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  Chromosome 1

Genes Linked with Cancer (202)

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 1; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
FAM46C 1p12 Somatic-Multiple Myeloma
CD58 1p13 ag3, LFA3, LFA-3-Colorectal Cancer
-Leukaemia
-Multiple Myeloma
NOTCH2 1p13-p11 hN2, AGS2, HJCYSSomatic-Brain and CNS Tumours
-Breast Cancer
RBM15 1p13 OTT, OTT1, SPENSomatic
Translocation
-Acute Myeloid Leukaemia
-Childhood Cancers
-Leukaemia
HSD3B2 1p13.1 HSDB, HSD3B, SDR11E2-Adrenocortical Cancer
-Bladder Cancer
-Ovarian Cancer
-Prostate Cancer
REG4 1p13.1-p12 GISP, RELP, REG-IV-Colorectal Cancer
-Prostate Cancer
-Stomach Cancer
RHOC 1p13.1 H9, ARH9, ARHC, RHOH9Many cancer types including:
-Breast Cancer
-Liver Cancer
-Lung Cancer
-Melanoma
-Ovarian Cancer
-Pancreatic Cancer
TRIM33 1p13.1 ECTO, PTC7, RFG7, TF1G, TIF1G, TIFGAMMA, TIF1GAMMASomatic
CHIA 1p13.2 CHIT2, AMCASE, TSA1902-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Nasopharyngeal Cancer
-Prostate Cancer
NRAS 1p13.2 NS6, CMNS, NCMS, ALPS4, N-ras, NRAS1SomaticMany cancer types including:
-Acute Myeloid Leukaemia
-Bladder Cancer
-Colorectal Cancer
-Leukaemia
-Melanoma
-Neuroblastoma
-Rhabdomyosarcoma
-Skin Cancer
-Thyroid Cancer
RAP1A 1p13.3 RAP1, C21KG, G-22K, KREV1, KREV-1, SMGP21-Breast Cancer
-Lung Cancer
-Thyroid Cancer
CSF1 1p13.3 MCSF, CSF-1-Breast Cancer
-Pancreatic Cancer
GSTM1 1p13.3 MU, H-B, GST1, GTH4, GTM1, MU-1, GSTM1-1, GSTM1a-1a, GSTM1b-1bMany cancer types including:
-Acute Lymphocytic Leukemia (ALL), child
-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Head and Neck Cancers
-Lung Cancer
-Oral Cavity Cancer
-Prostate Cancer
-Thyroid Cancer
GSTM3 1p13.3 GST5, GSTB, GTM3, GSTM3-3-Bladder Cancer
-Breast Cancer
-Laryngeal Cancer
-Lung Cancer
-Oral Cavity Cancer
-Skin Cancer
-Basal Cell Carcinoma (BCC) - Skin
-Stomach Cancer
DPYD 1p22 DHP, DPD, DHPDHASE-Colorectal Cancer
-Stomach Cancer
GFI1 1p22 SCN2, GFI-1, GFI1A, ZNF163-Leukaemia
BCL10 1p22 CLAP, mE10, CIPER, IMD37, c-E10, CARMENSomatic
Translocation
-MALT Lymphoma
-Skin Cancer
-Stomach Cancer
-Testicular Cancer
LMO4 1p22.3 -Breast Cancer
-Lung Cancer
-Neuroblastoma
CYR61 1p22.3 CCN1, GIG1, IGFBP10-Breast Cancer
-Esophageal Cancer
-Osteosarcoma
-Prostate Cancer
LEPR 1p31 OBR, OB-R, CD295, LEP-R, LEPRD-Breast Cancer
-Endometrial Cancer
-Liver Cancer
-Lung Cancer
-Non-Hodgkin Lymphoma
-Prostate Cancer
DIRAS3 1p31 ARHI, NOEY2-Breast Cancer
-Ovarian Cancer
FUBP1 1p31.1 FBP, FUBPSomatic-Brain Tumours, Childhood
DNAJB4 1p31.1 DjB4, HLJ1, DNAJW-Liver Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Stomach Cancer
GADD45A 1p31.2 DDIT1, GADD45-Breast Cancer
-Lung Cancer
-Pancreatic Cancer
-Prostate Cancer
IL23R 1p31.3 -Acute Myeloid Leukaemia
-Breast Cancer
-Colorectal Cancer
-Esophageal Cancer
-Haematological Malignancies
-Lung Cancer
-Stomach Cancer
STIL 1p32 SIL, MCPH7Somatic-Acute Lymphocytic Leukaemia (ALL)
