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TP53; Tumor protein p53 (Li-Fraumeni syndrome) (17p13.1)
TP53 Menu

    Summary Information - TP53
    Gene Database Entries for TP53
    Other TP53 Related Resources
    TP53 General Information
       - TP53 Regulated Genes
       - TP53 and Oncogenicity
    Li-Fraumeni Syndrome
    TP53 and Breast Cancer
       - TP53 Overexpression Predictive of Relapse in Breast Cancer
    TP53 and Ovarian Cancer
    TP53 and Osteosarcoma
    TP53 and Colorectal Cancer
    TP53 and Lung Cancer
       - TP53 and Drug Resistance in Lung Cancer
       - TP53 Gene Therapy for Lung Cancer (Experimental)
    TP53 and Bladder Cancer
    TP53 and Skin Cancer
       - TP53 and Melanoma
    TP53 and Soft Tissue Sarcoma
       - TP53 and Rhabdomyosarcoma
       - TP53 in Other Soft Tissue Sarcoma
    TP53 and Head and Neck Cancer
       - TP53 and Larngeal Cancer
    TP53 and Colorectal Cancer
    TP53 and Leukaemia
       - TP53 and Childhood Leukaemia
       - TP53 and Hairy Cell Leukaemia
       - TP53 and Chronic Lymphocytic Leukemia
       - TP53 and B-cell prolymphocytic leukemia
    TP53 and Other Cancers
    TP53 Related Gene Therapy Approaches (Experimental)
    TP53 and Gastrointestinal Cancers
       - TP53 and Gastric Cancer
       - TP53 and Liver Cancer
    TP53 and CNS Tumours
       - TP53 and Astrocytoma
    TP53 and Prostate Cancer
    TP53 and Fallopean Tube Cancer
    TP53 and Adrenocortical Carcinoma
    TP53 Mutations in Endometrial Cancer
    TP53 Mutations in Childhood Cancer
       - TP53 Transfer to Mesothelioma Cells (Experimental)
    TP53 Mutations in a Small Sub-set of Ewing's Sarcoma
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  Summary Information

TP53; Tumor protein p53 (Li-Fraumeni syndrome)

Location: 17p13.1

Aliases: p53, P53

involved in multiple cancers

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  Gene Database Entries for TP53

p53 Web site of the Institute Curie
OMIM
GeneCard (Weizmann Institute)
Atlas of Genetics and Cytogenetics in Oncology and Haematology
Human Gene Mutation Database (Cardiff, UK)
Tumor Gene Database
Swiss-Prot
Locus Link
UniGene
GenAtlas
GDB
Nomenclature (search for TP53)

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  Other Related Resources


P53 Tumour Supressor - Web Review (HotMolecBase) review by Michael Rebhan.
Recommendations on Predictive Testing for Germ Line p53 Mutations in Cancer­Prone Families JNCI Article - Frederick P. Li, Judy E. Garber, Stephen H. Friend, Louise C. Strong et al.
p53 Web site of the Institute Curie This includes a extensive database to which users can add new p53 mutations, search for mutations or run insertion or deletion analysis tools. There are also statistical tools and detailed references.
Neal's DNA Mutation Site - Database (USA) Databases and software for the analysis of mutations (lacl, p53, hprt, lacZ)
p53 / Professor Peter Hall (University of Dundee) research interests / publications
Li-Fraumeni Syndrome (University of Washington) part of the NCI funded Geneclinics.org site. Details of LFS, diagnosis, management, molecular biology, genetic counseling, resources, references etc.
IARC database of Somatic P53 Mutations in Human Tumours and Cell Lines (IARC) Web interface or download.
Reisman Lab p53 Tumor Suppressor Home Page (University of South Carolina, USA) information, references and links
TP53 Binding Protein (1q42)
TP73 (1p36)
Resources by Disease Type

  • Medline Search: TP53 (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]
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  • Medline Search: cancer AND gene AND (TP53[TI] OR p53[TI] OR P53[TI]) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]
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  •   TP53 General Information


