Leukemia - Molecular Biology

Overview

Literature Analysis

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Tag cloud generated 10 March, 2017 using data from PubMed, MeSH and CancerIndex

Mutated Genes and Abnormal Protein Expression (154)

How to use this data tableClicking on the Gene or Topic will take you to a separate more detailed page. Sort this list by clicking on a column heading e.g. 'Gene' or 'Topic'.

GeneLocationAliasesNotesTopicPapers
BCR 22q11.23 ALL, CML, PHL, BCR1, D22S11, D22S662 -t(9;22)(p24;q11.2) BCR-JAK2 fusion
-BCR and Leukaemia
3000
LMO1 11p15.4 TTG1, RBTN1, RHOM1 Translocation
-t(11;14)(p15;q11) and LMO1 in T-ALL
3000
FLT3 13q12 FLK2, STK1, CD135, FLK-2 -FLT3 and Leukaemia
1395
PML 15q22 MYL, RNF71, PP8675, TRIM19 Translocation
-t(15;17)(q21;q21) RARA-PML translocation in Acute Promyelocytic Leukaemia
-PML and Leukaemia
994
TP53 17p13.1 P53, BCC7, LFS1, TRP53 -TP53 and Leukaemia
838
JAK2 9p24.1 JTK10, THCYT3 Translocation
-JAK2 and Leukaemia
-t(9;12)(p24;p13) ETV6-JAK2 fusion in lymphoid and myeloid leukemia
-t(8;9)(p22;p24) PCM1-JAK2 fusion in Hematologic Malignancies
-t(9;22)(p24;q11.2) BCR-JAK2 fusion
482
NRAS 1p13.2 NS6, CMNS, NCMS, ALPS4, N-ras, NRAS1 -NRAS and Leukemia
487
CEBPA 19q13.1 CEBP, C/EBP-alpha -CEBPA and Myeloid Leukemia
405
CD33 19q13.41 p67, SIGLEC3, SIGLEC-3 -CD33 and Myeloid Leukemia
327
MYH11 16p13.11 AAT4, FAA4, SMHC, SMMHC -MYH11 and Myeloid Leukemia
244
RUNX1T1 8q22 CDR, ETO, MTG8, AML1T1, ZMYND2, CBFA2T1, AML1-MTG8 -RUNX1T1 and Myeloid Leukemia
165
NUP98 11p15.4 ADIR2, NUP96, NUP196 -NUP98 and Leukaemia
159
MECOM 3q26.2 EVI1, MDS1, PRDM3, MDS1-EVI1, AML1-EVI-1 Translocation
-t(3;12)(p13;q22) in Leukaemia
-MECOM and Leukaemia
155
GATA1 Xp11.23 GF1, GF-1, NFE1, XLTT, ERYF1, NF-E1, XLANP, XLTDA, GATA-1 -GATA1 and Myeloid Leukemia
153
CSF1R 5q32 FMS, CSFR, FIM2, HDLS, C-FMS, CD115, CSF-1R, M-CSF-R -CSF1R and Myeloid Leukemia
151
HLA-A 6p21.3 HLAA -HLA-A and Leukaemia
149
CBFB 16q22.1 PEBP2B -CBFB and Myeloid Leukemia
145
CSF3R 1p35-p34.3 CD114, GCSFR -CSF3R and Myeloid Leukemia
141
CD14 5q31.1 -CD14 and Myeloid Leukemia
140
PDGFRA 4q12 CD140A, PDGFR2, PDGFR-2, RHEPDGFRA Deletion / Translocation
-FIP1L1-PDGFRA fusion in Leukemia
-PDGFRA and Leukaemia
66
GALE 1p36-p35 SDR1E1 -GALE and Myeloid Leukemia
99
PTPN11 12q24 CFC, NS1, SHP2, BPTP3, PTP2C, PTP-1D, SH-PTP2, SH-PTP3 -PTPN11 and Myeloid Leukemia
