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  Chromosome 17

Genes Linked with Cancer (119)

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 17; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
CA9 9p13.3 MN, CAIX-Cervical Cancer
-Kidney Cancer
-Oral Cavity Cancer
-Thyroid Cancer
-Vulvar Cancer
SREBF1 17p11.2 SREBP1, bHLHd1, SREBP-1c-Breast Cancer
-Liver Cancer
-Prostate Cancer
FLCN 17p11.2 BHD, FLCLGermline-Breast Cancer
-Kidney Cancer
-Prostate Cancer
-Uterine Sarcoma
SPECC1 17p11.2 NSP, CYTSB, HCMOGT1, HCMOGT-1Somatic-Head and Neck Cancers
NCOR1 17p11.2 N-CoR, TRAC1, N-CoR1, hN-CoR, PPP1R109-Breast Cancer
-Prostate Cancer
ELAC2 17p11.2 ELC2, HPC2, COXPD17-Prostate Cancer
SHMT1 17p11.2 SHMT, CSHMT-Acute Lymphocytic Leukaemia (ALL)
-Bladder Cancer
-Breast Cancer
-Non-Hodgkin Lymphoma
-Prostate Cancer
-Stomach Cancer
MAP2K4 17p12 JNKK, MEK4, MKK4, SEK1, SKK1, JNKK1, SERK1, MAPKK4, PRKMK4, SAPKK1, SAPKK-1Somatic-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Ovarian Cancer
-Pancreatic Cancer
-Prostate Cancer
-Soft Tissue Sarcoma
-Stomach Cancer
PMP22 17p12 DSS, HNPP, CMT1A, CMT1E, GAS-3, Sp110, HMSNIA-Bone Cancer (primary)
-Brain Tumours, Childhood
-Breast Cancer
-Osteosarcoma
CD68 17p13 GP110, LAMP4, SCARD1-Brain Tumours, Childhood
-Breast Cancer
-Hodgkin Lymphoma
-Lung Cancer
-Melanoma
-Pancreatic Cancer
-Skin Cancer
CXCL16 17p13 SRPSOX, CXCLG16, SR-PSOX-Breast Cancer
-Liver Cancer
-Prostate Cancer
-Rectal Cancer
-Stomach Cancer
USP6 17p13 HRP1, TRE2, TRE17, Tre-2, TRESMCR, USP6-shortSomatic-Bone Cancer (primary)
-Breast Cancer
-Childhood Cancers
-Uterine Sarcoma
PER1 17p13.1 PER, hPER, RIGUISomatic-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Prostate Cancer
TP53 17p13.1 P53, BCC7, LFS1, TRP53Germline & SomaticMany cancer types including:
-Li-Fraumeni syndrome
-Adrenocortical Cancer
-Bladder Cancer
-Brain Tumours, Childhood
-Breast Cancer
-Childhood Leukaemia
-Chronic Lymphocytic Leukemia
-Colorectal Cancer
-Endometrial Cancer
-Esophageal Cancer
-Ewing's Sarcoma
-Fallopian tube cancer
-Hairy Cell Leukemia
-Laryngeal Cancer
-Leukaemia
-Liver Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Melanoma
-Mesothelioma
-Neuroblastoma
-Osteosarcoma
-Ovarian Cancer
-Pancreatic Cancer
-Prostate Cancer
-Rhabdomyosarcoma
AURKB 17p13.1 AIK2, AIM1, ARK2, AurB, IPL1, STK5, AIM-1, STK12, PPP1R48, aurkb-sv1, aurkb-sv2-Cervical Cancer
-Small Cell Lung Cancer
-Thyroid Cancer
EFNB3 17p13.1 EFL6, EPLG8, LERK8-Neuroblastoma
