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ATM; Ataxia telangiectasia mutated (includes complementation groups A, C and D) (11q22.3)
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    Summary Information - ATM
    Gene Database Entries for ATM
    Other ATM Related Resources
    Overview of ATM and Cancer
    Ataxia-telangiectasia
       - Ataxia-telangiectasia and Risk of Cancer
       - Ataxia-telangiectasia and Risk of Breast Cancer
    ATM and Breast Cancer
    ATM and T-cell prolymphocytic leukemia
    ATM and Mantle cell lymphoma
    Feedback / suggest a new topic for ATM


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  Summary Information

ATM; Ataxia telangiectasia mutated (includes complementation groups A, C and D)

Location: 11q22.3

Aliases: ATA, ATC

Overview: Ataxia-telangiectasia (AT) is an autosomal recessive disorder characterised by cerebellar ataxia, telangiectases, immunodeficiency, radiosensitivity and predisposition to lymphatic leukemias and other malignancies. There are a number of sub-types of AT and at least 4 of the complementation groups are associated with mutations in the ATM gene.

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  Gene Database Entries for ATM

OMIM
GeneCard (Weizmann Institute)
Atlas of Genetics and Cytogenetics in Oncology and Haematology
Human Gene Mutation Database (Cardiff, UK)
Locus Link
UniGene
GenAtlas
GDB
Nomenclature (search for ATM)

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  Other Related Resources

Search Medline for related articles (PubMed)
  • Medline Search: cancer AND gene AND (ATM[TI] OR ATA[TI] OR ATC[TI]) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]
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      Overview of ATM and Cancer

  • Khanna KK Cancer risk and the ATM gene: a continuing debate. J Natl Cancer Inst 2000 May 17;92(10):795-802    Related articles

  • Medline Search: atm AND cancer (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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  •   Ataxia-telangiectasia

  • Lavin MF ATM: the product of the gene mutated in ataxia-telangiectasia Int J Biochem Cell Biol 1999; 31(7):735-40    Related articles (PubMed)

  • Woods CG, et al. Unusual features in the inheritance of ataxia telangiectasia. Hum Genet 1990;84(6):555-62    Related articles (PubMed)

  • Medline Search: ataxia-telangiectasia (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Ataxia-Telangiectasia Children's Project, Inc. (USA) a non-profit organisation founded in 1993 to raise funds for international research into AT.The web site includes information for families and support providers, physicians and research scientists. Multilingual support.
    Ataxia-Telangiectasia (University of Washington) part of the NCI funded Geneclinics.org site. Details of AT, diagnosis, management, molecular biology, genetic counseling, cancer risk, resources, references etc
    National Organization to Treat Ataxia-telangiectasia (USA) a national non-profit organisation founded in 1992 to raise funds for research. The web site includes information for families, in case of cancer, research, toll-free helpline etc.
    Ataxia-telangiectasia (On-line Medelian Inheritance In Man, National Centre for Biotechnology Information, USA)

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  •   Ataxia-telangiectasia and Risk of Cancer

  • Angele S, Hall J The ATM gene and breast cancer: is it really a risk factor? Mutat Res 2000;462(2-3):167-78    Related articles (PubMed)

  • Stankovic T, et al. ATM mutations and phenotypes in ataxia-telangiectasia families in the British Isles: expression of mutant ATM and the risk of Am J Hum Genet 1998;62(2):334-45    Related articles (PubMed)

  • Medline Search: ataxia-telangiectasia AND cancer (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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  •   Ataxia-telangiectasia and Risk of Breast Cancer

  • Lavin M. Role of the ataxia-telangiectasia gene (ATM) in breast cancer. A-T heterozygotes seem to have an increased risk but its size is unknown. BMJ. 1998 Aug 22;317(7157):486-7    Related articles

  • Swift M, et al. Incidence of cancer in 161 families affected by ataxia-telangiectasia. N Engl J Med 1991 Dec 26;325(26):1831-6    Related articles (PubMed)

  • Borresen AL, et al. Breast cancer and other cancers in Norwegian families with ataxia-telangiectasia. Genes Chromosomes Cancer 1990;2(4):339-40    Related articles (PubMed)

  • Medline Search: breast cancer AND ataxia-telangiectasia (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Breast Cancer Genetics
    Breast Cancer : Clinical and Epidemiological Information

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  •   ATM and Breast Cancer

  • Kovalev S, et al. Lack of defective expression of the ATM gene in sporadic breast cancer tissues and cell lines. Int J Oncol 2000;16(4):825-31    Related articles (PubMed)

  • Angele S, Hall J The ATM gene and breast cancer: is it really a risk factor? Mutat Res 2000;462(2-3):167-78    Related articles (PubMed)

  • Izatt L, et al. Identification of germline missense mutations and rare allelic variants in the ATM gene in early-onset breast cancer. Genes Chromosomes Cancer 1999;26(4):286-94    Related articles (PubMed)

  • FitzGerald MG, et al. Heterozygous ATM mutations do not contribute to early onset of breast cancer. Nat Genet 1997;15(3):307-10    Related articles (PubMed)

  • Medline Search: atm AND breast cancer (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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  •   ATM and T-cell prolymphocytic leukemia

  • Stoppa-Lyonnet D, et al. Inactivation of the ATM gene in T-cell prolymphocytic leukemias Blood 1998; 91(10):3920-6    Related articles (PubMed)

  • Yuille MA, et al. ATM is usually rearranged in T-cell prolymphocytic leukaemia Oncogene 1998; 16(6):789-96    Related articles (PubMed)

  • Medline Search: atm AND prolymphocytic leukemia (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Leukaemia Genetics
    Leukaemia : Clinical and Epidemiological Information

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  •   ATM and Mantle cell lymphoma

  • Stilgenbauer S, et al. The ATM gene in the pathogenesis of mantle-cell lymphoma. Ann Oncol 2000;11 Suppl 1:127-30    Related articles (PubMed)

  • Schaffner C, et al. Mantle cell lymphoma is characterized by inactivation of the ATM gene. Proc Natl Acad Sci U S A 2000 Mar 7 2000; 97 2773-2778    Related articles

  • Medline Search: mantle cell lymphoma AND ATM (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Mantle Cell Lymphoma Genetics

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