TCTA; T-cell leukemia translocation altered (3p21)

Gene Summary

Gene:TCTA; T-cell leukemia translocation altered
Databases:OMIM, VEGA, HGNC, Ensembl, GeneCard, Gene
Protein:T-cell leukemia translocation-altered gene protein
Updated:14 December, 2014


What does this gene/protein do?
TCTA is implicated in:
- integral to membrane
Data from Gene Ontology via CGAP

Cancer Overview

Research Indicators

Publications Per Year (1989-2014)
Graph generated 14 December 2014 using data from PubMed using criteria.

Literature Analysis

Mouse over the terms for more detail; many indicate links which you can click for dedicated pages about the topic.

  • Genome, Human
  • Osteoclasts
  • Promoter Regions
  • Chromosome 1
  • Sequence Homology, Nucleic Acid
  • Cloning, Molecular
  • Aminomethyltransferase
  • Gene Deletion
  • Base Sequence
  • Chromosome 3
  • Arthritis, Rheumatoid
  • Synovial Membrane
  • Haplorhini
  • Pseudogenes
  • Proteins
  • Amino Acid Sequence
  • Genetic Linkage
  • Cancer DNA
  • Transcription
  • Cell Differentiation
  • Exons
  • Adult T-Cell Leukemia-Lymphoma
  • Lung Cancer
  • Translocation
  • Bone Resorption
  • Small Cell Lung Cancer
  • Physical Chromosome Mapping
  • TCTA
  • Small Cell Carcinoma
  • Introns
  • Hydroxymethyl and Formyl Transferases
  • Neoplasm Proteins
  • T-Cell Leukemia
  • Molecular Sequence Data
  • DNA Probes
  • Codon, Initiator
  • Dogs
Tag cloud generated 14 December, 2014 using data from PubMed, MeSH and CancerIndex

Related Links

Latest Publications: TCTA (cancer-related)

Leeb T, Breen M, Brenig B
Genomic structures and sequences of two closely linked genes (AMT, TCTA) on dog chromosome 20q15.1-->q15.2.
Cytogenet Cell Genet. 2000; 89(1-2):98-100 [PubMed] Related Publications
Analysis of genomic sequence from canine chromosome 20q15.1-->q15.2 revealed the presence of two closely linked genes. The two genes represent the corresponding canine orthologs of human aminomethyltransferase (AMT) and the human T-cell leukemia translocation associated (TCTA) gene. Aminomethyltransferase or glycine cleavage system T-protein is an important enzyme in glycine metabolism. The reported canine AMT gene spans 5 kb and consists of nine exons. It encodes a protein of 403 amino acids with 88% identity to human aminomethyltransferase. Human TCTA is located on 3p21 near the breakpoint of a t(1;3) translocation observed in some cancer cell lines. The 4-kb canine TCTA gene consists of three exons and probably represents a pseudogene. It is located adjacent to AMT and very close to DAG1 and BSN.

Aplan PD, Johnson BE, Russell E, et al.
Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation.
Cancer Res. 1995; 55(9):1917-21 [PubMed] Related Publications
We have cloned and characterized a novel gene at the site of a t(1;3)(p34;p21) translocation breakpoint in T-cell acute lymphoblastic leukemia. A cDNA for this gene, for which we propose the designation TCTA (T-cell leukemia translocation-associated gene), has been cloned. TCTA mRNA is expressed ubiquitously in normal tissues, with the highest levels of expression seen in the kidney. The TCTA gene is conserved throughout evolution in organisms ranging from Drosophila to humans. A short open reading frame encodes a predicted M(r) 12,000 protein without strong homology to any previously reported proteins. Of note, genomic Southern blots demonstrated a reduced TCTA signal in three of four small cell lung cancer cell lines tested, suggesting loss of one of the two copies of the gene.

Related: Chromosome 1 Chromosome 3 Lung Cancer


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Cite this page: Cotterill SJ. TCTA, Cancer Genetics Web: http://www.cancerindex.org/geneweb/TCTA.htm Accessed: date

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This page in Cancer Genetics Web by Simon Cotterill is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
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