RCVRN 17p13.1 RCV1-Bladder Cancer
-Eye Cancer
-Lung Cancer
-Small Cell Lung Cancer
-Retinoblastoma
XAF1 17p13.1 BIRC4BP, XIAPAF1, HSXIAPAF1-Colorectal Cancer
-Liver Cancer
-Prostate Cancer
-Stomach Cancer
SHBG 17p13.1 ABP, SBP, TEBG-Breast Cancer
-Cervical Cancer
-Prostate Cancer
SAT2 17p13.1 SSAT2-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Ovarian Cancer
-Prostate Cancer
-Stomach Cancer
CLDN7 17p13.1 CLDN-7, CEPTRL2, CPETRL2, Hs.84359, claudin-1-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Stomach Cancer
TNFSF13 17p13.1 APRIL, CD256, TALL2, ZTNF2, TALL-2, TRDL-1, UNQ383/PRO715-Cervical Cancer
-Chronic Lymphocytic Leukemia
-Colorectal Cancer
-Lung Cancer
-Multiple Myeloma
GAS7 17p13.1 MLL/GAS7Somatic-Childhood Cancers
-Leukaemia
-Neuroblastoma
-Osteosarcoma
RABEP1 17p13.2 RAB5EP, RABPT5Somatic-Breast Cancer
-Stomach Cancer
PIGS 17p13.2 -Breast Cancer
-Melanoma
-Thyroid Cancer
PELP1 17p13.2 MNAR, P160-Breast Cancer
-Ovarian Cancer
RPA1 17p13.3 HSSB, RF-A, RP-A, REPA1, RPA70, MST075-Breast Cancer
-Lung Cancer
-Skin Cancer
YWHAE 17p13.3 MDS, HEL2, MDCR, KCIP-1, 14-3-3ESomatic-Childhood Cancers
-Endometrial Cancer
-Kidney Cancer
-Liver Cancer
-Stomach Cancer
-Uterine Sarcoma
DPH1 17p13.3 DPH2L, OVCA1, DPH2L1-Acute Lymphocytic Leukaemia (ALL)
-Ovarian Cancer
CRK 17p13.3 p38, CRKII-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
ALOX15 17p13.3 12-LOX, 15LOX-1, 15-LOX-1-Colorectal Cancer
-Prostate Cancer
HIC1 17p13.3 hic-1, ZBTB29, ZNF901-Medulloblastoma
-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Stomach Cancer
HSD17B1 17q11-q21 HSD17, EDHB17, EDH17B2, SDR28C1-Breast Cancer
-Colorectal Cancer
-Endometrial Cancer
-Prostate Cancer
-Stomach Cancer
RAD51D 17q11 TRAD, R51H3, BROVCA4, RAD51L3-Breast Cancer
-Hereditary Breast and Ovarian Cancer Syndrome
-Ovarian Cancer
LASP1 17q11-q21.3 MLN50, Lasp-1Somatic-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Prostate Cancer
TAF15 17q11.1-q11.2 Npl3, RBP56, TAF2N, TAFII68Somatic
Translocation
-Bone Cancer (primary)
-Chondrosarcoma
-Ewing's Sarcoma
-Soft Tissue Sarcoma
THRA 17q11.2 AR7, EAR7, ERBA, CHNG6, ERBA1, NR1A1, THRA1, THRA2, ERB-T-1, c-ERBA-1-Breast Cancer
-Multiple Myeloma
NOS2 17q11.2 NOS, INOS, NOS2A, HEP-NOS-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Stomach Cancer
NF1 17q11.2 WSS, NFNS, VRNFGermline & Somatic-Adrenocortical Cancer
-Brain Tumours, Childhood
-Childhood Cancers
-Pheochromocytoma and Paraganglioma
-Uterine Sarcoma
STAT5A 17q11.2 MGF, STAT5-Breast Cancer
-Prostate Cancer
-Skin Cancer
CCL2 17q11.2-q12 HC11, MCAF, MCP1, MCP-1, SCYA2, GDCF-2, SMC-CF, HSMCR30-Breast Cancer
-Cervical Cancer
-Liver Cancer
-Lung Cancer
-Prostate Cancer
-Stomach Cancer
SUZ12 17q11.2 CHET9, JJAZ1Somatic-Breast Cancer
-Prostate Cancer
-Stomach Cancer
STAT5B 17q11.2 STAT5-Breast Cancer
CDK12 17q12 CRK7, CRKR, CRKRSSomatic-Ovarian Cancer
-Stomach Cancer
HNF1B 17q12 FJHN, HNF2, LFB3, TCF2, HPC11, LF-B3, MODY5, TCF-2, VHNF1, HNF-1B, HNF1beta-Kidney Cancer
-Liver Cancer
-Ovarian Cancer
-Prostate Cancer
CCL4 17q12 ACT2, G-26, HC21, LAG1, LAG-1, MIP1B, SCYA2, SCYA4, MIP1B1, AT744.1, MIP-1-beta-Liver Cancer
-Multiple Myeloma
GRB7 17q12 -Breast Cancer
-Stomach Cancer
PCGF2 17q12 MEL-18, RNF110, ZNF144-Breast Cancer
-Prostate Cancer
MED1 17q12 PBP, CRSP1, RB18A, TRIP2, PPARBP, CRSP200, DRIP205, DRIP230, PPARGBP, TRAP220-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Prostate Cancer
CCL3 17q12 MIP1A, SCYA3, G0S19-1, LD78ALPHA, MIP-1-alpha-Breast Cancer
-Multiple Myeloma
ERBB2 17q12 NEU, NGL, HER2, TKR1, CD340, HER-2, MLN 19, HER-2/neuSomatic
Gene Amplification
-Bladder Cancer
-Medulloblastoma
-Breast Cancer
-Fallopian tube cancer
-Lung Cancer
-Osteosarcoma
-Ovarian Cancer
-Prostate Cancer
-Uterine Sarcoma
CCL5 17q12 SISd, eoCP, SCYA5, RANTES, TCP228, D17S136E, SIS-delta-Breast Cancer
-Ovarian Cancer
-Stomach Cancer
CCR7 17q12-q21.2 BLR2, EBI1, CCR-7, CD197, CDw197, CMKBR7, CC-CKR-7-Breast Cancer
-Chronic Lymphocytic Leukemia
-Eye Cancer
-Liver Cancer
-Lung Cancer
-Melanoma
WNT3 17q21 INT4-Breast Cancer
-Liver Cancer
ETV4 17q21 E1AF, PEA3, E1A-F, PEAS3Somatic
Translocation
-Ewing's Sarcoma
-Prostate Cancer
GAST 17q21 GAS-Acute Lymphocytic Leukaemia (ALL)
-Melanoma
-Ovarian Cancer
-Skin Cancer
MLLT6 17q21 AF17Somatic-Acute Lymphocytic Leukaemia (ALL)
-Acute Myeloid Leukaemia
-Childhood Cancers
-Leukaemia
RARA 17q21 RAR, NR1B1Somatic
Translocation
-Acute Myeloid Leukaemia
-Childhood Cancers
-Leukaemia
GFAP 17q21 -Astrocytoma, Childhood
-Brain and CNS Tumours
-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
BRCA1 17q21 IRIS, PSCP, BRCAI, BRCC1, PNCA4, RNF53, BROVCA1, PPP1R53Germline & Somatic-Breast Cancer
-Breast Cancer, Familial
-Cancer Screening
-Colorectal Cancer
-Fallopian tube cancer
-Hereditary Breast and Ovarian Cancer Syndrome
-Ovarian Cancer
-Prostate Cancer
NGFR 17q21-q22 CD271, p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR-Brain Tumours, Childhood
-Medulloblastoma
