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  Chromosome 1

Genes Linked with Cancer (90)

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 1; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
FAM46C 1p12 Somatic
RBM15 1p13 OTT, OTT1, SPENSomatic
Translocation
-Leukaemia
NOTCH2 1p13-p11 hN2, AGS2, HJCYSSomatic-Brain and CNS Tumours
-Breast Cancer
TRIM33 1p13.1 ECTO, PTC7, RFG7, TF1G, TIF1G, TIFGAMMA, TIF1GAMMASomatic
RHOC 1p13.1 H9, ARH9, ARHC, RHOH9Many cancer types including:
-Breast Cancer
-Liver Cancer
-Lung Cancer
-Melanoma
-Ovarian Cancer
-Pancreatic Cancer
NRAS 1p13.2 NS6, CMNS, NCMS, ALPS4, N-ras, NRAS1SomaticMany cancer types including:
-Acute Myeloid Leukaemia
-Bowel Cancer
-Childhood Cancers
-Leukaemia
-Melanoma
-Rhabdomyosarcoma
-Skin Cancer
-Thyroid Cancer
RAP1A 1p13.3 RAP1, C21KG, G-22K, KREV1, KREV-1, SMGP21-Breast Cancer
-Lung Cancer
-Thyroid Cancer
GSTM1 1p13.3 MU, H-B, GST1, GTH4, GTM1, MU-1, GSTM1-1, GSTM1a-1a, GSTM1b-1bMany cancer types including:
-Acute Lymphocytic Leukemia (ALL), child
-Bladder Cancer
-Bowel Cancer
-Breast Cancer
-Head and Neck Cancers
-Lung Cancer
-Oral Cavity Cancer
-Prostate Cancer
-Thyroid Cancer
DPYD 1p22 DHP, DPD, DHPDHASE
BCL10 1p22 CLAP, mE10, CIPER, c-E10, CARMENSomatic
Translocation
-MALT Lymphoma
GFI1 1p22 SCN2, GFI-1, GFI1A, ZNF163-Leukaemia
FUBP1 1p31.1 FBP, FUBPSomatic-Brain Tumours, Childhood
TAL1 1p32 SCL, TCL5, tal-1, bHLHa17Somatic-Acute Lymphocytic Leukaemia (ALL) - adult
-Acute Lymphocytic Leukemia (ALL), child
JUN 1p32-p31 AP1, AP-1, c-JunSomatic
TACSTD2 1p32 EGP1, GP50, M1S1, EGP-1, TROP2, GA7331, GA733-1-Bladder Cancer
-Bowel Cancer
-Breast Cancer
-Ovarian Cancer
-Prostate Cancer
RAD54L 1p32 HR54, hHR54, RAD54A, hRAD54
EPS15 1p32 AF1P, AF-1P, MLLT5Somatic
Translocation
-Acute Myeloid Leukaemia
CDKN2C 1p32 p18, INK4C, p18-INK4CSomatic
BLYM 1p32
STIL 1p32 SIL, MCPH7Somatic-Acute Lymphocytic Leukaemia (ALL) - adult
-Acute Lymphocytic Leukemia (ALL), child
JAK1 1p32.3-p31.3 JTK3, JAK1A, JAK1BSomatic
MPL 1p34 MPLV, TPOR, C-MPL, CD110, THCYT2Germline & Somatic-Acute Myeloid Leukaemia
-Leukaemia
-Myeloproliferative Disorders
MUTYH 1p34.1 MYH, CYP2CGermline
MYCL 1p34.2 LMYC, MYCL1, bHLHe38Somatic
SLC2A1 1p34.2 PED, DYT9, GLUT, DYT17, DYT18, EIG12, GLUT1, HTLVR, GLUT-1, GLUT1DS-Breast Cancer
-Cervical Cancer
-Kidney Cancer
-Lung Cancer
-Prostate Cancer
-Soft Tissue Sarcoma
-Thyroid Cancer
LCK 1p34.3 LSK, YT16, IMD22, p56lck, pp58lckSomatic
SFPQ 1p34.3 PSF, POMP100Somatic
THRAP3 1p34.3 TRAP150Somatic
ARID1A 1p35.3 ELD, B120, OSA1, P270, hELD, BM029, MRD14, hOSA1, BAF250, C1orf4, BAF250a, SMARCF1Somatic
RUNX3 1p36 AML2, CBFA3, PEBP2aC
MDS2 1p36 RP11-223J15.1Somatic
SDHB 1p36.1-p35 IP, SDH, CWS2, PGL4, SDH1, SDH2, SDHIPGermline
CDC42 1p36.1 G25K, CDC42Hs
EPHB2 1p36.1-p35 DRT, EK5, ERK, CAPB, Hek5, PCBC, EPHT3, Tyro5
PAX7 1p36.13 HUP1, RMS2, PAX7BSomatic
Translocation
-Rhabdomyosarcoma
NBL1 1p36.13 NB, DAN, NO3, DAND1, D1S1733E
FGR 1p36.2-p36.1 SRC2, c-fgr, c-src2, p55-Fgr, p58-Fgr, p55c-fgr, p58c-fgr
PRDM2 1p36.21 RIZ, KMT8, RIZ1, RIZ2, MTB-ZF, HUMHOXY1
PRDM16 1p36.23-p33 MEL1, LVNC8, PFM13, CMD1LLSomatic
MTHFR 1p36.3
TP73 1p36.3 P73-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Neuroblastoma
RPL22 1p36.31 EAP, L22, HBP15, HBP15/L22Somatic
CAMTA1 1p36.31-p36.23 CANPMRSomatic