  • Medline Search: gene AND (tp53 OR p53) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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  •   TP53 Regulated Genes

  • Yu J, et al. Identification and classification of p53-regulated genes Proc Natl Acad Sci USA. 1999; 96(25):14517-22

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  •   TP53 and Oncogenicity

  • Wahl GM. et al. Maintaining genetic stability through TP53 mediated checkpoint control. Cancer Surv 1997;29:183-219    Related articles (PubMed)

  • Morgan SE. et al. p53 and ATM: cell cycle, cell death, and cancer. Adv Cancer Res. 1997;71:1-25. (Review)    Related articles (PubMed)

  • Medline Search: P53 AND cancer (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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  •   Li-Fraumeni Syndrome

    Li-Fraumeni syndrome is an autosomal-dominant condition which predisposes to a range of different types of cancer. Many members of Li-Fraumeni families have a germline mutation of the TP53 gene. Compared to the general population people who inherit a mutant TP53 allele have a 25-fold increase in the chance of developing cancer by 50 yrs of age.

  • Vahteristo P, et al. p53, CHK2, and CHK1 genes in Finnish families with Li-Fraumeni syndrome: further evidence of CHK2 in inherited cancer predisposition. Cancer Res 2001; 61(15):5718-22    Related articles (PubMed)

  • Malkin D. et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 1990; 250:1233-8    Related articles (PubMed)

  • Birch JM et al. Cancer phenotype correlates with constitutional TP53 genotype in families with the Li-Fraumeni syndrome. Oncogene 1998; 17:1061-8    Related articles (PubMed)

  • Evans SC, Lozano G The Li-Fraumeni syndrome: an inherited susceptibility to cancer. Mol Med Today 1997; 3:390-5    Related articles (PubMed)

  • Medline Search: Li-Fraumeni syndrome (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Genetic Counselling
    Li-Fraumeni Syndrome (University of Washington) part of the NCI funded Geneclinics.org site. Details of LFS, diagnosis, management, molecular biology, genetic counseling, resources, references etc.
    Li-Fraumeni Syndrome; LFS - Genetic information (OMIM, National Center for Biotechnology Information, USA)

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  •   TP53 and Breast Cancer

  • Eyfjord JE, Thorlacius S Genetic changes in breast carcinomas in an Icelandic population. Pharmacogenetics 1992;2:309-16    Related articles (PubMed)

  • Medline Search: p53 AND breast cancer (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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    Breast Cancer Genetics
    Breast Cancer : Clinical and Epidemiological Information

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  •   TP53 Overexpression Predictive of Relapse in Breast Cancer

  • Norberg T et al. Increased p53 mutation frequency during tumor progression--results from a breast cancer cohort. Cancer Res 2001;61(22):8317-21    Related articles (PubMed)

  • Turner BC, et al. Mutant p53 protein overexpression in women with ipsilateral breast tumor recurrence following lumpectomy and radiation therapy. Cancer 2000;88(5):1091-1098    Related articles (PubMed)

  • Medline Search: breast cancer AND relapse AND (tp53 OR p53) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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  •   TP53 and Ovarian Cancer

  • Skirnisdottir I et al. Prognostic importance of DNA ploidy and p53 in early stages of epithelial ovarian carcinoma. Int J Oncol 2001;19(6):1295-302    Related articles (PubMed)

  • Baekelandt M, et al. Clinical Significance of Apoptosis-Related Factors p53, Mdm2, and Bcl-2 in Advanced Ovarian Cancer. J Clin Oncol 1999; 17(7):2061    Related articles

  • Herod JJ, et al. The prognostic significance of Bcl-2 and p53 expression in ovarian carcinoma Cancer Res. 1996; 56(9):2178-84    Related articles (PubMed)

  • Medline Search: ovarian cancer AND p53 (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Ovarian Ca. Genetics
    Ovarian Ca. : Clinical and Epidemiological Information

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  •   TP53 and Osteosarcoma

  • Gokgoz N et al. Comparison of p53 mutations in patients with localized osteosarcoma and metastatic osteosarcoma. Cancer 2001;92(8):2181-9    Related articles (PubMed)

