Leukemia - Molecular Biology

Overview

Literature Analysis

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Tag cloud generated 29 August, 2019 using data from PubMed, MeSH and CancerIndex

Mutated Genes and Abnormal Protein Expression (162)

How to use this data tableClicking on the Gene or Topic will take you to a separate more detailed page. Sort this list by clicking on a column heading e.g. 'Gene' or 'Topic'.

GeneLocationAliasesNotesTopicPapers
BCR 22q11.23 ALL, CML, PHL, BCR1, D22S11, D22S662 -t(9;22)(p24;q11.2) BCR-JAK2 fusion
-BCR and Leukaemia
3000
LMO1 11p15.4 TTG1, RBTN1, RHOM1 Translocation
-t(11;14)(p15;q11) and LMO1 in T-ALL
3000
FLT3 13q12.2 FLK2, STK1, CD135, FLK-2 -FLT3 and Leukaemia
1604
PML 15q24.1 MYL, RNF71, PP8675, TRIM19 Translocation
-t(15;17)(q21;q21) RARA-PML translocation in Acute Promyelocytic Leukaemia
-PML and Leukaemia
1048
TP53 17p13.1 P53, BCC7, LFS1, TRP53 -TP53 and Leukaemia
838
NRAS 1p13.2 NS6, CMNS, NCMS, ALPS4, N-ras, NRAS1 -NRAS and Leukemia
629
JAK2 9p24.1 JTK10, THCYT3 Translocation
-JAK2 and Leukaemia
-t(9;12)(p24;p13) ETV6-JAK2 fusion in lymphoid and myeloid leukemia
-t(8;9)(p22;p24) PCM1-JAK2 fusion in Hematologic Malignancies
-t(9;22)(p24;q11.2) BCR-JAK2 fusion
482
CEBPA 19q13.11 CEBP, C/EBP-alpha -CEBPA and Myeloid Leukemia
435
CD33 19q13.41 p67, SIGLEC3, SIGLEC-3 -CD33 and Myeloid Leukemia
327
MYH11 16p13.11 AAT4, FAA4, SMHC, SMMHC -MYH11 and Myeloid Leukemia
257
RUNX1T1 8q21.3 CDR, ETO, MTG8, AML1T1, ZMYND2, CBFA2T1, AML1-MTG8 -RUNX1T1 and Myeloid Leukemia
184
CSF3R 1p34.3 SCN7, CD114, GCSFR -CSF3R and Myeloid Leukemia
180
GATA1 Xp11.23 GF1, GF-1, NFE1, XLTT, ERYF1, NF-E1, XLANP, XLTDA, GATA-1 -GATA1 and Myeloid Leukemia
179
MECOM 3q26.2 EVI1, MDS1, KMT8E, PRDM3, RUSAT2, MDS1-EVI1, AML1-EVI-1 Translocation
-t(3;12)(p13;q22) in Leukaemia
-MECOM and Leukaemia
171
NUP98 11p15.4 ADIR2, NUP96, NUP196 -NUP98 and Leukaemia
159
CBFB 16q22.1 PEBP2B -CBFB and Myeloid Leukemia
159
HLA-A 6p22.1 HLAA -HLA-A and Leukaemia
156
CD14 5q31.3 -CD14 and Myeloid Leukemia
142
PDGFRA 4q12 CD140A, PDGFR2, PDGFR-2 Deletion / Translocation
-FIP1L1-PDGFRA fusion in Leukemia
-PDGFRA and Leukaemia
72
GALE 1p36.11 SDR1E1 -GALE and Myeloid Leukemia
122
MPL 1p34.2 MPLV, TPOR, C-MPL, CD110, THPOR, THCYT2 -MPL and Myeloid Leukemia
108
PTPN11 12q24.13 CFC, NS1, JMML, SHP2, BPTP3, PTP2C, METCDS, PTP-1D, SH-PTP2, SH-PTP3 -PTPN11 and Myeloid Leukemia
94
GATA2 3q21.3 DCML, IMD21, NFE1B, MONOMAC -GATA2 and Myeloid Leukemia
76
FIP1L1 4q12 Rhe, FIP1, hFip1 Deletion / Translocation
