 Summary Information
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Location: 12q22-q24.1
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| Gene Database Entries for IGF1
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OMIM
GeneCard (Weizmann Institute)
Human Gene Mutation Database (Cardiff, UK)
Tumor Gene Database
Genbank
Swiss-Prot
Locus Link (search for IGF1)
UniGene
GenAtlas
GDB
Nomenclature (search for IGF1)
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| Other Related Resources
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- Search Medline for related articles (PubMed)
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- Medline Search: cancer AND gene AND IGF1[TI] (PubMed)
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| IGF1 and Cancer
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Smith GD, et al. Cancer and insulin-like growth factor-I. A potential mechanism linking the environment with cancer risk. BMJ 2000 Oct 7;321(7265):847-848 Related articles (PubMed)
Pollak M Insulin-like growth factor physiology and cancer risk. Eur J Cancer 2000 Jun;36(10):1224-8 Related articles (PubMed)
Grimberg A, et al. Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis. J Cell Physiol 2000 Apr;183(1):1-9 Related articles (PubMed)
Holly JM, et al. Growth hormone, IGF-I and cancer. Less intervention to avoid cancer? More intervention to prevent cancer? J Endocrinol 1999 Sep;162(3):321-30 Related articles (PubMed)
Medline Search: cancer AND (igf1 OR insulin like growth factor 1) (PubMed)
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| IGF1 Expression in Prostate Cancer
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Baffa R, et al. Low serum insulin-like growth factor 1 (IGF-1): a significant association with prostate cancer. Tech Urol 2000 Sep;6(3):236-9 Related articles (PubMed)
Grimberg A, et al. Growth hormone and prostate cancer: guilty by association? J Endocrinol Invest 1999;22(5 Suppl):64-73 Related articles (PubMed)
Wolk A, et al. Insulin-like growth factor 1 and prostate cancer risk: a population-based, case-control study. J Natl Cancer Inst 1998 Jun 17;90(12):911-5 Related articles (PubMed)
Chan JM, et al. Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science 1998 Jan 23;279(5350):563-6 Related articles (PubMed)
Medline Search: prostate cancer AND (igf1 OR insulin like growth factor 1) (PubMed)
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 Prostate Cancer Genetics
Prostate Cancer : Clinical and Epidemiological Information
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| IGF1 Expression in Breast Cancer
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Agurs-Collins T, et al. Insulin-like growth factor-1 and breast cancer risk in postmenopausal African-American women. Cancer Detect Prev 2000;24(3):199-206 Related articles (PubMed)
Perks CM, et al. Insulin-like growth factor binding proteins (IGFBPs) in breast cancer. J Mammary Gland Biol Neoplasia 2000 Jan;5(1):75-84 Related articles (PubMed)
Hankinson SE, et al. Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet 1998 May 9;351(9113):1393-6 Related articles (PubMed)
Medline Search: breast cancer AND (igf1 OR insulin like growth factor 1) (PubMed)
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Breast Cancer Genetics
Breast Cancer : Clinical and Epidemiological Information
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| IGF1 Expression in Lung Cancer
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Yu H, et al. Plasma levels of insulin-like growth factor-I and lung cancer risk: a case-control analysis. J Natl Cancer Inst 1999 Jan 20;91(2):151-6 Related articles (PubMed)
Medline Search: lung cancer AND (igf1 OR insulin like growth factor 1) (PubMed)
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Lung Cancer Genetics
Lung Cancer : Clinical and Epidemiological Information
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| IGF1 Expression in Colorectal Cancer
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Giovannucci E, et al. A prospective study of plasma insulin-like growth factor-1 and binding protein-3 and risk of colorectal neoplasia in women. Cancer Epidemiol Biomarkers Prev 2000 Apr;9(4):345-9 Related articles (PubMed)
Remacle-Bonnet MM, et al. Insulin-like growth factor-I protects colon cancer cells from death factor-induced apoptosis by potentiating tumor necrosis factor alpha-induced mitogen-activated protein kinase and nuclear factor kappaB signaling pathways. Cancer Res 2000 Apr 1;60(7):2007-17 Related articles (PubMed)
Hakam A, et al. Expression of insulin-like growth factor-1 receptor in human colorectal cancer. Hum Pathol 1999 Oct;30(10):1128-33 Related articles (PubMed)
- Related Resources
ColoRectal Cancers Genetics
ColoRectal Cancers : Clinical and Epidemiological Information
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| IGF1 Expression in Thyroid Cancer
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Maiorano E, et al. Insulin-like growth factor 1 expression in thyroid tumors. Appl Immunohistochem Molecul Morphol 2000 Jun;8(2):110-9 Related articles (PubMed)
Medline Search: thyroid cancer AND (igf1 OR insulin like growth factor 1) (PubMed)
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Thyroid Cancer Genetics
Thyroid Cancer : Clinical and Epidemiological Information
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| IGF1 Expression in Hepatocellular Carcinoma
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Stuver SO, et al. Insulin-like growth factor 1 in hepatocellular carcinoma and metastatic liver cancer in men. Int J Cancer 2000 Jul 1;87(1):118-21 Related articles (PubMed)
Medline Search: liver cancer AND (igf1 OR insulin like growth factor 1) (PubMed)
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Hepatocelular Carcinoma Genetics
Hepatocelular Carcinoma : Clinical and Epidemiological Information
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