|Gene:||MDM2; MDM2 proto-oncogene|
|Aliases:||HDMX, hdm2, ACTFS|
|Summary:||This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]|
|Databases:||VEGA, OMIM, HGNC, Ensembl, GeneCard, Gene|
|Protein:||E3 ubiquitin-protein ligase Mdm2|
|Source:||NCBIAccessed: 10 March, 2017|
What does this gene/protein do?
|Pathways:||What pathways are this gene/protein implicaed in?|
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Data table showing topics related to specific cancers and associated disorders. Scope includes mutations and abnormal protein expression.