-FIP1L1-PDGFRA fusion in Leukemia
72
BAALC 8q22.3 -BAALC and Myeloid Leukemia
71
MLLT3 9p21.3 AF9, YEATS3 -MLLT3 and Leukaemia
69
MN1 22q12.1 MGCR, MGCR1, MGCR1-PEN, dJ353E16.2 -MN1 and Myeloid Leukemia
59
MEIS1 2p14 -MEIS1 and Myeloid Leukemia
57
TFAP2A 6p24.3 AP-2, BOFS, AP2TF, TFAP2, AP-2alpha -TFAP2A and Myeloid Leukemia
52
TFAP2C 20q13.31 ERF1, TFAP2G, hAP-2g, AP2-GAMMA -TFAP2C and Myeloid Leukemia
51
PRAME 22q11.22 MAPE, OIP4, CT130, OIP-4 -PRAME and Leukaemia
48
HLF 17q22 -HLF and Leukaemia
47
MDS1 3q26 PRDM3, MDS1-EVI1 -MDS1 and Myeloid Leukemia
46
DNMT3B 20q11.21 ICF, ICF1, M.HsaIIIB -DNMT3B and Leukaemia
43
VAV1 19p13.3 VAV -VAV1 and Leukemia
41
GFI1 1p22.1 SCN2, GFI-1, GFI1A, ZNF163 -GFI1 and Leukaemia
41
DOT1L 19p13.3 DOT1, KMT4 -DOT1L and Leukaemia
41
ETV6 12p13.2 TEL, THC5, TEL/ABL Translocation
-t(5;12)(q33;p13) in Chronic Myelomonocytic Leukemia
-t(9;12)(p24;p13) ETV6-JAK2 fusion in lymphoid and myeloid leukemia
33
KAT6A 8p11.21 MOZ, MRD32, MYST3, MYST-3, ZNF220, RUNXBP2, ZC2HC6A -KAT6A and Myeloid Leukemia
34
RAG2 11p12 RAG-2 -RAG2 and Leukaemia
34
IL21R 16p12.1 NILR, CD360 -IL21R and Leukaemia
33
IL2RG Xq13.1 P64, CIDX, IMD4, CD132, SCIDX, IL-2RG, SCIDX1 -IL2RG and Leukaemia
33
TRB 7q34 TCRB, TRB@ -TRB and T-Cell Leukemia
33
TLX1 10q24.31 TCL3, HOX11 -TLX1 and T-Cell Leukemia
31
HOXA10 7p15.2 PL, HOX1, HOX1H, HOX1.8 -HOXA10 and Myeloid Leukemia
31
PRDM16 1p36.32 MEL1, KMT8F, LVNC8, PFM13, CMD1LL -PRDM16 and Leukaemia
31
MLLT1 19p13.3 ENL, LTG19, YEATS1 Translocation
-t(11;19)(q23;p13) in Leukaemia
-MLLT1 and Leukaemia
30
GSTM1 1p13.3 MU, H-B, GST1, GTH4, GTM1, MU-1, GSTM1-1, GSTM1a-1a, GSTM1b-1b Germline
Prognostic
-GSTM1 Polymorphisms and Susceptibility to Leukemia
28
TLX3 5q35.1 RNX, HOX11L2 -TLX3 and T-Cell Leukemia
27
CD36 7q21.11 FAT, GP4, GP3B, GPIV, CHDS7, PASIV, SCARB3, BDPLT10 -CD36 and Myeloid Leukemia
27
NSD1 5q35.3 STO, KMT3B, SOTOS, ARA267, SOTOS1 -NSD1 and Myeloid Leukemia
24
FES 15q26.1 FPS -FES and Myeloid Leukemia
24
HOXD13 2q31.1 BDE, SPD, BDSD, HOX4I -HOXD13 and Leukaemia
23
G6PD Xq28 G6PD1 -G6PD and Myeloid Leukemia
22
ETS2 21q22.2 ETS2IT1 -ETS2 and Leukaemia
22
SALL4 20q13.2 DRRS, HSAL4, ZNF797 -SALL4 and Leukaemia
21
HOXA5 7p15.2 HOX1, HOX1C, HOX1.3 -HOXA5 and Leukaemia
21
PBX3 9q33.3 -PBX3 and Leukaemia
21
TCL1A 14q32.13 TCL1 -TCL1A and T-Cell Leukemia
21
PCM1 8p22 PTC4, RET/PCM-1 Translocation
-PCM1 and Myeloid Leukemia
-t(8;9)(p22;p24) PCM1-JAK2 fusion in Hematologic Malignancies
10