-Breast Cancer
-Neuroblastoma
DDX5 17q21 p68, HLR1, G17P1, HUMP68Somatic-Breast Cancer
-Colorectal Cancer
-Prostate Cancer
-Stomach Cancer
BECN1 17q21 ATG6, VPS30, beclin1-Breast Cancer
-Cervical Cancer
-Liver Cancer
TOP2A 17q21-q22 TOP2, TP2A-Breast Cancer
-Colorectal Cancer
-Esophageal Cancer
-Lung Cancer
-Soft Tissue Sarcoma
-Stomach Cancer
KRT19 17q21.2 K19, CK19, K1CS-Breast Cancer
-Kidney Cancer
-Liver Cancer
-Uterine Sarcoma
IGFBP4 17q21.2 BP-4, IBP4, IGFBP-4, HT29-IGFBP-Breast Cancer
-Lung Cancer
HOXB13 17q21.2 PSGDGermline & Somatic-Prostate Cancer
KRT14 17q21.2 K14, NFJ, CK14, EBS3, EBS4-Breast Cancer
-Cervical Cancer
-Skin Cancer
KRT20 17q21.2 K20, CD20, CK20, CK-20, KRT21-Bladder Cancer
-Colorectal Cancer
-Skin Cancer
-Stomach Cancer
HOXB7 17q21.3 HOX2, HOX2C, HHO.C1, Hox-2.3-Breast Cancer
-Lung Cancer
-Pancreatic Cancer
CDC6 17q21.3 CDC18L, HsCDC6, HsCDC18-Breast Cancer
-Cervical Cancer
-Liver Cancer
-Prostate Cancer
NME2 17q21.3 PUF, NDKB, NDPKB, NM23B, NDPK-B, NM23-H2-Breast Cancer
-Neuroblastoma
NME1 17q21.3 NB, AWD, NBS, GAAD, NDKA, NM23, NDPKA, NDPK-A, NM23-H1-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Eye Cancer
-Lung Cancer
-Neuroblastoma
-Uterine Sarcoma
NBR1 17q21.31 IAI3B, M17S2, MIG19, 1A1-3B-Breast Cancer
-Ovarian Cancer
STAT3 17q21.31 APRF, HIES, ADMIO-Breast Cancer
-Liver Cancer
-Lung Cancer
-Osteosarcoma
HOXB4 17q21.32 HOX2, HOX2F, HOX-2.6-Acute Myeloid Leukaemia
-Cervical Cancer
-Leukaemia
-Wilms Tumour
TBX21 17q21.32 TBET, T-PET, T-bet, TBLYM-Breast Cancer
-Hodgkin Lymphoma
-Lung Cancer
-Paranasal Sinus and Nasal Cavity Cancer
-Stomach Cancer
ITGB3 17q21.32 GT, CD61, GP3A, BDPLT2, GPIIIa, BDPLT16-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Ovarian Cancer
-Prostate Cancer
DLX4 17q21.33 BP1, DLX7, DLX8, DLX9-Breast Cancer
-Cervical Cancer
-Leukaemia
-Lung Cancer
COL1A1 17q21.33 OI4Somatic
Translocation
-Breast Cancer
-Childhood Cancers
-Skin Cancer
-Dermatofibrosarcoma Protuberans
-Soft Tissue Sarcoma
-Vulvar Cancer
HLF 17q22 Somatic
Translocation
-Acute Lymphocytic Leukaemia (ALL)
-Childhood Cancers
-Leukaemia
-Liver Cancer
RAD51C 17q22 FANCO, R51H3, BROVCA3, RAD51L2-Breast Cancer
-Fanconi Anaemia
-Hereditary Breast and Ovarian Cancer Syndrome
-Ovarian Cancer
CACNA1G 17q22 NBR13, Cav3.1, Ca(V)T.1-Colorectal Cancer
-Eye Cancer
-Retinoblastoma
MSI2 17q22 MSI2HSomatic-Acute Myeloid Leukaemia
-Bladder Cancer
-Chronic Myelogenous Leukemia
-Leukaemia
-Stomach Cancer