94
ITGAM 16p11.2 CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6 -ITGAM and Myeloid Leukemia
87
MPL 1p34 MPLV, TPOR, C-MPL, CD110, THCYT2 -MPL and Myeloid Leukemia
85
BAALC 8q22.3 -BAALC and Myeloid Leukemia
68
FIP1L1 4q12 Rhe, FIP1, hFip1 Deletion / Translocation
-FIP1L1-PDGFRA fusion in Leukemia
66
MLLT3 9p22 AF9, YEATS3 -MLLT3 and Leukaemia
63
GATA2 3q21.3 DCML, IMD21, NFE1B, MONOMAC -GATA2 and Myeloid Leukemia
57
MEIS1 2p14 -MEIS1 and Myeloid Leukemia
57
TFAP2A 6p24 AP-2, BOFS, AP2TF, TFAP2, AP-2alpha -TFAP2A and Myeloid Leukemia
52
TFAP2C 20q13.2 ERF1, TFAP2G, hAP-2g, AP2-GAMMA -TFAP2C and Myeloid Leukemia
51
TFAP2B 6p12 AP-2B, AP2-B -TFAP2B and Myeloid Leukemia
51
MN1 22q12.1 MGCR, MGCR1, MGCR1-PEN, dJ353E16.2 -MN1 and Myeloid Leukemia
48
MDS1 3q26 PRDM3, MDS1-EVI1 -MDS1 and Myeloid Leukemia
46
PRAME 22q11.22 MAPE, OIP4, CT130, OIP-4 -PRAME and Leukaemia
44
HLF 17q22 -HLF and Leukaemia
43
ETV6 12p13 TEL, THC5, TEL/ABL Translocation
-t(5;12)(q33;p13) in Chronic Myelomonocytic Leukemia
-t(9;12)(p24;p13) ETV6-JAK2 fusion in lymphoid and myeloid leukemia
33
VAV1 19p13.2 VAV -VAV1 and Leukemia
34
RAG2 11p12 RAG-2 -RAG2 and Leukaemia
34
KAT6A 8p11 MOZ, MRD32, MYST3, MYST-3, ZNF220, RUNXBP2, ZC2HC6A -KAT6A and Myeloid Leukemia
34
TRB 7q34 TCRB, TRB@ -TRB and T-Cell Leukemia
33
TLX1 10q24 TCL3, HOX11 -TLX1 and T-Cell Leukemia
31
MLLT1 19p13.3 ENL, LTG19, YEATS1 Translocation
-t(11;19)(q23;p13) in Leukaemia
-MLLT1 and Leukaemia
30
HOXA10 7p15.2 PL, HOX1, HOX1H, HOX1.8 -HOXA10 and Myeloid Leukemia
29
IL2RG Xq13.1 P64, CIDX, IMD4, CD132, SCIDX, IL-2RG, SCIDX1 -IL2RG and Leukaemia
29
IL21R 16p11 NILR, CD360 -IL21R and Leukaemia
28
TLX3 5q35.1 RNX, HOX11L2 -TLX3 and T-Cell Leukemia
27
CD36 7q11.2 FAT, GP4, GP3B, GPIV, CHDS7, PASIV, SCARB3, BDPLT10 -CD36 and Myeloid Leukemia
26
GFI1 1p22 SCN2, GFI-1, GFI1A, ZNF163 -GFI1 and Leukaemia
26
GSTM1 1p13.3 MU, H-B, GST1, GTH4, GTM1, MU-1, GSTM1-1, GSTM1a-1a, GSTM1b-1b Germline
Prognostic
-GSTM1 Polymorphisms and Susceptibility to Leukemia
25
FES 15q26.1 FPS -FES and Myeloid Leukemia
24
PRDM16 1p36.23-p33 MEL1, LVNC8, PFM13, CMD1LL -PRDM16 and Leukaemia
24
HOXD13 2q31.1 BDE, SPD, BDSD, HOX4I -HOXD13 and Leukaemia
23
DOT1L 19p13.3 DOT1, KMT4 -DOT1L and Leukaemia
23
ETS2 21q22.2 ETS2IT1 -ETS2 and Leukaemia
20
TCL1A 14q32.1 TCL1 -TCL1A and T-Cell Leukemia
