 Summary Information
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Location: 1q21
Aliases: PUM, PEM
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| Gene Database Entries for MUC1
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OMIM
GeneCard (Weizmann Institute)
Tumor Gene Database
Swiss-Prot
Locus Link
UniGene
GenAtlas
GDB
Nomenclature (search for MUC1)
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| Other Related Resources
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Immuno-Recognition and Targetting Group- Nottingham (Cancer Research Laboratories, University of Nottingham, UK) The group is primarily involved in research into with the immunological interactions of antibodies and mucin, a tumour associated antigen.
 MUC1 gene (1q21)
MUC1 Immunotherapy
Medline Search: MUC1[Title] AND antigen AND cancer (PubMed)
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- Medline Search: cancer AND gene AND (MUC1[TI] OR PUM[TI] OR PEM[TI]) (PubMed)
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| Defining Texts
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Swallow DM, et al. The human tumour-associated epithelial mucins are coded by an expressed hypervariable gene locus PUM. Nature 1987; 328(6125):82-4 Related articles (PubMed)
Gendler SJ, et al. Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin. J Biol Chem 1990; 265(25):15286-93 Related articles (PubMed)
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| MUC1 and Cancer (General)
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Yonezawa S, Sato E Expression of mucin antigens in human cancers and its relationship with malignancy potential. [Review] Pathol Int 1997; 47(12):813-30 Related articles (PubMed)
Medline Search: MUC1[title] AND cancer (PubMed)
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| MUC1 and Breast Cancer
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von Mensdorff-Pouilly S, et al. Survival in Early Breast Cancer Patients Is Favorably Influenced by a Natural Humoral Immune Response to Polymorphic Epithelial Mucin J Clin Oncol 2000;18 574
Seregni E, et al. Hormonal regulation of MUC1 expression. Int J Biol Markers 1999; 14(1):29-35 [Review] Related articles (PubMed)
McGuckin MA, et al. Circulating tumour-associated mucin concentrations, determined by the CASA assay, in healthy women. Clin Chim Acta 1993;214(2):139-51 Related articles (PubMed)
Medline Search: MUC1[title] AND breast cancer (PubMed)
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Breast Cancer Genetics
Breast Cancer : Clinical and Epidemiological Information
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| MUC1 and Gastric Cancer
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Utsunomiya T, et al. Expression of MUC1 and MUC2 mucins in gastric carcinomas: its relationship with the prognosis of the patients. Clin Cancer Res 1998; 4(11):2605-14 Related articles (PubMed)
Carvalho F, et al. MUC1 gene polymorphism and gastric cancer--an epidemiological study. Glycoconj J 1997; 14(1):107-11 Related articles (PubMed)
Medline Search: MUC1[title] AND gastric cancer (PubMed)
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Stomach (Gastric) Cancer Genetics
Stomach (Gastric) Cancer : Clinical and Epidemiological Information
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| MUC1 and Colorectal Cancer
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Tanimoto T, et al. MUC1 expression in intramucosal colorectal neoplasms. Possible involvement in histogenesis and progression. Oncology 1999; 56(3):223-31 Related articles (PubMed)
Hiraga Y, et al. Immunoreactive MUC1 expression at the deepest invasive portion correlates with prognosis of colorectal cancer. Oncology 1998; 55(4):307-19 Related articles (PubMed)
Medline Search: MUC1[title] AND colorectal cancer (PubMed)
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ColoRectal Cancers Genetics
ColoRectal Cancers : Clinical and Epidemiological Information
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| MUC1 and Pancreatic Cancer
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Masaki Y, et al. Sialylated MUC1 mucin expression in normal pancreas, benign pancreatic lesions, and pancreatic ductal adenocarcinoma. Hepatogastroenterology. 1999; 46(28):2240-5 Related articles (PubMed)
Yonezawa S, Sato E Expression of mucin antigens in human cancers and its relationship with malignancy potential. [Review] Pathol Int 1997; 47(12):813-30 Related articles (PubMed)
Medline Search: MUC1[title] AND pancreatic cancer (PubMed)
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| MUC1 and Bladder Cancer
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Walsh MD, et al. Mucin expression by transitional cell carcinomas of the bladder. Br J Urol 1994;73(3):256-62 Related articles (PubMed)
Retz M, et al. Differential mucin MUC7 gene expression in invasive bladder carcinoma in contrast to uniform MUC1 and MUC2 gene expression in both normal urothelium and bladder carcinoma Cancer Res. 1998; 58(24):5662-6 Related articles (PubMed)
Medline Search: MUC1 AND bladder cancer (PubMed)
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Bladder Ca. Genetics
Bladder Ca. : Clinical and Epidemiological Information
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| MUC1 and Lung Cancer
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Nguyen PL, et al. Membrane-bound (MUC1) and secretory (MUC2, MUC3, and MUC4) mucin gene expression in human lung cancer. Tumour Biol 1996; 17(3):176-92 Related articles (PubMed)
Seregni E, et al. Pattern of mucin gene expression in normal and neoplastic lung tissues. Anticancer Res 1996; 16(4B):2209-13 Related articles (PubMed)
Medline Search: MUC1 AND lung cancer (PubMed)
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Lung Cancer Genetics
Lung Cancer : Clinical and Epidemiological Information
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| Autoantibody to MUC1 in NSCLC
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Hirasawa Y, et al. Natural Autoantibody to MUC1 Is a Prognostic Indicator for Non-Small Cell Lung Cancer. Am J Respir Crit Care Med 2000 Feb 1;161(2):589-594 Related articles (PubMed)
- Related Resources
Non-Small Cell Lung Cancer (NSCLC) : Clinical and Epidemiological Information
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| MUC1 and Immunotherapy [Experimental]
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Brossart P, et al. Identification of HLA-A2-restricted T-cell epitopes derived from the MUC1 tumor antigen for broadly applicable vaccine therapies. Blood. 1999; 93(12):4309-17 Related articles (PubMed)
Karanikas V, et al. Antibody and T cell responses of patients with adenocarcinoma immunized with mannan-MUC1 fusion protein. J Clin Invest 1997; 100(11):2783-92 Related articles (PubMed)
Reddish M, et al. Anti-MUC1 class I restricted CTLs in metastatic breast cancer patients immunized with a synthetic MUC1 peptide. Int J Cancer 1998; 76(6):817-23 Related articles (PubMed)
Medline Search: MUC1 AND immunotherapy (PubMed)
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Medline Search: MUC1[title] AND clinical trial AND cancer (PubMed)
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| t(1;14)(q21;q32) and MUC1 Overexpression in NHL
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Gilles F, et al. MUC1 dysregulation as the consequence of a t(1;14)(q21;q32) translocation in an extranodal lymphoma. Blood 2000 May 1;95(9):2930-2936 Related articles (PubMed)
Dyomin VG, et al. MUC1 is activated in a B-cell lymphoma by the t(1;14)(q21;q32) translocation and is rearranged and amplified in B-cell lymphoma subsets. Blood 2000 Apr 15;95(8):2666-71 Related articles (PubMed)
Medline Search: lymphoma AND muc1 AND translocation (PubMed)
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Non-Hodgkin's Lymphoma Genetics
Non-Hodgkin's Lymphoma : Clinical and Epidemiological Information
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[Home] This page created: 18/10/1999 Last revised: 29/04/2003 © Copyright 1999-
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