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  Chromosome 17

Genes Linked with Cancer

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 17; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
CA9 9p13.3 MN, CAIX
FLCN 17p11.2 BHD, FLCLGermline
SPECC1 17p11.2 NSP, CYTSB, HCMOGT1, HCMOGT-1Somatic
MAP2K4 17p12 JNKK, MEK4, MKK4, SEK1, SKK1, JNKK1, SERK1, MAPKK4, PRKMK4, SAPKK1, SAPKK-1Somatic
USP6 17p13 HRP1, TRE2, TRE17, Tre-2, USP6-shortSomatic
TP53 17p13.1 P53, BCC7, LFS1, TRP53Germline & SomaticMany cancer types including:
-Li-Fraumeni syndrome
-Bowel Cancer
-Breast Cancer
-Chronic Lymphocytic Leukemia
-Ewing's Sarcoma
-Lung Cancer
-Osteosarcoma
-Ovarian Cancer
-Pancreatic Cancer
PER1 17p13.1 PER, hPER, RIGUISomatic
RCVRN 17p13.1 RCV1
GAS7 17p13.1 MLL/GAS7Somatic
EFNB3 17p13.1 EFL6, EPLG8, LERK8
RABEP1 17p13.2 RAB5EP, RABPT5Somatic
CRK 17p13.3 p38, CRKII
YWHAE 17p13.3 MDS, HEL2, MDCR, KCIP-1, 14-3-3ESomatic
HIC1 17p13.3 hic-1, ZBTB29, ZNF901
LASP1 17q11-q21.3 MLN50, Lasp-1Somatic
TAF15 17q11.1-q11.2 Npl3, RBP56, TAF2N, TAFII68Somatic
Translocation
-Chondrosarcoma
NF1 17q11.2 WSS, NFNS, VRNFGermline & Somatic
THRA 17q11.2 AR7, EAR7, ERBA, CHNG6, ERBA1, NR1A1, THRA1, THRA2, ERB-T-1, c-ERBA-1
SUZ12 17q11.2 CHET9, JJAZ1Somatic
CDK12 17q12 CRK7, CRKR, CRKRSSomatic
CCR7 17q12-q21.2 BLR2, EBI1, CD197, CDw197, CMKBR7
HNF1B 17q12 FJHN, HNF2, LFB3, TCF2, HPC11, LF-B3, MODY5, TCF-2, VHNF1, HNF-1B, HNF1beta
ERBB2 17q12 NEU, NGL, HER2, TKR1, CD340, HER-2, MLN 19, HER-2/neuSomatic
Gene Amplification
-Bladder Cancer
-Medulloblastoma
-Breast Cancer
-Fallopian tube cancer
-Lung Cancer
-Osteosarcoma
-Ovarian Cancer
-Prostate Cancer
-Uterine Sarcoma
RARA 17q21 RAR, NR1B1Somatic
Translocation
-Acute Myeloid Leukaemia
-Leukaemia
TOP2A 17q21-q22 TOP2, TP2A
BRCA1 17q21 IRIS, PSCP, BRCAI, BRCC1, PNCA4, RNF53, BROVCA1, PPP1R53Germline & Somatic-Bowel Cancer
-Breast Cancer
-Breast Cancer, Familial
-Cancer Screening
-Fallopian tube cancer
-Hereditary Breast and Ovarian Cancer Syndrome
-Ovarian Cancer
-Prostate Cancer
MLLT6 17q21 AF17Somatic
DDX5 17q21 p68, HLR1, G17P1, HUMP68Somatic
ETV4 17q21 E1AF, PEA3, E1A-F, PEAS3Somatic
Translocation
-Ewing's Sarcoma
HOXB13 17q21.2 PSGDGermline & Somatic-Prostate Cancer
NME2 17q21.3 PUF, NDKB, NDPKB, NM23B, NDPK-B, NM23-H2
NME1 17q21.3 NB, AWD, NBS, GAAD, NDKA, NM23, NDPKA, NDPK-A, NM23-H1
NBR1 17q21.31 M17S2, MIG19, 1A1-3B
COL1A1 17q21.33 OI4Somatic
Translocation
-Dermatofibrosarcoma Protuberans
HLF 17q22 Somatic
Translocation
-Acute Lymphocytic Leukaemia (ALL) - adult
ABCC3 17q22 MLP2, MRP3, ABC31, MOAT-D, cMOAT2, EST90757-Breast Cancer
-Childhood Cancers
MSI2 17q22 MSI2HSomatic
BCL5 17q22 Somatic
BRIP1 17q22.2 OF, BACH1, FANCJGermline-Fanconi Anaemia
CD79B 17q23 B29, IGB, AGM6Somatic
AXIN2 17q23-q24 AXIL, ODCRCS
CLTC 17q23.1 Hc, CHC, CHC17, CLH-17, CLTCL2Somatic
MIR21 17q23.1 MIRN21, miR-21, miRNA21, hsa-mir-21-Bowel Cancer
-Breast Cancer
-Lung Cancer
-Squamous Cell Carcinoma - Skin
SSTR2 17q24
PRKAR1A 17q24.2 CAR, CNC, CNC1, PKR1, TSE1, ADOHR, PPNAD1, PRKAR1, ACRDYS1Germline & Somatic-Thyroid Cancer
TIMP2 17q25 DDC8, CSC-21K
BIRC5 17q25 API4, EPR-1-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Small Cell Lung Cancer
-Neuroblastoma
-Skin Cancer
-Thyroid Cancer
-Wilms Tumour
SEPT9 17q25 MSF, MSF1, NAPB, SINT1, PNUTL4, SeptD1, AF17q25Somatic
RHBDF2 17q25.1 TOC, TOCG, RHBDL5, RHBDL6
SRSF2 17q25.1 SC35, PR264, SC-35, SFRS2, SFRS2A, SRp30bSomatic
RNF213 17q25.3 ALO17, MYMY2, MYSTR, NET57, C17orf27, KIAA1618Somatic
MAFG 17q25.3 hMAF
ASPSCR1 17q25.3 TUG, ASPL, ASPS, RCC17, UBXD9, UBXN9, ASPCR1Somatic
Translocation
-Soft Tissue Sarcoma
CANT1 17q25.3 DBQD, SCAN1, SHAPY, SCAN-1Somatic