-Acute Lymphocytic Leukemia (ALL), child
TAL1 1p32 SCL, TCL5, tal-1, bHLHa17Somatic-Acute Lymphocytic Leukaemia (ALL)
-Acute Lymphocytic Leukemia (ALL), child
RAD54L 1p32 HR54, hHR54, RAD54A, hRAD54-Breast Cancer
-Colorectal Cancer
-Ovarian Cancer
-Pancreatic Cancer
TACSTD2 1p32 EGP1, GP50, M1S1, EGP-1, TROP2, GA7331, GA733-1-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Ovarian Cancer
-Prostate Cancer
CDKN2C 1p32 p18, INK4C, p18-INK4CSomatic-Wilms Tumour
VCAM1 1p32-p31 CD106, INCAM-100-Brain Tumours, Childhood
-Breast Cancer
-Kidney Cancer
-Liver Cancer
JUN 1p32-p31 AP1, AP-1, c-JunSomatic-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Ovarian Cancer
BLYM 1p32
ROR1 1p32-p31 NTRKR1, dJ537F10.1-Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Chronic Lymphocytic Leukemia
-Lung Cancer
-Stomach Cancer
EPS15 1p32 AF1P, AF-1P, MLLT5Somatic
Translocation
-Acute Myeloid Leukaemia
JAK1 1p32.3-p31.3 JTK3, JAK1A, JAK1BSomatic-Acute Lymphocytic Leukaemia (ALL)
-Myeloproliferative Disorders
-Stomach Cancer
EPB41 1p33-p32 HE, EL1, 4.1R-Prostate Cancer
TGFBR3 1p33-p32 BGCAN, betaglycan-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Prostate Cancer
-Soft Tissue Sarcoma
-Uterine Sarcoma
YBX1 1p34 YB1, BP-8, CSDB, DBPB, YB-1, CSDA2, NSEP1, NSEP-1, MDR-NF1-Breast Cancer
HDAC1 1p34 HD1, RPD3, GON-10, RPD3L1-Breast Cancer
-Cervical Cancer
MPL 1p34 MPLV, TPOR, C-MPL, CD110, THCYT2Germline & Somatic-Acute Myeloid Leukaemia
-Leukaemia
-Myeloproliferative Disorders
PTPRF 1p34 LAR, BNAH2-Breast Cancer
-Lung Cancer
-Melanoma
-Skin Cancer
PRDX1 1p34.1 PAG, PAGA, PAGB, PRX1, PRXI, MSP23, NKEFA, TDPX2, NKEF-A-Breast Cancer
-Esophageal Cancer
-Liver Cancer
-Lung Cancer
-Prostate Cancer
MUTYH 1p34.1 MYHGermline-Adenomatous Polyposis Coli
-Breast Cancer
-Childhood Cancers
-Colorectal Cancer
-Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
CDC20 1p34.1 CDC20A, p55CDC, bA276H19.3-Breast Cancer
SLC2A1 1p34.2 PED, DYT9, GLUT, DYT17, DYT18, EIG12, GLUT1, HTLVR, GLUT-1, GLUT1DS-Breast Cancer
-Cervical Cancer
-Kidney Cancer
-Lung Cancer
-Prostate Cancer
-Soft Tissue Sarcoma
-Thyroid Cancer
MYCL 1p34.2 LMYC, MYCL1, bHLHe38Somatic-Bladder Cancer
-Cervical Cancer
-Childhood Cancers
-Colorectal Cancer
-Lung Cancer
-Neuroblastoma
-Thyroid Cancer
THRAP3 1p34.3 TRAP150Somatic-Bone Cancer (primary)
-Parathyroid Cancer
SFPQ 1p34.3 PSF, POMP100, PPP1R140Somatic-Acute Lymphocytic Leukaemia (ALL)
-Acute Myeloid Leukaemia
-Colorectal Cancer
-Haematological Malignancies
LCK 1p34.3 LSK, YT16, IMD22, p56lck, pp58lckSomatic
CSF3R 1p35-p34.3 CD114, GCSFR-Acute Myeloid Leukaemia
-Bladder Cancer
-Leukaemia
PLA2G2A 1p35 MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2-Adenomatous Polyposis Coli
-Colorectal Cancer
-Lung Cancer
-Stomach Cancer
ARID1A 1p35.3 ELD, B120, OSA1, P270, hELD, BM029, MRD14, hOSA1, BAF250, C1orf4, BAF250a, SMARCF1Somatic-Breast Cancer
-Cervical Cancer
-Endometrial Cancer
