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  Mantle Cell Lymphoma

Mutated Genes and Abnormal Protein Expression (3)
Recurrent Chromosome Abnormalities (1)
Overview of Mantle Cell Lymphoma
t(11;14)(q13;q32) in Mantle Cell Lymphoma
PCR Detection of t(11;14)(q13;q32)
FISH Detection of t(11;14)(q13;q32)
  Mutated Genes and Abnormal Protein Expression
GeneLocationTopics
CCND1 ( D11S287E , Cyclin D , PRAD1 ) 11q13 -CCND1 Overexpression in Mantle Cell Lymphoma
BCL111q13.3 -BCL1 and Mantle Cell Lymphoma
ATM ( ATA , ATC ) 11q22.3 -ATM and Mantle cell lymphoma

 

  Recurrent Chromosome Abnormalities

t(11;14)(q13;q32) in Mantle Cell Lymphoma
  Overview of Mantle Cell Lymphoma

Mantle cell lymphoma (MCL) is a B-cell lymphoma recognised in the Revised European-American Classification of Lymphoid Neoplasms (REAL) classification, 1994. It is characterised by a t(11;14)(q13;q32) translocation. Deletion of the ATM gene (11q22) is frequent in MCL.

  • Campo E, et al. Mantle-cell lymphoma. Semin Hematol 1999;36(2):115-27    Related articles (PubMed)

  • Wong KF, et al. Mantle cell lymphoma in leukemic phase: characterization of its broad cytologic spectrum with emphasis on the importance of distinction from other chronic lymphoproliferative disorders. Cancer 1999 Sep 1;86(5):850-7    Related articles (PubMed)

  • Ott G, et al. The cytomorphological spectrum of mantle cell lymphoma is reflected by distinct biological features. Leuk Lymphoma 1998;32(1-2):55-63    Related articles (PubMed)

  • Medline Search: mantle cell lymphoma AND genetics (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Mantle Cell Lymphoma Genetics

     

  •   t(11;14)(q13;q32) in Mantle Cell Lymphoma

    Mantle cell lymphoma (MCL) is characterised by a t(11;14)(q13;q32) translocation. This juxtaposes the bcl-1 locus to the immunoglobulin (Ig) gene sequences and leads to deregulation of cyclin D1.

  • Espinet B, et al. Translocation (11;14)(q13;q32) and preferential involvement of chromosomes 1, 2, 9, 13, and 17 in mantle cell lymphoma. Cancer Genet Cytogenet. 1999; 111(1):92-8    Related articles (PubMed)

  • Stamatopoulos K, et al. Molecular analysis of bcl-1/IgH junctional sequences in mantle cell lymphoma: potential mechanism of the t(11;14) chromosomal translocation. Br J Haematol. 1999;105(1):190-7.    Related articles (PubMed)

  • Medline Search: mantle cell lymphoma and translocation (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Mantle Cell Lymphoma Genetics
    Chromosme 11
    Chromosme 14

     

  •   PCR Detection of t(11;14)(q13;q32)

  • Luthra R, et al. Real-time 5'-->3' exonuclease-based PCR assay for detection of the t(11;14)(q13;q32). Am J Clin Pathol 1999;112(4):524-30    Related articles (PubMed)

  • Medline Search: polymerase chain reaction AND translocation AND mantle cell lymphoma (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Mantle Cell Lymphoma Genetics

     

  •   FISH Detection of t(11;14)(q13;q32)

  • Li JY, et al. Detection of translocation t(11;14)(q13;q32) in mantle cell lymphoma by fluorescence in situ hybridization. Am J Pathol 1999;154(5):1449-52    Related articles (PubMed)

  • Medline Search: fluorescence in situ hybridization AND translocation AND mantle cell lymphoma (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Mantle Cell Lymphoma Genetics

     

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