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  Chromosome 18

Genes Linked with Cancer (30)

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 18; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
ADCYAP1 18p11 PACAP-Pituitary Tumors
MC2R 18p11.2 ACTHR-Adrenocortical Cancer
RALBP1 18p11.3 RIP1, RLIP1, RLIP76-Lung Cancer
-Lung Cancer, Non-Small Cell
-Pancreatic Cancer
-Prostate Cancer
YES1 18p11.31-p11.21 Yes, c-yes, HsT441, P61-YES-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Melanoma
TYMS 18p11.32 TS, TMS, HST422-Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Colorectal Cancer
-Stomach Cancer
EPB41L3 18p11.32 4.1B, DAL1, DAL-1-Breast Cancer
-Cervical Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
GATA6 18q11.1-q11.2 -Adrenocortical Cancer
-Ovarian Cancer
-Pancreatic Cancer
-Rectal Cancer
-Stomach Cancer
ROCK1 18q11.1 ROCK-I, P160ROCK-Breast Cancer
-Lung Cancer
-Prostate Cancer
-Stomach Cancer
CDH2 18q11.2 CDHN, NCAD, CD325, CDw325-Breast Cancer
-Cervical Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Prostate Cancer
-Testicular Cancer
MIB1 18q11.2 MIB, DIP1, ZZZ6, DIP-1, LVNC7, ZZANK2-Brain Tumours, Childhood
-Breast Cancer
-Cervical Cancer
-Pheochromocytoma and Paraganglioma
-Salivary Gland Cancer
-Testicular Cancer
IMPACT 18q11.2-q12.1 RWDD5-Acute Myeloid Leukaemia
-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Ovarian Cancer
-Prostate Cancer
ZNF521 18q11.2 EHZF, Evi3Somatic-Acute Lymphocytic Leukaemia (ALL)
-Medulloblastoma
RBBP8 18q11.2 RIM, COM1, CTIP, JWDS, SAE2, SCKL2-Breast Cancer
-Ovarian Cancer
SS18 18q11.2 SYT, SSXTSomatic
Translocation
-Synovial Sarcoma
MBD2 18q21 DMTase, NY-CO-41-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Prostate Cancer
-Stomach Cancer
-Uterine Sarcoma
MALT1 18q21 MLT, MLT1, IMD12Somatic
Translocation
-MALT Lymphoma
-Lung Cancer
-Skin Cancer
-Stomach Cancer
MBD1 18q21 RFT, PCM1, CXXC3-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Pancreatic Cancer
-Prostate Cancer
SMAD7 18q21.1 CRCS3, MADH7, MADH8-Breast Cancer
-Colorectal Cancer
-Pancreatic Cancer
-Stomach Cancer
-Uterine Sarcoma
SMAD4 18q21.1 JIP, DPC4, MADH4, MYHRSGermline & Somatic-Adenomatous Polyposis Coli
-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Pancreatic Cancer
-Stomach Cancer
SMAD2 18q21.1 JV18, MADH2, MADR2, JV18-1, hMAD-2, hSMAD2-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Eye Cancer
-Lung Cancer
-Pancreatic Cancer
-Uterine Sarcoma
TCF4 18q21.1 E2-2, ITF2, PTHS, SEF2, ITF-2, SEF-2, TCF-4, SEF2-1, SEF2-1A, SEF2-1B, SEF2-1D, bHLHb19-Colorectal Cancer
-Liver Cancer
POLI 18q21.1 RAD30B, RAD3OB-Acute Myeloid Leukaemia
-Brain Tumours, Childhood
-Cervical Cancer
-Lung Cancer
-Thyroid Cancer
SERPINB2 18q21.3 PAI, PAI2, PAI-2, PLANH2, HsT1201-Lung Cancer
-Prostate Cancer
BCL2 18q21.3 Bcl-2, PPP1R50Somatic
Translocation
-Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Cervical Cancer
-Childhood Cancers
-Lung Cancer
-Non-Hodgkin Lymphoma
DCC 18q21.3 CRC18, CRCR1, MRMV1, IGDCC1, NTN1R1-Colorectal Cancer
-Stomach Cancer
-Testicular Cancer
KDSR 18q21.3 DHSR, FVT1, SDR35C1Somatic
SERPINB5 18q21.33 PI5, maspin-Breast Cancer
-Lung Cancer
-Ovarian Cancer
-Prostate Cancer
-Stomach Cancer
PHLPP1 18q21.33 SCOP, PHLPP, PLEKHE1-Prostate Cancer
TNFRSF11A 18q22.1 FEO, OFE, ODFR, OSTS, PDB2, RANK, CD265, OPTB7, TRANCER, LOH18CR1-Breast Cancer
-Lung Cancer
-Multiple Myeloma
-Osteosarcoma
-Prostate Cancer
NFATC1 18q23 NFAT2, NFATc, NF-ATCSomatic
Translocation
-Bone Cancer (primary)
-Multiple Myeloma
-Pancreatic Cancer

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 18:

Abnormality Type Gene(s)
18q Loss in Colorectal CancerDeletion
18q LOH in Osteosarcoma and Paget's Disease of BoneLOH
t(14;18)(q32;q21) in Acute Lymphoblastic LeukaemiaTranslocationBCL2 (18q21.3)
t(14;18)(q32;q21) in Non-Hodgkin's LymphomaTranslocationBCL2 (18q21.3)
t(18;22)(q23;q12) EWSR1-NFATC1 fusion in hemangioma of the boneTranslocationNFATC1 (18q23)EWSR1 (22q12.2)
t(X;18)(p11.2;q11.2) SS18-SSX1 in Synovial SarcomaTranslocationSS18 (18q11.2)SSX1 (Xp11.23)
t(X;18)(p11.2;q11.2) SS18-SSX2 in Synovial SarcomaTranslocationSS18 (18q11.2)SSX2 (Xp11.22)
t(X;18)(p11.2;q11.2) SS18-SSX4 in Synovial SarcomaTranslocationSS18 (18q11.2)SSX4 (Xp11.23)
t(11;18)(q21;q21) MALT1-API2 in MALT lymphomasTranslocationMALT1 (18q21)BIRC3 (11q22)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


Further Resources (2 links)

Further Resources


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Cite this page: Cotterill SJ. Chromosome 18, Cancer Genetics Web: http://www.cancerindex.org/geneweb/clinkc18.htm Accessed: date

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