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  Chromosome 8

Genes Linked with Cancer

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 8; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
KAT6A 8p11 MOZ, MYST3, ZNF220, RUNXBP2, ZC2HC6ASomatic
WHSC1L1 8p11.2 NSD3, pp14328Somatic
HOOK3 8p11.21 HK3Somatic
Translocation
-Thyroid Cancer
FGFR1 8p12 CEK, FLG, HH2, OGD, FLT2, KAL2, BFGFR, CD331, FGFBR, FLT-2, HBGFR, N-SAM, FGFR-1, HRTFDS, bFGF-R-1Somatic
NRG1 8p12 GGF, HGL, HRG, NDF, ARIA, GGF2, HRG1, HRGA, SMDF, MST131
WRN 8p12 RECQ3, RECQL2, RECQL3Germline
PDGFRL 8p22-p21.3 PDGRL, PRLTS
DLC1 8p22 HP, ARHGAP7, STARD12, p122-RhoGAPSomatic
Deletion
Underexpressed
Many cancer types including:
-Breast Cancer
-Liver Cancer
TNFRSF10B 8p22-p21 DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2, KILLER/DR5
NAT1 8p22 AAC1, MNAT, NATI, NAT-1-Bladder Cancer
-Bowel Cancer
-Breast Cancer
-Lung Cancer
-Pancreatic Cancer
NAT2 8p22 AAC2, PNAT, NAT-2-Bladder Cancer
-Bowel Cancer
-Breast Cancer
-Laryngeal Cancer
-Lung Cancer
-Oral Cavity Cancer
-Thyroid Cancer
PCM1 8p22-p21.3 PTC4Somatic
ANGPT2 8p23.1 ANG2, AGPT2
FEZ1 11q24.2
MOS 8q11 MSV
TCEA1 8q11.2 SII, TCEA, TF2S, GTF2S, TFIISSomatic
IL7 8q12-q13 IL-7
PLAG1 8q12 PSA, SGPA, ZNF912Somatic
CHCHD7 8q12.1 COX23Somatic
LYN 8q13 JTK8, p53Lyn, p56Lyn
NCOA2 8q13.3 SRC2, TIF2, GRIP1, KAT13C, NCoA-2, bHLHe75Somatic
NBN 8q21 ATV, NBS, P95, NBS1, AT-V1, AT-V2Germline
HEY1 8q21 CHF2, OAF1, HERP2, HESR1, HRT-1, hHRT1, BHLHb31Somatic
TPD52 8q21 D52, N8L, PC-1, PrLZ, hD52
MYBL1 8q22 AMYB, A-MYB
EIF3E 8q22-q23 INT6, EIF3S6, EIF3-P48, eIF3-p46
RUNX1T1 8q22 CDR, ETO, MTG8, AML1T1, ZMYND2, CBFA2T1Somatic
Translocation
-Acute Myeloid Leukaemia
COX6C 8q22.2 Somatic
RNF139 8q24 RCA1, TRC8, HRCA1
Translocation
-Kidney Cancer
PVT1 8q24 LINC00079, NCRNA00079
NOV 8q24.1 CCN3, NOVh, IBP-9, IGFBP9, IGFBP-9
EXT1 8q24.11 EXT, LGS, TTV, LGCR, TRPS2Germline
PSCA 8q24.2 PRO232-Stomach Cancer
MYC 8q24.21 MRTL, MYCC, c-Myc, bHLHe39Somatic
NDRG1 8q24.3 GC4, RTP, DRG1, NDR1, NMSL, TDD5, CAP43, CMT4D, DRG-1, HMSNL, RIT42, TARG1, PROXY1Somatic-Bowel Cancer
-Breast Cancer
-Cervical Cancer
-Liver Cancer
-Lung Cancer
-Pancreatic Cancer
-Prostate Cancer
RECQL4 8q24.3 RECQ4Germline-Rothmund-Thomson Syndrome
-Osteosarcoma
-Non-Melanoma Skin Cancer (NMSC)
BAI1 8q24.3 GDAIF

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 8:

Abnormality Type Gene(s)
del(8p) in Colorectal Cancers [incl del(8q21)]Deletion
del(8p22) in Prostate CancerDeletion
Trisomy 8 in Ewing's SarcomaGain / Trisomy
t(8;14;12)(q24.1;q32.3;q24.1) in a Burkitt's lymphomaTranslocation
t(8;14)(q11.2;q32) in Childhood ALL (Down's associated)Translocation
t(8;21)(q22;q22) in Acute Myeloid LeukemiaTranslocationRUNX1T1 (8q22)RUNX1 (21q22.3)
t(3;8)(p14.2;q24.1) in Hereditary Renal Cell CarcinomaTranslocationRNF139 (8q24)FHIT (3p14.2)
t(8,10) HOOK-RET Reaarangements in Papillary Thyroid CancerTranslocationHOOK3 (8p11.21)RET (10q11.2)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


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