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  Chromosome 8

Genes Linked with Cancer (98)

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 8; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
KAT6A 8p11 MOZ, MYST3, ZNF220, RUNXBP2, ZC2HC6ASomatic-Acute Myeloid Leukaemia
-Leukaemia
WHSC1L1 8p11.2 NSD3, pp14328Somatic-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
STAR 8p11.2 STARD1-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Stomach Cancer
CEBPD 8p11.2-p11.1 CELF, CRP3, C/EBP-delta, NF-IL6-beta-Acute Myeloid Leukaemia
-Breast Cancer
-Liver Cancer
-Prostate Cancer
IKBKB 8p11.2 IKK2, IKKB, IMD15, NFKBIKB, IKK-beta-Kaposi Sarcoma
-Prostate Cancer
-Skin Cancer
-Thyroid Cancer
POLB 8p11.2 -Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Lung Cancer
-Pancreatic Cancer
-Transitional Cell Cancer of the Renal Pelvis and Ureter
SFRP1 8p11.21 FRP, FRP1, FrzA, FRP-1, SARP2-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Liver Cancer
HOOK3 8p11.21 HK3Somatic
Translocation
-Thyroid Cancer
ADAM9 8p11.22 MCMP, MDC9, CORD9, Mltng-Breast Cancer
-Lung Cancer
-Pancreatic Cancer
-Prostate Cancer
FGFR1 8p11.23-p11.22 CEK, FLG, HH2, OGD, FLT2, KAL2, BFGFR, CD331, FGFBR, FLT-2, HBGFR, N-SAM, FGFR-1, HRTFDS, bFGF-R-1Somatic-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Myeloproliferative Disorders
DUSP4 8p12-p11 TYP, HVH2, MKP2, MKP-2-Breast Cancer
-Colorectal Cancer
-Lung Cancer
EIF4EBP1 8p12 BP-1, 4EBP1, 4E-BP1, PHAS-I-Breast Cancer
PPP2CB 8p12 PP2CB, PP2Abeta-Breast Cancer
-Cervical Cancer
-Lung Cancer
-Skin Cancer
-Wilms Tumour
WRN 8p12 RECQ3, RECQL2, RECQL3Germline-Bladder Cancer
-Colorectal Cancer
-Stomach Cancer
IDO1 8p12-p11 IDO, INDO, IDO-1-Lung Cancer
-Non-Hodgkin Lymphoma
-Stomach Cancer
-Thyroid Cancer
NRG1 8p12 GGF, HGL, HRG, NDF, ARIA, GGF2, HRG1, HRGA, SMDF, MST131, MSTP131, NRG1-IT2-Breast Cancer
PLAT 8p12 TPA, T-PA-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Prostate Cancer
TNFRSF10A 8p21 DR4, APO2, CD261, TRAILR1, TRAILR-1-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-von Hippel-Lindau Disease
BNIP3L 8p21 NIX, BNIP3a-Breast Cancer
-Kidney Cancer
-Liver Cancer
CLU 8p21-p12 CLI, AAG4, APOJ, CLU1, CLU2, KUB1, SGP2, APO-J, SGP-2, SP-40, TRPM2, TRPM-2, NA1/NA2-Breast Cancer
-Cervical Cancer
-Ovarian Cancer
-Prostate Cancer
-Testicular Cancer
TNFRSF10D 8p21 DCR2, CD264, TRUNDD, TRAILR4, TRAIL-R4-Breast Cancer
-Lung Cancer
-Neuroblastoma
-Prostate Cancer
-von Hippel-Lindau Disease
NEFL 8p21 NFL, NF-L, NF68, CMT1F, CMT2E, PPP1R110-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Prostate Cancer
NKX3-1 8p21.2 NKX3, BAPX2, NKX3A, NKX3.1-Prostate Cancer
ADAM7 8p21.2 EAPI, GP83, GP-83, ADAM 7, ADAM-7Somatic-Melanoma
RHOBTB2 8p21.3 DBC2-Bladder Cancer
-Breast Cancer
-Head and Neck Cancers
DOK2 8p21.3 p56DOK, p56dok-2-Acute Lymphocytic Leukaemia (ALL)
-Acute Myeloid Leukaemia
-Leukaemia
-Lung Cancer
-Stomach Cancer