COIL 17q22 CLN80, p80-coilin-Breast Cancer
-Uterine Sarcoma
ABCC3 17q22 MLP2, MRP3, ABC31, MOAT-D, cMOAT2, EST90757-Breast Cancer
-Childhood Cancers
BCL5 17q22 Somatic-Leukaemia
PRKCA 17q22-q23.2 AAG6, PKCA, PRKACA, PKC-alpha-Breast Cancer
-Skin Cancer
-Stomach Cancer
-Thyroid Cancer
BRIP1 17q22.2 OF, BACH1, FANCJGermline-Fanconi Anaemia
CD79B 17q23 B29, IGB, AGM6Somatic-Acute Lymphocytic Leukaemia (ALL)
-Chronic Lymphocytic Leukemia
-Hodgkin Lymphoma
MIR21 17q23.1 MIRN21, miR-21, miRNA21, hsa-mir-21-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Squamous Cell Carcinoma - Skin
RPS6KB1 17q23.1 S6K, PS6K, S6K1, STK14A, p70-S6K, p70 S6KA, p70-alpha, S6K-beta-1, p70(S6K)-alpha-Breast Cancer
CLTC 17q23.1 Hc, CHC, CHC17, CLH-17, CLTCL2Somatic-Childhood Cancers
-Kidney Cancer
-Lung Cancer
TBX2 17q23.2 -Bladder Cancer
-Breast Cancer
-Melanoma
-Pancreatic Cancer
PPM1D 17q23.2 WIP1, PP2C-DELTA-Breast Cancer
-Ovarian Cancer
STRADA 17q23.3 LYK5, PMSE, Stlk, STRAD, NY-BR-96-Breast Cancer
-Pancreatic Cancer
-Prostate Cancer
PECAM1 17q23.3 CD31, PECA1, GPIIA', PECAM-1, endoCAM, CD31/EndoCAM-Breast Cancer
-Liver Cancer
-Lung Cancer
GRB2 17q24-q25 ASH, Grb3-3, MST084, NCKAP2, MSTP084, EGFRBP-GRB2-Breast Cancer
-Chronic Myelogenous Leukemia
SSTR2 17q24 -Medulloblastoma
-Breast Cancer
-Lung Cancer
-Neuroblastoma
-Pancreatic Cancer
-Pituitary Tumors
-Stomach Cancer
AXIN2 17q24.1 AXIL, ODCRCS-Adenomatous Polyposis Coli
-Colorectal Cancer
PRKAR1A 17q24.2 CAR, CNC, CNC1, PKR1, TSE1, ADOHR, PPNAD1, PRKAR1, ACRDYS1Germline & Somatic-Multiple Endocrine Neoplasia
-Pituitary Tumors
-Skin Cancer
-Thyroid Cancer
SOX9 17q24.3 CMD1, SRA1, CMPD1-Colorectal Cancer
-Pancreatic Cancer
-Prostate Cancer
FASN 17q25 FAS, OA-519, SDR27X1-Breast Cancer
-Colorectal Cancer
-Prostate Cancer
-Uterine Sarcoma
TIMP2 17q25 DDC8, CSC-21K, KIAA1731NL-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Chondrosarcoma
-Liver Cancer
-Lung Cancer
-Melanoma
-Prostate Cancer
ITGB4 17q25 CD104-Bladder Cancer
-Breast Cancer
-Pancreatic Cancer
BIRC5 17q25 API4, EPR-1-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Small Cell Lung Cancer
-Neuroblastoma
-Skin Cancer
-Thyroid Cancer
-Wilms Tumour
SEPT9 17q25 MSF, MSF1, NAPB, SINT1, PNUTL4, SeptD1, AF17q25Somatic-Acute Myeloid Leukaemia
-Cancer Screening
-Childhood Cancers
-Colorectal Cancer
SRSF2 17q25.1 SC35, PR264, SC-35, SFRS2, SFRS2A, SRp30bSomatic-Acute Myeloid Leukaemia
-Chronic Myelogenous Leukemia
-Haematological Malignancies
-Myelodysplastic Syndromes
