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  Chromosome 11

Genes Linked with Cancer (146)

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 11; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
ACCS 11p11 ACS, PHACS-Adenoid Cystic Carcinoma
-Adrenocortical Cancer
CREB3L1 11p11.2 OASISSomatic-Cervical Cancer
-Childhood Cancers
-Soft Tissue Sarcoma
CRY2 11p11.2 HCRY2, PHLL2-Breast Cancer
-Liver Cancer
-Prostate Cancer
PTPRJ 11p11.2 DEP1, SCC1, CD148, HPTPeta, R-PTP-ETA-Breast Cancer
-Childhood Cancers
-Colorectal Cancer
-Thyroid Cancer
SPI1 11p11.2 OF, PU.1, SFPI1, SPI-1, SPI-A
CD82 11p11.2 R2, 4F9, C33, IA4, ST6, GR15, KAI1, SAR2, TSPAN27Many cancer types including:
-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Lung Cancer
-Prostate Cancer
-Retinoblastoma
-Stomach Cancer
-Thyroid Cancer
EXT2 11p12-p11 SOTVGermline-Chondrosarcoma
-Multiple Hereditary Exostoses
DDB2 11p12-p11 DDBB, UV-DDB2Germline-Breast Cancer
-Lung Cancer
-Melanoma
-Skin Cancer
TRAF6 11p12 RNF85, MGC:3310-Bladder Cancer
-Breast Cancer
-Lung Cancer
WT1 11p13 GUD, AWT1, WAGR, WT33, NPHS4, WIT-2, EWS-WT1Germline & Somatic
Translocation
Overexpression
Many cancer types including:
-Acute Myeloid Leukaemia
-Childhood Leukaemia
-DSRC
-Lung Cancer, Non-Small Cell
-Mesothelioma
-Myelodysplastic Syndromes
-Ovarian Cancer
-Wilms Tumour
CD44 11p13 IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, CDW44, CSPG8, HCELL, HUTCH-I, ECMR-III-Bladder Cancer
-Breast Cancer
-Eye Cancer
-Neuroblastoma
-Osteosarcoma
-Prostate Cancer
-Stomach Cancer
RAG2 11p13 RAG-2-Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Leukaemia
-Lung Cancer
BDNF 11p13 ANON2, BULN2-Brain Tumours, Childhood
-Cervical Cancer
-Lung Cancer
-Neuroblastoma
-Oral Cavity Cancer
-Uterine Sarcoma
PAX6 11p13 AN, AN2, FVH1, MGDA, WAGR, D11S812E-Brain Tumours, Childhood
-Eye Cancer
-Kidney Cancer
-Wilms Tumour
CD59 11p13 1F5, EJ16, EJ30, EL32, G344, MIN1, MIN2, MIN3, MIRL, HRF20, MACIF, MEM43, MIC11, MSK21, 16.3A5, HRF-20, MAC-IP, p18-20-Breast Cancer
-Chronic Myelogenous Leukemia
-Melanoma
-Pancreatic Cancer
RAG1 11p13 RAG-1, RNF74-Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Leukaemia
-Ovarian Cancer
LMO2 11p13 TTG2, RBTN2, RHOM2, RBTNL1Somatic-Acute Lymphocytic Leukaemia (ALL)
WT1-AS 11p13 WIT1, WIT-1, WT1AS, WT1-AS1-Acute Myeloid Leukaemia
-Kidney Cancer
-Leukaemia
ST2 11p14.3-p12 -Acute Myeloid Leukaemia
-Bone Cancer (primary)
-Brain Tumours, Childhood
-Pancreatic Cancer
ST5 11p15 HTS1, p126, DENND2B-Lung Cancer
-Thyroid Cancer
ARNTL 11p15 TIC, JAP3, MOP3, BMAL1, PASD3, BMAL1c, bHLHe5-Breast Cancer
-Colorectal Cancer
-Melanoma
-Prostate Cancer