LOXL2 8p21.3 LOR2, WS9-14-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
MTUS1 8p22 ATBP, ATIP, ICIS, MP44, MTSG1-Breast Cancer
-Colorectal Cancer
-Prostate Cancer
TNFRSF10B 8p22-p21 DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2, KILLER/DR5-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Head and Neck Cancers
-Lung Cancer
-Prostate Cancer
MTSS1 8p22 MIM, MIMA, MIMB-Bladder Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Prostate Cancer
-Stomach Cancer
PDGFRL 8p22-p21.3 PDGRL, PRLTS-Breast Cancer
-Esophageal Cancer
-Kidney Cancer
-Ovarian Cancer
LZTS1 8p22 F37, FEZ1-Breast Cancer
-Eye Cancer
-Lung Cancer
-Ovarian Cancer
-Prostate Cancer
TNFRSF10C 8p22-p21 LIT, DCR1, TRID, CD263, TRAILR3, TRAIL-R3, DCR1-TNFR-Breast Cancer
-Colorectal Cancer
-Neuroblastoma
-Pancreatic Cancer
-Prostate Cancer
DLC1 8p22 HP, ARHGAP7, STARD12, p122-RhoGAPSomatic
Deletion
Underexpressed
Many cancer types including:
-Breast Cancer
-Liver Cancer
-Lung Cancer
-Nasopharyngeal Cancer
-Prostate Cancer
MSR1 8p22 SRA, SR-A, CD204, phSR1, phSR2, SCARA1-Prostate Cancer
CTSB 8p22 APPS, CPSB-Breast Cancer
-Cervical Cancer
-Esophageal Cancer
-Prostate Cancer
-Stomach Cancer
-Thyroid Cancer
PCM1 8p22-p21.3 PTC4Somatic-Breast Cancer
-Childhood Cancers
-Chronic Myelogenous Leukemia
-Colorectal Cancer
-Haematological Malignancies
-Leukaemia
-Myeloproliferative Disorders
-Thyroid Cancer
NAT1 8p22 AAC1, MNAT, NATI, NAT-1-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Pancreatic Cancer
NAT2 8p22 AAC2, PNAT, NAT-2-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Laryngeal Cancer
-Lung Cancer
-Oral Cavity Cancer
-Thyroid Cancer
PINX1 8p23 LPTL, LPTS-Breast Cancer
-Cervical Cancer
-Esophageal Cancer
-Liver Cancer
-Prostate Cancer
-Stomach Cancer
TNKS 8p23.1 TIN1, ARTD5, PARPL, TINF1, TNKS1, pART5, PARP5A, PARP-5a-Bladder Cancer
-Brain Tumours, Childhood
-Breast Cancer
-Lung Cancer
-Ovarian Cancer
-Stomach Cancer
GATA4 8p23.1-p22 TOF, ASD2, VSD1, TACHD-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Ovarian Cancer
-Rectal Cancer
-Stomach Cancer
ANGPT2 8p23.1 ANG2, AGPT2-Breast Cancer
-Liver Cancer
-Neuroblastoma
-Stomach Cancer
FEZ1 11q24.2 -Bladder Cancer
-Breast Cancer
-Esophageal Cancer
-Prostate Cancer
-Stomach Cancer
MOS 8q11 MSV-Breast Cancer
-Lung Cancer
-Salivary Gland Cancer
-Stomach Cancer
-Wilms Tumour
PRKDC 8q11 HYRC, p350, DNAPK, DNPK1, HYRC1, IMD26, XRCC7, DNA-PKcs-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Breast Cancer
-Lung Cancer
SNAI2 8q11 SLUG, WS2D, SLUGH1, SNAIL2-Brain Tumours, Childhood
-Breast Cancer
-Lung Cancer
-Ovarian Cancer
-Prostate Cancer
TCEA1 8q11.2 SII, TCEA, TF2S, GTF2S, TFIISSomatic-Salivary Gland Cancer
MCM4 8q11.2 NKCD, CDC21, CDC54, NKGCD, hCdc21, P1-CDC21-Bladder Cancer
-Cervical Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Melanoma
-Skin Cancer
SOX17 8q11.23 VUR3-Breast Cancer
-Testicular Cancer
PLAG1 8q12 PSA, SGPA, ZNF912Somatic-Adenoid Cystic Carcinoma
