Mantle cell lymphoma (MCL) is a B-cell lymphoma recognised in the Revised European-American Classification of Lymphoid Neoplasms (REAL) classification, 1994.
It is characterised by a t(11;14)(q13;q32) translocation. Deletion of the ATM gene (11q22) is frequent in MCL.
Campo E, et al. Mantle-cell lymphoma. Semin Hematol 1999;36(2):115-27 Related articles (PubMed)
Wong KF, et al. Mantle cell lymphoma in leukemic phase: characterization of its broad cytologic spectrum with emphasis on the importance of distinction from other chronic lymphoproliferative disorders. Cancer 1999 Sep 1;86(5):850-7 Related articles (PubMed)
Ott G, et al. The cytomorphological spectrum of mantle cell lymphoma is reflected by distinct biological features. Leuk Lymphoma 1998;32(1-2):55-63 Related articles (PubMed)
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 Mantle Cell Lymphoma Genetics
 t(11;14)(q13;q32) in Mantle Cell Lymphoma
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Mantle cell lymphoma (MCL) is characterised by a t(11;14)(q13;q32) translocation. This juxtaposes the bcl-1 locus to the
immunoglobulin (Ig) gene sequences and leads to deregulation of cyclin D1.
Espinet B, et al. Translocation (11;14)(q13;q32) and preferential involvement of chromosomes 1, 2, 9, 13, and 17 in mantle cell lymphoma. Cancer Genet Cytogenet. 1999; 111(1):92-8 Related articles (PubMed)
Stamatopoulos K, et al. Molecular analysis of bcl-1/IgH junctional sequences in mantle cell lymphoma: potential mechanism of the t(11;14) chromosomal translocation. Br J Haematol. 1999;105(1):190-7. Related articles (PubMed)
Medline Search: mantle cell lymphoma and translocation (PubMed)
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Mantle Cell Lymphoma Genetics
Chromosme 11
Chromosme 14
| PCR Detection of t(11;14)(q13;q32)
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Luthra R, et al. Real-time 5'-->3' exonuclease-based PCR assay for detection of the t(11;14)(q13;q32). Am J Clin Pathol 1999;112(4):524-30 Related articles (PubMed)
Medline Search: polymerase chain reaction AND translocation AND mantle cell lymphoma (PubMed)
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Mantle Cell Lymphoma Genetics
| FISH Detection of t(11;14)(q13;q32)
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Li JY, et al. Detection of translocation t(11;14)(q13;q32) in mantle cell lymphoma by fluorescence in situ hybridization. Am J Pathol 1999;154(5):1449-52 Related articles (PubMed)
Medline Search: fluorescence in situ hybridization AND translocation AND mantle cell lymphoma (PubMed)
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Mantle Cell Lymphoma Genetics
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