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  Chromosome 3

Genes Linked with Cancer (127)

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 3; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
POU1F1 3p11 PIT1, CPHD1, GHF-1, Pit-1, POU1F1a-Breast Cancer
-Pituitary Tumors
EPHA3 3p11.2 EK4, ETK, HEK, ETK1, HEK4, TYRO4
ROBO1 3p12 SAX3, DUTT1-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Pancreatic Cancer
LRIG1 3p14 LIG1, LIG-1-Bladder Cancer
-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Breast Cancer
-Stomach Cancer
FOXP1 3p14.1 QRF1, 12CC4, hFKH1B, HSPC215Somatic-Stomach Cancer
-Thyroid Cancer
ADAMTS9 3p14.1 -Colorectal Cancer
-Esophageal Cancer
-Multiple Myeloma
-Nasopharyngeal Cancer
-Pancreatic Cancer
-Stomach Cancer
FHIT 3p14.2 FRA3B, AP3AaseSomatic
Translocation
-Acute Lymphocytic Leukaemia (ALL)
-Bladder Cancer
-Cervical Cancer
-Kidney Cancer
-Ovarian Cancer
-Pancreatic Cancer
-Stomach Cancer
MITF 3p14.2-p14.1 MI, WS2, CMM8, WS2A, bHLHe32Somatic-Kidney Cancer
-Melanoma
-Skin Cancer
MST1 3p21 MSP, HGFL, NF15S2, D3F15S2, DNF15S2-Liver Cancer
-Prostate Cancer
CCR1 3p21 CKR1, CD191, CKR-1, HM145, CMKBR1, MIP1aR, SCYAR1-Bone Cancer (primary)
-Liver Cancer
-Lung Cancer
-Ovarian Cancer
-Uterine Sarcoma
PBRM1 3p21 PB1, BAF180Somatic-Kidney Cancer
-Pancreatic Cancer
CDC25A 3p21 CDC25A2-Breast Cancer
WNT5A 3p21-p14 hWNT5A-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Melanoma
-Prostate Cancer
TCTA 3p21
NCKIPSD 3p21 DIP, DIP1, ORF1, WISH, VIP54, AF3P21, SPIN90, WASLBPSomatic-Stomach Cancer
CTNNB1 3p21 CTNNB, MRD19, armadilloSomatic-Adrenocortical Cancer
-Breast Cancer
-Colorectal Cancer
-Hepatoblastoma
-Liver Cancer
-Lung Cancer
-Melanoma
-Ovarian Cancer
-Prostate Cancer
-Stomach Cancer
-Thyroid Cancer
PTPRG 3p21-p14 PTPG, HPTPG, RPTPG, R-PTP-GAMMA-Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Skin Cancer
GNL3 3p21.1 NS, E2IG3, NNP47, C77032-Acute Myeloid Leukaemia
-Bladder Cancer
-Cervical Cancer
-Prostate Cancer
-Stomach Cancer
RBM5 3p21.3 G15, H37, RMB5, LUCA15-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
RASSF1 3p21.3 123F2, RDA32, NORE2A, RASSF1A, REH3P21
Methylation
-Breast Cancer
-Liver Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Prostate Cancer
SEMA3F 3p21.3 SEMA4, SEMAK, SEMA-IV-Lung Cancer
-Salivary Gland Cancer
GPX1 3p21.3 GPXD, GSHPX1-Bladder Cancer
-Breast Cancer
-Liver Cancer
-Lung Cancer
-Prostate Cancer
-Stomach Cancer
CTDSPL 3p21.3 PSR1, SCP3, HYA22, RBSP3, C3orf8-Acute Myeloid Leukaemia
-Breast Cancer
-Cervical Cancer
-Lung Cancer, Non-Small Cell
-Prostate Cancer
TLR9 3p21.3 CD289-Breast Cancer
-Cervical Cancer
-Chronic Lymphocytic Leukemia
-Prostate Cancer
RHOA 3p21.3 ARHA, ARH12, RHO12, RHOH12-Bladder Cancer
-Breast Cancer
-Liver Cancer
-Lung Cancer
LIMD1 3p21.3 -Breast Cancer
-Head and Neck Cancers
-Lung Cancer
CISH 3p21.3 CIS, G18, SOCS, CIS-1, BACTS2-Breast Cancer
-Lung Cancer
-Stomach Cancer
-Uterine Sarcoma
