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  Chromosome 18

Genes Linked with Cancer

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 18; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
ADCYAP1 18p11 PACAP-Pituitary Tumors
MC2R 18p11.2 ACTHR
YES1 18p11.31-p11.21 Yes, c-yes, HsT441, P61-YES
ZNF521 18q11.2 EHZF, Evi3Somatic
SS18 18q11.2 SYT, SSXTSomatic
Translocation
-Synovial Sarcoma
RBBP8 18q11.2 RIM, COM1, CTIP, JWDS, SAE2, SCKL2-Breast Cancer
-Ovarian Cancer
MALT1 18q21 MLT, MLT1, IMD12Somatic
Translocation
-MALT Lymphoma
SMAD2 18q21.1 JV18, MADH2, MADR2, JV18-1, hMAD-2, hSMAD2
SMAD4 18q21.1 JIP, DPC4, MADH4, MYHRSGermline & Somatic
BCL2 18q21.3 Bcl-2, PPP1R50Somatic
Translocation
-Acute Lymphocytic Leukaemia (ALL) - adult
-Non-Hodgkin Lymphoma
DCC 18q21.3 CRC18, CRCR1, MRMV1, IGDCC1
KDSR 18q21.3 DHSR, FVT1, SDR35C1Somatic
SERPINB5 18q21.33 PI5, maspin-Breast Cancer
-Lung Cancer
-Ovarian Cancer
-Prostate Cancer
-Stomach Cancer
TNFRSF11A 18q22.1 FEO, OFE, ODFR, OSTS, PDB2, RANK, CD265, OPTB7, TRANCER, LOH18CR1
NFATC1 18q23 NFAT2, NFATc, NF-ATCSomatic
Translocation
-Bone Cancer (primary)

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 18:

Abnormality Type Gene(s)
18q Loss in Colorectal CancerDeletion
18q LOH in Osteosarcoma and Paget's Disease of BoneLOH
t(14;18)(q32;q21) in Acute Lymphoblastic LeukaemiaTranslocationBCL2 (18q21.3)
t(14;18)(q32;q21) in Non-Hodgkin's LymphomaTranslocationBCL2 (18q21.3)
t(18;22)(q23;q12) EWSR1-NFATC1 fusion in hemangioma of the boneTranslocationNFATC1 (18q23)EWSR1 (22q12.2)
t(X;18)(p11.2;q11.2) SS18-SSX1 in Synovial SarcomaTranslocationSS18 (18q11.2)SSX1 (Xp11.23)
t(X;18)(p11.2;q11.2) SS18-SSX2 in Synovial SarcomaTranslocationSS18 (18q11.2)SSX2 (Xp11.22)
t(X;18)(p11.2;q11.2) SS18-SSX4 in Synovial SarcomaTranslocationSS18 (18q11.2)SSX4 (Xp11.23)
t(11;18)(q21;q21) MALT1-API2 in MALT lymphomasTranslocationMALT1 (18q21)BIRC3 (11q22)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


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