 Summary Information
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Location: 12q13-q14
Amplified in certain tumors esp. sarcomas
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| Gene Database Entries for MDM2
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OMIM
Tumor Gene Database
Genbank
Swiss-Prot
Locus Link
UniGene
GDB
Nomenclature (search for MDM2)
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| Other Related Resources
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- Search Medline for related articles (PubMed)
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- Medline Search: cancer AND gene AND MDM2[TI] (PubMed)
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| MDM2 and Osteosarcoma
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Miller CW et al. Alterations of the p53, Rb and MDM2 genes in osteosarcoma. J Cancer Res Clin Oncol 1996; 122:559-65 Related articles (PubMed)
Lonardo F. et al. p53 and MDM2 alterations in osteosarcomas: correlation with clinicopathologic features and proliferative rate. Cancer 1997; 79:1541-7 Related articles (PubMed)
Wunder JS, et al. Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas. Oncogene 1999; 18(3):783-8 Related articles (PubMed)
Ragazzini P, et al. Analysis of SAS gene and CDK4 and MDM2 proteins in low-grade osteosarcoma Cancer Detect Prev 1999;23(2):129-36 Related articles (PubMed)
Medline Search: MDM2 AND osteosarcoma (PubMed)
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 TP53 gene- RB1 gene
Osteosarcoma Genetics
Osteosarcoma : Clinical and Epidemiological Information
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| MDM2 and Rhabdomyosarcoma
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Keleti J, et al. The MDM2 oncoprotein is overexpressed in rhabdomyosarcoma cell lines and stabilizes wild-type p53 protein. Am J Pathol 1996;149(1):143-51 Related articles (PubMed)
Boman F, et al. Gene alterations and apoptosis in rhabdomyosarcoma. Pediatr Pathol Lab Med 1997; 17(2):233-47 Related articles (PubMed)
Medline Search: rhabdomyosarcoma AND mdm2 (PubMed)
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Childhood Soft Tissue Sarcoma Genetics
Childhood Soft Tissue Sarcoma : Clinical and Epidemiological Information
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| MDM2 and Ovarian Cancer
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Baekelandt M, et al. Clinical Significance of Apoptosis-Related Factors p53, Mdm2, and Bcl-2 in Advanced Ovarian Cancer. J Clin Oncol 1999; 17(7):2061 Related articles
Skomedal H, et al. TP53 protein accumulation and gene mutation in relation to overexpression of MDM2 protein in ovarian borderline tumours and stage I carcinomas. J Pathol. 1997; 181(2):158-65 Related articles (PubMed)
Tanner B, et al. mdm 2 mRNA expression is associated with survival in ovarian cancer. Int J Cancer 1997; 74(4):438-42 Related articles (PubMed)
Medline Search: ovarian cancer AND mdm2 (PubMed)
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Ovarian Ca. Genetics
Ovarian Ca. : Clinical and Epidemiological Information
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| MDM2 and Testicular Cancer
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Eid H, et al. mdm-2 expression in human testicular germ-cell tumors and its clinical value. Anticancer Res. 1999; 19(4C):3485-90 Related articles (PubMed)
Riou G, et al. The p53 and mdm-2 genes in human testicular germ-cell tumors. Mol Carcinog. 1995;12(3):124-31 Related articles (PubMed)
Medline Search: mdm2 and testicular cancer (PubMed)
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Testicular Cancer Genetics
Testicular Cancer : Clinical and Epidemiological Information
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| MDM2 and Leukaemia
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Medline Search: leukemia AND MDM2 (PubMed)
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Leukaemia Genetics
Leukaemia : Clinical and Epidemiological Information
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| MDM2 and Childhood Leukaemia
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Gustafsson B, et al. Cellular expression of MDM2 and p53 in childhood leukemias with poor prognosis. Med Pediatr Oncol 2000;34(2):117-24 Related articles (PubMed)
Zhou M, et al. Incidence and prognostic significance of MDM2 oncoprotein leukemia. Leukemia 2000;14(1):61-7 Related articles (PubMed)
Gustafsson B, et al. Overexpression of MDM2 in acute childhood lymphoblastic leukemia. Pediatr Hematol Oncol. 1998 Nov-Dec;15(6):519-26 Related articles (PubMed)
Zhou M, et al. Overexpression of the MDM2 gene by childhood acute lymphoblastic leukemia cells expressing the wild-type p53 gene Blood. 1995 Mar 15;85(6):1608-14. Related articles (PubMed)
Medline Search: childhood leukemia AND MDM2 (PubMed)
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[Home] This page created: 09/10/1999 Last revised: 29/04/2003 © Copyright 1999-
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