 Summary Information
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Location: 18q21.3
Overview:
B-cell follicular lymphoma is sometimes associated with a reciprocal translocation; t(14;18)(q32;q21). This causes deregulated expression of the BCL2 gene, which interferes with normal apoptosis (controlled cell death) of B-cell lymphocytes.
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| Gene Database Entries for BCL2
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OMIM
GeneCard (Weizmann Institute)
Atlas of Genetics and Cytogenetics in Oncology and Haematology
Human Gene Mutation Database (Cardiff, UK)
Tumor Gene Database
Swiss-Prot
Locus Link
UniGene
GenAtlas
GDB
Nomenclature (search for BCL2)
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| Other Related Resources
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 Chronic Lymphocytic Leukaemia
Lymphoma Resources
Medline Search: BCL2 (PubMed)
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- Medline Search: cancer AND gene AND BCL2[TI] (PubMed)
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| BCL2 Family of Genes and Apoptosis
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- The BCL2 Family of Genes / Proteins:
- BCL2
BCL-XL ("BCL2-like 1")
BCL-W ("BCL2-like 2")
MCL1 ("Myeloid cell leukemia sequence 1 (BCL2-related)")
BFL1 ("BCL2-related protein A1")
BAG1 ("BCL2-associated athanogene")
BAD("BCL2-antagonist of cell death")
BAX ("BCL2-associated X protein")
BAK1 ("BCL2-antagonist/killer 1")
BIK ("BCL2-interacting killer (apoptosis-inducing)")
BID ("BH3 interacting domain death agonist")
HRK ("Harakiri, BCL2-interacting protein (contains only BH3 domain)")
BIM
MTD
Tsujimoto Y Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria? Genes Cells 1998; 3(11):697-707 Related articles (PubMed)
Medline Search: apoptosis[TI] AND (bcl-2 OR bcl2) (PubMed)
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Resources by Disease Type
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| BCL2 and Non-Hodgkin's Lymphoma
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Medline Search: lymphoma AND (bcl-2 OR bcl2) (PubMed)
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Non-Hodgkin's Lymphoma Genetics
Non-Hodgkin's Lymphoma : Clinical and Epidemiological Information
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| t(14;18)(q32;q21) in Non-Hodgkin's Lymphoma
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Yunis JJ, et al. Distinctive chromosomal abnormalities in histologic subtypes of non-Hodgkin's lymphoma. N Engl J Med 1982; 307(20):1231-6 Related articles (PubMed)
Medline Search: translocation AND lymphoma AND (bcl-2 OR bcl2) (PubMed)
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Non-Hodgkin's Lymphoma Genetics
Non-Hodgkin's Lymphoma : Clinical and Epidemiological Information
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| BLC2 Amplification in Diffuse Large B-cell Lymphoma
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Monni O, et al. BCL2 overexpression in diffuse large B-cell lymphoma. Leuk Lymphoma 1999; 34(1-2):45-52 Related articles (PubMed)
Monni O, et al. BCL2 overexpression associated with chromosomal amplification in diffuse large B-cell lymphoma. Blood 1997; 90(3):1168-74 Related articles (PubMed)
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Non-Hodgkin's Lymphoma : Clinical and Epidemiological Information
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| BCL2 Expression in MALT lymphoma
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Dogusoy G, et al. Histopathologic features and expression of Bcl-2 and p53 proteins in primary gastric lymphomas. Pathol Oncol Res 1999;5(1):36-40 Related articles (PubMed)
Nakamura S, et al. Inverse correlation between the expression of bcl-2 and p53 proteins in primary gastric lymphoma. Hum Pathol 1996;27(3):225-33 Related articles (PubMed)
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MALT Lymphoma Genetics
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| t(14;18)(q32;q21) in Acute Lymphoblastic Leukaemia
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Medline Search: leukemia AND (bcl-2 OR bcl2) (PubMed)
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Acute Lymphocytic Leukaemia Genetics
Acute Lymphocytic Leukaemia : Clinical and Epidemiological Information
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| BCL2 and Acute Myelogenous Leukaemia