-Ovarian Cancer
-Uterine Sarcoma
E2F2 1p36 E2F-2-Bone Cancer (primary)
-Breast Cancer
-Osteosarcoma
-Ovarian Cancer
MDS2 1p36 Somatic
CD52 1p36 CDW52-Chronic Lymphocytic Leukemia
-Leukaemia
-Multiple Myeloma
RUNX3 1p36 AML2, CBFA3, PEBP2aC-Colorectal Cancer
-Eye Cancer
-Liver Cancer
-Stomach Cancer
-Uterine Sarcoma
TNFRSF9 1p36 ILA, 4-1BB, CD137, CDw137-Melanoma
EPHA2 1p36 ECK, CTPA, ARCC2, CTPP1, CTRCT6-Breast Cancer
-Cervical Cancer
-Lung Cancer
-Ovarian Cancer
GALE 1p36-p35 SDR1E1-Acute Lymphocytic Leukaemia (ALL)
-Acute Myeloid Leukaemia
-Chronic Myelogenous Leukemia
-Leukaemia
ERRFI1 1p36 MIG6, RALT, MIG-6, GENE-33
EXTL1 1p36.1 EXTL-Breast Cancer
-Multiple Hereditary Exostoses
-Neuroblastoma
NR0B2 1p36.1 SHP, SHP1-Liver Cancer
SLC9A1 1p36.1-p35 APNH, NHE1, NHE-1, PPP1R143-Breast Cancer
-Cervical Cancer
-Chronic Myelogenous Leukemia
-Liver Cancer
-Pancreatic Cancer
RAP1GAP 1p36.1-p35 RAPGAP, RAP1GA1, RAP1GAP1, RAP1GAPII-Kidney Cancer
-Melanoma
SDHB 1p36.1-p35 IP, SDH, CWS2, PGL4, SDH1, SDH2, SDHIPGermline-Adrenocortical Cancer
-Childhood Cancers
-Gastrointestinal Stromal Tumors
-Head and Neck Cancers
-Kidney Cancer
-Pheochromocytoma and Paraganglioma
EPHB2 1p36.1-p35 DRT, EK5, ERK, CAPB, Hek5, PCBC, EPHT3, Tyro5-Colorectal Cancer
-Neuroblastoma
-Prostate Cancer
-Wilms Tumour
CDC42 1p36.1 G25K, CDC42Hs-Breast Cancer
-Lung Cancer
STMN1 1p36.11 Lag, SMN, OP18, PP17, PP19, PR22, LAP18, C1orf215-Breast Cancer
-Liver Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
KDM1A 1p36.12 AOF2, KDM1, LSD1, BHC110-Breast Cancer
-Prostate Cancer
NBL1 1p36.13 NB, DAN, NO3, DAND1, D1S1733E-Neuroblastoma
-Prostate Cancer
PAX7 1p36.13 HUP1, RMS2, PAX7BSomatic
Translocation
-Childhood Cancers
-Rhabdomyosarcoma
-Soft Tissue Sarcoma
-Urinary System Cancers
TNFRSF25 1p36.2 DR3, TR3, DDR3, LARD, APO-3, TRAMP, WSL-1, WSL-LR, TNFRSF12-Bladder Cancer
-Neuroblastoma
-Pancreatic Cancer
-Prostate Cancer
-Urinary System Cancers
ENO1 1p36.2 NNE, PPH, MPB1, ENO1L1-Brain Tumours, Childhood
-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Neuroblastoma
-Prostate Cancer
MTOR 1p36.2 FRAP, FRAP1, FRAP2, RAFT1, RAPT1-Bladder Cancer
-Breast Cancer
KIF1B 1p36.2 KLP, CMT2, CMT2A, CMT2A1, HMSNII, NBLST1-Adrenocortical Cancer
-Liver Cancer
-Neuroblastoma
-Pheochromocytoma and Paraganglioma
FGR 1p36.2-p36.1 SRC2, c-fgr, c-src2, p55-Fgr, p58-Fgr, p55c-fgr, p58c-fgr-Breast Cancer
-Childhood Cancers
PDPN 1p36.21 T1A, GP36, GP40, Gp38, OTS8, T1A2, TI1A, T1A-2, AGGRUS, HT1A-1, PA2.26-Brain Tumours, Childhood
-Lung Cancer
-Oral Cavity Cancer
CASP9 1p36.21 MCH6, APAF3, APAF-3, PPP1R56, ICE-LAP6-Cervical Cancer
-Prostate Cancer
-Thyroid Cancer
PRDM2 1p36.21 RIZ, KMT8, RIZ1, RIZ2, MTB-ZF, HUMHOXY1-Breast Cancer
-Colorectal Cancer
-Liver Cancer
TNFRSF1B 1p36.22 p75, TBPII, TNFBR, TNFR2, CD120b, TNFR1B, TNFR80, TNF-R75, p75TNFR, TNF-R-II-Lung Cancer
MIR34A 1p36.22 mir-34, MIRN34A, miRNA34A-Chronic Lymphocytic Leukemia
-Leukaemia