HYAL2 3p21.3 LUCA2-Lung Cancer
-Lung Cancer, Non-Small Cell
SEMA3B 3p21.3 SemA, SEMA5, SEMAA, semaV, LUCA-1-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
CCR3 3p21.3 CKR3, CD193, CMKBR3, CC-CKR-3-Liver Cancer
-Ovarian Cancer
-Skin Cancer
-Uterine Sarcoma
TUSC2 3p21.3 PAP, FUS1, PDAP2, C3orf11-Lung Cancer
-Lung Cancer, Non-Small Cell
MLH1 3p21.3 FCC2, COCA2, HNPCC, hMLH1, HNPCC2Germline & Somatic-Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
-Lynch Syndrome II
NPRL2 3p21.3 NPR2, NPR2L, TUSC4-Lung Cancer, Non-Small Cell
CX3CR1 3p21.3 V28, CCRL1, GPR13, CMKDR1, GPRV28, CMKBRL1-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Pancreatic Cancer
-Skin Cancer
ZMYND10 3p21.3 BLU, FLU, CILD22-Lung Cancer
-Lung Cancer, Non-Small Cell
-Nasopharyngeal Cancer
-Neuroblastoma
-Ovarian Cancer
CAMP 3p21.3 LL37, CAP18, CRAMP, HSD26, CAP-18, FALL39, FALL-39-Adrenocortical Cancer
-Breast Cancer
-Prostate Cancer
-Skin Cancer
DLEC1 3p21.3 F56, DLC1, CFAP81-Bladder Cancer
-Breast Cancer
-Liver Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Nasopharyngeal Cancer
-Uterine Sarcoma
PRKCD 3p21.31 MAY1, PKCD, ALPS3, CVID9, nPKC-delta-Breast Cancer
-Cervical Cancer
CDCP1 3p21.31 CD318, TRASK, SIMA135-Breast Cancer
-Kidney Cancer
-Lung Cancer
-Pancreatic Cancer
HYAL1 3p21.31 NAT6, LUCA1, HYAL-1-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Ovarian Cancer
-Prostate Cancer
TDGF1 3p21.31 CR, CRGF, CRIPTO-Breast Cancer
-Colorectal Cancer
-Liver Cancer
BAP1 3p21.31-p21.2 UCHL2, hucep-6, HUCEP-13Somatic-Breast Cancer
-Intraocular (Eye) Melanoma
-Kidney Cancer
-Lung Cancer
-Melanoma
-Mesothelioma
-Skin Cancer
SETD2 3p21.31 HYPB, SET2, HIF-1, HIP-1, KMT3A, HBP231, HSPC069, p231HBPSomatic-Kidney Cancer
GNAI2 3p21.31 GIP, GNAI2B, H_LUCA15.1, H_LUCA16.1-Ovarian Cancer
CCR2 3p21.31 CKR2, CCR-2, CCR2A, CCR2B, CD192, CKR2A, CKR2B, CMKBR2, MCP-1-R, CC-CKR-2-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Prostate Cancer
CCR5 3p21.31 CKR5, CCR-5, CD195, CKR-5, CCCKR5, CMKBR5, IDDM22, CC-CKR-5-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Kaposi Sarcoma
-Prostate Cancer
-Salivary Gland Cancer
-Uterine Sarcoma
MYD88 3p22 MYD88DSomatic-Chronic Lymphocytic Leukemia
-Skin Cancer
-Testicular Cancer
-Waldenstrom's Macroglobulinemia
VIPR1 3p22 II, HVR1, RDC1, V1RG, VIPR, VIRG, VAPC1, VPAC1, VPAC1R, VIP-R-1, VPCAP1R, PACAP-R2, PACAP-R-2-Cervical Cancer
-Lung Cancer
TGFBR2 3p22 AAT3, FAA3, LDS2, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TGFR-2, TGFbeta-RII-Breast Cancer
-Colorectal Cancer
-Ewing's Sarcoma
-Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
-Lung Cancer
-Pancreatic Cancer
-Stomach Cancer
-Thyroid Cancer
TGM4 3p22-p21.33 TGP, hTGP-Prostate Cancer
PTH1R 3p22-p21.1 PFE, PTHR, PTHR1-Bone Cancer (primary)
-Multiple Hereditary Exostoses
-Osteosarcoma
PLCD1 3p22-p21.3 NDNC3, PLC-III-Breast Cancer
-Chronic Myelogenous Leukemia
-Esophageal Cancer
-Lung Cancer
