Summary Information - PDGFRB
    Gene Database Entries for PDGFRB
    Other PDGFRB Related Resources
    t(5;12)(q33;p13) in Chronic Myelomonocytic Leukemia
    PDGFRB and Neurofibrosarcoma
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PDGFRB; Platelet-derived growth factor receptor, beta polypeptide

Location: 5q31-q32

Aliases: JTK12, PDGFR

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OMIM
GeneCard (Weizmann Institute)
Tumor Gene Database
Genbank
Swiss-Prot
Locus Link (search for PDGFRB)
UniGene
GenAtlas
GDB
Nomenclature (search for PDGFRB)

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Search Medline for related articles (PubMed)

Medline Search: cancer AND gene AND (PDGFRB[TI] OR JTK12[TI] OR PDGFR[TI]) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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Chronic myelomonocytic leukaemia (CMML) is a myelodysplastic syndrome and is characterized dysplastic monocytosis, hypercellular bone marrow, splenomegaly, and progression to acute myelogenous leukemia (AML). A sub-set of CMMLs have a t(5;12)(q33;p13) balanced translocation involving the PDGFRB and ETV6 (TEL) genes.

Golub TR, et al. Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 1994; 77(2):307-16    Related articles (PubMed)

Carroll M, et al. The TEL/platelet-derived growth factor beta receptor (PDGF beta Proc Natl Acad Sci USA. 1996; 93(25):14845-50    Related articles

Medline Search: chronic myelomonocytic leukemia AND (pdgfr OR pdgfrb) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

Related Resources
Leukaemia Genetics
Leukaemia : Clinical and Epidemiological Information

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Badache A, De Vries GH Neurofibrosarcoma-derived Schwann cells overexpress platelet-derived growth factor (PDGF) receptors and are induced to proliferate by PDGF BB. J Cell Physiol 1998;177(2):334-42    Related articles (PubMed)

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