20
G6PD Xq28 G6PD1 -G6PD and Myeloid Leukemia
20
NSD1 5q35 STO, KMT3B, SOTOS, ARA267, SOTOS1 -NSD1 and Myeloid Leukemia
19
PCM1 8p22-p21.3 PTC4, RET/PCM-1 Translocation
-PCM1 and Myeloid Leukemia
-t(8;9)(p22;p24) PCM1-JAK2 fusion in Hematologic Malignancies
10
PBX3 9q33.3 -PBX3 and Leukaemia
18
HOXA5 7p15.2 HOX1, HOX1C, HOX1.3 -HOXA5 and Leukaemia
17
MYB 6q22-q23 efg, Cmyb, c-myb, c-myb_CDS -Genes, myb and Myeloid Leukemia
16
SALL4 20q13.2 DRRS, HSAL4, ZNF797, dJ1112F19.1 -SALL4 and Leukaemia
16
MLF1 3q25.1 -MLF1 and Myeloid Leukemia
16
CBFA2T3 16q24 ETO2, MTG16, MTGR2, ZMYND4 -CBFA2T3 and Leukaemia
16
SEPT6 Xq24 SEP2, SEPT2 -SEPT6 and Leukaemia
15
BCL11B 14q32.2 ATL1, RIT1, CTIP2, CTIP-2, ZNF856B, ATL1-beta, ATL1-alpha, ATL1-delta, ATL1-gamma, hRIT1-alpha -BCL11B and T-Cell Leukemia
15
HOXA7 7p15.2 ANTP, HOX1, HOX1A, HOX1.1 -HOXA7 and Myeloid Leukemia
14
WT1-AS 11p13 WIT1, WIT-1, WT1AS, WT1-AS1 -WT1-AS and Leukaemia
14
ITGB2 21q22.3 LAD, CD18, MF17, MFI7, LCAMB, LFA-1, MAC-1 -ITGB2 and Myeloid Leukemia
14
MKL1 22q13 MAL, BSAC, MRTF-A Translocation
-t(1;22)(p13;q13) in Acute Megakaryocytic Leukemia
-MKL1 and Myeloid Leukemia
13
BCL2A1 15q24.3 GRS, ACC1, ACC2, BFL1, ACC-1, ACC-2, HBPA1, BCL2L5 -BCL2A1 and Leukemia
13
HLA-DPB1 6p21.3 DPB1, HLA-DP, HLA-DPB, HLA-DP1B -HLA-DPB1 and Leukaemia
13
BOLL 2q33 BOULE -BOLL and Myeloid Leukemia
12
MLLT6 17q21 AF17 -MLLT6 and Leukaemia
12
DDX10 11q22.3 HRH-J8 -DDX10 and Myeloid Leukemia
12
HCK 20q11-q12 JTK9, p59Hck, p61Hck -HCK and Leukaemia
12
TET1 10q21 LCX, CXXC6, bA119F7.1 -TET1 mutations in Leukemia
12
STAM 10p14-p13 STAM1, STAM-1 -STAM and Myeloid Leukemia
12
MNX1 7q36 HB9, HLXB9, SCRA1, HOXHB9 -MNX1 and Leukaemia
12
ID2 2p25 GIG8, ID2A, ID2H, bHLHb26 -ID2 in Leukemia & Lymphoma
11
CD3D 11q23.3 T3D, IMD19, CD3-DELTA -CD3D and Leukaemia
11
ITGAL 16p11.2 CD11A, LFA-1, LFA1A -ITGAL and Myeloid Leukemia
11
HOXB4 17q21.32 HOX2, HOX2F, HOX-2.6 -HOXB4 and Myeloid Leukemia
11
MSI2 17q22 MSI2H -MSI2 and Leukaemia
10
MTCP1 Xq28 p8MTCP1, P13MTCP1 -MTCP1 and T-Cell Leukemia
9
RPN1 3q21.3 OST1, RBPH1 -RPN1 and Myeloid Leukemia
9
THY1 11q23.3 CD90, CDw90 -THY1 and Leukaemia
9
RAP1GDS1 4q23-q25 GDS1, SmgGDS -RAP1GDS1 and Leukaemia
9
ARHGAP26 5q31 GRAF, GRAF1, OPHN1L, OPHN1L1 -ARHGAP26 and Myeloid Leukemia
8
HOXA11 7p15.2 HOX1, HOX1I -HOXA11 and Myeloid Leukemia
7