KCNQ1OT1 11p15 LIT1, KvDMR1, KCNQ10T1, KCNQ1-AS2, KvLQT1-AS, NCRNA00012-Adrenocortical Cancer
-Beckwith-Wiedemann syndrome
-Wilms Tumour
LYVE1 11p15 HAR, XLKD1, LYVE-1, CRSBP-1-Breast Cancer
-Liver Cancer
-Pancreatic Cancer
FANCF 11p15 FAFGermline-Fanconi Anaemia
LMO1 11p15 TTG1, RBTN1, RHOM1Germline & Somatic
Translocation
-Acute Lymphocytic Leukaemia (ALL)
-Leukaemia
-Neuroblastoma
TSG101 11p15 TSG10, VPS23-Breast Cancer
-Lung Cancer
-Ovarian Cancer
-Prostate Cancer
RASSF10 11p15.2 -Acute Lymphocytic Leukaemia (ALL)
-Brain Tumours, Childhood
-Prostate Cancer
-Stomach Cancer
CALCA 11p15.2 CT, KC, CGRP, CALC1, CGRP1, CGRP-I-Bladder Cancer
-Kidney Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Ovarian Cancer
-Thyroid Cancer
-Wilms Tumour
DKK3 11p15.2 RIG, REIC-Breast Cancer
-Cervical Cancer
-Lung Cancer
-Prostate Cancer
-Stomach Cancer
SOX6 11p15.3 SOXD, HSSOX6
Amplification
-Bone Cancer (primary)
-Brain Tumours, Childhood
-Ewing's Sarcoma
-Liver Cancer
LDHA 11p15.4 LDH1, LDHM, GSD11, PIG19, HEL-S-133P-Brain Tumours, Childhood
-Breast Cancer
SMPD1 11p15.4-p15.1 ASM, NPD, ASMASE-Bladder Cancer
-Breast Cancer
-Lung Cancer
WEE1 11p15.4 WEE1A, WEE1hu-Breast Cancer
CCKBR 11p15.4 GASR, CCK-B, CCK2R-Colorectal Cancer
-Gastrointestinal Cancers
-Pancreatic Cancer
-Thyroid Cancer
MYOD1 11p15.4 PUM, MYF3, MYOD, bHLHc1-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Rhabdomyosarcoma
-Soft Tissue Sarcoma
PRKCDBP 11p15.4 SRBC, HSRBC, CAVIN3, cavin-3-Brain Tumours, Childhood
-Breast Cancer
-Colorectal Cancer
-Lung Cancer
CD81 11p15.5 S5.7, CVID6, TAPA1, TSPAN28-Liver Cancer
-Lung Cancer
-Multiple Myeloma
-Neuroblastoma
MUC5AC 11p15.5 TBM, leB, MUC5-Colorectal Cancer
-Lung Cancer
-Pancreatic Cancer
-Prostate Cancer
-Stomach Cancer
CD151 11p15.5 GP27, MER2, RAPH, SFA1, PETA-3, TSPAN24-Brain Tumours, Childhood
-Breast Cancer
-Liver Cancer
-Lung Cancer
-Prostate Cancer
-Skin Cancer
MUC5B 11p15.5 MG1, MUC5, MUC9, MUC-5B-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Ovarian Cancer
-Pancreatic Cancer
-Stomach Cancer
MUC6 11p15.5 MUC-6-Pancreatic Cancer
-Prostate Cancer
-Stomach Cancer
IRF7 11p15.5 IRF7A, IRF7B, IRF7C, IRF7H, IRF-7H-Bladder Cancer
-Lung Cancer
SLC22A18 11p15.5 HET, ITM, BWR1A, IMPT1, TSSC5, ORCTL2, BWSCR1A, SLC22A1L, p45-BWR1A-Beckwith-Wiedemann syndrome
-Breast Cancer
-Kidney Cancer
-Liver Cancer
-Prostate Cancer
-Wilms Tumour
LSP1 11p15.5 WP34, pp52-Breast Cancer
-Ovarian Cancer
STIM1 11p15.5 GOK, TAM, TAM1, IMD10, STRMK, D11S4896E-Breast Cancer
-Cervical Cancer
-Kidney Cancer
-Prostate Cancer
-Uterine Sarcoma
-Wilms Tumour
WT2 11p15.5 ADCR, MTACR1-Beckwith-Wiedemann syndrome
-Wilms Tumour
