There is a three-fold increase in risk of CLL in relatives of patients. There have been a number of reports that affected offspring are diagnosed with CLL at a younger age than their parents. Yuille (Leukemia, 1998) in a systematic study of 10 CLL families
found that offspring were diagnosed an average of 22 years younger than their parents and offspring as consistent with other reports.
The cause(s) of familial clustering of CLL remain unknown, there might be environmental causes and/or genetic susceptibility. Bevan (Leukemia, 1999) found no evidence of linkage between ATM (the Ataxia Telangiectasia gene) and CLL
in 24 CLL families. Payelle-Brogard (Blood, 1999) likewise found no evidence for common CD79b gene mutations in 10 CLL families.
Pritsch O, et al. VH gene usage by family members affected with chronic lymphocytic leukaemia. Br J Haematol 1999;107(3):616-24 Related articles (PubMed)
Yuille MR, et al. Anticipation in familial chronic lymphocytic leukaemia. Leukemia 1998;12(11):1696-8 Related articles (PubMed)
Payelle-Brogard B, et al. Analysis of the B-cell receptor B29 (CD79b) gene in familial chronic lymphocytic leukemia. Blood 1999 Nov 15;94(10):3516-22 Related articles (PubMed)
Bevan S, et al. Linkage analysis for ATM in familial B cell chronic lymphocytic leukaemia. Leukemia 1999;13(10):1497-500 Related articles (PubMed)
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Mutated Genes and Abnormal Protein Expression