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    t(X;18)(p11.2;q11.2) in Synovial Sarcoma
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SSXT; Synovial sarcoma, translocated to X chromosome

Location: 18q11.2
Alias: SYT

Seen in t(x;18) tranlocations which are frequent in synovial sarcomas (ssxt-ssx1 or ssxt-ssx2)

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Medline Search: cancer AND gene AND (SSXT[TI] OR SYT[TI]) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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A SYT-SSX fusion gene resulting from the chromosomal translocation t(X;18)(p11;q11) is characteristic of synovial sarcomas. This translocation fuses the SSXT (SYT) gene from chromosome 18 to either of two homologous genes at Xp11, SSX1 or SSX2.

Crew AJ, et al. Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma. EMBO J 1995 May 15;14(10):2333-40    Related articles (PubMed)

de Leeuw B, et al. Identification of two alternative fusion genes, SYT-SSX1 and SYT-SSX2, in t(X;18)(p11.2;q11.2)-positive synovial sarcomas. Hum Mol Genet 1995; 4(6):1097-9    Related articles (PubMed)

Kawai A, et al. SYT-SSX gene fusion as a determinant of morphology and prognosis in synovial sarcoma. N Engl J Med 1998; 338(3):153-60    Related articles (PubMed)

Medline Search: synovial sarcoma AND (syt OR ssxt) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

Related Resources

SSX1 gene

SSX2 gene
Synovial Sarcoma Genetics
Synovial Sarcoma : Clinical and Epidemiological Information

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