www.Cancer-Genetics.org
Navigate
  Chromosome 11

Genes Linked with Cancer

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 11; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
SPI1 11p11.2 OF, PU.1, SFPI1, SPI-1, SPI-A
CD82 11p11.2 R2, 4F9, C33, IA4, ST6, GR15, KAI1, SAR2, TSPAN27Many cancer types including:
-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Lung Cancer
-Prostate Cancer
-Retinoblastoma
-Stomach Cancer
-Thyroid Cancer
PTPRJ 11p11.2 DEP1, SCC1, CD148, HPTPeta, R-PTP-ETA
CREB3L1 11p11.2 OASISSomatic
DDB2 11p12-p11 DDBB, UV-DDB2Germline
EXT2 11p12-p11 SOTVGermline
CD44 11p13 IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, CDW44, CSPG8, HCELL, HUTCH-I, ECMR-III
WT1 11p13 GUD, AWT1, WAGR, WT33, NPHS4, WIT-2, EWS-WT1Germline & Somatic
Translocation
Overexpression
Many cancer types including:
-Acute Myeloid Leukaemia
-Childhood Leukaemia
-DSRC
-Lung Cancer, Non-Small Cell
-Mesothelioma
-Myelodysplastic Syndromes
-Ovarian Cancer
-Wilms Tumour
LMO2 11p13 TTG2, RBTN2, RHOM2, RBTNL1Somatic-Acute Lymphocytic Leukaemia (ALL) - adult
ST2 11p14.3-p12
FANCF 11p15 FAFGermline-Fanconi Anaemia
TSG101 11p15 TSG10, VPS23
ST5 11p15 HTS1, p126, DENND2B
LMO1 11p15 TTG1, RBTN1, RHOM1Germline & Somatic
Translocation
-Acute Lymphocytic Leukaemia (ALL) - adult
RASSF10 11p15.2
SOX6 11p15.3 SOXD, HSSOX6
Amplification
-Ewing's Sarcoma
LDHA 11p15.4 LDH1, LDHM, GSD11, PIG19, HEL-S-133P
HRAS 11p15.5 CTLO, HAMSV, HRAS1, K-RAS, N-RAS, RASH1, C-H-RAS, H-RASIDX, C-BAS/HAS, C-HA-RAS1Germline & Somatic
CTSD 11p15.5 CPSD, CLN10, HEL-S-130P
CDKN1C 11p15.5 BWS, WBS, p57, BWCR, KIP2, p57Kip2
RASSF7 11p15.5 HRC1, HRAS1, C11orf13
Methylation
-Neuroblastoma
IGF2-AS 11p15.5 PEG8, IGF2AS, IGF2-AS1
IGF2 11p15.5 IGF-II, PP9974, C11orf43
Imprinting errors
Overexpression
Many cancer types including:
-Adrenocortical Cancer
-Bladder Cancer
-Bowel Cancer
-Breast Cancer
-Liver Cancer
-Stomach Cancer
-Wilms Tumour
CARS 11p15.5 CARS1, CYSRS, MGC:11246Somatic
MUC2 11p15.5 MLP, SMUC, MUC-2
MUC5AC 11p15.5 TBM, leB, MUC5
MUC5B 11p15.5 MG1, MUC5, MUC9, MUC-5B
MUC6 11p15.5 MUC-6
WT2 11p15.5 ADCR, MTACR1-Beckwith-Wiedemann syndrome
-Wilms Tumour
SLC22A18 11p15.5 HET, ITM, BWR1A, IMPT1, TSSC5, ORCTL2, BWSCR1A, SLC22A1L, p45-BWR1A
NUP98 11p15.5 ADIR2, NUP96, NUP196Somatic
Translocation
-Acute Myeloid Leukaemia
-Childhood Cancers
-Chronic Myelogenous Leukemia
-Leukaemia
-Myelodysplastic Syndromes
H19 11p15.5 ASM, BWS, WT2, ASM1, PRO2605, D11S813E, LINC00008, NCRNA00008
RASSF5 1q32.1 RAPL, Maxp1, NORE1, NORE1A, NORE1B, RASSF3
Methylation
-Neuroblastoma
MTA2 11q12-q13.1 PID, MTA1L1
CLP1 11q12 HEAB, hClp1Somatic
SLC43A1 11q12.1 LAT3, PB39, POV1, R00504
SDHAF2 11q12.2 PGL2, SDH5, C11orf79Germline
FGF3 11q13 INT2, HBGF-3
MEN1 11q13 MEAI, SCG2Germline & Somatic
CCND1 11q13 BCL1, PRAD1, U21B31, D11S287ESomatic
VEGFB 11q13 VRF, VEGFL
ST3 11q13-q23 CCTS, TSHL
NUMA1 11q13 NUMASomatic
RELA 11q13 p65, NFKB3
STIP1 11q13 HOP, P60, STI1, STI1L, HEL-S-94n, IEF-SSP-3521-Ovarian Cancer
GSTP1 11q13 PI, DFN7, GST3, GSTP, FAEES3, HEL-S-22
FOSL1 11q13 FRA, FRA1, fra-1
CTTN 11q13 EMS1
BAD 11q13.1 BBC2, BCL2L8
MALAT1 11q13.1 HCN, NEAT2, MALAT-1, PRO2853, mascRNA, LINC00047, NCRNA00047Somatic
FGF4 11q13.3 HST, KFGF, HST-1, HSTF1, K-FGF, HBGF-4
FOLR1 11q13.3-q14.1 FBP, FOLR
PICALM 11q14 LAP, CALM, CLTHSomatic
Translocation
-Acute Lymphocytic Leukaemia (ALL) - adult
-Uterine Sarcoma
MAML2 11q21 MAM2, MAM3, MAM-3, MLL-MAML2Somatic
MMP7 11q21-q22 MMP-7, MPSL1, PUMP-1
BIRC3 11q22 AIP1, API2, MIHC, CIAP2, HAIP1, HIAP1, MALT2, RNF49, c-IAP2Somatic
Translocation
-MALT Lymphoma
ATM 11q22-q23 AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, TELO1Germline & Somatic
DDX10 11q22-q23 HRH-J8Somatic
MMP3 11q22.3 SL-1, STMY, STR1, CHDS6, MMP-3, STMY1
MMP12 11q22.3 ME, HME, MME, MMP-12
MMP1 11q22.3 CLG, CLGN
PAFAH1B2 11q23 HEL-S-303Somatic
SDHD 11q23 PGL, CBT1, CWS3, PGL1, QPs3, SDH4, cybS, CII-4Germline
KMT2A 11q23 HRX, MLL, MLL1, TRX1, ALL-1, CXXC7, HTRX1, MLL1A, WDSTS, MLL/GAS7, TET1-MLLSomatic
Translocation
-Acute Lymphocytic Leukaemia (ALL) - adult
-Acute Lymphocytic Leukemia (ALL), child
-Acute Myeloid Leukaemia
-Leukaemia
PCSK7 11q23-q24 LPC, PC7, PC8, SPC7Somatic
ZBTB16 11q23.1 PLZF, ZNF145Somatic
Translocation
-Acute Myeloid Leukaemia
POU2AF1 11q23.1 BOB1, OBF1, OCAB, OBF-1Somatic
Translocation
-Leukaemia
PPP2R1B 11q23.2 PR65B, PP2A-Abeta
CBL 11q23.3 CBL2, NSLL, C-CBL, RNF55, FRA11BSomatic
ARHGEF12 11q23.3 LARG, PRO2792Somatic
DDX6 11q23.3 P54, RCK, HLR2Somatic
ETS1 11q23.3 ETS-1, EWSR2
FLI1 11q24.1-q24.3 EWSR2, SIC-1Somatic
Translocation
-Ewing's Sarcoma