-Childhood Cancers
-Salivary Gland Cancer
IL7 8q12-q13 IL-7-Bone Cancer (primary)
-Prostate Cancer
CHCHD7 8q12.1 COX23Somatic-Leukaemia
-Lung Cancer
-Salivary Gland Cancer
TTPA 8q12.3 ATTP, AVED, TTP1, alphaTTP-Breast Cancer
-Prostate Cancer
-Uterine Sarcoma
LYN 8q13 JTK8, p53Lyn, p56Lyn-Chronic Lymphocytic Leukemia
-Chronic Myelogenous Leukemia
-Lung Cancer
COPS5 8q13.1 CSN5, JAB1, SGN5, MOV-34-Breast Cancer
-Liver Cancer
MYBL1 8q13.1 AMYB, A-MYB-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Childhood Cancers
-Chronic Lymphocytic Leukemia
SULF1 8q13.2 SULF-1, HSULF-1-Breast Cancer
-Liver Cancer
-Ovarian Cancer
-Pancreatic Cancer
-Stomach Cancer
NCOA2 8q13.3 SRC2, TIF2, GRIP1, KAT13C, NCoA-2, bHLHe75Somatic-Acute Myeloid Leukaemia
-Breast Cancer
-Childhood Cancers
-Chondrosarcoma, Mesenchymal
-Prostate Cancer
CYP11B2 8q21-q22 CPN2, ALDOS, CYP11B, CYP11BL, CYPXIB2, P450C18, P-450C18, P450aldo-Adrenocortical Cancer
NBN 8q21 ATV, NBS, P95, NBS1, AT-V1, AT-V2Germline-Breast Cancer
-Cervical Cancer
-Ovarian Cancer
-Prostate Cancer
-Stomach Cancer
-Wilms Tumour
HEY1 8q21 CHF2, OAF1, HERP2, HESR1, HRT-1, hHRT1, BHLHb31Somatic-Childhood Cancers
-Chondrosarcoma, Mesenchymal
CYP11B1 8q21 FHI, CPN1, CYP11B, P450C11-Adrenocortical Cancer
FABP5 8q21.13 EFABP, KFABP, E-FABP, PAFABP, PA-FABP-Bladder Cancer
-Liver Cancer
-Prostate Cancer
-Vulvar Cancer
TPD52 8q21.13 D52, N8L, PC-1, PrLZ, hD52-Breast Cancer
-Prostate Cancer
E2F5 8q21.2 E2F-5-Breast Cancer
-Ovarian Cancer
-Prostate Cancer
EIF3E 8q22-q23 INT6, EIF3S6, EIF3-P48, eIF3-p46-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Prostate Cancer
TP53INP1 8q22 SIP, Teap, p53DINP1, TP53DINP1, TP53INP1A, TP53INP1B-Breast Cancer
-Cervical Cancer
-Esophageal Cancer
-Liver Cancer
-Pancreatic Cancer
-Stomach Cancer
RUNX1T1 8q22 CDR, ETO, MTG8, AML1T1, ZMYND2, CBFA2T1Somatic
Translocation
-Acute Myeloid Leukaemia
-Childhood Cancers
-Leukaemia
LAPTM4B 8q22.1 LC27, LAPTM4beta-Breast Cancer
-Cervical Cancer
-Gallbladder Cancer
-Liver Cancer
-Pituitary Tumors
-Rectal Cancer
-Stomach Cancer
CDH17 8q22.1 HPT1, CDH16, HPT-1-Liver Cancer
-Lung Cancer
-Stomach Cancer
MTDH 8q22.1 3D3, AEG1, AEG-1, LYRIC, LYRIC/3D3-Brain Tumours, Childhood
-Breast Cancer
-Cervical Cancer
-Liver Cancer
-Lung Cancer
-Ovarian Cancer
CCNE2 8q22.1 CYCE2-Breast Cancer
-Eye Cancer
-Ovarian Cancer
-Vulvar Cancer
COX6C 8q22.2 Somatic-Breast Cancer
-Childhood Cancers
-Esophageal Cancer
-Uterine Sarcoma
BAALC 8q22.3 -Acute Myeloid Leukaemia
-Leukaemia
EBAG9 8q23 EB9, PDAF-Breast Cancer
-Endometrial Cancer
-Liver Cancer
-Ovarian Cancer
-Uterine Sarcoma
YWHAZ 8q23.1 HEL4, YWHAD, KCIP-1, HEL-S-3, 14-3-3-zeta-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Liver Cancer
-Prostate Cancer
-Stomach Cancer
RRM2B 8q23.1 P53R2, MTDPS8A, MTDPS8B-Cervical Cancer
-Colorectal Cancer
-Esophageal Cancer
-Skin Cancer
-Urinary System Cancers
ANGPT1 8q23.1 AGP1, AGPT, ANG1-Brain Tumours, Childhood