  • Miller CW et al. Alterations of the p53, Rb and MDM2 genes in osteosarcoma. J Cancer Res Clin Oncol 1996; 122:559-65    Related articles (PubMed)

  • Lonardo F. et al. p53 and MDM2 alterations in osteosarcomas: correlation with clinicopathologic features and proliferative rate. Cancer 1997; 79:1541-7    Related articles (PubMed)

  • Medline Search: p53 AND osteosarcoma (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    MDM2 gene
    Osteosarcoma Genetics
    Osteosarcoma : Clinical and Epidemiological Information

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  •   TP53 and Colorectal Cancer

  • Kaklamanis L, et al. Bcl-2 protein expression: association with p53 and prognosis in colorectal cancer Br J Cancer. 1998; 77(11):1864-9    Related articles (PubMed)

  • Manne U, et al. Prognostic significance of Bcl-2 expression and p53 nuclear accumulation in colorectal adenocarcinoma. Int J Cancer. 1997; 74(3):346-58 [Review]    Related articles (PubMed)

  • Medline Search: p53 AND colorectal cancer (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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  •   TP53 and Lung Cancer

  • Sanchez-Cespedes M, et al. Inactivation of the INK4A/ARF locus frequently coexists with TP53 mutations in non-small cell lung cancer. Oncogene 1999; 18(43):5843-9    Related articles (PubMed)

  • Kohno H, et al. p53 mutation and allelic loss of chromosome 3p, 9p of preneoplastic lesions in patients with nonsmall cell lung carcinoma. Cancer. 1999; 85(2):341-7    Related articles (PubMed)

  • Horio Y, et al. Prognostic significance of p53 mutations and 3p deletions in primary resected non-small cell lung cancer. Cancer Res. 1993; 53(1):1-4    Related articles (PubMed)

  • Fukuyama Y, et al. K-ras and p53 mutations are an independent unfavourable prognostic indicator in patients with non-small-cell lung cancer. Br J Cancer 1997; 75(8):1125-30    Related articles (PubMed)

  • Medline Search: lung cancer[TI] AND (p53[TI] OR tp53[TI]) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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    Lung Cancer Genetics
    Lung Cancer : Clinical and Epidemiological Information

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  •   TP53 and Drug Resistance in Lung Cancer

  • Nakanishi Y, et al. Expression of p53 and Glutathione S-Transferase-pi Relates to Clinical Drug Resistance in Non-Small Cell Lung Cancer. Oncology. 1999; 57(4):318-323.    Related articles (PubMed)

  • Rusch V, et al. Aberrant p53 expression predicts clinical resistance to cisplatin-based chemotherapy in locally advanced non-small cell lung cancer. Cancer Res. 1995; 55(21):5038-42    Related articles (PubMed)

  • Medline Search: drug resistance AND lung cancer[TI] AND (p53[TI] OR tp53[TI]) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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    Lung Cancer Genetics
    Lung Cancer : Clinical and Epidemiological Information

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  •   TP53 Gene Therapy for Lung Cancer (Experimental)

  • Nemunaitis J, et al. Adenovirus-Mediated p53 Gene Transfer in Sequence With Cisplatin to Tumors of Patients With Non-Small-Cell Lung Cancer J Clin Oncol 2000;18 609

  • Medline Search: lung cancer AND gene therapy AND (p53 OR tp53) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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    Lung Cancer Genetics
    Lung Cancer : Clinical and Epidemiological Information

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  •   TP53 and Bladder Cancer

  • Cote RJ, et al. Elevated and absent pRb expression is associated with bladder cancer progression and has cooperative effects with p53. Cancer Res. 1998; 58(6):1090-4    Related articles (PubMed)

  • Grossman HB, et al. p53 and RB expression predict progression in T1 bladder cancer. Clin Cancer Res. 1998; 4(4):829-34    Related articles (PubMed)