PRDM16 1p36.23-p33 MEL1, LVNC8, PFM13, CMD1LLSomatic-Acute Myeloid Leukaemia
-Childhood Cancers
-Chronic Myelogenous Leukemia
-Leukaemia
-Myelodysplastic Syndromes
WNT4 1p36.23-p35.1 WNT-4, SERKAL-Breast Cancer
-Pituitary Tumors
-Prostate Cancer
PARK7 1p36.23 DJ1, DJ-1, HEL-S-67p-Breast Cancer
-Eye Cancer
-Laryngeal Cancer
-Pancreatic Cancer
-Prostate Cancer
-Uterine Sarcoma
PER3 1p36.23 GIG13-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Prostate Cancer
TP73 1p36.3 P73-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Neuroblastoma
MTHFR 1p36.3 -Acute Lymphocytic Leukaemia (ALL)
-Colorectal Cancer
-Small Cell Lung Cancer
-Skin Cancer
-Stomach Cancer
-Thyroid Cancer
RPL22 1p36.31 EAP, L22, HBP15, HBP15/L22Somatic-Childhood Cancers
-Nasopharyngeal Cancer
-Paranasal Sinus and Nasal Cavity Cancer
CHD5 1p36.31 CHD-5-Colorectal Cancer
-Neuroblastoma
CAMTA1 1p36.31-p36.23 CANPMRSomatic-Brain Tumours, Childhood
-Neuroblastoma
TNFRSF14 1p36.32 TR2, ATAR, HVEA, HVEM, CD270, LIGHTRSomatic-Esophageal Cancer
SKI 1p36.33 SGS, SKV-Breast Cancer
-Melanoma
ISG15 1p36.33 G1P2, IP17, UCRP, IFI15, hUCRP-Breast Cancer
-Cervical Cancer
-Melanoma
PMAIP1 18q21.32 APR, NOXA-Breast Cancer
-Chronic Lymphocytic Leukemia
IFNG 12q14 IFG, IFI-Cervical Cancer
PDE4DIP 1q12 MMGL, CMYA2Somatic-Esophageal Cancer
HRPT2 1q21-q31 HPT-JTGermline & Somatic-Childhood Cancers
-Parathyroid Cancer
-Uterine Sarcoma
SHC1 1q21 SHC, SHCA-Breast Cancer
-Lung Cancer
-Multiple Endocrine Neoplasia Type 2a
S100A11 1q21 MLN70, S100C, HEL-S-43-Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Skin Cancer
-Stomach Cancer
ETV3 1q21-q23 PE1, METS, PE-1, bA110J1.4-Breast Cancer
-Childhood Cancers
-Chronic Lymphocytic Leukemia
-Colorectal Cancer
S100A8 1q21 P8, MIF, NIF, CAGA, CFAG, CGLA, L1Ag, MRP8, CP-10, MA387, 60B8AG-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Esophageal Cancer
-Skin Cancer
-Stomach Cancer
-Vulvar Cancer
NTRK1 1q21-q22 MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkASomatic
Translocation
Fusion
-Lung Cancer
-Neuroblastoma
-Thyroid Cancer
S100A7 1q21 PSOR1, S100A7c-Bladder Cancer
-Breast Cancer
-Skin Cancer
-Stomach Cancer
S100A10 1q21 42C, P11, p10, GP11, ANX2L, CAL1L, CLP11, Ca[1], ANX2LG-Esophageal Cancer
-Lung Cancer
-Skin Cancer
-Stomach Cancer
S100A9 1q21 MIF, NIF, P14, CAGB, CFAG, CGLB, L1AG, LIAG, MRP14, 60B8AG, MAC387-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Esophageal Cancer
-Lung Cancer
-Skin Cancer
-Stomach Cancer
MUC1 1q21 EMA, MCD, PEM, PUM, KL-6, MAM6, MCKD, PEMT, CD227, H23AG, MCKD1, MUC-1, ADMCKD, ADMCKD1, CA 15-3, MUC-1/X, MUC1/ZD, MUC-1/SECSomatic
Translocation
Overexpression
Many cancer types including:
-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Non-Hodgkin Lymphoma
-Pancreatic Cancer
-Stomach Cancer
APCS 1q21-q23 SAP, PTX2, HEL-S-92n-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
SPRR1B 1q21-q22 SPRR1, GADD33, CORNIFIN-Esophageal Cancer
-Lung Cancer
