Mutated Genes and Abnormal Protein Expression (23)
Recurrent Chromosome Abnormalities (2)
Overview of the Molecular Genetics of Ovarian Cancer
LOH Chromosome 17 in Ovarian Carcinoma
Microsatellite Instability in Ovarian Tumours
Ovarian Ca.: Clinical and Epidemiological Resources

LOH in 6q27 in Serous Ovarian Carcinoma
LOH Chromosome 17 in Ovarian Carcinoma

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Recurrent Chromosome Abnormalities - Ovary (Cancer Genome Anatomy Project)

Approximately 10% of all epithelial ovarian carcinomas are associated with autosomal dominant genetic predisposition, primarily by inherited mutations in the BRCA1 or BRCA2 tumour supressor genes (Boyd 1998). Mutations of these genes are also seen in some sporadic ovarian cancers. Other genetic features tend to relate to specific types of ovarian cancer;

Invasive serous and undifferentiated ovarian carcinomas are characterized by TP53 mutations and TP53 protein accumulation. Loss of genetic material from chromosome 17 is also common.

Overexpression of BCL2 is seen in most endometrioid carcinomas (90% of cases). These tumours can also show microsatellite instability

KRAS mutations are characteristic for mucinous carcinomas (40-50% of cases). In mucinous tumors with low malignant potential (LMP) KRAS mutations are less frequent ( about 30% of cases).

Diebold J Molecular genetics of ovarian carcinomas Histol Histopathol 1999; 14(1):269-77    Related articles (PubMed)

Stratton JF, et al. The genetic epidemiology of early-onset epithelial ovarian cancer: a population-based study. Am J Hum Genet 1999;65(6):1725-32    Related articles (PubMed)

Boyd J Molecular genetics of hereditary ovarian cancer. [Review] Oncology (Huntingt) 1998 Mar;12(3):399-406    Related articles (PubMed)

Pieretti M, et al. Genetic alterations distinguish different types of ovarian tumors. Int J Cancer 1995; 64(6):434-40    Related articles (PubMed)

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Ovarian Ca. Genetics
Ovarian Ca. : Clinical and Epidemiological Information

 

Chenevix-Trench G, et al. Analysis of loss of heterozygosity and KRAS2 mutations in ovarian neoplasms: clinicopathological correlations. Genes Chromosomes Cancer 1997; 18(2):75-83    Related articles (PubMed)

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Chromosme 17

 

Haas CJ, et al. Microsatellite analysis in serous tumors of the ovary Int J Gynecol Pathol 1999; 18(2):158-62    Related articles (PubMed)

Medline Search: microsatellite instability AND ovarian tumors (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

Ovarian Ca. Genetics
Ovarian Ca. : Clinical and Epidemiological Information