 Summary Information
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Location: 3p22
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| Gene Database Entries for TGFBR2
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OMIM
GeneCard (Weizmann Institute)
Human Gene Mutation Database (Cardiff, UK)
Genbank
Swiss-Prot
Locus Link (search for TGFBR2)
UniGene
GenAtlas
GDB
Nomenclature (search for TGFBR2)
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| Other Related Resources
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- Search Medline for related articles (PubMed)
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- Medline Search: cancer AND gene AND TGFBR2[TI] (PubMed)
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| TGFBR2 and Thyroid Cancer
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Matoba H, et al. Expression of transforming growth factor-beta1 and transforming growth factor-beta Type-II receptor mRNA in papillary thyroid carcinoma. Horm Metab Res 1998; 30(10):624-8 Related articles (PubMed)
Turco A, et al. Overexpression of transforming growth factor beta-type II receptor reduces tumorigenicity and metastastic potential of K-ras-transformed thyroid cells. Int J Cancer. 1999; 80(1):85-91 Related articles (PubMed)
Lazzereschi D, et al. Human malignant thyroid tumors displayed reduced levels of transforming growth factor beta receptor type II messenger RNA and protein. Cancer Res. 1997; 57(10):2071-6 Related articles (PubMed)
Medline Search: transforming growth factor AND receptor AND gene AND thyroid cancer (PubMed)
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- Related Resources
 Thyroid Cancer Genetics
Thyroid Cancer : Clinical and Epidemiological Information
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| TGFBR2 and Colorectal Cancer
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Togo G, et al. Does mutation of transforming growth factor-beta type II receptor gene play an important role in colorectal polyps? Dig Dis Sci. 1999; 44(9):1803-9 Related articles (PubMed)
Markowitz S, et al. Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science 1995; 268(5215):1336-8 Related articles (PubMed)
Medline Search: colorectal cancer AND transforming growth factors AND receptor (PubMed)
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ColoRectal Cancers Genetics
ColoRectal Cancers : Clinical and Epidemiological Information
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| TGFBR2 and Gastric Cancer
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Iacopetta BJ, et al. Gastric carcinomas with microsatellite instability: clinical features and mutations to the TGF-beta type II receptor, IGFII receptor, and BAX genes. J Pathol 1999; 187(4):428-32 Related articles (PubMed)
Medline Search: gastric cancer AND transforming growth factors AND receptor (PubMed)
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Stomach (Gastric) Cancer Genetics
Stomach (Gastric) Cancer : Clinical and Epidemiological Information
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| TGFBR2 and Pancreatic Cancer
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Goggins M, et al. Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas. Cancer Res 1998; 58(23):5329-32 Related articles (PubMed)
Medline Search: pancreatic cancer AND transforming growth factors AND receptor (PubMed)
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Pancreatic Cancer Genetics
Pancreatic Cancer : Clinical and Epidemiological Information
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| TGFBR2 in EHLA and Risk of Breast Cancer
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Gobbi H, et al. Transforming Growth Factor-ß and Breast Cancer Risk in Women With Mammary Epithelial Hyperplasia J Natl Cancer Inst. 1999; 91(24): 2096-2101 Related articles
Medline Search: breast cancer AND transforming growth factors AND receptor AND gene (PubMed)
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Breast Cancer Genetics
Breast Cancer : Clinical and Epidemiological Information
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| TGFBR2 Suppression by Ewing's Sarcoma EWS/FLI1 Fusion Genes
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Hahm and colleagues (Nat Genet, 1999) reported that TGFBR2, a putative tumour suppresser gene, is a direct target of the EWS-FLI1 fusion protein. They found that Ewing’s sarcoma cell lines and primary tumours with the EWSR1-FLI1 expressed low or
undetectable levels of TGFBR2 mRNA and protein product. However, in ES cell lines antisense to EWSR1-FLI1 restored TGFBR2 expression and introduction of normal TGFBR2-beta restored TGF-beta sensitivity and blocked tumorigenicity. They later demonstrated
(Cancer Res, 2000) similar effects of EWS-ETV1 and EWS-ERG fusion proteins on the expression of TGFBR2 gene in ES cell lines.
Im YH, et al. EWS-FLI1, EWS-ERG, and EWS-ETV1 oncoproteins of Ewing tumor family all suppress transcription of transforming growth factor beta type II receptor gene. Cancer Res 2000 Mar 15;60(6):1536-40 Related articles (PubMed)
Hahm KB, et al. Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein. Nat Genet 1999;23(2):222-7 Related articles (PubMed)
Medline Search: Ewing's sarcoma AND transforming growth factors AND receptor AND gene (PubMed)
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Ewing's Sarcoma Genetics
Ewing's Sarcoma : Clinical and Epidemiological Information
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[Home] This page created: 16/12/1999 Last revised: 29/04/2003 © Copyright 1999-
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