HOXA13 7p15.2 HOX1, HOX1J -HOXA13 and Myeloid Leukemia
7
HOXB3 17q21.3 HOX2, HOX2G, Hox-2.7 -HOXB3 and Myeloid Leukemia
7
RAG1 11p12 RAG-1, RNF74 -RAG1 and T-Cell Leukemia
7
SBDS 7q11.21 SDS, SWDS, CGI-97 -SBDS and Leukaemia
7
CD52 1p36 CDW52 -CD52 and T-Cell Leukemia
7
HOXA4 7p15.2 HOX1, HOX1D -HOXA4 and Myeloid Leukemia
7
AFF4 5q31 MCEF, AF5Q31 -AFF4 and Leukaemia
7
SUV39H1 Xp11.23 MG44, KMT1A, SUV39H, H3-K9-HMTase 1 -SUV39H1 and Leukaemia
7
FGFR1OP 6q27 FOP -FGFR1OP and Myeloid Leukemia
6
HOXC13 12q13.3 HOX3, ECTD9, HOX3G -HOXC13 and Myeloid Leukemia
6
POU2AF1 11q23.1 BOB1, OBF1, OCAB, OBF-1 Translocation
-t(3;11)(q27;q23) in B-Cell Leukaemia
-POU2AF1 and Leukaemia
5
ZNF384 12p12 NP, CIZ, NMP4, CAGH1, ERDA2, TNRC1, CAGH1A -ZNF384 and Leukaemia
6
ELF4 Xq26 MEF, ELFR -ELF4 and Myeloid Leukemia
6
MIR34A 1p36.22 mir-34, MIRN34A, mir-34a, miRNA34A -MIR34A and Leukaemia
6
DLX4 17q21.33 BP1, DLX7, DLX8, DLX9 -DLX4 and Leukaemia
5
CD58 1p13 ag3, LFA3, LFA-3 -CD58 and Myeloid Leukemia
5
PDCD5 19q13.11 TFAR19 -PDCD5 and Leukaemia
5
TCF12 15q21 HEB, CRS3, HTF4, TCF-12, bHLHb20, HsT17266 -TCF12 and Leukaemia
5
PSIP1 9p22.3 p52, p75, PAIP, DFS70, LEDGF, PSIP2 -PSIP1 and Leukaemia
5
XRCC5 2q35 KU80, KUB2, Ku86, NFIV, KARP1, KARP-1 -XRCC5 and Myeloid Leukemia
5
MARS 12q13.3 MRS, ILLD, CMT2U, ILFS2, METRS, MTRNS, SPG70 -MARS and Myeloid Leukemia
5
SH3GL1 19p13.3 EEN, CNSA1, SH3P8, SH3D2B -SH3GL1 and Leukaemia
5
ELL 19p13.1 MEN, ELL1, PPP1R68, C19orf17 -ELL and Childhood Leukaemia
5
NUMA1 11q13.4 NUMA, NMP-22 -NUMA1 and Myeloid Leukemia
5
CD48 1q21.3-q22 BCM1, BLAST, hCD48, mCD48, BLAST1, SLAMF2, MEM-102 -CD48 and Leukaemia
5
AKAP12 6q24-q25 SSeCKS, AKAP250 -AKAP12 and Myeloid Leukemia
5
LRRC3B 3p24 LRP15 -LRRC3B and Leukaemia
5
TJP1 15q13 ZO-1 -TJP1 and Leukaemia
5
SETD2 3p21.31 HYPB, SET2, HIF-1, HIP-1, KMT3A, HBP231, HSPC069, p231HBP -SETD2 and Leukaemia
4
FLT4 5q35.3 PCL, FLT41, LMPH1A, VEGFR3 -FLT4 and Leukaemia
4
GAS7 17p13.1 MLL/GAS7 -GAS7 and Leukaemia
4
SLC19A2 1q23.3 TC1, THT1, TRMA, THMD1, THTR1 -SLC19A2 and T-Cell Leukemia
3
GRASP 12q13.13 TAMALIN -GRASP and Leukaemia
3
DDIT4 10q22.1 Dig2, REDD1, REDD-1 -DDIT4 and Myeloid Leukemia
3
ABI2 2q33 ABI-2, ABI2B, AIP-1, AblBP3, argBP1, SSH3BP2, argBPIA, argBPIB -ABI2 and Leukaemia
3
PCDH10 4q28.3 PCDH19, OL-PCDH -PCDH10 and Leukaemia
3
DOK2 8p21.3 p56DOK, p56dok-2 -DOK2 and Leukaemia
3