  • Niehans GA, et al. G1 checkpoint protein and p53 abnormalities occur in most invasive transitional cell carcinomas of the urinary bladder. Br J Cancer 1999; 80(8):1175-84    Related articles (PubMed)

  • Medline Search: bladder cancer AND (p53 OR tp53) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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    Bladder Ca. Genetics
    Bladder Ca. : Clinical and Epidemiological Information

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  •   TP53 and Skin Cancer


  • Medline Search: skin cancer AND (p53 OR tp53) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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    Skin Cancer : Clinical and Epidemiological Information

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  •   TP53 and Melanoma

  • Radhi JM Malignant melanoma arising from nevi, p53, p16, and bcl-2: expression in benign versus malignant components. J Cutan Med Surg 1999; 3(6):293-7    Related articles (PubMed)

  • Medline Search: melanoma[TI] AND (p53 OR tp53) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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    Melanoma Genetics
    Melanoma : Clinical and Epidemiological Information

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  •   TP53 and Soft Tissue Sarcoma


  • Medline Search: sarcoma AND p53 (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Adult Soft Tissue Sarcoma Genetics
    Adult Soft Tissue Sarcoma : Clinical and Epidemiological Information

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  •   TP53 and Rhabdomyosarcoma

  • Wurl P, et al. Frequent occurrence of p53 mutations in rhabdomyosarcoma and leiomyosarcoma, but not in fibrosarcoma and malignant neural tumors. Int J Cancer 1996; 69(4):317-23    Related articles (PubMed)

  • Medline Search: rhabdomyosarcoma AND (p53 OR tp53) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Childhood Soft Tissue Sarcoma Genetics
    Childhood Soft Tissue Sarcoma : Clinical and Epidemiological Information

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  •   TP53 in Other Soft Tissue Sarcoma

  • Rieske P, et al. A comparative study of P53/MDM2 genes alterations and P53/MDM2 proteins immunoreactivity in soft-tissue sarcomas. J Exp Clin Cancer Res 1999 Sep;18(3):403-16    Related articles (PubMed)

  • Wurl P, et al. Frequent occurrence of p53 mutations in rhabdomyosarcoma and leiomyosarcoma, but not in fibrosarcoma and malignant neural tumors. Int J Cancer 1996; 69(4):317-23    Related articles (PubMed)

  • Stefanou DG, et al. p53/MDM-2 immunohistochemical expression correlated with proliferative activity in different subtypes of human sarcomas: a ten-year follow-up study. Anticancer Res 1998; 18(6B):4673-81    Related articles (PubMed)

  • Medline Search: sarcoma AND (p53 or tp53) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Adult Soft Tissue Sarcoma Genetics
    Adult Soft Tissue Sarcoma : Clinical and Epidemiological Information

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  •   TP53 and Head and Neck Cancer

  • Temam S, et al. p53 Gene Status as a Predictor of Tumor Response to Induction Chemotherapy of Patients With Locoregionally Advanced Squamous Cell Carcinomas of the Head and Neck J Clin Oncol 2000;18 385

  • Medline Search: head and neck cancer AND (p53 OR tp53) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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    Head and Neck Cancer Genetics
    Head and Neck Cancer : Clinical and Epidemiological Information

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  •   TP53 and Larngeal Cancer

  • Ioachim E, et al. Altered patterns of retinoblastoma gene product expression in benign, premalignant and malignant epithelium of the larynx: an immunohistochemical study including correlation with p53, bcl-2 and proliferating indices. Anticancer Res. 1999; 19(1A):541-5    Related articles (PubMed)

  • Gorgoulis V, et al. Molecular analysis of p53 gene in laryngeal premalignant and malignant lesions. p53 protein immunohistochemical expression is positively related to proliferating cell nuclear antigen labelling index. Virchows Arch. 1995;426(4):339-44    Related articles (PubMed)

  • Poljak M, et al. Overexpression of p53 protein in benign and malignant laryngeal epithelial lesions. Anticancer Res 1996; 16(4A):1947-51    Related articles (PubMed)