-Skin Cancer
MCL1 1q21 TM, EAT, MCL1L, MCL1S, Mcl-1, BCL2L3, MCL1-ES, bcl2-L-3, mcl1/EAT-Chronic Lymphocytic Leukemia
-Lung Cancer
MLLT11 1q21 AF1QSomatic
Translocation
-Acute Myeloid Leukaemia
S100A4 1q21 42A, 18A2, CAPL, FSP1, MTS1, P9KA, PEL98-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Osteosarcoma
-Pancreatic Cancer
-Skin Cancer
-Stomach Cancer
S100A2 1q21 CAN19, S100L-Breast Cancer
-Cervical Cancer
-Esophageal Cancer
-Head and Neck Cancers
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Melanoma
-Stomach Cancer
S100A1 1q21 S100, S100A, S100-alpha-Bladder Cancer
S100A6 1q21 2A9, PRA, 5B10, CABP, CACY-Brain and CNS Tumours
-Liver Cancer
-Melanoma
-Pancreatic Cancer
-Soft Tissue Sarcoma
-Stomach Cancer
SPRR2C 1q21-q22 -Esophageal Cancer
-Lung Cancer
-Skin Cancer
SPRR2B 1q21-q22 -Esophageal Cancer
-Lung Cancer
-Skin Cancer
FCRL4 1q21 FCRH4, IGFP2, IRTA1, CD307dSomatic-Acute Lymphocytic Leukaemia (ALL)
SPRR2A 1q21-q22 -Esophageal Cancer
-Lung Cancer
-Skin Cancer
BCL9 1q21 LGSSomatic
Translocation
-Colorectal Cancer
-Multiple Myeloma
-Non-Hodgkin Lymphoma
ARNT 1q21 HIF1B, TANGO, bHLHe2, HIF1BETA, HIF-1beta, HIF1-beta, HIF-1-betaSomatic-Breast Cancer
-Lung Cancer
-Prostate Cancer
SPRR1A 1q21-q22 SPRK-Esophageal Cancer
-Lung Cancer
-Skin Cancer
S100A3 1q21 S100E-Bladder Cancer
-Breast Cancer
-Esophageal Cancer
-Stomach Cancer
-Transitional Cell Cancer of the Renal Pelvis and Ureter
PRCC 1q21.1 TPRC, RCCP1Somatic
Translocation
-Childhood Cancers
-Kidney Cancer
TXNIP 1q21.1 THIF, VDUP1, HHCPA78, EST01027-Acute Myeloid Leukaemia
-Breast Cancer
-Liver Cancer
TPM3 1q21.2 TM3, TM5, TRK, CFTD, NEM1, TM-5, TM30, CAPM1, TM30nm, TPMsk3, hscp30, HEL-189, HEL-S-82p, OK/SW-cl.5Somatic-Breast Cancer
-Childhood Cancers
-Lung Cancer
-Thyroid Cancer
CKS1B 1q21.2 CKS1, ckshs1, PNAS-16, PNAS-18-Breast Cancer
-Multiple Myeloma
-Skin Cancer
CRTC2 1q21.3 TORC2, TORC-2-Uterine Sarcoma
ADAR 1q21.3 DSH, AGS6, G1P1, IFI4, P136, ADAR1, DRADA, DSRAD, IFI-4, K88DSRBP-Astrocytoma, Childhood
-Brain Tumours, Childhood
-Liver Cancer
-Prostate Cancer
AIM2 1q22 PYHIN4-Colorectal Cancer
-Gastrointestinal Cancers
-Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
-Prostate Cancer
LMNA 1q22 FPL, IDC, LFP, CDDC, EMD2, FPLD, HGPS, LDP1, LMN1, LMNC, PRO1, CDCD1, CMD1A, FPLD2, LMNL1, CMT2B1, LGMD1B-Colorectal Cancer
-Laryngeal Cancer
-Stomach Cancer
USF1 1q22-q23 UEF, FCHL, MLTF, FCHL1, MLTFI, HYPLIP1, bHLHb11-Breast Cancer
-Colorectal Cancer
-Liver Cancer
RAB25 1q22 CATX-8, RAB11C-Breast Cancer
-Kidney Cancer
-Ovarian Cancer
-Wilms Tumour
ATF6 1q22-q23 ATF6A-Colorectal Cancer
-Liver Cancer
-Prostate Cancer
-Soft Tissue Sarcoma
YY1AP1 1q22 YAP, HCCA1, HCCA2, YY1AP-Breast Cancer
-Liver Cancer
-Melanoma
ASH1L 1q22 ASH1, KMT2H, ASH1L1-Esophageal Cancer
-Lung Cancer
-Pituitary Tumors
FCGR2A 1q23 CD32, FCG2, FcGR, CD32A, CDw32, FCGR2, IGFR2, FCGR2A1-Breast Cancer
-Colorectal Cancer
-Multiple Myeloma
PBX1 1q23 Somatic