TNFRSF14 1p36.32 TR2, ATAR, HVEA, HVEM, CD270, LIGHTRSomatic
SKI 1p36.33 SGS, SKV
PDE4DIP 1q12 MMGL, CMYA2Somatic
S100A8 1q21 P8, MIF, NIF, CAGA, CFAG, CGLA, L1Ag, MRP8, CP-10, MA387, 60B8AG
S100A7 1q21 PSOR1, S100A7c
S100A6 1q21 2A9, PRA, 5B10, CABP, CACY-Brain and CNS Tumours
-Liver Cancer
-Melanoma
-Pancreatic Cancer
-Soft Tissue Sarcoma
-Stomach Cancer
S100A4 1q21 42A, 18A2, CAPL, FSP1, MTS1, P9KA, PEL98-Bowel Cancer
-Breast Cancer
-Lung Cancer
-Osteosarcoma
-Pancreatic Cancer
-Skin Cancer
-Stomach Cancer
S100A3 1q21 S100E
S100A2 1q21 CAN19, S100L-Breast Cancer
-Cervical Cancer
-Head and Neck Cancers
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Melanoma
-Oesophageal Cancer
-Stomach Cancer
S100A1 1q21 S100, S100A, S100-alpha-Bladder Cancer
MCL1 1q21 TM, EAT, MCL1L, MCL1S, Mcl-1, BCL2L3, MCL1-ES, bcl2-L-3, mcl1/EAT
FCRL4 1q21 FCRH4, IGFP2, IRTA1, CD307dSomatic
NTRK1 1q21-q22 MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkASomatic
Translocation
Fusion
-Lung Cancer
-Neuroblastoma
-Thyroid Cancer
HRPT2 1q21-q31 HPT-JTGermline & Somatic
S100A9 1q21 MIF, NIF, P14, CAGB, CFAG, CGLB, L1AG, LIAG, MRP14, 60B8AG, MAC387
MUC1 1q21 EMA, PEM, PUM, KL-6, MAM6, PEMT, CD227, H23AG, MCKD1, MUC-1, CA 15-3, MUC-1/X, MUC1/ZD, MUC-1/SECSomatic
Translocation
Overexpression
Many cancer types including:
-Bladder Cancer
-Bowel Cancer
-Breast Cancer
-Lung Cancer
-Non-Hodgkin Lymphoma
-Pancreatic Cancer
-Stomach Cancer
ETV3 1q21-q23 PE1, METS, PE-1, bA110J1.4
BCL9 1q21 LGSSomatic
Translocation
-Non-Hodgkin Lymphoma
ARNT 1q21 HIF1B, TANGO, bHLHe2, HIF1BETA, HIF-1beta, HIF1-beta, HIF-1-betaSomatic
MLLT11 1q21 AF1QSomatic
Translocation
-Acute Myeloid Leukaemia
PRCC 1q21.1 TPRC, RCCP1Somatic
Translocation
-Kidney Cancer
TPM3 1q21.2 TM3, TM5, TRK, CFTD, NEM1, TM-5, TM30, CAPM1, TM30nm, TPMsk3, hscp30, OK/SW-cl.5Somatic
PBX1 1q23 Somatic
Translocation
-Acute Lymphocytic Leukemia (ALL), child
FCGR2B 1q23 CD32, FCG2, CD32B, FCGR2, IGFR2Somatic
CRP 1q23.2 PTX1
SLAMF1 1q23.3 SLAM, CD150, CDw150
SH2D1B 1q23.3 EAT2-Ewing's Sarcoma
SDHC 1q23.3 CYBL, PGL3, QPS1, SDH3, CYB560Germline
PRRX1 1q24 PMX1, PRX1, AGOTC, PHOX1, PRX-1Somatic
TPR 1q25 Somatic
ABL2 1q25.2 ARG, ABLLSomatic
Translocation
-Acute Lymphocytic Leukaemia (ALL) - adult
PTGS2 1q25.2-q25.3 COX2, COX-2, PHS-2, PGG/HS, PGHS-2, hCox-2, GRIPGHS
CACNA1E 1q25.3 BII, CACH6, Cav2.3, CACNL1A6Overexpression-Wilms Tumour
PSEN2 1q31-q42 AD4, PS2, AD3L, STM2, CMD1V
IL10 1q31-q32 CSIF, TGIF, GVHDS, IL-10, IL10AMany cancer types including:
-Bladder Cancer
-Cervical Cancer
-Prostate Cancer
-Stomach Cancer
PTPRC 1q31-q32 LCA, LY5, B220, CD45, L-CA, T200, CD45R, GP180
KISS1 1q32 HH13, KiSS-1-Bowel Cancer
-Breast Cancer
-Eye Cancer
-Kidney Cancer
-Melanoma
ELK4 1q32 SAP1Somatic
IL24 1q32 C49A, FISP, MDA7, MOB5, ST16, IL10B-Melanoma
MDM4 1q32 HDMX, MDMX, MRP1Somatic-Brain Tumours, Childhood
-Breast Cancer
-Retinoblastoma
-Soft Tissue Sarcoma
SLC45A3 1q32.1 PRST, IPCA6, IPCA-2, IPCA-6, IPCA-8, PCANAP2, PCANAP6, PCANAP8Somatic
LRRN2 1q32.1 GAC1, LRRN5, LRANK1, FIGLER7
KIF14 1q32.1 -Retinoblastoma
PARP1 1q41-q42 PARP, PPOL, ADPRT, ARTD1, ADPRT1, PARP-1, ADPRT 1, pADPRT-1-Breast Cancer
-Lung Cancer
-Melanoma
-Ovarian Cancer
TP53BP2 1q41 BBP, 53BP2, ASPP2, P53BP2, PPP1R13A
FH 1q42.1 MCL, LRCC, HLRCC, MCUL1Germline
H3F3A 1q42.12 H3F3, H3.3ASomatic