  • Medline Search: laryngeal cancer AND p53 (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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    Larynx, hypopharynx, oropharynx Ca. Genetics
    Larynx, hypopharynx, oropharynx Ca. : Clinical and Epidemiological Information

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  •   TP53 and Colorectal Cancer

  • Tortola S, et al. p53 and K-ras gene mutations correlate with tumor aggressiveness but are not of routine prognostic value in colorectal cancer. J Clin Oncol 1999; 17(5):1375-81    Related articles (PubMed)

  • Toyota M, et al. Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype Proc Natl Acad Sci USA. 2000; 97(2): 710-5

    Related Resources
    ColoRectal Cancers Genetics
    ColoRectal Cancers : Clinical and Epidemiological Information

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  •   TP53 and Leukaemia


  • Medline Search: leukemia AND (p53 OR tp53) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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    Leukaemia Genetics
    Leukaemia : Clinical and Epidemiological Information

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  •   TP53 and Childhood Leukaemia

  • Gustafsson B, et al. Cellular expression of MDM2 and p53 in childhood leukemias with poor prognosis. Med Pediatr Oncol 2000;34(2):117-24    Related articles (PubMed)

  • Malkin D, et al. The role of p53 in megakaryocyte differentiation and the megakaryocytic leukemias of Down syndrome. Cancer Genet Cytogenet 2000 Jan 1;116(1):1-5    Related articles (PubMed)

  • Zhou M, et al. Overexpression of the MDM2 gene by childhood acute lymphoblastic leukemia cells expressing the wild-type p53 gene Blood. 1995 Mar 15;85(6):1608-14.    Related articles (PubMed)

  • Medline Search: childhod leukemia AND (p53 OR tp53) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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    Childhood Leukaemia Genetics
    Childhood Leukaemia : Clinical and Epidemiological Information

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  •   TP53 and Hairy Cell Leukaemia

  • Vallianatou K, et al. p53 gene deletion and trisomy 12 in hairy cell leukemia and its variant. Leuk Res. 1999;23(11):1041-5.    Related articles (PubMed)

  • Medline Search: hairy cell leukemia AND (p53 OR tp53) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Hairy Cell Leukaemia Genetics
    Hairy Cell Leukaemia : Clinical and Epidemiological Information

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  •   TP53 and Chronic Lymphocytic Leukemia

  • Amiel A, et al. Monoallelic p53 deletion in chronic lymphocytic leukemia detected by interphase cytogenetics. Cancer Genet Cytogenet 1997; 97(2):97-100    Related articles (PubMed)

  • Cano I, et al. Trisomy 12 and p53 deletion in chronic lymphocytic leukemia detected by fluorescence in situ hybridization: association with morphology and resistance to conventional chemotherapy. Cancer Genet Cytogenet. 1996; 90(2):118-24.    Related articles (PubMed)

  • Medline Search: chronic lymphocytic leukemia AND (p53 OR tp53) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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    Chronic Lymphocytic Leukaemia Genetics
    Chronic Lymphocytic Leukaemia : Clinical and Epidemiological Information

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  •   TP53 and B-cell prolymphocytic leukemia

  • Lens D, et al. p53 abnormalities in B-cell prolymphocytic leukemia. Blood 1997 Mar 15;89(6):2015-23    Related articles (PubMed)

  • Medline Search: prolymphocytic leukemia AND (p53 OR tp53) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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    Leukaemia Genetics
    Leukaemia : Clinical and Epidemiological Information

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  •   TP53 and Other Cancers

  • Fulci G et al p53 and brain tumors: from gene mutations to gene therapy. Brain Pathol. 1998; 8:599-613. (Review)    Related articles (PubMed)

  • Smolewski P, et al. Expression of proliferating cell nuclear antigen (PCNA) and p53, bcl-2 or C-erb B-2 proteins on Reed-Sternberg cells: prognostic significance in Hodgkin's disease Neoplasma. 1998;45(3):140-7.    Related articles (PubMed)

  • Ferec C. et al. TP53 and oesophageal cancer. Pathol Biol. 1997; 45:871-5    Related articles (PubMed)