Translocation
-Acute Lymphocytic Leukaemia (ALL)
-Acute Lymphocytic Leukemia (ALL), child
-Cervical Cancer
-Childhood Cancers
-Wilms Tumour
FCGR2B 1q23 CD32, FCG2, CD32B, FCGR2, IGFR2Somatic-Acute Lymphocytic Leukaemia (ALL)
-Leukaemia
-Waldenstrom's Macroglobulinemia
FCGR3A 1q23 CD16, FCG3, CD16A, FCGR3, IGFR3, IMD20, FCR-10, FCRIII, FCGRIII, FCRIIIA-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Kaposi Sarcoma
-Non-Hodgkin Lymphoma
SELL 1q23-q25 TQ1, LAM1, LEU8, LNHR, LSEL, CD62L, LYAM1, PLNHR, LECAM1-Wilms Tumour
FASLG 1q23 APTL, FASL, CD178, CD95L, ALPS1B, CD95-L, TNFSF6, APT1LG1-Bladder Cancer
-Rectal Cancer
-Skin Cancer
-Stomach Cancer
HDGF 1q23.1 HMG1L2-Bone Cancer (primary)
-Chronic Myelogenous Leukemia
-Liver Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Wilms Tumour
CD1D 1q23.1 R3, CD1A-Brain Tumours, Childhood
-Chronic Lymphocytic Leukemia
-Multiple Myeloma
-Uterine Sarcoma
CD1A 1q23.1 R4, T6, CD1, FCB6, HTA1-Acute Lymphocytic Leukaemia (ALL)
-Colorectal Cancer
-Langerhans Cell Histiocytosis
-Skin Cancer
-Soft Tissue Sarcoma
CRP 1q23.2 PTX1-Acute Myeloid Leukaemia
-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Esophageal Cancer
-Lung Cancer
-Prostate Cancer
-Waldenstrom's Macroglobulinemia
DDR2 1q23.3 TKT, MIG20a, NTRKR3, TYRO10-Cervical Cancer
-Hodgkin Lymphoma
-Lung Cancer
-Lung Cancer, Non-Small Cell
SH2D1B 1q23.3 EAT2-Bone Cancer (primary)
-Ewing's Sarcoma
SLAMF1 1q23.3 SLAM, CD150, CDw150-Chronic Lymphocytic Leukemia
-Leukaemia
-Multiple Myeloma
SDHC 1q23.3 CYBL, PGL3, QPS1, SDH3, CYB560Germline-Adrenocortical Cancer
-Childhood Cancers
-Gastrointestinal Stromal Tumors
-Head and Neck Cancers
-Pheochromocytoma and Paraganglioma
PRRX1 1q24 PMX1, PRX1, AGOTC, PHOX1, PRX-1Somatic-Esophageal Cancer
-Leukaemia
-Prostate Cancer
POU2F1 1q24.2 OCT1, OTF1, oct-1B-Breast Cancer
-Cervical Cancer
-Chronic Myelogenous Leukemia
LAMC2 1q25-q31 B2T, CSF, EBR2, BM600, EBR2A, LAMB2T, LAMNB2-Bladder Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Oral Cavity Cancer
-Vulvar Cancer
TPR 1q25 Somatic-Cervical Cancer
-Stomach Cancer
-Thyroid Cancer
CDC73 1q25 HYX, FIHP, HPTJT, HRPT1, HRPT2, C1orf28-Parathyroid Cancer
-Uterine Sarcoma
RNASEL 1q25 RNS4, PRCA1
PLA2G4A 1q25 PLA2G4, cPLA2-alpha-Breast Cancer
-Colorectal Cancer
-Esophageal Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
PRDX6 1q25.1 PRX, p29, AOP2, 1-Cys, NSGPx, aiPLA2, HEL-S-128m-Breast Cancer
-Lung Cancer
-Ovarian Cancer
PTGS2 1q25.2-q25.3 COX2, COX-2, PHS-2, PGG/HS, PGHS-2, hCox-2, GRIPGHS-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Esophageal Cancer
-Head and Neck Cancers
-Lung Cancer
-Prostate Cancer
-Skin Cancer
-Stomach Cancer
ABL2 1q25.2 ARG, ABLLSomatic
Translocation
-Acute Lymphocytic Leukaemia (ALL)
CACNA1E 1q25.3 BII, CACH6, Cav2.3, CACNL1A6Overexpression-Wilms Tumour
MYOG 1q31-q41 MYF4, myf-4, bHLHc3-Rhabdomyosarcoma
-Soft Tissue Sarcoma
-Wilms Tumour
PTPRC 1q31-q32 LCA, LY5, B220, CD45, L-CA, T200, CD45R, GP180-Cervical Cancer
-Myelodysplastic Syndromes
-Skin Cancer
-Soft Tissue Sarcoma
-Testicular Cancer
-Thyroid Cancer
-Waldenstrom's Macroglobulinemia
IL10 1q31-q32 CSIF, TGIF, GVHDS, IL-10, IL10AMany cancer types including:
-Bladder Cancer
-Cervical Cancer
-Prostate Cancer
-Stomach Cancer
BTG2 1q32 PC3, TIS21-Breast Cancer
-Liver Cancer
-Lung Cancer
-Prostate Cancer
KISS1 1q32 HH13, KiSS-1-Breast Cancer
-Colorectal Cancer
-Eye Cancer
-Kidney Cancer
-Melanoma
CD34 1q32 -Acute Lymphocytic Leukaemia (ALL)
-Acute Myeloid Leukaemia
-Chronic Myelogenous Leukemia
ELK4 1q32 SAP1Somatic-Breast Cancer
-Prostate Cancer
MAPKAPK2 1q32 MK2, MK-2, MAPKAP-K2-Lung Cancer
-Neuroblastoma
AVPR1B 1q32 AVPR3-Adrenocortical Cancer
-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Pituitary Tumors
CD55 1q32 CR, TC, DAF, CROM-Acute Lymphocytic Leukaemia (ALL)
-Cervical Cancer
-Chronic Myelogenous Leukemia
-Colorectal Cancer
-Stomach Cancer
MDM4 1q32 HDMX, MDMX, MRP1Somatic-Brain Tumours, Childhood
-Breast Cancer
-Retinoblastoma
-Soft Tissue Sarcoma
LAMB3 1q32 LAM5, LAMNB1, BM600-125KDA-Bladder Cancer
-Cervical Cancer
-Lung Cancer
-Prostate Cancer
-Skin Cancer
-Stomach Cancer
CD46 1q32 MCP, TLX, AHUS2, MIC10, TRA2.10-Breast Cancer
-Cervical Cancer
-Liver Cancer
-Lung Cancer
-Ovarian Cancer
SNRPE 1q32 SME, Sm-E, B-raf, HYPT11-Lung Cancer
-Ovarian Cancer
IL24 1q32 C49A, FISP, MDA7, MOB5, ST16, IL10B-Brain Tumours, Childhood
-Liver Cancer
-Lung Cancer
-Melanoma
-Neuroblastoma
IKBKE 1q32.1 IKKE, IKKI, IKK-E, IKK-i-Breast Cancer
-Lung Cancer
-Prostate Cancer
KIF14 1q32.1 -Retinoblastoma
CHI3L1 1q32.1 GP39, ASRT7, GP-39, YKL40, CGP-39, YKL-40, YYL-40, HC-gp39, HCGP-3P, hCGP-39-Astrocytoma, Childhood
-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Breast Cancer
LRRN2 1q32.1 GAC1, LRRN5, LRANK1, FIGLER7-Astrocytoma, Childhood
-Brain and CNS Tumours
-Brain Stem Glioma, Childhood
-Neuroblastoma
NR5A2 1q32.1 B1F, CPF, FTF, B1F2, LRH1, LRH-1, FTZ-F1, hB1F-2, FTZ-F1beta-Breast Cancer
-Liver Cancer
-Pancreatic Cancer
SLC45A3 1q32.1 PRST, IPCA6, IPCA-2, IPCA-6, IPCA-8, PCANAP2, PCANAP6, PCANAP8Somatic-Cervical Cancer
-Prostate Cancer
-Stomach Cancer
KDM5B 1q32.1 CT31, PLU1, PUT1, PLU-1, JARID1B, PPP1R98, RBBP2H1A-Breast Cancer
-Melanoma
-Skin Cancer
ADIPOR1 1q32.1 CGI45, PAQR1, ACDCR1, CGI-45, TESBP1A-Breast Cancer
-Colorectal Cancer
-Endometrial Cancer
-Prostate Cancer
ELF3 1q32.2 ERT, ESX, EPR-1, ESE-1-Breast Cancer
-Esophageal Cancer
-Prostate Cancer
-Stomach Cancer
ATF3 1q32.3 -Breast Cancer
-Colorectal Cancer
-Eye Cancer
-Lung Cancer
-Melanoma
-Prostate Cancer
NEK2 1q32.3 NLK1, RP67, NEK2A, HsPK21, PPP1R111-Breast Cancer
-Lung Cancer
-Prostate Cancer
PROX1 1q41 -Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Pancreatic Cancer
PARP1 1q41-q42 PARP, PPOL, ADPRT, ARTD1, ADPRT1, PARP-1, ADPRT 1, pADPRT-1-Breast Cancer
-Lung Cancer
-Melanoma
-Ovarian Cancer