RRM1 11p15.5 R1, RR1, RIR1-Bladder Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Small Cell Lung Cancer
-Pancreatic Cancer
-Wilms Tumour
RASSF7 11p15.5 HRC1, HRAS1, C11orf13
Methylation
-Neuroblastoma
-Stomach Cancer
MUC2 11p15.5 MLP, SMUC, MUC-2-Colorectal Cancer
-Prostate Cancer
-Stomach Cancer
H19 11p15.5 ASM, BWS, WT2, ASM1, PRO2605, D11S813E, LINC00008, NCRNA00008-Bladder Cancer
-Cervical Cancer
-Lung Cancer
-Stomach Cancer
-Uterine Sarcoma
-Wilms Tumour
SIRT3 11p15.5 SIR2L3-Breast Cancer
-Lung Cancer
CTSD 11p15.5 CPSD, CLN10, HEL-S-130P-Breast Cancer
-Nasopharyngeal Cancer
-Ovarian Cancer
-Prostate Cancer
-Stomach Cancer
IGF2-AS 11p15.5 PEG8, IGF2AS, IGF2-AS1-Kidney Cancer
-Liver Cancer
-Wilms Tumour
IGF2 11p15.5 IGF-II, PP9974, C11orf43
Imprinting errors
Overexpression
Many cancer types including:
-Adrenocortical Cancer
-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Stomach Cancer
-Wilms Tumour
CARS 11p15.5 CARS1, CYSRS, MGC:11246Somatic-Childhood Cancers
-Ovarian Cancer
-Prostate Cancer
CDKN1C 11p15.5 BWS, WBS, p57, BWCR, KIP2, p57Kip2-Beckwith-Wiedemann syndrome
-Childhood Cancers
-Kidney Cancer
-Thyroid Cancer
-Uterine Sarcoma
NUP98 11p15.5 ADIR2, NUP96, NUP196Somatic
Translocation
-Acute Myeloid Leukaemia
-Childhood Cancers
-Chronic Myelogenous Leukemia
-Leukaemia
-Myelodysplastic Syndromes
HRAS 11p15.5 CTLO, HAMSV, HRAS1, RASH1, p21ras, C-H-RAS, H-RASIDX, C-BAS/HAS, C-HA-RAS1Germline & Somatic-Breast Cancer
-Childhood Cancers
-Eye Cancer
-Melanoma
-Skin Cancer
RASSF5 1q32.1 RAPL, Maxp1, NORE1, NORE1A, NORE1B, RASSF3
Methylation
-Cervical Cancer
-Liver Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Neuroblastoma
CTNND1 11q11 CAS, p120, CTNND, P120CAS, P120CTN, p120(CAS), p120(CTN)-Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Endometrial Cancer
-Lung Cancer
PYGM 11q12-q13.2 -Breast Cancer
-Carcinoid Tumours
-Multiple Endocrine Neoplasia
-Parathyroid Cancer
-Pituitary Tumors
-Skin Cancer
-Thyroid Cancer
CLP1 11q12 HEAB, hClp1Somatic-Brain and CNS Tumours
-Brain Stem Glioma, Childhood
-Testicular Cancer
MTA2 11q12-q13.1 PID, MTA1L1-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Ovarian Cancer
-Pancreatic Cancer
DDB1 11q12-q13 XPE, DDBA, XAP1, XPCE, XPE-BF, UV-DDB1
MS4A1 11q12 B1, S7, Bp35, CD20, CVID5, MS4A2, LEU-16-Chronic Lymphocytic Leukemia
-Skin Cancer
-Vaginal Cancer
FEN1 11q12 MF1, RAD2, FEN-1-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
SLC43A1 11q12.1 LAT3, PB39, POV1, R00504-Prostate Cancer
-Testicular Cancer
SDHAF2 11q12.2 PGL2, SDH5, C11orf79Germline-Adrenocortical Cancer
-Childhood Cancers
-Head and Neck Cancers
-Pheochromocytoma and Paraganglioma
PLA2G16 11q12.3 AdPLA, HRSL3, HRASLS3, HREV107, HREV107-1, HREV107-3, H-REV107-1-Nasopharyngeal Cancer
-Ovarian Cancer
CCND1 11q13 BCL1, PRAD1, U21B31, D11S287ESomatic
Translocation
-Breast Cancer
-Lung Cancer
-Mantle-Cell Lymphoma
-Rectal Cancer
-Rhabdomyosarcoma
PAK1 11q13-q14 PAKalpha-Breast Cancer
-Ovarian Cancer
NUMA1 11q13 NUMA, NMP-22Somatic-Bladder Cancer
-Breast Cancer
-Leukaemia
SCGB2A2 11q13 MGB1, UGB2-Breast Cancer
-Ovarian Cancer
YAP1 11q13 YAP, YKI, COB1, YAP2, YAP65-Brain Tumours, Childhood
-Breast Cancer
-Liver Cancer
SIPA1 11q13 SPA1-Breast Cancer
-Cervical Cancer
BRMS1 11q13-q13.2 -Breast Cancer
-Lung Cancer
-Melanoma
CST6 11q13 -Breast Cancer
-Cervical Cancer
-Uterine Sarcoma
RELA 11q13 p65, NFKB3-Breast Cancer
-Lung Cancer
-Prostate Cancer
FGF3 11q13 INT2, HBGF-3-Breast Cancer
-Kaposi Sarcoma
-Stomach Cancer
-Urinary System Cancers
UCP2 11q13 UCPH, BMIQ4, SLC25A8-Breast Cancer
-Pancreatic Cancer
-Prostate Cancer
ST3 11q13-q23 CCTS, TSHL-Breast Cancer
VEGFB 11q13 VRF, VEGFL-Lung Cancer
-Neuroblastoma
GSTP1 11q13 PI, DFN7, GST3, GSTP, FAEES3, HEL-S-22-Bladder Cancer
-Breast Cancer
-Small Cell Lung Cancer
-Thyroid Cancer
FOSL1 11q13 FRA, FRA1, fra-1-Breast Cancer
-Colorectal Cancer
-Lung Cancer
STIP1 11q13 HOP, P60, STI1, STI1L, HEL-S-94n, IEF-SSP-3521-Ovarian Cancer
KAT5 11q13 TIP, ESA1, PLIP, TIP60, cPLA2, HTATIP, ZC2HC5, HTATIP1-Bladder Cancer
-Prostate Cancer
-Thyroid Cancer
CTTN 11q13 EMS1
Amplification
-Breast Cancer
-Esophageal Cancer
-Head and Neck Cancers
-Oral Cavity Cancer
-Salivary Gland Cancer
-Stomach Cancer
MEN1 11q13 MEAI, SCG2Germline & Somatic-Adrenocortical Cancer
-Carcinoid Tumours
-Childhood Cancers
-Multiple Endocrine Neoplasia
-Pancreatic Cancer
-Parathyroid Cancer
-Thyroid Cancer
FGF19 11q13.1 -Bladder Cancer
-Breast Cancer
-Esophageal Cancer
-Liver Cancer
-Lung Cancer
-Oral Cavity Cancer
BAD 11q13.1 BBC2, BCL2L8-Breast Cancer
-Lung Cancer
-Osteosarcoma
MALAT1 11q13.1 HCN, NEAT2, MALAT-1, PRO2853, mascRNA, LINC00047, NCRNA00047Somatic-Bladder Cancer
-Breast Cancer
-Liver Cancer
-Lung Cancer
-Stomach Cancer
RIN1 11q13.2 -Bladder Cancer
-Colorectal Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Wilms Tumour
ANO1 11q13.3 DOG1, TAOS2, ORAOV2, TMEM16A-Bladder Cancer
-Breast Cancer
-Esophageal Cancer
-Gastrointestinal Cancers
-Gastrointestinal Stromal Tumors
-Stomach Cancer
FOLR1 11q13.3-q14.1 FBP, FOLR-Lung Cancer
-Lung Cancer, Non-Small Cell
-Ovarian Cancer
-Uterine Sarcoma
FGF4 11q13.3 HST, KFGF, HST-1, HSTF1, K-FGF, HBGF-4-Bladder Cancer
-Breast Cancer
-Esophageal Cancer
-Kaposi Sarcoma
-Oral Cavity Cancer
FADD 11q13.3 GIG3, MORT1-Stomach Cancer
LRP5 11q13.4 HBM, LR3, OPS, EVR1, EVR4, LRP7, OPPG, BMND1, LRP-5, OPTA1, VBCH2-Bone Cancer (primary)