  • Puisieux A. et al. TP53 and hepatocellular carcinoma. Pathol Biol. 1997; 45:864-70. (Review)    Related articles (PubMed)

  • Gleich LL, et al. The loss of heterozygosity in retinoblastoma and p53 suppressor genes as a prognostic indicator for head and neck cancer. Laryngoscope 1996; 106(11):1378-81    Related articles (PubMed)

  • Medline Search: p53 AND cancer (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Cancer Resources by Disease Type

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  •   TP53 Related Gene Therapy Approaches (Experimental)

  • Watanabe T, Sullenger BA. Induction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcripts Proc. Natl. Acad. Sci. USA 2000; 97(15);8490-8494    Related articles

  • Hietanen S, et al. Activation of p53 in cervical carcinoma cells by small molecules. Proc Natl Acad Sci USA 2000; 97(15): 8501-8506    Related articles (PubMed)

  • Roth JA, et al. p53 tumor suppressor gene therapy for cancer. [Review] Oncology (Huntingt). 1999;13(10 Suppl 5):148-54    Related articles (PubMed)

  • Gallagher WM, Brown R p53-oriented cancer therapies: current progress. Ann Oncol 1999;10(2):139-50    Related articles (PubMed)

  • Medline Search: cancer AND gene therapy AND (p53[ti] OR tp53[ti]) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

  • Medline Search: p53 AND gene therapy AND clinical trial[PT] (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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  •   TP53 and Gastrointestinal Cancers

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      TP53 and Gastric Cancer

  • Kataoka M, et al. Aberration of p53 and DCC in gastric and colorectal cancer. Oncol Rep 2000 Jan-Feb;7(1):99-103    Related articles (PubMed)

  • Medline Search: gastric cancer AND (tp53 OR p53) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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    Stomach (Gastric) Cancer Genetics
    Stomach (Gastric) Cancer : Clinical and Epidemiological Information

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  •   TP53 and Liver Cancer

  • Puisieux A. et al. TP53 and hepatocellular carcinoma. Pathol Biol. 1997; 45:864-70. (Review)    Related articles (PubMed)

  • Caruso ML, Valentini AM Overexpression of p53 in a large series of patients with hepatocellular carcinoma: a clinicopathological correlation. Anticancer Res 1999 Sep-Oct;19(5B):3853-6    Related articles (PubMed)

  • Kirk GD, et al. Ser-249 p53 mutations in plasma DNA of patients with hepatocellular carcinoma from The Gambia. J Natl Cancer Inst 2000 Jan 19;92(2):148-53    Related articles (PubMed)

  • Medline Search: hepatocellular carcinoma AND (p53 OR tp53) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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    Hepatocelular Carcinoma Genetics
    Hepatocelular Carcinoma : Clinical and Epidemiological Information

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  •   TP53 and CNS Tumours

  • Pomeroy SL. The p53 tumor suppressor gene and pediatric brain tumors. [Review] Curr Opin Pediatr. 1994;6(6):632-5    Related articles (PubMed)

  • Medline Search: brain tumor AND (p53 OR tp53) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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    Brain and CNS Tumours : Clinical and Epidemiological Information

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  •   TP53 and Astrocytoma

  • Leenstra S, et al. Genetic sub-types of human malignant astrocytoma correlate with survival. Int J Cancer 1998 Apr 17;79(2):159-65    Related articles (PubMed)

  • Medline Search: astrocytoma AND (p53 OR tp53) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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  •   TP53 and Prostate Cancer

  • Koivisto PA, Rantala I Amplification of the androgen receptor gene is associated with P53 mutation in hormone-refractory recurrent prostate cancer. J Pathol 1999;187(2):237-41    Related articles (PubMed)

  • Medline Search: prostate cancer AND (p53 or tp53) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Prostate Cancer Genetics
    Prostate Cancer : Clinical and Epidemiological Information

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  •   TP53 and Fallopean Tube Cancer

  • Chung TK, et al. Overexpression of p53 and HER-2/neu and c-myc in primary fallopian tube carcinoma. Gynecol Obstet Invest 2000;49(1):47-51    Related articles (PubMed)

