 Summary Information
|
Location: 9p21
Aliases: P16, INK4A
 Return to CDKN2A Contents
|
| Gene Database Entries for CDKN2A
|
OMIM
GeneCard (Weizmann Institute)
Human Gene Mutation Database (Cardiff, UK)
Swiss-Prot
Locus Link
UniGene
GenAtlas
GDB (search for CDKN2A)
Nomenclature (search for CDKN2A)
Return to CDKN2A Contents
|
| Other Related Resources
|
Familial Melanoma and the CDKN2A gene (National Center for Biotechnology Information) an overview of melanoma and the CDKN2 gene with links to other gene databases.
 Melanoma Resources
Medline Search: CDKN2A and Cancer (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
Medline Search: CDKN2A and Melanoma (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Search Medline for related articles (PubMed)
-
- Medline Search: cancer AND gene AND (CDKN2A[TI] OR P16[TI] OR INK4A[TI]) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
Return to CDKN2A Contents
|
| CDKN2A and Cancer
|
Robertson KD, et al. Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locus. Oncogene 1999 Jul 1;18(26):3810-20 Related articles (PubMed)
Tsihlias J, et al. The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer. [review] Annu Rev Med 1999;50:401-23 Related articles (PubMed)
Medline Search: cancer AND (CDKN2A OR P16 OR INK4A) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
Return to CDKN2A Contents
|
| CDKN2A Germline Mutations in Melanoma Prone Families
|
Piepkorn M Melanoma genetics: an update with focus on the CDKN2A(p16)/ARF tumor suppressors. J Am Acad Dermatol 2000 May;42(5 Pt 1):705-22; quiz 723-6 Related articles (PubMed)
Goldstein AM, et al. Genotype-phenotype relationships in U.S. melanoma-prone families with CDKN2A and CDK4 mutations. J Natl Cancer Inst 2000 Jun 21;92(12):1006-10 Related articles (PubMed)
Ruiz A, et al. CDKN2A mutations in Spanish cutaneous malignant melanoma families and patients with multiple melanomas and other neoplasia. J Med Genet 1999 Jun;36(6):490-3 Related articles (PubMed)
Gruis NA, et al. Familial melanoma; CDKN2A and beyond. J Investig Dermatol Symp Proc 1999; 4(1):50-4 Related articles (PubMed)
Medline Search: melanoma AND (CDKN2A OR P16 OR INK4A) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
Melanoma Genetics
Melanoma : Clinical and Epidemiological Information
Return to CDKN2A Contents
|
| Screening for CDKN2A Mutations in Melanoma Prone Families
|
Yakobson EA, et al. Screening for tumour suppressor p16(CDKN2A) germline mutations in Israeli melanoma families. Clin Chem Lab Med 1998 Aug;36(8):645-8 Related articles (PubMed)
Medline Search: screening AND familial melanoma AND (CDKN2A OR P16 OR INK4A) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
Melanoma Genetics
Melanoma : Clinical and Epidemiological Information
Return to CDKN2A Contents
|
| CDKN2A Mutations in Ocular Melanoma
|
Wang X, et al. Constitutional alterations in p16 in patients with uveal melanoma. Melanoma Res 1996 Dec;6(6):405-10 Related articles (PubMed)
Medline Search: ocular melanoma AND (CDKN2A OR P16 OR INK4A) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
IntraOcular Melanoma Genetics
IntraOcular Melanoma : Clinical and Epidemiological Information
Return to CDKN2A Contents
|
| CDKN2A Polymorphisms and Mole Density ?
