 Summary Information
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Location: 13q12.3
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| Gene Database Entries for BRCA2
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OMIM
GeneCard (Weizmann Institute)
Human Gene Mutation Database (Cardiff, UK)
Tumor Gene Database
Swiss-Prot
Locus Link
UniGene
GenAtlas
GDB
Nomenclature (search for BRCA2)
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| Other Related Resources
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BRCA1 and BRCA2 Hereditary Breast Cancer (University of Washington) part of the NCI funded Geneclinics.org site. Details of BRCA1 and BRCA2 breast cancer, risk assessment, diagnosis, management, molecular biology, genetic counseling, resources, references etc
BRCA1 / BRCA2 in Breast and Ovarian Cancer (National Center for Biotechnology Information) an overview of the BRCA1 and BRCA2 genes with links to other gene databases.
CancerGene - computer program (University of Texas / Duke University) for health professionals: a computer program for estimating the likelihood that a family carries a mutation in one of the cancer predisposition genes BRCA1, BRCA2, MSH2 or MLH1
 Breast Cancer Resources
Ovarian Cancer Resources
BRCA1 Resources
Medline Search: BRCA2 (PubMed)
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- Medline Search: cancer AND gene AND BRCA2[TI] (PubMed)
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| BRCA2 and Breast Cancer
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Spain BH, et al. Truncated BRCA2 is cytoplasmic: Implications for cancer-linked mutations Proc Natl Acad Sci USA. 1999; 96(24):13920-5 Related articles
Wooster R, et al, Identification of the breast cancer susceptibility gene BRCA2. Nature 1995; 378(6559):789-92 Related articles (PubMed)
Miki Y, et al. Mutation analysis in the BRCA2 gene in primary breast cancers Nat Genet 1996; 13(2):245-7 Related articles (PubMed)
Medline Search: BRCA2 AND breast cancer (PubMed)
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Breast Cancer Genetics
Breast Cancer : Clinical and Epidemiological Information
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| BRCA2 in Familial Breast Cancer
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Malone KE, et al. Frequency of BRCA1/BRCA2 mutations in a population-based sample of young breast carcinoma cases. Cancer 2000;88(6):1393-1402 Related articles (PubMed)
Thorlacius S, et al. A single BRCA2 mutation in male and female breast cancer families from Iceland with varied cancer phenotypes Nat Genet. 1996; 13(1):117-9 Related articles (PubMed)
Couch FJ, et al. BRCA2 germline mutations in male breast cancer cases and breast cancer families. Nat Genet 1996; 13(1):123-5 Related articles (PubMed)
Medline Search: BRCA2 AND familial breast cancer (PubMed)
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- BRCA1 gene
Breast Cancer Genetics
Breast Cancer : Clinical and Epidemiological Information
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| BRCA2 and Outcome in Breast Cancer
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Verhoog LC, et al. Survival in Hereditary Breast Cancer Associated With Germline Mutations of BRCA2. J Clin Oncol 1999; 17(11):3396-3402 Related articles
Phillips KA, et al. Breast Carcinomas Arising in Carriers of Mutations in BRCA1 or BRCA2: Are They Prognostically Different? [Review] J Clin Oncol. 1999; 17(11):3653-3663 Related articles
Medline Search: BRCA2 AND breast cancer AND survival (PubMed)
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Breast Cancer Genetics
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| BRCA2 and Breast Cancer During Pregnancy
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Jernstrom H, et al. Pregnancy and risk of early breast cancer in carriers of BRCA1 and BRCA2. Lancet. 1999; 354(9193):1846-50. Related articles (PubMed)
Shen T, et al. High frequency of allelic loss of BRCA2 gene in pregnancy-associated breast carcinoma. J Natl Cancer Inst. 1999; 91(19):1686-7 Related articles
Medline Search: BRCA2 AND pregnancy (PubMed)
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| Prophylactic Treatments for Women with BRAC2 mutations
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Lu KH, et al. Occult Ovarian Tumors in Women With BRCA1 or BRCA2 Mutations Undergoing Prophylactic Oophorectomy J Clin Oncol 2000: 18:2728-2732
Eisen A, et al. Prophylactic Surgery in Women With a Hereditary Predisposition to Breast and Ovarian Cancer. [Review] J Clin Oncol 2000 May 9;18(9):1980-1995 Related articles (PubMed)
Schrag D, et al. Life expectancy gains from cancer prevention strategies for women with breast cancer and BRCA1 or BRCA2 mutations. JAMA 2000; 283(5):617-24 Related articles (PubMed)
Schrag D, et al. Decision analysis--effects of prophylactic mastectomy and oophorectomy on life expectancy among women with BRCA1 or BRCA2 mutations. N Engl J Med 1997; 336(20):1465-71 Related articles (PubMed)
Medline Search: BRCA2 AND prophylactic treatment (PubMed)
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| BRCA2 and Ovarian Cancer
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Boyd J, et al. Clinicopathologic Features of BRCA-Linked and Sporadic Ovarian Cancer JAMA. 2000;283:2260-2265
Gayther SA. et al. The Contribution of Germline BRCA1 and BRCA2 Mutations to Familial Ovarian Cancer: No Evidence for Other Ovarian Cancer-Susceptibility Genes. Am J Hum Genet 1999; 65:1021-1029 Related articles (PubMed)
Foster KA, et al. Somatic and germline mutations of the BRCA2 gene in sporadic ovarian cancer. Cancer Res. 1996; 56:3622-5 Related articles (PubMed)
Medline Search: BRCA1 AND ovarian cancer (PubMed)
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Ovarian Ca. Genetics
Ovarian Ca. : Clinical and Epidemiological Information
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| BRCA2 and Pancreatic Cancer
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Germline mutations of the BRCA2 gene are estimated to be present in 5-10% of patients with pancreatic cancer.
Goggins M. et al Progress in cancer genetics: lessons from pancreatic cancer. Ann Oncol 1999;10 Suppl 4:4-8 [Review] Related articles (PubMed)
Goggins M, et al. Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas. Cancer Res. 1996; 56(23):5360-4 Related articles (PubMed)
Medline Search: BRCA2 AND pancreatic cancer (PubMed)
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Pancreatic Cancer Genetics
Pancreatic Cancer : Clinical and Epidemiological Information
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| BRCA2 and Ocular Melanoma
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Sinilnikova OM, et al. Germline brca2 sequence variants in patients with ocular melanoma. Int J Cancer 1999; 82(3):325-8 Related articles (PubMed)
Houlston RS, Damato BE Genetic predisposition to ocular melanoma. Eye 1999; 13 (1):43-6 Related articles (PubMed)
Medline Search: ocular melanoma AND BRAC2 (PubMed)
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IntraOcular Melanoma Genetics
IntraOcular Melanoma : Clinical and Epidemiological Information
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