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  Chromosome 3

Genes Linked with Cancer

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 3; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
EPHA3 3p11.2 EK4, ETK, HEK, ETK1, HEK4, TYRO4
FOXP1 3p14.1 QRF1, 12CC4, hFKH1B, HSPC215Somatic
MITF 3p14.2-p14.1 MI, WS2, CMM8, WS2A, bHLHe32Somatic
FHIT 3p14.2 FRA3B, AP3AaseSomatic
Translocation
-Kidney Cancer
TCTA 3p21
NCKIPSD 3p21 DIP, DIP1, ORF1, WISH, VIP54, AF3P21, SPIN90, WASLBPSomatic
CTNNB1 3p21 CTNNB, MRD19, armadilloSomatic
PBRM1 3p21 PB1, BAF180Somatic
DLEC1 3p21.3 F56, DLC1
MLH1 3p21.3 FCC2, COCA2, HNPCC, hMLH1, HNPCC2Germline & Somatic-Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
-Lynch Syndrome II
RHOA 3p21.3 ARHA, ARH12, RHO12, RHOH12
RASSF1 3p21.3 123F2, RDA32, NORE2A, RASSF1A, REH3P21
Methylation
-Breast Cancer
-Liver Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Prostate Cancer
SETD2 3p21.31 HYPB, SET2, HIF-1, HIP-1, KMT3A, HBP231, HSPC069, p231HBPSomatic
BAP1 3p21.31-p21.2 UCHL2, hucep-6, HUCEP-13Somatic
MYD88 3p22 MYD88DSomatic
TGFBR2 3p22 AAT3, FAA3, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TGFR-2, TGFbeta-RII-Ewing's Sarcoma
TGM4 3p22-p21.33 TGP, hTGP
VIPR1 3p22 II, HVR1, RDC1, V1RG, VIPR, VIRG, VAPC1, VPAC1, VPAC1R, VIP-R-1, VPCAP1R, PACAP-R2, PACAP-R-2
NKTR 3p22.1 p104
CCK 3p22.1 -Bowel Cancer
-Ewing's Sarcoma
-Liver Cancer
-Pancreatic Cancer
-Thyroid Cancer
SCLC1 3p23-p21 SCCL, SCLC
TOP2B 3p24 TOPIIB, top2beta
THRB 3p24.2 GRTH, PRTH, THR1, ERBA2, NR1A2, THRB1, THRB2, C-ERBA-2, C-ERBA-BETA
RARB 3p24.2 HAP, RRB2, NR1B2, MCOPS12
XPC 3p25 XP3, RAD4, XPCCGermline
PPARG 3p25 GLM1, CIMT1, NR1C3, PPARG1, PPARG2, PPARgammaSomatic
RAF1 3p25 NS5, CRAF, Raf-1, c-RafSomatic
SRGAP3 3p25.3 WRP, MEGAP, SRGAP2, ARHGAP14Somatic
VHL 3p25.3 RCA1, VHL1, pVHL, HRCA1Germline & Somatic-Adrenocortical Cancer
-Bladder Cancer
-Childhood Cancers
-Head and Neck Cancers
-Kidney Cancer
-Pheochromocytoma and Paraganglioma
FANCD2 3p26 FA4, FAD, FACD, FAD2, FA-D2, FANCDGermline-Fanconi Anaemia
TFG 3q12.2 TF6, HMSNP, SPG57, TRKT3Somatic
CBLB 3q13.11 Cbl-b, RNF56, Nbla00127Somatic
TM4SF1 3q21-q25 L6, H-L6, M3S1, TAAL6
CNBP 3q21 DM2, ZNF9, CNBP1, PROMM, RNF163, ZCCHC22Somatic
GATA2 3q21.3 DCML, NFE1B, MONOMACSomatic
RPN1 3q21.3 OST1, RBPH1Somatic
ACPP 3q22.1 PAP, ACP3, 5'-NT, ACP-3
WWTR1 3q23-q24 TAZSomatic
FOXL2 3q23 BPES, PFRK, POF3, BPES1, PINTOSomatic
GMPS 3q24 Somatic
MLF1 3q25.1 Somatic
MME 3q25.2 NEP, SFE, CD10, CALLA
IL12A 3q25.33 P35, CLMF, NFSK, NKSF1, IL-12A
MDS1 3q26 PRDM3, MDS1-EVI1Somatic
TERC 3q26 TR, hTR, TRC3, DKCA1, PFBMFT2, SCARNA19
TNFSF10 3q26 TL2, APO2L, CD253, TRAIL, Apo-2L
PDCD10 3q26.1 CCM3, TFAR15
ECT2 3q26.1-q26.2 ARHGEF31
MECOM 3q26.2 EVI1, MDS1, PRDM3, MDS1-EVI1, AML1-EVI-1Somatic
Translocation
-Acute Myeloid Leukaemia
-Leukaemia
SOX2 3q26.3-q27 ANOP3, MCOPS3Somatic
PIK3CA 3q26.3 MCM, CWS5, MCAP, PI3K, CLOVE, MCMTC, p110-alphaSomatic
BCL6 3q27 BCL5, LAZ3, BCL6A, ZNF51, ZBTB27Somatic
Translocation
-Leukaemia
-Non-Hodgkin Lymphoma
ABCC5 3q27 MRP5, SMRP, ABC33, MOATC, MOAT-C, pABC11, EST277145
EIF4A2 3q28 DDX2B, EIF4A, EIF4F, BM-010, eIF4A-II, eIF-4A-IISomatic
ETV5 3q28 ERMSomatic
SST 3q28 SMST
LPP 3q28 Somatic
TFRC 3q29 T9, TR, TFR, p90, CD71, TFR1, TRFRSomatic
MUC4 3q29 ASGP, MUC-4, HSA276359

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 3:

Abnormality Type Gene(s)
del(3p) in Lung CancerDeletion
t(3;11)(q27;q23) in B-Cell LeukaemiaTranslocationBCL6 (3q27)POU2AF1 (11q23.1)
t(3;14)(q27;q32) in B-cell non-Hodgkin's lymphomaTranslocationBCL6 (3q27)
t(3;12)(p13;q22) in LeukaemiaTranslocationMECOM (3q26.2)RUNX1 (21q22.3)
t(3;21)(q26;q22) in Secondary Leukaemia / MDSTranslocationMECOM (3q26.2)RUNX1 (21q22.3)
t(3;8)(p14.2;q24.1) in Hereditary Renal Cell CarcinomaTranslocationFHIT (3p14.2)RNF139 (8q24)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


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