-Brain and CNS Tumours
-Brain Stem Glioma, Childhood
WNT11 11q13.5 HWNT11-Prostate Cancer
-Stomach Cancer
PICALM 11q14 LAP, CALM, CLTHSomatic
Translocation
-Acute Lymphocytic Leukaemia (ALL)
-Uterine Sarcoma
GAB2 11q14.1 -Acute Myeloid Leukaemia
-Breast Cancer
-Chronic Myelogenous Leukemia
-Ovarian Cancer
NOX4 11q14.2-q21 KOX, KOX-1, RENOX-Bladder Cancer
-Breast Cancer
-Kidney Cancer
-Liver Cancer
-Melanoma
-Pancreatic Cancer
FAT3 11q14.3 CDHF15, CDHR10Somatic
MAML2 11q21 MAM2, MAM3, MAM-3, MLL-MAML2Somatic-Adenoid Cystic Carcinoma
-Cervical Cancer
-Childhood Cancers
-Lung Cancer
-Salivary Gland Cancer
MRE11A 11q21 ATLD, HNGS1, MRE11, MRE11B-Breast Cancer
-Colorectal Cancer
-Ovarian Cancer
MMP7 11q21-q22 MMP-7, MPSL1, PUMP-1-Cervical Cancer
-Colorectal Cancer
-Esophageal Cancer
-Lung Cancer
-Stomach Cancer
ATM 11q22-q23 AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, TELO1Germline & Somatic-Breast Cancer
-Chronic Lymphocytic Leukemia
-Eye Cancer
-Thyroid Cancer
BIRC3 11q22 AIP1, API2, MIHC, CIAP2, HAIP1, HIAP1, MALT2, RNF49, c-IAP2Somatic
Translocation
-MALT Lymphoma
-Breast Cancer
-Chronic Lymphocytic Leukemia
-Multiple Myeloma
-Uterine Sarcoma
BIRC2 11q22 API1, MIHB, HIAP2, RNF48, cIAP1, Hiap-2, c-IAP1-Cervical Cancer
-Colorectal Cancer
-Esophageal Cancer
-Multiple Myeloma
DDX10 11q22-q23 HRH-J8Somatic-Acute Myeloid Leukaemia
-Childhood Cancers
-Haematological Malignancies
-Leukaemia
-Myelodysplastic Syndromes
IL18 11q22.2-q22.3 IGIF, IL-18, IL-1g, IL1F4-Breast Cancer
-Small Cell Lung Cancer
-Melanoma
-Ovarian Cancer
-Prostate Cancer
-Skin Cancer
CASP4 11q22.2-q22.3 TX, ICH-2, Mih1/TX, ICEREL-II, ICE(rel)II-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Ovarian Cancer
CASP5 11q22.2-q22.3 ICH-3, ICEREL-III, ICE(rel)III-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
-Lung Cancer
MMP3 11q22.3 SL-1, STMY, STR1, CHDS6, MMP-3, STMY1-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Melanoma
-Stomach Cancer
-Urinary System Cancers
MMP12 11q22.3 ME, HME, MME, MMP-12-Bladder Cancer
-Colorectal Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
MMP10 11q22.3 SL-2, STMY2-Cervical Cancer
-Lung Cancer
-Oral Cavity Cancer
-Ovarian Cancer
-Skin Cancer
-Stomach Cancer
MMP13 11q22.3 CLG3, MANDP1, MMP-13-Bone Cancer (primary)
-Breast Cancer
-Thyroid Cancer
MMP1 11q22.3 CLG, CLGN-Breast Cancer
-Chondrosarcoma
-Lung Cancer
-Melanoma
-Stomach Cancer
DRD2 11q23 D2R, D2DR-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Esophageal Cancer
-Lung Cancer
-Pituitary Tumors
-Uterine Sarcoma
SDHD 11q23 PGL, CBT1, CWS3, PGL1, QPs3, SDH4, cybS, CII-4Germline-Adrenocortical Cancer
-Childhood Cancers
-Gastrointestinal Stromal Tumors
-Head and Neck Cancers
-Pheochromocytoma and Paraganglioma
CASP1 11q23 ICE, P45, IL1BC-Breast Cancer
-Cervical Cancer
-Prostate Cancer
-Stomach Cancer
PCSK7 11q23-q24 LPC, PC7, PC8, SPC7Somatic-Lung Cancer
-Non-Hodgkin Lymphoma
PAFAH1B2 11q23 HEL-S-303Somatic-Childhood Cancers
-Neuroblastoma
-Prostate Cancer
KMT2A 11q23 HRX, MLL, MLL1, TRX1, ALL-1, CXXC7, HTRX1, MLL1A, WDSTS, MLL/GAS7, TET1-MLLSomatic
Translocation
-Acute Lymphocytic Leukaemia (ALL)
-Acute Lymphocytic Leukemia (ALL), child
-Acute Myeloid Leukaemia
-Childhood Cancers
-Leukaemia
-Prostate Cancer
RARRES3 11q23 RIG1, TIG3, HRSL4, HRASLS4, PLA1/2-3-Breast Cancer
-Cervical Cancer
-Kidney Cancer
-Skin Cancer
-Stomach Cancer
-Wilms Tumour
POU2AF1 11q23.1 BOB1, OBF1, OCAB, OBF-1Somatic
Translocation
-Hodgkin Lymphoma
-Leukaemia
-Multiple Myeloma
ZBTB16 11q23.1 PLZF, ZNF145Somatic
Translocation
-Acute Myeloid Leukaemia
NCAM1 11q23.1 CD56, NCAM, MSK39-Pheochromocytoma and Paraganglioma
-Skin Cancer
CADM1 11q23.2 BL2, ST17, IGSF4, NECL2, RA175, TSLC1, IGSF4A, Necl-2, SYNCAM, sgIGSF, sTSLC-1, synCAM1-Lung Cancer
-Lung Cancer, Non-Small Cell
-Skin Cancer
TAGLN 11q23.2 SM22, SMCC, TAGLN1, WS3-10-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Prostate Cancer
PPP2R1B 11q23.2 PR65B, PP2A-Abeta-Breast Cancer
-Cervical Cancer
-Lung Cancer
-Wilms Tumour
CXCR5 11q23.3 BLR1, CD185, MDR15-Breast Cancer
-Chronic Lymphocytic Leukemia
-Non-Hodgkin Lymphoma
ETS1 11q23.3 p54, ETS-1, EWSR2-Breast Cancer
-Cervical Cancer
DDX6 11q23.3 P54, RCK, HLR2Somatic
THY1 11q23.3 CD90-Leukaemia
-Nasopharyngeal Cancer
CBL 11q23.3 CBL2, NSLL, C-CBL, RNF55, FRA11BSomatic-Acute Myeloid Leukaemia
-Childhood Cancers
-Lung Cancer
-Myelodysplastic Syndromes
H2AFX 11q23.3 H2AX, H2A.X, H2A/X-Breast Cancer
-Cervical Cancer
ARHGEF12 11q23.3 LARG, PRO2792Somatic-Breast Cancer
-Colorectal Cancer
-Prostate Cancer
MCAM 11q23.3 CD146, MUC18Somatic-Breast Cancer
-Melanoma
-Prostate Cancer
KCNJ5 11q24 CIR, GIRK4, KATP1, LQT13, KIR3.4-Adrenocortical Cancer
-Pheochromocytoma and Paraganglioma
ST14 11q24-q25 HAI, MTSP1, SNC19, ARCI11, MT-SP1, PRSS14, TADG15, TMPRSS14-Breast Cancer
-Colorectal Cancer
-Ovarian Cancer
-Pancreatic Cancer
-Prostate Cancer
CLMP 11q24.1 ACAM, ASAM, CSBM, CSBS-Bladder Cancer
-Cervical Cancer
-Lung Cancer
-Ovarian Cancer
-Prostate Cancer
-Urinary System Cancers
FLI1 11q24.1-q24.3 EWSR2, SIC-1Somatic
Translocation
-Ewing's Sarcoma
HSPA8 11q24.1 LAP1, HSC54, HSC70, HSC71, HSP71, HSP73, LAP-1, NIP71, HEL-33, HSPA10, HEL-S-72p-Breast Cancer
-Cervical Cancer
-Melanoma
-Skin Cancer
BLID 11q24.1 BRCC2-Breast Cancer
-Ovarian Cancer
CHEK1 11q24.2 CHK1-Acute Myeloid Leukaemia
-Breast Cancer
-Colorectal Cancer
