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  IntraOcular Melanoma

Mutated Genes and Abnormal Protein Expression (4)
Overview of Intraocular Melanoma Genetics
Familial Clustering of Uveal Melanoma
IntraOcular Melanoma: Clinical and Epidemiological Resources
  Mutated Genes and Abnormal Protein Expression
GeneLocationTopics
CDKN2A ( P16 , INK4A , MTS1 ) 9p21 -CDKN2A Mutations in Ocular Melanoma
BRCA213q12.3 -BRCA2 and Ocular Melanoma
RBL2 ( RB2 , P130 ) 16q12.2 -RBL2 and Ocular Melanoma
PCNA20p12 -PCNA and Ocular Melanoma

 

  Overview of Intraocular Melanoma Genetics

  • Bataille V, et al. Genetics of Risk Factors for Melanoma: an Adult Twin Study of Nevi and Freckles J Natl Cancer Inst. 2000; 92(6): 457-463    Related articles

  • Chana JS, et al. c-myc, p53, and Bcl-2 expression and clinical outcome in uveal melanoma. Br J Ophthalmol 1999; 83(1):110-4    Related articles (PubMed)

  • Houlston RS, Damato BE Genetic predisposition to ocular melanoma. Eye 1999; 13 (1):43-6    Related articles (PubMed)

  • Medline Search: ocular melanoma AND genetics (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    IntraOcular Melanoma Genetics
    IntraOcular Melanoma : Clinical and Epidemiological Information

     

  •   Familial Clustering of Uveal Melanoma

    Some studies have shown a modest increased risk of uveal melanoma in people with relatives diagnosed with this condition. However, it is not clear if this represents hereditary genetic risk factors (as yet unidentified) or common exposure to environmental factors.

  • Soufir N, et al. Individuals with presumably hereditary uveal melanoma do not harbour germline mutations in the coding regions of either the P16INK4A, P14ARF or cdk4 genes Br J Cancer 2000 Feb;82(4):818-22    Related articles (PubMed)

  • Singh AD, et al. Familial uveal melanoma, III. Is the occurrence of familial uveal melanoma coincidental?. Arch Ophthalmol 1996 Sep;114(9):1101-4    Related articles (PubMed)

  • Singh AD, et al. Familial uveal melanoma. Clinical observations on 56 patients. Arch Ophthalmol 1996 Apr;114(4):392-9    Related articles (PubMed)

  • Medline Search: familial uveal melanoma (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    IntraOcular Melanoma Genetics
    IntraOcular Melanoma : Clinical and Epidemiological Information

     

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