|
Zhu G, et al. A major quantitative-trait locus for mole density is linked to the familial melanoma gene CDKN2A: a maximum-likelihood combined linkage and association analysis in twins and their sibs. Am J Hum Genet 1999 Aug;65(2):483-92 Related articles (PubMed)
Medline Search: (CDKN2A OR P16 OR INK4A) AND mole density (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
Melanoma Genetics
Melanoma : Clinical and Epidemiological Information
Return to CDKN2A Contents
|
| CDKN2A Mutations in Non-Melanoma Skin Cancer
|
Soufir N, et al. P16 UV mutations in human skin epithelial tumors. Oncogene 1999 Sep 23;18(39):5477-81 Related articles (PubMed)
Medline Search: non-melanoma skin cancer AND (CDKN2A OR P16 OR INK4A) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
Non-Melanoma Skin Cancer Genetics
Non-Melanoma Skin Cancer : Clinical and Epidemiological Information
Return to CDKN2A Contents
|
| CDKN2A Expression and UVB Irradiation
|
Piepkorn M The expression of p16(INK4a), the product of a tumor suppressor gene for melanoma, is upregulated in human melanocytes by UVB irradiation. J Am Acad Dermatol 2000 May;42(5 Pt 1):741-5 Related articles (PubMed)
Soufir N, et al. P16 UV mutations in human skin epithelial tumors. Oncogene 1999 Sep 23;18(39):5477-81 Related articles (PubMed)
Medline Search: ultraviolet light AND (CDKN2A OR P16 OR INK4A) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
Melanoma Genetics
Melanoma : Clinical and Epidemiological Information
Return to CDKN2A Contents
|
| CDKN2A Mutation in Pancreatic Cancer
|
Borg A, et al. High Frequency of Multiple Melanomas and Breast and Pancreas Carcinomas in CDKN2A Mutation-Positive Melanoma Families. J Natl Cancer Inst 2000 Aug 2;92(15):1260-1266 Related articles (PubMed)
Lal G, et al. Patients with both pancreatic adenocarcinoma and melanoma may harbor germline CDKN2A mutations. Genes Chromosomes Cancer 2000 Apr;27(4):358-61 Related articles (PubMed)
Lal G, et al. Inherited predisposition to pancreatic adenocarcinoma: role of family history and germ-line p16, BRCA1, and BRCA2 mutations. Cancer Res 2000 Jan 15;60(2):409-16 Related articles (PubMed)
Moskaluk CA, et al. Novel germline p16(INK4) allele (Asp145Cys) in a family with multiple pancreatic carcinomas. Mutations in brief no. 148. Online. Hum Mutat 1998;12(1):70 Related articles (PubMed)
Medline Search: pancreatic cancer AND (CDKN2A OR P16 OR INK4A) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
Pancreatic Cancer Genetics
Pancreatic Cancer : Clinical and Epidemiological Information
Return to CDKN2A Contents
|
| CDKN2A Mutation and Breast Cancer
|
Borg A, et al. High Frequency of Multiple Melanomas and Breast and Pancreas Carcinomas in CDKN2A Mutation-Positive Melanoma Families. J Natl Cancer Inst 2000 Aug 2;92(15):1260-1266 Related articles (PubMed)
Medline Search: breast cancer AND (CDKN2A OR P16 OR INK4A) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
Breast Cancer Genetics
Breast Cancer : Clinical and Epidemiological Information
Return to CDKN2A Contents
|
| CDKN2A Mutations in Head and Neck Cancer
|
CDKN2A is one of the most frequently altered genes in head and neck cancers. Hypermethylation and LOH lead to inactivation of the gene.
Miracca EC, et al. High prevalence of p16 genetic alterations in head and neck tumours. Br J Cancer 1999 Oct;81(4):677-83 Related articles (PubMed)
Cerilli LA, et al. Analysis of chromosome 9p21 deletion and p16 gene mutation in salivary gland carcinomas. Hum Pathol 1999 Oct;30(10):1242-6 Related articles (PubMed)
Riese U, et al. Tumor suppressor gene p16 (CDKN2A) mutation status and promoter inactivation in head and neck cancer. Int J Mol Med 1999 Jul;4(1):61-5 Related articles (PubMed)
Medline Search: head and neck cancer AND (CDKN2A OR P16 OR INK4A) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
Head and Neck Cancer Genetics
Head and Neck Cancer : Clinical and Epidemiological Information
Return to CDKN2A Contents
|
| CDKN2A Expression and Prognosis in Head and Neck Cancers
|
Bova RJ, et al. Cyclin D1 and p16INK4A expression predict reduced survival in carcinoma of the anterior tongue. Clin Cancer Res 1999 Oct;5(10):2810-9 Related articles (PubMed)
Medline Search: prognosis AND head and neck cancer AND (CDKN2A OR P16 OR INK4A) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
Head and Neck Cancer Genetics
