 Summary Information
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Location: 3p14.2
Overview:
Gene mutations in FHIT are found in a range of different cancers suggesting that defects in these genes my have a role in tumor development. However, the significance of FHITalterations in carcinogenesis is controversial since aberrant transcripts of FHIT
gene have also been identified in normal non-cancerous tissues (see Wang et al. 1999).
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| Gene Database Entries for FHIT
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OMIM
GeneCard (Weizmann Institute)
Tumor Gene Database
Swiss-Prot
Locus Link (search for FHIT)
UniGene
GenAtlas
GDB
Nomenclature (search for FHIT)
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| Other Related Resources
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- Search Medline for related articles (PubMed)
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- Medline Search: cancer AND gene AND FHIT[TI] (PubMed)
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| FHIT and Cancer
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Wang NM, Chang JG Are aberrant transcripts of FHIT, TSG101, and PTEN/MMAC1 oncogenesis related? Int J Mol Med 1999; 3(5):491-5 Related articles (PubMed)
Bugert P, et al. FHIT gene and the FRA3B region are not involved in the genetics of renal cell carcinomas. Genes Chromosomes Cancer 1997; 20:9-15 Related articles (PubMed)
Ohta M et al. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell 1996; 84:587-97 Related articles (PubMed)
Medline Search: FHIT AND cancer (PubMed)
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 Resources by Disease Type
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| FHIT and Lung Cancer
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Sato H, et al. Alternative splicing, but not allelic loss, of the FHIT gene increases with development of lung cancer. Int J Oncol. 1999; 15:81-8. Related articles (PubMed)
Medline Search: FHIT AND lung cancer (PubMed)
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Lung Cancer Genetics
Lung Cancer : Clinical and Epidemiological Information
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| FHIT and Prognosis in Lung Cancer
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Burke L et al. Allelic deletion analysis of the FHIT gene predicts poor survival in non-small cell lung cancer. Cancer Res 1998; 58:2533-6 Related articles (PubMed)
Medline Search: FHIT AND lung cancer AND prognosis (PubMed)
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Lung Cancer Genetics
Lung Cancer : Clinical and Epidemiological Information
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| FHIT and Tabacco
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Nelson HH, et al. Chromosome 3p14 alterations in lung cancer: evidence that FHIT exon deletion is a target of tobacco carcinogens and asbestos. Cancer Res 1998; 58:1804-7 Related articles (PubMed)
Sozzi G, et al. Association between cigarette smoking and FHIT gene alterations in lung cancer. Cancer Res. 1997; 57:2121-3 Related articles (PubMed)
Medline Search: FHIT AND (tabacco OR smoking) (PubMed)
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Lung Cancer Genetics
Lung Cancer : Clinical and Epidemiological Information
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| FHIT and Cervical Carcinoma
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Greenspan DL, et al. Loss of FHIT expression in cervical carcinoma cell lines and primary tumors. Cancer Res. 1997; 57(21):4692-8 Related articles (PubMed)
Hendricks DT et al. FHIT gene expression in human ovarian, endometrial, and cervical cancer cell lines. Cancer Res 1997; 57(11):2112-5 Related articles (PubMed)
Medline Search: FHIT AND cervical cancer (PubMed)
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Cervical Ca. Genetics
Cervical Ca. : Clinical and Epidemiological Information
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| FHIT and Gastric Cancers
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Chen YJ. et al. Aberrant FHIT transcripts in cancerous and corresponding non-cancerous lesions of the digestive tract. Int J Cancer 1997; 72(6):955-8 Related articles (PubMed)
Gemma A, et al. FHIT mutations in human primary gastric cancer. Cancer Res 1997; 57(8):1435-7 Related articles (PubMed)
Tamura G, et al. Analysis of the fragile histidine triad gene in primary gastric carcinomas and gastric carcinoma cell lines. Genes Chromosomes Cancer. 1997; 20(1):98-102 Related articles (PubMed)
Ohta M et al. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell 1996; 84:587-97 Related articles (PubMed)
Medline Search: gastric cancer AND FHIT (PubMed)
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Stomach (Gastric) Cancer Genetics
Stomach (Gastric) Cancer : Clinical and Epidemiological Information
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| t(3;8)(p14.2;q24.1) in Hereditary Renal Cell Carcinoma
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Gemmill RM, et al. The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8. Proc Natl Acad Sci USA 1998 Aug 4;95(16):9572-7 Related articles (PubMed)
Boldog FL, et al. Positional cloning of the hereditary renal carcinoma 3;8 chromosome translocation breakpoint. Proc Natl Acad Sci USA 1993; 90(18):8509-13 Related articles (PubMed)
Medline Search: renal cell carcinoma AND (rca1 OR hrca1) (PubMed)
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Medline Search: hereditary renal cell carcinoma (PubMed)
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Renal Cell Carcinoma Genetics
Renal Cell Carcinoma : Clinical and Epidemiological Information
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