  • Runnebaum IB, et al. p53 mutation is associated with high S-phase fraction in primary fallopian tube adenocarcinoma. Br J Cancer. 1996;74(8):1157-60    Related articles (PubMed)

  • Lacy MQ, et al. c-erbB-2 and p53 expression in fallopian tube carcinoma. Cancer 1995 Jun 15;75(12):2891-6    Related articles (PubMed)

  • Medline Search: fallopean tube cancer AND (p53 OR tp53) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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    Fallopian Tube ca. : Clinical and Epidemiological Information

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  •   TP53 and Adrenocortical Carcinoma

  • Venara M, et al. Functional adrenal cortical tumors in childhood: a study of ploidy, p53-protein and nucleolar organizer regions (AgNORs) as prognostic markers. J Pediatr Endocrinol Metab 1998 Sep-Oct;11(5):597-605 (PubMed)

  • McNicol AM, et al. Expression of p53 in adrenocortical tumours: clinicopathological correlations. J Pathol 1997;181(2):146-52    Related articles (PubMed)

  • Edgren M, et al. Biological characteristics of adrenocortical carcinoma: a study of p53, IGF, EGF-r, Ki-67 and PCNA in 17 adrenocortical carcinomas. Anticancer Res 1997 Mar-Apr;17(2B):1303-9    Related articles (PubMed)

  • Medline Search: adrenocortical carcinoma AND (tp53 OR p53) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Adrenocortical Carcinoma Genetics
    Adrenocortical Carcinoma : Clinical and Epidemiological Information

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  •   TP53 Mutations in Endometrial Cancer

  • Lax SF, et al. The frequency of p53, K-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma: evidence of distinct molecular genetic pathways. Cancer 2000 Feb 15;88(4):814-24    Related articles (PubMed)

  • Medline Search: endometrial cancer AND (tp53 OR p53) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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    Uterus / Endometrium Ca. Genetics
    Uterus / Endometrium Ca. : Clinical and Epidemiological Information

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  •   TP53 Mutations in Childhood Cancer

  • Chompret A, et al. P53 germline mutations in childhood cancers and cancer risk for carrier individuals. Br J Cancer 2000;82(12):1932-7    Related articles (PubMed)

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  •   TP53 Transfer to Mesothelioma Cells (Experimental)

  • Giuliano M, et al. Adenovirus-mediated wild-type p53 overexpression reverts tumourigenicity of human mesothelioma cells. Int J Mol Med 2000 Jun;5(6):591-6    Related articles (PubMed)

  • Procopio A, et al. Human malignant mesothelioma of the pleura: new perspectives for diagnosis and therapy. Monaldi Arch Chest Dis 1998 Apr;53(2):241-3    Related articles (PubMed)

  • Medline Search: mesothelioma AND (p53 OR TP53) AND gene therapy (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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    Mesothelioma Genetics
    Mesothelioma : Clinical and Epidemiological Information

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  •   TP53 Mutations in a Small Sub-set of Ewing's Sarcoma

  • de Alava E, et al. Prognostic impact of P53 status in Ewing sarcoma. Cancer 2000 Aug 15;89(4):783-92    Related articles (PubMed)

  • Abudu A, et al. Overexpression of p53 protein in primary Ewing's sarcoma of bone: relationship to tumour stage, response and prognosis. Br J Cancer 1999 Mar;79(7-8):1185-9    Related articles (PubMed)

  • Radig K, et al. p53 and ras mutations in Ewing's sarcoma. Pathol Res Pract 1998;194(3):157-62    Related articles (PubMed)

  • Kovar H, et al. Narrow spectrum of infrequent p53 mutations and absence of MDM2 amplification in Ewing tumours. Oncogene 1993 Oct;8(10):2683-90    Related articles (PubMed)

  • Medline Search: ewing's sarcoma AND (p53 OR tp53) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Ewing's Sarcoma Genetics
    Ewing's Sarcoma : Clinical and Epidemiological Information

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