-Myeloproliferative Disorders
RHBDF2 17q25.1 TEC, TOC, TOCG, RHBDL5, RHBDL6, iRhom2-Esophageal Cancer
-Ovarian Cancer
SLC9A3R1 17q25.1 EBP50, NHERF, NHERF1, NHERF-1, NPHLOP2
SPHK1 17q25.2 SPHK-Breast Cancer
-Colorectal Cancer
-Stomach Cancer
TMC6 17q25.3 EV1, EVER1, EVIN1, LAK-4P-Cervical Cancer
-Skin Cancer
ASPSCR1 17q25.3 TUG, ASPL, ASPS, RCC17, UBXD9, UBXN9, ASPCR1Somatic
Translocation
-Childhood Cancers
-Kidney Cancer
-Lung Cancer
-Soft Tissue Sarcoma
SOCS3 17q25.3 CIS3, SSI3, ATOD4, Cish3, SSI-3, SOCS-3-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Prostate Cancer
RNF213 17q25.3 ALO17, MYMY2, MYSTR, NET57, C17orf27, KIAA1618Somatic-Head and Neck Cancers
MAFG 17q25.3 hMAF-Chronic Myelogenous Leukemia
-Colorectal Cancer
-Lung Cancer
TMC8 17q25.3 EV2, EVER2, EVIN2-Cervical Cancer
-Skin Cancer
ZNF750 17q25.3 ZFP750
Deletion
-Esophageal Cancer
CANT1 17q25.3 DBQD, SCAN1, SHAPY, SCAN-1Somatic-Prostate Cancer

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 17:

Abnormality Type Gene(s)
Loss of 17p in Childhood CNS tumoursDeletion
Gain of Chromosome 17q in NeuroblastomaGain
Isochromosome 17q in MedulloblastomaIsochromosome
LOH 17p in Colorectal CancerLoss
der(17)t(X;17) (p11.2;q25) in Alveolar Soft-Part SarcomaTranslocation
t(17;22)(q22;q13) COL1A1-PDGFB in Dermatofibrosarcoma ProtuberansTranslocationCOL1A1 (17q21.33)PDGFB (22q13.1)
t(17;22)(q12;q12) EWSR1-E1AF Translocation in Ewing's SarcomaTranslocationETV4 (17q21)EWSR1 (22q12.2)
t(11;17) ALL1-MLLT6 in Acute LeukaemiasTranslocationMLLT6 (17q21)KMT2A (11q23)
t(5;17)(q32;q11) RARA-NPM translocations in Acute Promyelocytic LeukemiaTranslocationRARA (17q21)NPM1 (5q35.1)
t(11;17)(q32;q21) RARA-PLZF in Acute Promyelocytic LeukemiaTranslocationRARA (17q21)ZBTB16 (11q23.1)
t(15;17)(q21;q21) RARA-PML translocation in Acute Promyelocytic LeukaemiaTranslocationRARA (17q21)PML (15q22)
t(17;19)(q22;p13) TCF3-HLF fusion in Acute Lymphoblastic LeukemiaTranslocationHLF (17q22)TCF3 (19p13.3)
der(17)t(X;17)(p11.2;q25) in Alveolar Soft-Part SarcomaTranslocationASPSCR1 (17q25.3)TFE3 (Xp11.22)
t(9;17)(q22;q11) in Extraskeletal Myxoid ChondrosarcomaTranslocationTAF15 (17q11.1-q11.2)NR4A3 (9q22)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


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Cite this page: Cotterill SJ. Chromosome 17, Cancer Genetics Web: http://www.cancerindex.org/geneweb/clinkc17.htm Accessed: date

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