-Liver Cancer
-Stomach Cancer
RAD21 8q24 HR21, MCD1, NXP1, SCC1, CDLS4, hHR21, HRAD21-Acute Myeloid Leukaemia
-Breast Cancer
RNF139 8q24 RCA1, TRC8, HRCA1
Translocation
-Kidney Cancer
AGO2 8q24 Q10, EIF2C2-Breast Cancer
-Liver Cancer
-Lung Cancer
-Small Cell Lung Cancer
PVT1 8q24 LINC00079, NCRNA00079-Childhood Cancers
-Lung Cancer
TNFRSF11B 8q24 OPG, TR1, OCIF-Breast Cancer
-Multiple Myeloma
-Osteosarcoma
-Prostate Cancer
NOV 8q24.1 CCN3, NOVh, IBP-9, IGFBP9, IGFBP-9-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer, Non-Small Cell
EXT1 8q24.11 EXT, LGS, TTV, LGCR, TRPS2Germline-Chondrosarcoma
-Multiple Hereditary Exostoses
-Osteosarcoma
HAS2 8q24.12 -Bone Cancer (primary)
-Breast Cancer
-Ovarian Cancer
TRPS1 8q24.12 GC79, LGCR-Breast Cancer
-Prostate Cancer
PSCA 8q24.2 PRO232-Pancreatic Cancer
-Prostate Cancer
-Stomach Cancer
MYC 8q24.21 MRTL, MYCC, c-Myc, bHLHe39Somatic-Breast Cancer
-Colorectal Cancer
WISP1 8q24.22 CCN4, WISP1c, WISP1i, WISP1tc-Breast Cancer
-Colorectal Cancer
-Lung Cancer
PTP4A3 8q24.3 PRL3, PRL-3, PRL-R-Cervical Cancer
-Colorectal Cancer
-Eye Cancer
-Liver Cancer
-Stomach Cancer
BAI1 8q24.3 GDAIF-Bladder Cancer
-Brain Tumours, Childhood
-Colorectal Cancer
-Stomach Cancer
RECQL4 8q24.3 RECQ4Germline-Rothmund-Thomson Syndrome
-Breast Cancer
-Cervical Cancer
-Laryngeal Cancer
-Osteosarcoma
-Non-Melanoma Skin Cancer (NMSC)
PTK2 8q24.3 FAK, FADK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK-Brain Tumours, Childhood
-Breast Cancer
-Liver Cancer
-Lung Cancer
-Stomach Cancer
NDRG1 8q24.3 GC4, RTP, DRG1, NDR1, NMSL, TDD5, CAP43, CMT4D, DRG-1, HMSNL, RIT42, TARG1, PROXY1Somatic-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Pancreatic Cancer
-Prostate Cancer
SCRIB 8q24.3 CRIB1, SCRB1, SCRIB1, Vartul-Breast Cancer
-Cervical Cancer
HSF1 8q24.3 HSTF1-Breast Cancer

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 8:

Abnormality Type Gene(s)
del(8p) in Colorectal Cancers [incl del(8q21)]Deletion
del(8p22) in Prostate CancerDeletion
Trisomy 8 in Ewing's SarcomaGain / Trisomy
t(8;14;12)(q24.1;q32.3;q24.1) in a Burkitt's lymphomaTranslocation
t(8;14)(q11.2;q32) in Childhood ALL (Down's associated)Translocation
t(8;21)(q22;q22) in Acute Myeloid LeukemiaTranslocationRUNX1T1 (8q22)RUNX1 (21q22.3)
t(3;8)(p14.2;q24.1) in Hereditary Renal Cell CarcinomaTranslocationRNF139 (8q24)FHIT (3p14.2)
t(8;9)(p22;p24) PCM1-JAK2 fusion in Hematologic MalignanciesTranslocationPCM1 (8p22-p21.3)JAK2 (9p24)
t(8,10) RET-HOOK Reaarangements in Papillary Thyroid CancerTranslocationHOOK3 (8p11.21)RET (10q11.2)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


Further Resources (2 links)

Further Resources


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Cite this page: Cotterill SJ. Chromosome 8, Cancer Genetics Web: http://www.cancerindex.org/geneweb/clinkc08.htm Accessed: date

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