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TSG101; Tumor susceptibility gene 101 (11p15.2-p15.1)
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  Summary Information

TSG101; Tumor susceptibility gene 101

Location: 11p15.2-p15.1

Overview: Gene mutations in TSG101 are found in breast cancer and other types of neoplasm suggesting that defects in these genes my have a role in tumor development. However, the significance of TSG101 alterations in carcinogenesis is controversial since aberrant transcripts of TSG101 gene have also been identified in normal non-cancerous tissues (see Wang et al. 1999 and others). TSG101 abnormalities in breast cancer were shown to relate to aberrant splicing (see Lee and Feinberg, 1997) and it was suggested that the TSG101 abnormalities due to a relaxing of RNA splicing fidelity may be an oncodevelopmental marker.

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  Gene Database Entries for TSG101

GeneCard (Weizmann Institute)
Tumor Gene Database
Locus Link (search for TSG101)
Nomenclature (search for TSG101)

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  Other Related Resources

Search Medline for related articles (PubMed)
  • Medline Search: cancer AND gene AND TSG101[TI] (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]
  • Selected Reference(s) (links to Medline abstracts in PubMed)

    Wang NM, Chang JG Are aberrant transcripts of FHIT, TSG101, and PTEN/MMAC1 oncogenesis related? Int J Mol Med 1999; 3(5):491-5    Related articles

    Li L, et al. The TSG101 tumor susceptibility gene is located in chromosome 11 band p15 and is mutated in human breast cancer. Cell 1997; 88(1):143-54    Related articles

    Xu CF, et al. Truncated TSG101 transcripts are present in peripheral blood from both familial breast cancer patients and controls. Eur J Cancer. 1998; 34(7):1077-80    Related articles

    Lee MP, Feinberg AP Aberrant splicing but not mutations of TSG101 in human breast cancer. Cancer Res 1997; 57(15):3131-4    Related articles

    Chang JG, et al. Analysis of TSG101 tumour susceptibility gene transcripts in cervical and endometrial cancers. Br J Cancer 1999; 79(3-4):445-50    Related articles

    Related Internet Resources

    (Guide to Internet Resources for Cancer)

    Breast Cancer Genetics
    Breast Cancer : Clinical and Epidemiological Information

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