CSF1R 5q32 FMS, CSFR, FIM2, HDLS, C-FMS, CD115, CSF-1R, M-CSF-R -CSF1R and Myeloid Leukemia
18
MRTFA 22q13.1-q13.2 MAL, MKL, BSAC, MKL1, MRTF-A Translocation
-t(1;22)(p13;q13) in Acute Megakaryocytic Leukemia
-MKL1 and Myeloid Leukemia
18
MLF1 3q25.32 -MLF1 and Myeloid Leukemia
18
TET1 10q21.3 LCX, CXXC6, bA119F7.1 -TET1 mutations in Leukemia
18
MYB 6q23.3 efg, Cmyb, c-myb, c-myb_CDS -Genes, myb and Myeloid Leukemia
17
CBFA2T3 16q24.3 ETO2, MTG16, MTGR2, ZMYND4, RUNX1T3 -CBFA2T3 and Leukaemia
17
BCL2A1 15q25.1 GRS, ACC1, ACC2, BFL1, ACC-1, ACC-2, HBPA1, BCL2L5 -BCL2A1 and Leukemia
15
MSI2 17q22 MSI2H -MSI2 and Leukaemia
15
BCL11B 14q32.2 ATL1, RIT1, CTIP2, IMD49, CTIP-2, ZNF856B, ATL1-beta, ATL1-alpha, ATL1-delta, ATL1-gamma, hRIT1-alpha -BCL11B and T-Cell Leukemia
15
HCK 20q11.21 JTK9, p59Hck, p61Hck -HCK and Leukaemia
15
HOXA7 7p15.2 ANTP, HOX1, HOX1A, HOX1.1 -HOXA7 and Myeloid Leukemia
15
WT1-AS 11p13 WIT1, WIT-1, WT1AS, WT1-AS1 -WT1-AS and Leukaemia
14
HLA-DPB1 6p21.32 DPB1, HLA-DP, HLA-DPB, HLA-DP1B -HLA-DPB1 and Leukaemia
14
HOXB4 17q21.32 HOX2, HOX2F, HOX-2.6 -HOXB4 and Myeloid Leukemia
13
BOLL 2q33 BOULE -BOLL and Myeloid Leukemia
12
MLLT6 17q12 AF17 -MLLT6 and Leukaemia
12
DDX10 11q22.3 HRH-J8 -DDX10 and Myeloid Leukemia
12
STAM 10p12.33 STAM1, STAM-1 -STAM and Myeloid Leukemia
12
MNX1 7q36.3 HB9, HLXB9, SCRA1, HOXHB9 -MNX1 and Leukaemia
12
ID2 2p25 GIG8, ID2A, ID2H, bHLHb26 -ID2 in Leukemia & Lymphoma
11
MTCP1 Xq28 p8MTCP1, P13MTCP1 -MTCP1 and T-Cell Leukemia
11
SEPTIN6 Xq24 SEP2, SEPT2, SEPT6 -SEPT6 and Leukaemia
11
ZNF384 12p13.31 NP, CIZ, NMP4, CAGH1, ERDA2, TNRC1, CAGH1A -ZNF384 and Leukaemia
11
CD3D 11q23.3 T3D, IMD19, CD3-DELTA -CD3D and Leukaemia
11
RPN1 3q21.3 OST1, RBPH1 -RPN1 and Myeloid Leukemia
10
CD52 1p36.11 HE5, CDW52, EDDM5 -CD52 and T-Cell Leukemia
10
ITGAM 16p11.2 CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6 -ITGAM and Myeloid Leukemia
10
RAP1GDS1 4q23 GDS1, SmgGDS -RAP1GDS1 and Leukaemia
10
THY1 11q23.3 CD90, CDw90 -THY1 and Leukaemia
9
SUV39H1 Xp11.23 MG44, KMT1A, SUV39H, H3-K9-HMTase 1 -SUV39H1 and Leukaemia
9
HOXB3 17q21.32 HOX2, HOX2G, Hox-2.7 -HOXB3 and Myeloid Leukemia
9
ARHGAP26 5q31.3 GRAF, GRAF1, OPHN1L, OPHN1L1 -ARHGAP26 and Myeloid Leukemia
8
SETD2 3p21.31 LLS, HYPB, SET2, HIF-1, HIP-1, KMT3A, HBP231, HSPC069, p231HBP -SETD2 and Leukaemia
8
HOXA4 7p15.2 HOX1, HOX1D -HOXA4 and Myeloid Leukemia
8
DLX4 17q21.33 BP1, DLX7, DLX8, DLX9, OFC15 -DLX4 and Leukaemia
8
HOXA11 7p15.2 HOX1, HOX1I, RUSAT1 -HOXA11 and Myeloid Leukemia
7
MIR34A 1p36.22 mir-34, MIRN34A, mir-34a, miRNA34A -MIR34A and Leukaemia