-Stomach Cancer
NKTR 3p22.1 p104-Prostate Cancer
CCK 3p22.1 -Colorectal Cancer
-Ewing's Sarcoma
-Liver Cancer
-Pancreatic Cancer
-Thyroid Cancer
SCLC1 3p23-p21 SCCL, SCLC-Lung Cancer
-Lung Cancer, Non-Small Cell
SATB1 3p23 -Breast Cancer
-Liver Cancer
-Lung Cancer
-Stomach Cancer
LRRC3B 3p24 LRP15-Acute Lymphocytic Leukaemia (ALL)
-Acute Myeloid Leukaemia
-Leukaemia
-Stomach Cancer
CCR4 3p24 CKR4, K5-5, CD194, CMKBR4, ChemR13, CC-CKR-4, HGCN:14099-Breast Cancer
-Skin Cancer
TOP2B 3p24 TOPIIB, top2beta
THRB 3p24.2 GRTH, PRTH, THR1, ERBA2, NR1A2, THRB1, THRB2, C-ERBA-2, C-ERBA-BETA-Cervical Cancer
-Eye Cancer
-Prostate Cancer
-Thyroid Cancer
-von Hippel-Lindau Disease
RARB 3p24.2 HAP, RRB2, NR1B2, MCOPS12-Breast Cancer
-Cervical Cancer
-Eye Cancer
-Lung Cancer
-Prostate Cancer
-Urinary System Cancers
PPARG 3p25 GLM1, CIMT1, NR1C3, PPARG1, PPARG2, PPARgammaSomatic
Translocation
-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Prostate Cancer
-Stomach Cancer
-Thyroid Cancer
WNT7A 3p25 -Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Ovarian Cancer
RAF1 3p25 NS5, CRAF, Raf-1, c-Raf, CMD1NNSomatic-Bladder Cancer
-Brain and CNS Tumours
-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Melanoma
XPC 3p25.1 XP3, RAD4, XPCC, p125Germline-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Melanoma
-Skin Cancer
SLC6A6 3p25.1 TAUT
IRAK2 3p25.3 IRAK-2-Breast Cancer
-Cervical Cancer
-Prostate Cancer
-Waldenstrom's Macroglobulinemia
ATG7 3p25.3 GSA7, APG7L, APG7-LIKE-Breast Cancer
-Chronic Myelogenous Leukemia
-Liver Cancer
-Lung Cancer
SRGAP3 3p25.3 WRP, MEGAP, SRGAP2, ARHGAP14Somatic-Astrocytoma, Childhood
-Brain Tumours, Childhood
-Breast Cancer
-Neuroblastoma
VHL 3p25.3 RCA1, VHL1, pVHL, HRCA1Germline & Somatic-Adrenocortical Cancer
-Bladder Cancer
-Head and Neck Cancers
-Kidney Cancer
-Pheochromocytoma and Paraganglioma
-von Hippel-Lindau Disease
FANCD2 3p26 FA4, FAD, FACD, FAD2, FA-D2, FANCDGermline-Fanconi Anaemia
OGG1 3p26.2 HMMH, MUTM, OGH1, HOGG1-Breast Cancer
-Colorectal Cancer
-Head and Neck Cancers
-Lung Cancer
MINA 3q11.2 ROX, MDIG, NO52, MINA53-Breast Cancer
-Colorectal Cancer
-Kidney Cancer
-Lung Cancer
TFG 3q12.2 TF6, HMSNP, SPG57, TRKT3Somatic-Chondrosarcoma
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Soft Tissue Sarcoma
-Thyroid Cancer
NIT2 3q12.2 HEL-S-8a
CASR 3q13 CAR, FHH, FIH, HHC, EIG8, HHC1, NSHPT, PCAR1, GPRC2A, HYPOC1-Colorectal Cancer
-Parathyroid Cancer
-Prostate Cancer
CD47 3q13.1-q13.2 IAP, OA3, MER6-Bladder Cancer
-Esophageal Cancer
-Multiple Myeloma
ALCAM 3q13.1 MEMD, CD166-Breast Cancer
-Colorectal Cancer
CBLB 3q13.11 Cbl-b, RNF56, Nbla00127Somatic-Acute Myeloid Leukaemia
-Chronic Myelogenous Leukemia
KIAA1524 3q13.13 p90, CIP2A-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Liver Cancer
-Lung Cancer
-Oral Cavity Cancer
CD200 3q13.2 MRC, MOX1, MOX2, OX-2-Acute Myeloid Leukaemia
-Breast Cancer
-Chronic Lymphocytic Leukemia
-Mantle-Cell Lymphoma
