Adult Soft Tissue Sarcoma - Genetics

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Adult Soft Tissue Sarcoma
Mutated Genes and Abnormal Protein Expression (11) Recurrent Chromosome Abnormalities (3) Overview of Soft Tissue Sarcoma Genetics Gastrointestinal Stromal Tumours (GIST) der(17)t(X;17) (p11.2;q25) in Alveolar Soft-Part Sarcoma Adult Soft Tissue Sarcoma: Clinical and Epidemiological Resources

Mutated Genes and Abnormal Protein Expression
Gene	Location	Topics
KIT ( CD117 , SCFR , cKit )	4p11-q22	-KIT and Gastrointestinal Stromal Tumours
CDKN2A ( P16 , INK4A , MTS1 )	9p21	-CDKN2A and Soft Tissue Sarcoma
SAS	12q13-q14
DDIT3 ( CHOP , GADD153 , CHOP10 )	12q13.1-q13.2	-t(12;16)(q13;p11) in Mixoid Liposarcoma
HMGIC	12q15	-HMGIC and Sarcomas
FUS ( TLS )	16p11.2	-t(12;16)(q13;p11) in Mixoid Liposarcoma
TP53 ( p53 , P53 )	17p13.1	-TP53 and Soft Tissue Sarcoma -TP53 in Other Soft Tissue Sarcoma
SSXT ( SYT )	18q11.2	-t(X;18)(p11.2;q11.2) in Synovial Sarcoma
ELK1	Xp11.2	-ELK1 Located Near the t(X;18) Breakpoint in Synovial Sarcoma
SSX1	Xp11.2	-SSX1 and Synovial Sarcoma
SSX2 ( HD21 , SSX )	Xp11.23-Xp11.22	-SSX2 and Synovial Sarcoma

Recurrent Chromosome Abnormalities
t(12;16)(q13;p11) in Mixoid Liposarcoma t(X;18)(p11.2;q11.2) in Synovial Sarcoma der(17)t(X;17) (p11.2;q25) in Alveolar Soft-Part Sarcoma Related links: Recurrent Chromosome Abnormalities - Synovial sarcoma (Cancer Genome Anatomy Project) Recurrent Chromosome Abnormalities - Liposarcoma (Cancer Genome Anatomy Project)

Overview of Soft Tissue Sarcoma Genetics
Bennicelli JL, Barr FG Genetics and the biologic basis of sarcomas. [Review] Curr Opin Oncol 1999;11(4):267-74 Related articles (PubMed) *Medline Search:* soft tissue sarcoma AND genetics (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Adult Soft Tissue Sarcoma Genetics Adult Soft Tissue Sarcoma : Clinical and Epidemiological Information
Gastrointestinal Stromal Tumours (GIST)
Miettinen M, et al. Gastrointestinal stromal tumors: recent advances in understanding of their biology. Hum Pathol 1999;30(10):1213-20 Related articles (PubMed) *Medline Search:* gastrointestinal stromal tumor AND genetics (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Adult Soft Tissue Sarcoma Genetics Adult Soft Tissue Sarcoma : Clinical and Epidemiological Information
der(17)t(X;17) (p11.2;q25) in Alveolar Soft-Part Sarcoma
Joyama S, et al. Chromosome rearrangement at 17q25 and xp11.2 in alveolar soft-part sarcoma: A case report and review of the literature. Cancer 1999; 86(7):1246-50 Related articles (PubMed) *Medline Search:* alveolar soft-part sarcoma AND genetics (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Adult Soft Tissue Sarcoma Genetics Adult Soft Tissue Sarcoma : Clinical and Epidemiological Information Chromosme 17 Chromosme X
Overview of Synovial Sarcoma Genetics
A SYT-SSX fusion gene resulting from the chromosomal translocation t(X;18)(p11;q11) is characteristic of synovial sarcomas. This translocation fuses the SSXT (SYT) gene from chromosome 18 to either of two homologous genes at Xp11, SSX1 or SSX2. *Medline Search:* synovial sarcoma AND genetics (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Synovial Sarcoma Genetics Synovial Sarcoma : Clinical and Epidemiological Information
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