Pancreatic cancers are frequently associated with mutation of the KRAS oncogene and inactivating mutations of multiple tumor suppressor genes, particularly TP53, MADH4 (DPC4), CDKN2A (P16), and BRCA2. Also, overexpression of growth factors (EGF, TGF alpha, TGF beta 1-3, aFGF, bTGF) and their associated receptors are also common.
Familial clustering of pancreatic cancer has been reported, germline mutations of BRCA2 and CDKN2A predispose to pancreatic cancer. Mutations in the STk11gene
also predisopse to pancreatic cancer in patients with Peutz-Jeghers Syndrome.
Coppola D Molecular prognostic markers in pancreatic cancer. Cancer Control 2000 Sep-Oct;7(5):421-7 Related articles (PubMed)
Sakorafas GH, et al. Molecular biology of pancreatic cancer; oncogenes, tumour suppressor genes, growth factors, and their receptors from a clinical perspective. Cancer Treat Rev 2000;26(1):29-52 Related articles (PubMed)
Tascilar M, et al. Role of tumor markers and mutations in cells and pancreatic juice in the diagnosis of pancreatic cancer [Review] Ann Oncol 1999;10 Suppl 4:107-10 Related articles (PubMed)
Goggins M. et al Progress in cancer genetics: lessons from pancreatic cancer. Ann Oncol 1999;10 Suppl 4:4-8 [Review] Related articles (PubMed)
Lamerz R Role of tumour markers, cytogenetics. {{in biliopancreatic malignancies}} Ann Oncol 1999;10 Suppl 4:145-9 Related articles (PubMed)
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Banke MG, et al. Inheritance of pancreatic cancer in pancreatic cancer-prone families. Med Clin North Am 2000 May;84(3):677-90 Related articles (PubMed)
Hruban RH,et al. Familial pancreatic cancer. Ann Oncol 1999;10 Suppl 4:69-73 Related articles (PubMed)
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