FGR - Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene - aka: SRC2

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FGR; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene (1p36.2-p36)
FGR Menu Summary Information - FGR Gene Database Entries for FGR Other FGR Related Resources Defining Texts FGR and Cancer Epstein-Barr virus and FGR activation Feedback / suggest a new topic for FGR
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Summary Information
FGR; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene Location: 1p36.2-p36 Alias: SRC2 Return to FGR Contents
Gene Database Entries for FGR
OMIM GeneCard (Weizmann Institute) Tumor Gene Database Genbank Swiss-Prot Locus Link UniGene GenAtlas GDB Nomenclature (search for FGR) Return to FGR Contents
Other Related Resources
Search Medline for related articles (PubMed) *Medline Search:* cancer AND gene AND (FGR[TI] OR SRC2[TI]) (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Return to FGR Contents
Defining Texts
Tronick SR. et al. Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family. Proc Natl Acad Sci USA 1985; 82:6595-9 Related articles (PubMed) Nishizawa M. et al. Structure, expression, and chromosomal location of the human c-fgr gene. Mol Cell Biol 1986; 6:511-7 Related articles (PubMed) Dracopoli NC. et al. Localization of the FGR protooncogene on the genetic linkage map of human chromosome 1p. Genomics 1988; 3:124-8 Related articles (PubMed) Return to FGR Contents
FGR and Cancer
In a LOH study of 96 primary human breast carcinomas (Bieche I. et al, 1999) excluded FGR from the common 1p32-pter regions of deletion frequently seen in breast cancer. Bieche I. et al. Deletion mapping of chromosomal region 1p32-pter in primary breast cancer. Genes Chromosomes Cancer 1999; 24:255-63 Related articles (PubMed) *Medline Search:* fgr AND chromosome 1 AND cancer (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Return to FGR Contents
Epstein-Barr virus and FGR activation
Several studies have shown that C-FGR is expressed in the B cells of Epstein-Barr virus-associated lymphoproliferative diseases, and in chronic lymphocytic leukaemia. However, Link and Zutter (1995) demonstrated that p55c-fgr is expressed in a subpopulation of normal B-lymphocytes and therefore suggested that its expression in B-cell lymphoproliferative disease may be an indirect consequence of, rather than the primary cause of carcinogenesis in these conditions. Link DC, Zutter M. The proto-oncogene c-fgr is expressed in normal mantle zone B lymphocytes and is developmentally regulated during myelomonocytic differentiation in vivo. Blood 1995; 85:472-9 Related articles (PubMed) Patel M. et al. The c-fgr proto-oncogene: expression in Epstein-Barr-virus-infected B lymphocytes and in cells of the myelomonocytic and granulocytic lineages. Pathobiology 1991; 59:289-92 Related articles (PubMed) Cheah MS et al. fgr proto-oncogene mRNA induced in B lymphocytes by Epstein-Barr virus infection. Nature 1986; 319:238-40 Related articles (PubMed) Klein C. et al. Expression of the c-fgr related transcripts in Epstein-Barr virus-associated malignancies. Int J Cancer 1988; 42:29-35 Related articles (PubMed) *Medline Search:* Epstein-Barr virus AND fgr AND gene (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Related Resources Haematological malignancies Return to FGR Contents
[Home] This page created: 09/10/1999 Last revised: 29/04/2003 © Copyright 1999-

FGR; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene