Adrenocortical Carcinoma - Molecular Biology

Overview

Literature Analysis

Mouse over the terms for more detail; many indicate links which you can click for dedicated pages about the topic.

Tag cloud generated 10 March, 2017 using data from PubMed, MeSH and CancerIndex

Mutated Genes and Abnormal Protein Expression (47)

How to use this data tableClicking on the Gene or Topic will take you to a separate more detailed page. Sort this list by clicking on a column heading e.g. 'Gene' or 'Topic'.

GeneLocationAliasesNotesTopicPapers
RET 10q11.2 PTC, MTC1, HSCR1, MEN2A, MEN2B, RET51, CDHF12, CDHR16, RET-ELE1 GWS
-RET and Adrenocortical Cancer
277
SDHD 11q23.1 PGL, CBT1, CWS3, PGL1, QPs3, SDH4, cybS, CII-4 -SDHD and Adrenocortical Cancer
187
SDHB 1p36.1-p35 IP, SDH, CWS2, PGL4, SDH1, SDH2, SDHIP -SDHB and Adrenocortical Cancer
185
VHL 3p25.3 RCA1, VHL1, pVHL, HRCA1 -VHL and Adrenocortical Cancer
97
MEN1 11q13.1 MEAI, SCG2 GWS
-MEN1 and Adrenocortical Cancer
89
SDHC 1q23.3 CYBL, PGL3, QPS1, SDH3, CYB560 -SDHC and Adrenocortical Cancer
89
TP53 17p13.1 P53, BCC7, LFS1, TRP53 GWS
-TP53 and Adrenocortical Carcinoma
82
NF1 17q11.2 WSS, NFNS, VRNF -NF1 and Adrenocortical Cancer
77
ACCS 11p11.2 ACS, PHACS -ACCS and Adrenocortical Cancer
59
KCNJ5 11q24.3 CIR, GIRK4, KATP1, LQT13, KIR3.4 -KCNJ5 and Adrenocortical Cancer
44
CAMP 3p21.3 LL37, CAP18, CRAMP, HSD26, CAP-18, FALL39, FALL-39 -CAMP and Adrenocortical Cancer
41
PGLS 19p13.2 6PGL -PGLS and Adrenocortical Cancer
40
TMEM127 2q11.2 -TMEM127 and Adrenocortical Cancer
38
SDHAF2 11q12.2 PGL2, SDH5, C11orf79 -SDHAF2 and Adrenocortical Cancer
34
CTNNB1 3p22.1 CTNNB, MRD19, armadillo GWS
-CTNNB1 and Adrenocortical Carcinoma
34
CYP11B2 8q21-q22 CPN2, ALDOS, CYP11B, CYP11BL, CYPXIB2, P450C18, P-450C18, P450aldo -CYP11B2 and Adrenocortical Cancer
33
SDHA 5p15 FP, PGL5, SDH1, SDH2, SDHF, CMD1GG -SDHA and Adrenocortical Cancer
30
CYP11B1 8q21 FHI, CPN1, CYP11B, P450C11 -CYP11B1 and Adrenocortical Cancer
27
IGF2 11p15.5 GRDF, IGF-II, PP9974, C11orf43 -IGF2 Expression in Adrenocortical Carcinoma
25
PDE11A 2q31.2 PPNAD2 -PDE11A and Adrenocortical Cancer
11
NR5A1 9q33 ELP, SF1, FTZ1, POF7, SF-1, AD4BP, FTZF1, SPGF8, SRXY3 -NR5A1 and Adrenocortical Cancer
10
EPAS1 2p21-p16 HLF, MOP2, ECYT4, HIF2A, PASD2, bHLHe73 -EPAS1 and Adrenocortical Cancer
8
CYP11A1 15q23-q24 CYP11A, CYPXIA1, P450SCC -CYP11A1 and Adrenocortical Cancer
7
EGLN1 1q42.1 HPH2, PHD2, SM20, ECYT3, HALAH, HPH-2, HIFPH2, ZMYND6, C1orf12, HIF-PH2 -EGLN1 and Adrenocortical Cancer
6
GDNF 5p13.1-p12 ATF1, ATF2, HSCR3, HFB1-GDNF -GDNF and Adrenocortical Cancer
6
MAX 14q23 bHLHd4 -MAX and Adrenocortical Cancer
6
EGLN3 14q13.1 PHD3, HIFPH3, HIFP4H3 -EGLN3 and Adrenocortical Cancer
6
RB1 13q14.2 RB, pRb, OSRC, pp110, p105-Rb, PPP1R130 GWS
-RB1 and Adrenocortical Carcinoma
6
NR3C2 4q31.1 MR, MCR, MLR, NR3C2VIT -NR3C2 and Adrenocortical Cancer
5
GATA6 18q11.1-q11.2 -GATA6 and Adrenocortical Cancer
5
RBP3 10q11.2 IRBP, RBPI, RP66, D10S64, D10S65, D10S66 -RBP3 and Adrenocortical Cancer
5
NR0B1 Xp21.3 AHC, AHX, DSS, GTD, HHG, AHCH, DAX1, DAX-1, NROB1, SRXY2 -NR0B1 and Adrenocortical Cancer
4
HSD3B2 1p13.1 HSDB, HSD3B, SDR11E2 -HSD3B2 and Adrenocortical Cancer
4
CDKN2A 9p21.3 ARF, MLM, P14, P16, P19, CMM2, INK4, MTS1, TP16, CDK4I, CDKN2, INK4A, MTS-1, P14ARF, P19ARF, P16INK4, P16INK4A, P16-INK4A GWS
-CDKN2A and Adrenocortical Carcinoma
4
AVPR1A 12q14.2 V1aR, AVPR1, AVPR V1a -AVPR1A and Adrenocortical Cancer
3
NR4A2 2q22-q23 NOT, RNR1, HZF-3, NURR1, TINUR -NR4A2 and Adrenocortical Cancer
3
KIF1B 1p36.2 KLP, CMT2, CMT2A, CMT2A1, HMSNII, NBLST1 -KIF1B and Adrenocortical Cancer
3
AVPR1B 1q32 AVPR3 -AVPR1B and Adrenocortical Cancer
3
MC2R 18p11.2 ACTHR -MC2R and Adrenocortical Cancer
3
TERT 5p15.33 TP2, TRT, CMM9, EST2, TCS1, hTRT, DKCA2, DKCB4, hEST2, PFBMFT1 GWS
-TERT and Adrenocortical Carcinoma
2
WISP2 20q13.12 CCN5, CT58, CTGF-L -WISP2 and Adrenocortical Cancer
2
LHCGR 2p21 HHG, LHR, LCGR, LGR2, ULG5, LHRHR, LSH-R, LH/CGR, LH/CG-R -LHCGR and Adrenocortical Cancer
2
KCNQ1OT1 11p15.5 LIT1, Kncq1, KvDMR1, KCNQ10T1, KCNQ1-AS2, KvLQT1-AS, NCRNA00012 -KCNQ1OT1 and Adrenocortical Cancer
2
DAXX 6p21.3 DAP6, EAP1, BING2 GWS
-DAXX and Adrenorortical Carcinoma
2
AGTR2 Xq22-q23 AT2, ATGR2, MRX88 -AGTR2 and Adrenocortical Cancer
2
MED12 Xq13 OKS, FGS1, HOPA, OPA1, OHDOX, ARC240, CAGH45, MED12S, TNRC11, TRAP230 GWS
-MED12 and Adrenocortical Carcinoma
1
ZNRF3 22q12.1 RNF203, BK747E2.3 GWS
-ZNRF3 and Adrenocortical Cancer
1

Note: list is not exhaustive. Number of papers are based on searches of PubMed (click on topic title for arbitrary criteria used).

GWS - Genome/Exome Wide Study, large-scale/significant (selected):
Assié G et al. Integrated genomic characterization of adrenocortical carcinoma. Nat Genet. 2014; 46(6):607-12

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