Head and Neck Cancer : Clinical and Epidemiological Information
Return to CDKN2A Contents
|
| CDKN2A Inactivation in Lung Cancer
|
Sanchez-Cespedes M, et al. Inactivation of the INK4A/ARF locus frequently coexists with TP53 mutations in non-small cell lung cancer. Oncogene 1999; 18(43):5843-9 Related articles (PubMed)
Kelley MJ, et al. Differential inactivation of CDKN2 and Rb protein in non-small-cell and small-cell lung cancer cell lines. Related articles (PubMed)
Otterson GA, et al. Absence of p16INK4 protein is restricted to the subset of lung cancer lines that retains wildtype RB. Oncogene. 1994; 9(11):3375-8 Related articles (PubMed)
Medline Search: lung cancer AND (CDKN2A OR P16 OR INK4A) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
- RB1 gene
Lung Cancer Genetics
Lung Cancer : Clinical and Epidemiological Information
Return to CDKN2A Contents
|
| CDKN2A Deletion in Mesothelioma
|
Prins JB, et al. The gene for the cyclin-dependent-kinase-4 inhibitor, CDKN2A, is preferentially deleted in malignant mesothelioma. Int J Cancer 1998 Feb 9;75(4):649-53 Related articles (PubMed)
Cheng JQ, et al. p16 alterations and deletion mapping of 9p21-p22 in malignant mesothelioma. Cancer Res 1994 Nov 1;54(21):5547-51 Related articles (PubMed)
Medline Search: mesothelioma AND (CDKN2A OR P16 OR INK4A) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
Mesothelioma Genetics
Mesothelioma : Clinical and Epidemiological Information
Return to CDKN2A Contents
|
| Malignant Transformation in Neurofibromatosis 1
|
Nielsen GP, et al. Malignant transformation of neurofibromas in neurofibromatosis 1 is associated with CDKN2A/p16 inactivation. Am J Pathol. 1999; 155(6):1879-84 Related articles (PubMed)
Kourea HP, et al. Deletions of the INK4A gene occur in malignant peripheral nerve sheath tumors but not in neurofibromas. Am J Pathol. 1999; 155(6):1855-60 Related articles (PubMed)
Wu R, et al. Germline mutations in NF1 patients with malignancies. Genes Chromosomes Cancer 1999; 26(4):376-80 Related articles (PubMed)
- Related Resources
- CDKN2A gene
Return to CDKN2A Contents
|
| Experimental Gene Therapy Using CDKN2A Adenovirus Vectors
|
Kobayashi S, et al. P16INK4a expression adenovirus vector to suppress pancreas cancer cell proliferation. Clin Cancer Res 1999 Dec;5(12):4182-5 Related articles (PubMed)
Allay JA, et al. Adenovirus p16 gene therapy for prostate cancer. World J Urol 2000 Apr;18(2):111-20 Related articles (PubMed)
Schreiber M, et al. Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity. Oncogene 1999 Mar 4;18(9):1663-76 Related articles (PubMed)
Craig C, et al. Effects of adenovirus-mediated p16INK4A expression on cell cycle arrest are determined by endogenous p16 and Rb status in human cancer cells. Oncogene 1998 Jan 15;16(2):265-72 Related articles (PubMed)
Fueyo J, et al. Adenovirus-mediated p16/CDKN2 gene transfer induces growth arrest and modifies the transformed phenotype of glioma cells. Oncogene 1996 Jan 4;12(1):103-10 Related articles (PubMed)
Rocco JW, et al. p16INK4A adenovirus-mediated gene therapy for human head and neck squamous cell cancer. Clin Cancer Res 1998 Jul;4(7):1697-704 Related articles (PubMed)
Medline Search: gene therapy AND (CDKN2A OR P16 OR INK4A) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
Return to CDKN2A Contents
|
| CDKN2A and Colorectal Cancer
|
Liang JT, et al. Hypermethylation of the p16 gene in sporadic T3N0M0 stage colorectal cancers: association with DNA replication error and shorter survival. Oncology 1999;57(2):149-56 Related articles (PubMed)
Wiencke JK, et al. Aberrant methylation of p16INK4a in anatomic and gender-specific subtypes of sporadic colorectal cancer. Cancer Epidemiol Biomarkers Prev. 1999;8(6):501-6. Related articles (PubMed)
Medline Search: colorectal cancer AND (CDKN2A OR P16 OR INK4A) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
ColoRectal Cancers Genetics
ColoRectal Cancers : Clinical and Epidemiological Information
Return to CDKN2A Contents
|
| CDKN2A and Soft Tissue Sarcoma
|
In a LOH study of 135 soft tissue sarcomas (Schneider-Stock, 1998) allelic loss of CDKN2A was found in just 7 cases (5%) and characteristic of poorly differentiated tumours. The authors suggest that alterations of the CDKN2A gene do not contribute to the
oncogenesis in the majority of soft tissue tumors.