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 1:

Abnormality Type Gene(s)
1q Gain in Ewing's Sarcoma
del(1p36) in Ewing's SarcomaDeletion
del(1p36) in NeuroblastomaDeletion
RET-NTRK1 Rearangements in Papillary Thyroid CancerFusionNTRK1 (1q21-q22)RET (10q11.2)
der(16)t(1;16) in Ewing's SarcomaTranslocation
t(1;12)(q25;p13) in Leukaemia (AML & ALL)TranslocationABL2 (1q25.2)ETV6 (12p13)
t(1;14)(q21;q32) BCL9/IGHTranslocationBCL9 (1q21)IGH (14q32.33)
CD74-NTRK1 fusion in Lung CancerTranslocationNTRK1 (1q21-q22)CD74 (5q32)
t(1;13)(p36;q14) in RhabdomyosarcomaTranslocationPAX7 (1p36.13)FOXO1 (13q14.1)
t(1;14)(q21;q32) and MUC1 Overexpression in NHLTranslocationMUC1 (1q21)IGH (14q32.33)
t(1;11)(p32;q23) MLL-EPS15 fusion in Mcute Myelogeneous LeukemiaTranslocationEPS15 (1p32)KMT2A (11q23)
t(1;19)(q23;p13.3) TCF3-PBX1 fusion in pre-B-cell ALLTranslocationPBX1 (1q23)TCF3 (19p13.3)
t(X;1)(p11;q21) in Papillary Renal Cell CarcinomaTranslocationPRCC (1q21.1)TFE3 (Xp11.22)
t(1;14)(p22;q32) in MALT B cell lymphomaTranslocationBCL10 (1p22)
t(1;22)(p13;q13) in Acute Megakaryocytic LeukemiaTranslocationRBM15 (1p13)MKL1 (22q13)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


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