ADAM7

Gene Summary

Gene:ADAM7; ADAM metallopeptidase domain 7
Aliases: EAPI, GP83, GP-83, ADAM 7, ADAM-7
Location:8p21.2
Summary:This gene encodes a member of the ADAMs family of zinc proteases. These transmembrane proteins play roles in multiple processes including cell signaling, adhesion and migration. The encoded protein lacks protease activity and may play roles in protein-protein interactions and cell adhesion processes including sperm-egg fusion. Mutations in this gene may be involved in the progression of melanoma. [provided by RefSeq, Oct 2011]
Databases:VEGA, OMIM, HGNC, Ensembl, GeneCard, Gene
Protein:disintegrin and metalloproteinase domain-containing protein 7
Source:NCBIAccessed: 15 March, 2017

Ontology:

What does this gene/protein do?
Show (5)

Cancer Overview

Research Indicators

Publications Per Year (1992-2017)
Graph generated 15 March 2017 using data from PubMed using criteria.

Literature Analysis

Mouse over the terms for more detail; many indicate links which you can click for dedicated pages about the topic.

  • Melanoma
  • Neoplasm Metastasis
  • Extracellular Matrix Proteins
  • Mutation
  • Cell Movement
  • ADAM7
  • ADAM29
  • Skin Diseases
  • DNA Mutational Analysis
  • Cell Adhesion
  • Chromosome 8
  • ADAM Proteins
  • Membrane Glycoproteins
  • Adolescents
Tag cloud generated 15 March, 2017 using data from PubMed, MeSH and CancerIndex

Specific Cancers (1)

Data table showing topics related to specific cancers and associated disorders. Scope includes mutations and abnormal protein expression.

Note: list is not exhaustive. Number of papers are based on searches of PubMed (click on topic title for arbitrary criteria used).

Latest Publications: ADAM7 (cancer-related)

Wei X, Moncada-Pazos A, Cal S, et al.
Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma.
Hum Mutat. 2011; 32(6):E2148-75 [PubMed] Free Access to Full Article Related Publications
We performed a mutational analysis of the 19 disintegrin-metalloproteinases (ADAMs) genes in human cutaneous metastatic melanoma and identified eight to be somatically mutated in 79 samples, affecting 34% of the melanoma tumors analyzed. Functional analysis of the two frequently mutated ADAM genes, ADAM29 and ADAM7 demonstrated that the mutations affect adhesion of melanoma cells to specific extracellular matrix proteins and in some cases increase their migration ability. This suggests that mutated ADAM genes could play a role in melanoma progression.

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Cite this page: Cotterill SJ. ADAM7, Cancer Genetics Web: http://www.cancer-genetics.org/ADAM7.htm Accessed:

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This page in Cancer Genetics Web by Simon Cotterill is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
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