-Multiple Myeloma
CD80 3q13.3-q21 B7, BB1, B7-1, B7.1, LAB7, CD28LG, CD28LG1-Chronic Lymphocytic Leukemia
-Eye Cancer
-Melanoma
CD86 3q21 B70, B7-2, B7.2, LAB72, CD28LG2-Melanoma
-Stomach Cancer
CNBP 3q21 DM2, ZNF9, CNBP1, PROMM, RNF163, ZCCHC22Somatic
TM4SF1 3q21-q25 L6, H-L6, M3S1, TAAL6-Breast Cancer
-Colorectal Cancer
-Pancreatic Cancer
-Prostate Cancer
-Stomach Cancer
MCM2 3q21 BM28, CCNL1, CDCL1, cdc19, D3S3194, MITOTIN-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Pheochromocytoma and Paraganglioma
-Wilms Tumour
GATA2 3q21.3 DCML, IMD21, NFE1B, MONOMACSomatic-Acute Myeloid Leukaemia
-Leukaemia
-Myelodysplastic Syndromes
-Prostate Cancer
MBD4 3q21.3 MED1-Colorectal Cancer
-Lung Cancer
-Prostate Cancer
RPN1 3q21.3 OST1, RBPH1Somatic-Acute Myeloid Leukaemia
-Chronic Myelogenous Leukemia
-Haematological Malignancies
-Leukaemia
-Myelodysplastic Syndromes
TOPBP1 3q22.1 TOP2BP1-Breast Cancer
-Colorectal Cancer
-Ovarian Cancer
ACPP 3q22.1 ACP3, 5'-NT, ACP-3-Prostate Cancer
PIK3CB 3q22.3 PI3K, PIK3C1, P110BETA, PI3KBETA-Breast Cancer
-Endometrial Cancer
-Thyroid Cancer
RBP1 3q23 CRBP, RBPC, CRBP1, CRBPI, CRABP-I-Brain Tumours, Childhood
-Breast Cancer
-Cervical Cancer
-Uterine Sarcoma
WWTR1 3q23-q24 TAZSomatic-Bone Cancer (primary)
-Breast Cancer
-Colorectal Cancer
FOXL2 3q23 BPES, PFRK, POF3, BPES1, PINTOSomatic-Ovarian Cancer
-Testicular Cancer
GMPS 3q24 Somatic-Acute Myeloid Leukaemia
MLF1 3q25.1 Somatic-Acute Myeloid Leukaemia
-Leukaemia
-Myelodysplastic Syndromes
-Stomach Cancer
HLTF 3q25.1-q26.1 ZBU1, HLTF1, RNF80, HIP116, SNF2L3, HIP116A, SMARCA3-Cervical Cancer
-Colorectal Cancer
-Stomach Cancer
MME 3q25.2 NEP, SFE, CD10, CALLA-Breast Cancer
-Mesothelioma
-Prostate Cancer
RARRES1 3q25.32 LXNL, TIG1-Breast Cancer
-Esophageal Cancer
-Prostate Cancer
-Stomach Cancer
IL12A 3q25.33 P35, CLMF, NFSK, NKSF1, IL-12A-Bladder Cancer
-Cervical Cancer
-Colorectal Cancer
-Kaposi Sarcoma
-Liver Cancer
-Non-Hodgkin Lymphoma
-Stomach Cancer
-Vulvar Cancer
SKIL 3q26 SNO, SnoA, SnoI, SnoN-Breast Cancer
-Esophageal Cancer
-Lung Cancer
-Ovarian Cancer
-Skin Cancer
TNFSF10 3q26 TL2, APO2L, CD253, TRAIL, Apo-2L
TERC 3q26 TR, hTR, TRC3, DKCA1, PFBMFT2, SCARNA19-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Eye Cancer
-Lung Cancer
-Melanoma
-Neuroblastoma
-Testicular Cancer
-Thyroid Cancer
-Uterine Sarcoma
-Vulvar Cancer
MDS1 3q26 PRDM3, MDS1-EVI1Somatic-Acute Myeloid Leukaemia
-Leukaemia
-Myelodysplastic Syndromes
BCHE 3q26.1-q26.2 E1, CHE1, CHE2-Bladder Cancer
-Brain Tumours, Childhood
-Lung Cancer
-Myelodysplastic Syndromes
-Neuroblastoma
ECT2 3q26.1-q26.2 ARHGEF31-Brain Stem Glioma, Childhood
-Lung Cancer
PDCD10 3q26.1 CCM3, TFAR15-Brain and CNS Tumours
-Brain Tumours, Childhood
MECOM 3q26.2 EVI1, MDS1, PRDM3, MDS1-EVI1, AML1-EVI-1Somatic
Translocation
-Acute Myeloid Leukaemia
-Chronic Myelogenous Leukemia
-Leukaemia
-Myelodysplastic Syndromes
SOX2 3q26.3-q27 ANOP3, MCOPS3Somatic-Brain Tumours, Childhood