-Ovarian Cancer
OPCML 11q25 OPCM, OBCAM, IGLON1-Bladder Cancer
-Cervical Cancer
-Lung Cancer
-Ovarian Cancer

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 11:

Abnormality Type Gene(s)
11p15 Abnormalities in Adrenocortical CarcinomaDeletion
t(11;14)(q13;q32) in MyelomaTranslocation
t(11;14)(q13;q32) in Mantle Cell LymphomaTranslocationCCND1 (11q13)IGH (14q32.33)
t(3;11)(q27;q23) in B-Cell LeukaemiaTranslocationPOU2AF1 (11q23.1)BCL6 (3q27)
t(11;14)(q23;q32) IGH-DDX6 Translocations in Hematologic CancersTranslocationDDX6 (11q23.3)IGH (14q32.33)
t(11;22)(p13;q12): EWSR1-WT1 in Desmoplastic Small Round Cell TumourTranslocationWT1 (11p13)EWSR1 (22q12.2)
t(11;22)(q24;q12) EWSR1-FLI1 Translocation in Ewing's SarcomaTranslocationFLI1 (11q24.1-q24.3)EWSR1 (22q12.2)
t(11;14)(p15;q11) and LMO1 in T-ALLTranslocationLMO1 (11p15)
t(1;11)(p32;q23) MLL-EPS15 fusion in Mcute Myelogeneous LeukemiaTranslocationKMT2A (11q23)EPS15 (1p32)
t(11;17) ALL1-MLLT6 in Acute LeukaemiasTranslocationKMT2A (11q23)MLLT6 (17q21)
t(11;19)(q23;p13.1) MLL-ELL translocation in acute leukaemiaTranslocationKMT2A (11q23)ELL (19p13.1)
t(11;19)(q23;p13) in LeukaemiaTranslocationKMT2A (11q23)MLLT1 (19p13.3)
t(4;11)(q21;q23) in Infant LeukaemiaTranslocationKMT2A (11q23)AFF1 (4q21)
t(4;11)(q21;q23) MLL-AFF1 in adult acute lymphoblastic leukemiaTranslocationKMT2A (11q23)AFF1 (4q21)
t(9;11) in Acute Myeloid LeukaemiaTranslocationKMT2A (11q23)MLLT3 (9p22)
t(6;11)(q27;q23) in Acute Myeloid LeukemiaTranslocationKMT2A (11q23)MLLT4 (6q27)
t(7;11)(p15;p15) in Acute Myelogenous LeukaemiaTranslocationNUP98 (11p15.5)HOXA9 (7p15.2)
t(11;17)(q32;q21) RARA-PLZF in Acute Promyelocytic LeukemiaTranslocationZBTB16 (11q23.1)RARA (17q21)
t(11;20) (p15;q11) NUP98-TOP1 Fusion in AMLTranslocationNUP98 (11p15.5)TOP1 (20q12-q13.1)
t(10;11)(p12;q23) AF10-MLL translocation in Acute LeukaemiaTranslocationKMT2A (11q23)MLLT10 (10p12)
t(10;11)(p13;q14) AF10-PICALM translocation in Acute LeukaemiaTranslocationPICALM (11q14)MLLT10 (10p12)
t(10;11)(p11.2;q23) ABI1-MLL translocation in LeukemiaTranslocationKMT2A (11q23)ABI1 (10p11.2)
t(11;18)(q21;q21) MALT1-API2 in MALT lymphomasTranslocationBIRC3 (11q22)MALT1 (18q21)
ins(5;11)(q31;q31q23) MLL-AFF4 in Infant Acute lymphoblastic LeukemiaTranslocationKMT2A (11q23)AFF4 (5q31)
t(10;11) MLL-TET1 rearrangement in acute leukemiasTranslocationKMT2A (11q23)TET1 (10q21)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


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Cite this page: Cotterill SJ. Chromosome 11, Cancer Genetics Web: http://www.cancerindex.org/geneweb/clinkc11.htm Accessed: date

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