Gene mutations in TSG101 are found in breast cancer and other types of neoplasm suggesting that defects in these genes my have a role in tumor development. However, the significance of TSG101 alterations in carcinogenesis is controversial since aberrant
transcripts of TSG101 gene have also been identified in normal non-cancerous tissues (see Wang et al. 1999 and others). TSG101 abnormalities in breast cancer were shown to relate to aberrant splicing (see Lee and Feinberg, 1997) and it was suggested that
the TSG101 abnormalities due to a relaxing of RNA splicing fidelity may be an oncodevelopmental marker.
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