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Kornblau SM, et al. The prognostic impact of BCL2 protein expression in acute myelogenous leukemia varies with cytogenetics. Clin Cancer Res 1999; 5(7):1758-66 Related articles (PubMed)
Medline Search: acute myelogenous leukemia AND (bcl-2 OR bcl2) (PubMed)
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Acute Myeloid Leukaemia Genetics
Acute Myeloid Leukaemia : Clinical and Epidemiological Information
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| BCL2 and Ovarian Cancer
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Baekelandt M, et al. Clinical Significance of Apoptosis-Related Factors p53, Mdm2, and Bcl-2 in Advanced Ovarian Cancer. J Clin Oncol 1999; 17(7):2061 Related articles
Herod JJ, et al. The prognostic significance of Bcl-2 and p53 expression in ovarian carcinoma Cancer Res. 1996; 56(9):2178-84 Related articles (PubMed)
Kassim SK, et al. Increased bcl-2 expression is associated with primary resistance to chemotherapy in human epithelial ovarian cancer Clin Biochem. 1999; 32(5):333-8 Related articles (PubMed)
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Ovarian Ca. Genetics
Ovarian Ca. : Clinical and Epidemiological Information
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| BCL2 and Colorectal Cancer
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Leahy DT, et al. bcl-2 protein expression is associated with better prognosis in colorectal cancer. Histopathology. 1999; 35(4):360-367 Related articles (PubMed)
Kaklamanis L, et al. Bcl-2 protein expression: association with p53 and prognosis in colorectal cancer Br J Cancer. 1998; 77(11):1864-9 Related articles (PubMed)
Manne U, et al. Prognostic significance of Bcl-2 expression and p53 nuclear accumulation in colorectal adenocarcinoma. Int J Cancer. 1997; 74(3):346-58 [Review] Related articles (PubMed)
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ColoRectal Cancers Genetics
ColoRectal Cancers : Clinical and Epidemiological Information
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| BCL2 Expression in Neuroblastoma
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van Golen CM, et al. IGF-I receptor activation and BCL-2 overexpression prevent early apoptotic events in human neuroblastoma. Cell Death Differ. 2000 Jul;7(7):654-665. Related articles (PubMed)
Hanada M, et al. Regulation of Bcl-2 oncoprotein levels with differentiation of human neuroblastoma cells. Cancer Res. 1993; 53(20):4978-86 (PubMed)
Castle VP, et al. Expression of the apoptosis-suppressing protein bcl-2, in neuroblastoma is associated with unfavorable histology and N-myc amplification Am J Pathol. 1993; 143(6):1543-50 Related articles (PubMed)
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Neuroblastoma Genetics
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| BCL2 and Lung Cancer
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Brambilla E, et al. p53 mutant immunophenotype and deregulation of p53 transcription pathway (Bcl2, Bax, and Waf1) in precursor bronchial lesions of lung cancer. Clin Cancer Res. 1998 ;4(7):1609-18 Related articles (PubMed)
Fontanini G, et al. Bcl2 and p53 regulate vascular endothelial growth factor (VEGF)-mediated angiogenesis in non-small cell lung carcinoma. Eur J Cancer. 1998; 34(5):718-23 Related articles (PubMed)
Ohmori T, et al. Apoptosis of lung cancer cells caused by some anti-cancer agents (MMC, CPT-11, ADM) is inhibited by bcl-2. Biochem Biophys Res Commun. 1993; 192(1):30-6 Related articles (PubMed)
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Lung Cancer Genetics
Lung Cancer : Clinical and Epidemiological Information
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| BCL2 and Hodgkin's Disease
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Smolewski P, et al. Expression of proliferating cell nuclear antigen (PCNA) and p53, bcl-2 or C-erb B-2 proteins on Reed-Sternberg cells: prognostic significance in Hodgkin's disease Neoplasma. 1998;45(3):140-7. Related articles (PubMed)
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Hodgkin's Disease : Clinical and Epidemiological Information
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[Home] This page created: 09/10/1999 Last revised: 29/04/2003 © Copyright 1999-
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