TP53BP2 1q41 BBP, 53BP2, ASPP2, P53BP2, PPP1R13A-Breast Cancer
-Liver Cancer
TGFB2 1q41 LDS4, TGF-beta2-Brain and CNS Tumours
-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Breast Cancer
-Liver Cancer
-Pancreatic Cancer
AIDA 1q41 C1orf80-Lung Cancer
-Oral Cavity Cancer
-Ovarian Cancer
-Prostate Cancer
WNT3A 1q42 -Breast Cancer
-Colorectal Cancer
-Stomach Cancer
ARF1 1q42 -Bladder Cancer
-Breast Cancer
-Ovarian Cancer
EXO1 1q42-q43 HEX1, hExoI-Cervical Cancer
-Colorectal Cancer
-Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
-Lung Cancer
-Rectal Cancer
-Stomach Cancer
EGLN1 1q42.1 HPH2, PHD2, SM20, ECYT3, HPH-2, HIFPH2, ZMYND6, C1orf12, HIF-PH2-Adrenocortical Cancer
-Breast Cancer
-Cervical Cancer
-Kidney Cancer
-Pheochromocytoma and Paraganglioma
-Waldenstrom's Macroglobulinemia
EPHX1 1q42.1 MEH, EPHX, EPOX, HYL1-Bladder Cancer
-Cervical Cancer
-Colorectal Cancer
-Lung Cancer
FH 1q42.1 MCL, LRCC, HLRCC, MCUL1Germline-Bladder Cancer
-Breast Cancer
-Childhood Cancers
-Kidney Cancer
-Ovarian Cancer
-Skin Cancer
-Stomach Cancer
-Uterine Sarcoma
-Wilms Tumour
H3F3A 1q42.12 H3F3, H3.3ASomatic-Astrocytoma, Childhood
-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Childhood Cancers
PSEN2 1q42.13 AD4, PS2, AD3L, STM2, CMD1V-Breast Cancer
SMYD3 1q44 KMT3E, ZMYND1, ZNFN3A1, bA74P14.1-Breast Cancer
-Colorectal Cancer
-Liver Cancer
AKT3 1q44 MPPH, PKBG, MPPH2, PRKBG, STK-2, PKB-GAMMA, RAC-gamma, RAC-PK-gamma-Breast Cancer
-Melanoma
-Ovarian Cancer
-Skin Cancer

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 1:

Abnormality Type Gene(s)
1q Gain in Ewing's Sarcoma
del(1p36) in Ewing's SarcomaDeletion
del(1p36) in NeuroblastomaDeletion
RET-NTRK1 Rearangements in Papillary Thyroid CancerFusionNTRK1 (1q21-q22)RET (10q11.2)
der(16)t(1;16) in Ewing's SarcomaTranslocation
t(1;12)(q25;p13) in Leukaemia (AML & ALL)TranslocationABL2 (1q25.2)ETV6 (12p13)
t(1;14)(q21;q32) BCL9/IGHTranslocationBCL9 (1q21)IGH (14q32.33)
CD74-NTRK1 fusion in Lung CancerTranslocationNTRK1 (1q21-q22)CD74 (5q32)
t(1;13)(p36;q14) in RhabdomyosarcomaTranslocationPAX7 (1p36.13)FOXO1 (13q14.1)
t(1;14)(q21;q32) and MUC1 Overexpression in NHLTranslocationMUC1 (1q21)IGH (14q32.33)
t(1;11)(p32;q23) MLL-EPS15 fusion in Mcute Myelogeneous LeukemiaTranslocationEPS15 (1p32)KMT2A (11q23)
t(1;19)(q23;p13.3) TCF3-PBX1 fusion in pre-B-cell ALLTranslocationPBX1 (1q23)TCF3 (19p13.3)
t(X;1)(p11;q21) in Papillary Renal Cell CarcinomaTranslocationPRCC (1q21.1)TFE3 (Xp11.22)
t(1;14)(p22;q32) in MALT B cell lymphomaTranslocationBCL10 (1p22)
t(1;22)(p13;q13) in Acute Megakaryocytic LeukemiaTranslocationRBM15 (1p13)MKL1 (22q13)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


Further Resources (2 links)

Further Resources


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Cite this page: Cotterill SJ. Chromosome 1, Cancer Genetics Web: http://www.cancerindex.org/geneweb/clinkc01.htm Accessed: date

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