CHIC2 4q11 BTL -CHIC2 and Myeloid Leukemia
3
PRRX1 1q24 PMX1, PRX1, AGOTC, PHOX1, PRX-1 -PRRX1 and Leukaemia
3
CASP2 7q34-q35 ICH1, NEDD2, CASP-2, NEDD-2, PPP1R57 -CASP2 and Leukaemia
3
SLAMF1 1q23.3 SLAM, CD150, CDw150 -SLAMF1 and Leukaemia
2
CASC5 15q14 D40, CT29, KNL1, Spc7, hKNL-1, AF15Q14, PPP1R55, hSpc105 -CASC5 and Leukaemia
2
PNN 14q21.1 DRS, DRSP, SDK3, memA -PNN and Leukaemia
2
KMT2A 11q23.3 HRX, MLL, MLL1, TRX1, ALL-1, CXXC7, HTRX1, MLL1A, WDSTS Translocation
-t(11;19)(q23;p13) in Leukaemia
-t(10;11)(p11.2;q23) ABI1-MLL translocation in Leukemia
2
DACH1 13q22 DACH -DACH1 and Myeloid Leukemia
2
ABI1 10p11.2 E3B1, ABI-1, ABLBP4, NAP1BP, SSH3BP, SSH3BP1 Translocation
-t(10;11)(p11.2;q23) ABI1-MLL translocation in Leukemia
2
ACSL6 5q31.1 ACS2, FACL6, LACS2, LACS5, LACS 6 -ACSL6 and Myeloid Leukemia
2
TCL6 14q32.1 TNG1, TNG2 -TCL6 and T-Cell Leukemia
1
PDGFRB 5q33.1 IMF1, IBGC4, JTK12, PDGFR, CD140B, PDGFR1, PDGFR-1 Translocation
-t(5;12)(q33;p13) in Chronic Myelomonocytic Leukemia
1
HERPUD1 16q13 SUP, HERP, Mif1 -HERPUD1 and Leukaemia
1
MAS1 6q25.3-q26 MAS, MGRA -MAS1 and Leukaemia
1
FCGR2B 1q23 CD32, FCG2, CD32B, FCGR2, IGFR2 -FCGR2B and Myeloid Leukemia
1
BCL5 17q22 -BCL5 and Leukaemia
1
CHCHD7 8q12.1 COX23 -CHCHD7 and Myeloid Leukemia
1
PRTN3 19p13.3 MBN, MBT, NP4, P29, PR3, ACPA, AGP7, NP-4, PR-3, CANCA, C-ANCA -PRTN3 and Myeloid Leukemia
1
PDCD2 6q27 RP8, ZMYND7 -PDCD2 and Leukaemia
1
BCL6 3q27 BCL5, LAZ3, BCL6A, ZNF51, ZBTB27 Translocation
-t(3;11)(q27;q23) in B-Cell Leukaemia
1
ERG 21q22.3 p55, erg-3 Translocation
-t(16;21)(p11;q22) in Leukemia (ANLL)
FUS 16p11.2 TLS, ALS6, ETM4, FUS1, POMP75, HNRNPP2 Translocation
-t(16;21)(p11;q22) in Leukemia (ANLL)
RBM15 1p13 OTT, OTT1, SPEN Translocation
-t(1;22)(p13;q13) in Acute Megakaryocytic Leukemia
RUNX1 21q22.3 AML1, CBFA2, EVI-1, AMLCR1, PEBP2aB, AML1-EVI-1 Translocation
-t(3;12)(p13;q22) in Leukaemia
NPM1 5q35.1 B23, NPM Translocation
-t(5;17)(q32;q11) RARA-NPM translocations in Acute Promyelocytic Leukemia
RARA 17q21 RAR, NR1B1 Translocation
-t(5;17)(q32;q11) RARA-NPM translocations in Acute Promyelocytic Leukemia
-t(15;17)(q21;q21) RARA-PML translocation in Acute Promyelocytic Leukaemia

Note: list is not exhaustive. Number of papers are based on searches of PubMed (click on topic title for arbitrary criteria used).

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