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 17:

Abnormality Type Gene(s)
Loss of 17p in Childhood CNS tumoursDeletion
Gain of Chromosome 17q in NeuroblastomaGain
Isochromosome 17q in MedulloblastomaIsochromosome
LOH 17p in Colorectal CancerLoss
der(17)t(X;17) (p11.2;q25) in Alveolar Soft-Part SarcomaTranslocation
t(17;22)(q22;q13) COL1A1-PDGFB in Dermatofibrosarcoma ProtuberansTranslocationCOL1A1 (17q21.33)PDGFB (22q13.1)
t(17;22)(q12;q12) EWSR1-E1AF Translocation in Ewing's SarcomaTranslocationETV4 (17q21)EWSR1 (22q12.2)
t(11;17) ALL1-MLLT6 in Acute LeukaemiasTranslocationMLLT6 (17q21)KMT2A (11q23)
t(5;17)(q32;q11) RARA-NPM translocations in Acute Promyelocytic LeukemiaTranslocationRARA (17q21)NPM1 (5q35.1)
t(11;17)(q32;q21) RARA-PLZF in Acute Promyelocytic LeukemiaTranslocationRARA (17q21)ZBTB16 (11q23.1)
t(15;17)(q21;q21) RARA-PML translocation in Acute Promyelocytic LeukaemiaTranslocationRARA (17q21)PML (15q22)
t(17;19)(q22;p13) TCF3-HLF fusion in Acute Lymphoblastic LeukemiaTranslocationHLF (17q22)TCF3 (19p13.3)
der(17)t(X;17)(p11.2;q25) in Alveolar Soft-Part SarcomaTranslocationASPSCR1 (17q25.3)TFE3 (Xp11.22)
t(9;17)(q22;q11) in Extraskeletal Myxoid ChondrosarcomaTranslocationTAF15 (17q11.1-q11.2)NR4A3 (9q22)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


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