Summary Information - FYN
    Gene Database Entries for FYN
    Other FYN Related Resources
    FYN and Cancer
    Feedback / suggest a new topic for FYN

FYN; FYN oncogene related to SRC, FGR, YES

Location: 6q21

Overview: FYN has approximately 80% homology with the YES1 and FGR genes. It was first dentified by Semba et al. (1986) by genomic screening with a YES1 gene probe as a member of the tyrosine kinase oncogene family. They went on to find that FYN had high levels of expression in methylcholanthrene-induced fibrosarcoma cells compared to the parent clone (Semba, 1993). Mice administered FYN-transfected cells had significantly increased metastatic nodules compared to controls (Semba, 1993).

Return to FYN Contents
 

OMIM
GeneCard (Weizmann Institute)
Tumor Gene Database
Swiss-Prot
Locus Link
UniGene
GenAtlas
GDB
Nomenclature (search for FYN)

Return to FYN Contents
 

Search Medline for related articles (PubMed)

Medline Search: cancer AND gene AND FYN[TI] (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

Return to FYN Contents
 

Takayama T, et al. A role for the fyn oncogene in metastasis of methylcholanthrene-induced fibrosarcoma A cells. Int J Cancer 1993 Jul 9;54(5):875-9    Related articles (PubMed)

Kawakami Y, et al. Identification of fyn-encoded proteins in normal human blood cells. Oncogene 1989 Mar;4(3):389-91    Related articles (PubMed)

Kawakami T, et al. Acquisition of transforming properties by FYN, a normal SRC-related human gene. Proc Natl Acad Sci U S A 1988 Jun;85(11):3870-4    Related articles (PubMed)

Semba K, et al. yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family. Proc Natl Acad Sci USA 1986 Aug;83(15):5459-63    Related articles (PubMed)

Return to FYN Contents