 Summary Information
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Location: 17q25(?)
Aliases: survivin, SVV
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| Gene Database Entries for BIRC5
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OMIM
GeneCard (Weizmann Institute)
Genbank
Locus Link
UniGene
GenAtlas
GDB
Nomenclature (search for BIRC5)
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| Other Related Resources
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- Search Medline for related articles (PubMed)
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- Medline Search: cancer AND gene AND (BIRC5[TI] OR survivin[TI] OR SVV[TI]) (PubMed)
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| Survivin and Apoptosis
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Suzuki A, et al. Survivin initiates procaspase 3/p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death. Oncogene 2000 Mar 2;19(10):1346-53 Related articles (PubMed)
Mahotka C, et al. Survivin-deltaEx3 and survivin-2B: two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties. Cancer Res 1999 Dec 15;59(24):6097-102 Related articles (PubMed)
Li F et al. Control of apoptosis and mitotic spindle checkpoint by survivin. Nature 1998 Dec 10;396(6711):580-4 Related articles (PubMed)
Ambrosini G et al. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med 1997;3(8):917-21 Related articles (PubMed)
Medline Search: apoptosis AND (survivin OR API4) (PubMed)
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| Survivin Expression in Neuroblastoma
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Sandler A, et al. The survivin: Fas ratio is predictive of recurrent disease in neuroblastoma. J Pediatr Surg 2002;37(3):507-11 Related articles (PubMed)
Azuhata T, et al. The inhibitor of apoptosis protein survivin is associated with high-risk behavior of neuroblastoma. J Pediatr Surg 2001;36(12):1785-91 Related articles (PubMed)
Islam A et al. High expression of Survivin, mapped to 17q25, is significantly associated with poor prognostic factors and promotes cell survival in human neuroblastoma. Oncogene 2000 ;19(5):617-23 Related articles (PubMed)
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 Neuroblastoma Genetics
Neuroblastoma : Clinical and Epidemiological Information
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| Survivin Expression in Colorectal Cancer
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Sarela AI, et al. Expression of the antiapoptosis gene, survivin, predicts death from recurrent colorectal carcinoma. Gut 2000;46(5):645-50 Related articles (PubMed)
Rohayem J, et al. Antibody response to the tumor-associated inhibitor of apoptosis protein survivin in cancer patients. Cancer Res 2000 Apr 1;60(7):1815-7 Related articles (PubMed)
Medline Search: colorectal cancer AND (survivin OR API4) (PubMed)
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ColoRectal Cancers Genetics
ColoRectal Cancers : Clinical and Epidemiological Information
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| Survivin Expression in Breast Cancer
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Tanaka K, et al. Expression of survivin and its relationship to loss of apoptosis in breast carcinomas. Clin Cancer Res 2000;6(1):127-34 Related articles (PubMed)
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Breast Cancer Genetics
Breast Cancer : Clinical and Epidemiological Information
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| Survivin Expression in Lung Cancer
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Researchers in Germany (Monzo, 1999) used RT-PCR to detect survivin gene transcripts in 83 NSCLC tumour samples and in paired normal lung tissues.
The survivin gene transcript was found in 71 (86%) of the tumours and in only 10 (12%) of the normal lung samples. Moreover, the 12 patients without survivin expression were found to have significantly better survival than the 71 patients with survivin
expression.
Monzo M, et al. A novel anti-apoptosis gene: Re-expression of survivin messenger RNA as a prognosis marker in non-small-cell lung cancers. J Clin Oncol 1999 Jul;17(7):2100-4 Related articles (PubMed)
Olie RA, et al. A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy. Cancer Res 2000 Jun 1;60(11):2805-9 Related articles (PubMed)
Rohayem J, et al. Antibody response to the tumor-associated inhibitor of apoptosis protein survivin in cancer patients. Cancer Res 2000 Apr 1;60(7):1815-7 Related articles (PubMed)
Medline Search: lung cancer AND (survivin OR API4) (PubMed)
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Lung Cancer Genetics
Lung Cancer : Clinical and Epidemiological Information
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| Survivin Expression in Hepatocellular Carcinoma
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Ito T, et al. Survivin promotes cell proliferation in human hepatocellular carcinoma. Hepatology 2000;31(5):1080-5 Related articles (PubMed)
Medline Search: hepatocellular carcinoma AND (survivin OR API4) (PubMed)
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Hepatocelular Carcinoma Genetics
Hepatocelular Carcinoma : Clinical and Epidemiological Information
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| Survivin Expression in Lymphoma
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Ambrosini G et al. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med 1997;3(8):917-21 Related articles (PubMed)
Medline Search: lymphoma ANS (survivin OR API4) (PubMed)
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Non-Hodgkin's Lymphoma Genetics
Non-Hodgkin's Lymphoma : Clinical and Epidemiological Information
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[Home] This page created: 09/10/1999 Last revised: 29/04/2003 © Copyright 1999-
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