21q22.3)MECOM (3q26.2)
t(21;22) EWSR1-ERG Translocations in Ewing's SarcomaTranslocationERG (21q22.3)EWSR1 (22q12.2)
t(16;21)(p11;q22) FUS-ERG in Acute Myelogenous LeukemiaTranslocationERG (21q22.3)FUS (16p11.2)
Trisomy 21 / Chromosome 21 Mutations in Childhood LeukaemiaTrisomy

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


Further Resources (2 links)

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Cite this page: Cotterill SJ. Chromosome 21, Cancer Genetics Web: http://www.cancerindex.org/geneweb/clinkc21.htm Accessed: date

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