7
HOXA13 7p15.2 HOX1, HOX1J -HOXA13 and Myeloid Leukemia
7
RAG1 11p12 RAG-1, RNF74 -RAG1 and T-Cell Leukemia
7
SBDS 7q11.21 SDS, SWDS, CGI-97 -SBDS and Leukaemia
7
AFF4 5q31.1 MCEF, CHOPS, AF5Q31 -AFF4 and Leukaemia
7
TCF12 15q21.3 HEB, CRS3, HTF4, TCF-12, bHLHb20, HsT17266 -TCF12 and Leukaemia
6
MEF2C 5q14.3 DEL5q14.3, C5DELq14.3 -MEF2C and Myeloid Leukemia
6
FGFR1OP 6q27 FOP -FGFR1OP and Myeloid Leukemia
6
AKAP12 6q25.1 SSeCKS, AKAP250 -AKAP12 and Myeloid Leukemia
6
HOXC13 12q13.13 HOX3, ECTD9, HOX3G -HOXC13 and Myeloid Leukemia
6
POU2AF1 11q23.1 BOB1, OBF1, OCAB, OBF-1 Translocation
-t(3;11)(q27;q23) in B-Cell Leukaemia
-POU2AF1 and Leukaemia
5
TJP1 15q13.1 ZO-1 -TJP1 and Leukaemia
6
ELF4 Xq26.1 MEF, ELFR -ELF4 and Myeloid Leukemia
6
CD58 1p13.1 ag3, LFA3, LFA-3 -CD58 and Myeloid Leukemia
6
CD48 1q23.3 BCM1, BLAST, hCD48, mCD48, BLAST1, SLAMF2, MEM-102 -CD48 and Leukaemia
5
MARS 12q13.3 MRS, ILLD, CMT2U, ILFS2, METRS, MTRNS, SPG70 -MARS and Myeloid Leukemia
5
PDCD5 19q13.11 TFAR19 -PDCD5 and Leukaemia
5
PSIP1 9p22.3 p52, p75, PAIP, DFS70, LEDGF, PSIP2 -PSIP1 and Leukaemia
5
XRCC5 2q35 KU80, KUB2, Ku86, NFIV, KARP1, KARP-1 -XRCC5 and Myeloid Leukemia
5
SH3GL1 19p13.3 EEN, CNSA1, SH3P8, SH3D2B -SH3GL1 and Leukaemia
5
ELL 19p13.11 MEN, ELL1, PPP1R68, C19orf17 -ELL and Childhood Leukaemia
5
NUMA1 11q13.4 NUMA, NMP-22 -NUMA1 and Myeloid Leukemia
5
LRRC3B 3p24.1 LRP15 -LRRC3B and Leukaemia
5
XRCC6 22q13.2 ML8, KU70, TLAA, CTC75, CTCBF, G22P1 -XRCC6 and Myeloid Leukemia
4
GRASP 12q13.13 TAMALIN -GRASP and Leukaemia
4
SLAMF1 1q23.3 SLAM, CD150, CDw150 -SLAMF1 and Leukaemia
4
CHAT 10q11.23 CMS6, CMS1A, CMS1A2, CHOACTASE -CHAT and Myeloid Leukemia
4
FLT4 5q35.3 PCL, FLT-4, FLT41, LMPH1A, VEGFR3, VEGFR-3 -FLT4 and Leukaemia
4
DOK2 8p21.3 p56DOK, p56dok-2 -DOK2 and Leukaemia
4
GAS7 17p13.1 -GAS7 and Leukaemia
4
DDIT4 10q22.1 Dig2, REDD1, REDD-1 -DDIT4 and Myeloid Leukemia
3
PCDH10 4q28.3 PCDH19, OL-PCDH -PCDH10 and Leukaemia
3
NSD3 8p11.23 KMT3F, KMT3G, WHISTLE, WHSC1L1, pp14328 -WHSC1L1 and Myeloid Leukemia
3
ABI2 2q33 ABI-2, ABI2B, AIP-1, AblBP3, argBP1, SSH3BP2, argBPIA, argBPIB -ABI2 and Leukaemia
3
SLC19A2 1q24.2 TC1, THT1, TRMA, THMD1, THTR1 -SLC19A2 and T-Cell Leukemia
3
CHIC2 4q12 BTL -CHIC2 and Myeloid Leukemia
3
CASP2 7q34 ICH1, NEDD2, CASP-2, NEDD-2, PPP1R57 -CASP2 and Leukaemia
3
PRRX1 1q24.2 PMX1, PRX1, AGOTC, PHOX1, PRX-1 -PRRX1 and Leukaemia
3
KNL1 15q15.1 D40, CT29, Spc7, CASC5, MCPH4, hKNL-1, AF15Q14, PPP1R55, hSpc105 -CASC5 and Leukaemia
2