Orlow I, et al. Alterations of INK4A and INK4B genes in adult soft tissue sarcomas: effect on survival. J Natl Cancer Inst 1999 Jan 6;91(1):73-9 Related articles (PubMed)
Schneider-Stock R, et al. Gene alterations at the CDKN2A (p16/MTS1) locus in soft tissue tumors. Int J Oncol 1998; 13(2):325-9 Related articles (PubMed)
Medline Search: sarcoma AND (CDKN2A OR P16 OR INK4A) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
Adult Soft Tissue Sarcoma Genetics
Adult Soft Tissue Sarcoma : Clinical and Epidemiological Information
Return to CDKN2A Contents
|
| CDKN2A and Rhabdomyosarcoma
|
Iolascon A, et al. Analysis of cyclin-dependent kinase inhibitor genes (CDKN2A, CDKN2B, and CDKN2C) in childhood rhabdomyosarcoma. Genes Chromosomes Cancer 1996;15(4):217-22 Related articles (PubMed)
Urashima M, et al. Restoration of p16INK4A protein induces myogenic differentiation in RD rhabdomyosarcoma cells. Br J Cancer 1999; 79(7-8):1032-6 Related articles (PubMed)
Medline Search: rhabdomyosarcoma AND (CDKN2A OR P16 OR INK4A) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
Childhood Soft Tissue Sarcoma Genetics
Childhood Soft Tissue Sarcoma : Clinical and Epidemiological Information
Return to CDKN2A Contents
|
| CDKN2A Expression in Hodgkin's Disease
|
Guenova M, et al. p16INK4A is regularly expressed in Hodgkin's disease: comparison with retinoblastoma, p53 and MDM2 protein status, and the presence of Epstein-Barr virus. Mod Pathol 1999;12(11):1062-71 Related articles (PubMed)
Medline Search: Hodgkin's disease AND (CDKN2A OR P16 OR INK4A) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
Hodgkin's Disease Genetics
Hodgkin's Disease : Clinical and Epidemiological Information
Return to CDKN2A Contents
|
| CDKN2A and Osteosarcoma
|
Wei G, et al. CDK4 gene amplification in osteosarcoma: reciprocal relationship with INK4A gene alterations and mapping of 12q13 amplicons. Int J Cancer 1999 Jan 18;80(2):199-204 Related articles (PubMed)
Medline Search: osteosarcoma AND (CDKN2A OR P16 OR INK4A) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
Osteosarcoma Genetics
Osteosarcoma : Clinical and Epidemiological Information
Return to CDKN2A Contents
|
| CDKN2A and Bladder Cancer
|
Baud E, et al. p16 involvement in primary bladder tumors: analysis of deletions and mutations. Int J Oncol. 1999;14(3):441-5 Related articles (PubMed)
Orlow I, et al. Deletions of the INK4A gene in superficial bladder tumors. Association with recurrence. Am J Pathol. 1999;155(1):105-13. Related articles (PubMed)
Tsutsumi M, et al. Early acquisition of homozygous deletions of p16/p19 during squamous cell carcinogenesis and genetic mosaicism in bladder cancer. Oncogene. 1998 Dec 10;17(23):3021-7. Related articles (PubMed)
Williamson MP, et al. p16 (CDKN2) is a major deletion target at 9p21 in bladder cancer Hum Mol Genet. 1995 Sep;4(9):1569-77 Related articles (PubMed)
Medline Search: bladder cancer AND (CDKN2A OR P16 OR INK4A) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
Bladder Ca. Genetics
Bladder Ca. : Clinical and Epidemiological Information
Return to CDKN2A Contents
|
| CDKN2A Expression in Wilms' Tumour
|
Arcellana-Panlilio MY, et al. Decreased expression of the INK4 family of cyclin-dependent kinase inhibitors in wilms tumor. Genes Chromosomes Cancer 2000 Sep;29(1):63-9 Related articles (PubMed)
Medline Search: Wilms tumor AND (CDKN2A OR P16 OR INK4A) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
Wilms' Tumour Genetics
Wilms' Tumour : Clinical and Epidemiological Information
Return to CDKN2A Contents
|
| CDKN2A Deletion in Ewing's Sarcoma
|
Wei G, et al. Prognostic impact of INK4A deletion in Ewing sarcoma. Cancer 2000 Aug 15;89(4):793-9 Related articles (PubMed)
Kovar H, et al. Among genes involved in the RB dependent cell cycle regulatory cascade, the p16 tumor suppressor gene is frequently lost in the Ewing family of tumors. Oncogene 1997 Oct;15(18):2225-32 Related articles (PubMed)
Medline Search: ewing's sarcoma AND (CDKN2A OR P16 OR INK4A) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
Ewing's Sarcoma Genetics
Ewing's Sarcoma : Clinical and Epidemiological Information
Return to CDKN2A Contents
|
|
[Home] This page created: 09/10/1999 Last revised: 29/04/2003 © Copyright 1999-
|