-Breast Cancer
-Esophageal Cancer
-Lung Cancer
PIK3CA 3q26.3 MCM, CWS5, MCAP, PI3K, CLOVE, MCMTC, p110-alphaSomatic-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Cowden Syndrome
-Endometrial Cancer
-Esophageal Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Soft Tissue Sarcoma
ADIPOQ 3q27 ACDC, ADPN, APM1, APM-1, GBP28, ACRP30, ADIPQTL1-Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Colorectal Cancer
-Prostate Cancer
ABCC5 3q27 MRP5, SMRP, ABC33, MOATC, MOAT-C, pABC11, EST277145-Breast Cancer
BCL6 3q27 BCL5, LAZ3, BCL6A, ZNF51, ZBTB27Somatic
Translocation
-Leukaemia
-Non-Hodgkin Lymphoma
EPHB3 3q27.1 ETK2, HEK2, TYRO6-Colorectal Cancer
-Lung Cancer
PARL 3q27.1 PSARL, PSARL1, RHBDS1, PRO2207, PSENIP2-Breast Cancer
ETV5 3q28 ERMSomatic-Bone Cancer (primary)
-Cervical Cancer
-Endometrial Cancer
-Ovarian Cancer
-Prostate Cancer
EIF4A2 3q28 DDX2B, EIF4A, EIF4F, BM-010, eIF4A-II, eIF-4A-IISomatic-Breast Cancer
-Non-Hodgkin Lymphoma
SST 3q28 SMST-Brain Tumours, Childhood
-Gastrointestinal Cancers
-Pancreatic Cancer
-Prostate Cancer
-Stomach Cancer
HES1 3q28-q29 HHL, HRY, HES-1, bHLHb39-Brain Tumours, Childhood
-Liver Cancer
-Lung Cancer
-Myelodysplastic Syndromes
TP63 3q28 AIS, KET, LMS, NBP, RHS, p40, p51, p63, EEC3, OFC8, p73H, p73L, SHFM4, TP53L, TP73L, p53CP, TP53CP, B(p51A), B(p51B)-Breast Cancer
-Head and Neck Cancers
-Lung Cancer
CLDN1 3q28-q29 CLD1, SEMP1, ILVASC-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Stomach Cancer
-Vulvar Cancer
LPP 3q28 Somatic-Lung Cancer
-Mycosis Fungoides
-Skin Cancer
MUC4 3q29 ASGP, MUC-4, HSA276359-Lung Cancer
-Pancreatic Cancer
-Prostate Cancer
-Soft Tissue Sarcoma
-Stomach Cancer
TFRC 3q29 T9, TR, TFR, p90, CD71, TFR1, TRFRSomatic-Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Cervical Cancer
DLG1 3q29 hdlg, DLGH1, SAP97, SAP-97, dJ1061C18.1.1-Breast Cancer
-Cervical Cancer
-Lung Cancer, Non-Small Cell
-Prostate Cancer
APOD 3q29 -Astrocytoma, Childhood
-Breast Cancer
-Cervical Cancer
-Ovarian Cancer
-Prostate Cancer

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 3:

Abnormality Type Gene(s)
del(3p) in Lung CancerDeletion
t(3;11)(q27;q23) in B-Cell LeukaemiaTranslocationBCL6 (3q27)POU2AF1 (11q23.1)
t(3;14)(q27;q32) in B-cell non-Hodgkin's lymphomaTranslocationBCL6 (3q27)
t(3;12)(p13;q22) in LeukaemiaTranslocationMECOM (3q26.2)RUNX1 (21q22.3)
t(3;21)(q26;q22) in Secondary Leukaemia / MDSTranslocationMECOM (3q26.2)RUNX1 (21q22.3)
t(3;8)(p14.2;q24.1) in Hereditary Renal Cell CarcinomaTranslocationFHIT (3p14.2)RNF139 (8q24)
PAX8-PPARG fusion in Folicular Thyroid CancerTranslocationPPARG (3p25)PAX8 (2q13)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


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Cite this page: Cotterill SJ. Chromosome 3, Cancer Genetics Web: http://www.cancerindex.org/geneweb/clinkc03.htm Accessed: date

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