DACH1 13q21.33 DACH -DACH1 and Myeloid Leukemia
2
ITGB2 21q22.3 LAD, CD18, MF17, MFI7, LCAMB, LFA-1, MAC-1 -ITGB2 and Myeloid Leukemia
2
PNN 14q21.1 DRS, DRSP, SDK3, memA -PNN and Leukaemia
2
KMT2A 11q23.3 HRX, MLL, MLL1, TRX1, ALL-1, CXXC7, HTRX1, MLL1A, WDSTS Translocation
-t(11;19)(q23;p13) in Leukaemia
-t(10;11)(p11.2;q23) ABI1-MLL translocation in Leukemia
2
ABI1 10p12.1 E3B1, ABI-1, ABLBP4, NAP1BP, SSH3BP, SSH3BP1 Translocation
-t(10;11)(p11.2;q23) ABI1-MLL translocation in Leukemia
2
PRTN3 19p13.3 MBN, MBT, NP4, P29, PR3, ACPA, AGP7, NP-4, PR-3, CANCA, C-ANCA -PRTN3 and Myeloid Leukemia
2
ACSL6 5q31.1 ACS2, FACL6, LACS2, LACS5, LACS 6 -ACSL6 and Myeloid Leukemia
2
IFNA17 9p21.3 IFNA, INFA, LEIF2C1, IFN-alphaI -IFNA17 and Leukaemia
1
TCL6 14q32.13 TNG1, TNG2 -TCL6 and T-Cell Leukemia
1
PDCD2 6q27 RP8, ZMYND7 -PDCD2 and Leukaemia
1
PDGFRB 5q32 IMF1, KOGS, IBGC4, JTK12, PDGFR, PENTT, CD140B, PDGFR1, PDGFR-1 Translocation
-t(5;12)(q33;p13) in Chronic Myelomonocytic Leukemia
1
HERPUD1 16q13 SUP, HERP, Mif1 -HERPUD1 and Leukaemia
1
MAS1 6q25.3 MAS, MGRA -MAS1 and Leukaemia
1
MIR1256 1p36.12 MIRN1256, hsa-mir-1256 -MIRN1256 microRNA, human and Leukaemia
1
FCGR2B 1q23.3 CD32, FCG2, CD32B, FCGR2, IGFR2, FCGR2C, FcRII-c -FCGR2B and Myeloid Leukemia
1
IFNA2 9p21.3 IFNA, INFA2, IFNA2B, IFN-alphaA -IFNA2 and Leukaemia
1
BCL5 17q22 -BCL5 and Leukaemia
1
CHCHD7 8q12.1 COX23 -CHCHD7 and Myeloid Leukemia
1
BCL6 3q27.3 BCL5, LAZ3, BCL6A, ZNF51, ZBTB27 Translocation
-t(3;11)(q27;q23) in B-Cell Leukaemia
1
ITGAL 16p11.2 CD11A, LFA-1, LFA1A -ITGAL and Myeloid Leukemia
TFAP2B 6p12.3 PDA2, AP-2B, AP2-B -TFAP2B and Myeloid Leukemia
ERG 21q22.2 p55, erg-3 Translocation
-t(16;21)(p11;q22) in Leukemia (ANLL)
FUS 16p11.2 TLS, ALS6, ETM4, FUS1, POMP75, HNRNPP2 Translocation
-t(16;21)(p11;q22) in Leukemia (ANLL)
RBM15 1p13.3 OTT, OTT1, SPEN Translocation
-t(1;22)(p13;q13) in Acute Megakaryocytic Leukemia
RUNX1 21q22.12 AML1, CBFA2, EVI-1, AMLCR1, PEBP2aB, CBF2alpha, AML1-EVI-1, PEBP2alpha Translocation
-t(3;12)(p13;q22) in Leukaemia
NPM1 5q35.1 B23, NPM Translocation
-t(5;17)(q32;q11) RARA-NPM translocations in Acute Promyelocytic Leukemia
RARA 17q21.2 RAR, NR1B1 Translocation
-t(5;17)(q32;q11) RARA-NPM translocations in Acute Promyelocytic Leukemia
-t(15;17)(q21;q21) RARA-PML translocation in Acute Promyelocytic Leukaemia

Note: list is not exhaustive. Number of papers are based on searches of PubMed (click on topic title for arbitrary criteria used).

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