 Summary Information
|
Location: 21q22.3
Aliases: AML1, PEBP2A2
 Return to CBFA2 Contents
|
| Gene Database Entries for CBFA2
|
OMIM
GeneCard (Weizmann Institute)
Atlas of Genetics and Cytogenetics in Oncology and Haematology
Swiss-Prot
Locus Link
UniGene
GenAtlas
GDB
Nomenclature (search for CBFA2)
Return to CBFA2 Contents
|
| Other Related Resources
|
- Search Medline for related articles (PubMed)
-
- Medline Search: cancer AND gene AND (CBFA2[TI] OR AML1[TI] OR PEBP2A2[TI]) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
Return to CBFA2 Contents
|
| t(12;21) TEL-AML1 Translocation in Leukaemia
|
Medline Search: leukemia AND (TEL-AML1 OR 12;21) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
Return to CBFA2 Contents
|
| t(12;21) in Childhood Acute Lymphoblastic Leukaemia
|
The t(12;21)(p13;q22), TEL-AML1 translocation, is observed in approximately 20-25% of childhood B-lineage acute lymphoblastic leukemia (ALL) cases in both Asian and Caucasian populations (Kobayashi H et al., 1997). It is the most frequent known genetic
abnormality in childhood B-cell ALL.
Wiemels JL, Greaves M Structure and possible mechanisms of TEL-AML1 gene fusions in childhood acute lymphoblastic leukemia. Cancer Res 1999; 59:4075-82 Related articles (PubMed)
Kobayashi H. et al. Detection of the Der (21)t(12;21) chromosome forming the TEL-AML1 fusion gene in childhood acute lymphoblastic leukemia. (Review) Leuk Lymphoma 1997; 28:43-50 Related articles (PubMed)
Medline Search: child AND leukemia AND (TEL-AML1 OR 12;21) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
 CBFA2 (AML1) gene- ETV6 (TEL) gene
Childhood Leukaemia Genetics
Childhood Leukaemia : Clinical and Epidemiological Information
Return to CBFA2 Contents
|
| t(12;21) in Adult Lyphocytic Leukaemias
|
The t(12;21)(p13;q22), TEL-AML1 translocation, is observed in approximately 3% of adult acute lymphoblastic leukaemias (ALL) while it occurs in about a quarter of childhood B-cell ALL cases.
Aguiar RC. et al. TEL-AML1 fusion in acute lymphoblastic leukaemia of adults. M.R.C. Adult Leukaemia Working Party. Br J Haematol. 1996; 95:673-7 Related articles (PubMed)
Kwong YL, Wong KF Low frequency of TEL/AML1 in adult acute lymphoblastic leukemia. Cancer Genet Cytogenet 1997; 98:137-8 Related articles (PubMed)
Hoshino K. et al. TEL/AML1 fusion gene resulting from a cryptic t(12;21) is uncommon in adult patients with B-cell lineage ALL and CML lymphoblastic transformation. Int J Hematol 1997; 66:213-8 Related articles (PubMed)
Medline Search: adult AND leukemia AND (TEL-AML1 OR 12;21) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
- CBFA2 (AML1) gene
- ETV6 (TEL) gene
Return to CBFA2 Contents
|
| t(8;21)(q22;q22) in Acute Myeloid Leukemia
|
The t(8;21) translocation is the most frequent cytogenetic abnormality in acute myeloid leukaemia (AML). The translocation fuses the CBFA2(AML1) gene on chromosome 21q to the CBFA2T1(MTG8 / ETO) gene on
chromosome 8q. The resulting fusion gene AML1-ETO occurs more frequently, though not exclusively, in the AML-M2 sub-type. It is detected in approximately 20% of adult and 40% of paediatric patients with AML-M2.
McNeil S, et al. The t(8;21) chromosomal translocation in acute myelogenous leukemia modifies intranuclear targeting of the AML1/CBF2 transcription factor Proc Natl Acad Sci USA. 1999; 96(26):14882-7 Related articles
Tobal K, Liu Yin JA Molecular monitoring of minimal residual disease in acute myeloblastic leukemia with t(8;21) by RT-PCR Leuk Lymphoma 1998;31(1-2):115-20 Related articles (PubMed)
Andrieu V, et al. Molecular detection of t(8;21)/AML1-ETO in AML M1/M2: correlation with cytogenetics, morphology and immunophenotype. Br J Haematol 1996; 92(4):855-65 Related articles (PubMed)
Medline Search: acute myelogenous leukemia AND translocation AND aml1 AND eto (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
Acute Myeloid Leukaemia Genetics
Acute Myeloid Leukaemia : Clinical and Epidemiological Information
Return to CBFA2 Contents
|
|
[Home] This page created: 09/10/1999 Last revised: 29/04/2003 © Copyright 1999-
|
