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CAV1; Caveolin 1 caveolae protein, 22kD

Location: 7q31.1
Alias: Caveolin-1

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Medline Search: cancer AND gene AND (CAV1[TI] OR Caveolin-1[TI]) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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Caveolin-1 is overexpressed in some human prostate cancers. Animal studies suggest that suppression of caveolin expression induces androgen sensitivity in high-caveolin, androgen-insensitive prostate cancer cells. Caveolin-1 may be a a candidate gene for hormone-resistant prostate cancer. In a study of 189 confined prostate cancers (Yang, 1999) 25% were positive for caveolin-1 immunostaining, and caveolin-1 was found to be a significant prognostic factor.

Thompson TC Metastasis-related genes in prostate cancer: the role of caveolin-1. [Review] Cancer Metastasis Rev 1998-99;17(4):439-42    Related articles (PubMed)

Yang G,et al. Caveolin-1 expression in clinically confined human prostate cancer: a novel prognostic marker. Cancer Res 1999; 59(22):5719-23    Related articles (PubMed)

Medline Search: prostate cancer AND caveolin (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

Related Resources
Prostate Cancer Genetics
Prostate Cancer : Clinical and Epidemiological Information

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