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AR; Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease)

Location: Xq11.2-q12
Alias: DHTR

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OMIM
Human Gene Mutation Database (Cardiff, UK)
Swiss-Prot
Locus Link
UniGene
GDB
Nomenclature (search for AR)

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Medline Search: cancer AND gene AND (AR[TI] OR DHTR[TI]) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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Androgens exert their effects via the androgen receptor (AR). They are essential for the development, growth, and maintenance of the normal prostate. Likewise prostate cancers are dependent on androgens for growth and survival. Therefore, androgen ablation and antiandrogen therapy are important in the treatment of the disease. However, most patients go on to develop resistant androgen-independent prostate cancer. Mutations which alter AR function/regulation may provide a selective growth advantage for a subpopulation of prostate cancer cells enablining them to proliferate in an androgen-deprived environment.

Koivisto PA, Rantala I Amplification of the androgen receptor gene is associated with P53 mutation in hormone-refractory recurrent prostate cancer. J Pathol 1999;187(2):237-41    Related articles (PubMed)

Jenster G. The role of the androgen receptor in the development and progression of prostate cancer. Semin Oncol. 1999; 26(4):407-21. [Review]    Related articles (PubMed)

Cude KJ, et al. The androgen receptor: genetic considerations in the development and treatment of prostate cancer. J Mol Med 1999; 77(5):419-26    Related articles (PubMed)

Giovannucci E, et al. The CAG repeat within the androgen receptor gene and its relationship to prostate cancer. Proc Natl Acad Sci USA 1997; 94(7):3320-3    Related articles (PubMed)

Irvine RA, et al. The CAG and GGC microsatellites of the androgen receptor gene are in linkage disequilibrium in men with prostate cancer. Cancer Res 1995; 55(9):1937-40    Related articles (PubMed)

Related Resources
Prostate Cancer Genetics
Prostate Cancer : Clinical and Epidemiological Information

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