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 11:

Abnormality Type Gene(s)
11p15 Abnormalities in Adrenocortical CarcinomaDeletion
t(11;14)(q13;q32) in Mantle Cell LymphomaTranslocation
t(11;14)(q13;q32) in MyelomaTranslocation
t(3;11)(q27;q23) in B-Cell LeukaemiaTranslocationPOU2AF1 (11q23.1)BCL6 (3q27)
t(11;22)(p13;q12): EWSR1-WT1 in Desmoplastic Small Round Cell TumourTranslocationWT1 (11p13)EWSR1 (22q12.2)
t(11;22)(q24;q12) EWSR1-FLI1 Translocation in Ewing's SarcomaTranslocationFLI1 (11q24.1-q24.3)EWSR1 (22q12.2)
t(11;14)(p15;q11) and LMO1 in T-ALLTranslocationLMO1 (11p15)
t(1;11)(p32;q23) MLL-EPS15 fusion in Mcute Myelogeneous LeukemiaTranslocationKMT2A (11q23)EPS15 (1p32)
t(11;17) ALL1-MLLT6 in Acute LeukaemiasTranslocationKMT2A (11q23)MLLT6 (17q21)
t(11;19)(q23;p13) in LeukaemiaTranslocationKMT2A (11q23)MLLT1 (19p13.3)
t(4;11)(q21;q23) in Infant LeukaemiaTranslocationKMT2A (11q23)AFF1 (4q21)
t(4;11)(q21;q23) MLL-AFF1 in adult acute lymphoblastic leukemiaTranslocationKMT2A (11q23)AFF1 (4q21)
t(9;11) in Acute Myeloid LeukaemiaTranslocationKMT2A (11q23)MLLT3 (9p22)
t(6;11)(q27;q23) in Acute Myeloid LeukemiaTranslocationKMT2A (11q23)MLLT4 (6q27)
t(7;11)(p15;p15) in Acute Myelogenous LeukaemiaTranslocationNUP98 (11p15.5)HOXA9 (7p15.2)
t(11;17)(q32;q21) RARA-PLZF translocation in APLTranslocationZBTB16 (11q23.1)RARA (17q21)
t(10;11)(p12;q23) AF10-MLL translocation in Acute LeukaemiaTranslocationKMT2A (11q23)MLLT10 (10p12)
t(10;11)(p13;q14) AF10-PICALM translocation in Acute LeukaemiaTranslocationPICALM (11q14)MLLT10 (10p12)
t(11;18)(q21;q21) MALT1-API2 in MALT lymphomasTranslocationBIRC3 (11q22)MALT1 (18q21)
ins(5;11)(q31;q31q23) MLL-AFF4 in Infant Acute lymphoblastic LeukemiaTranslocationKMT2A (11q23)AFF4 (5q31)
t(10;11) MLL-TET1 rearrangement in acute leukemiasTranslocationKMT2A (11q23)TET1 (10q21)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


Further Resources (2 links)


Contents

Found this page useful?

Disclaimer: This site is for educational purposes only; it can not be used in diagnosis or treatment.

 [Home]    Page last revised: 31 March, 2014     © Copyright 1999-