Summary Information - FLI1
    Gene Database Entries for FLI1
    Other FLI1 Related Resources
    t(11;22)(q24;q12) EWS-FLI1 Translocation in Ewing's Sarcoma
       - EWS-FLI1 and the Ewing's Family of Tumours
       - EWS-FLI1 Transcript Detection by PCR
       - EWS-FLI1 Fusion Transcript Structure and Prognosis
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FLI1; Friend leukemia virus integration 1

Location: 11q24.1-q24.3

Aliases: EWSR2, SIC-1

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OMIM
GeneCard (Weizmann Institute)
Tumor Gene Database
Swiss-Prot
Locus Link
UniGene
GenAtlas
GDB
Nomenclature (search for FLI1)

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FLI1 (UniGene)
EWSR1 (22q12)
Ewing's Sarcoma Resources

Medline Search: FLI1 (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

Medline Search: EWS-FLI1 (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

Search Medline for related articles (PubMed)

Medline Search: cancer AND gene AND (FLI1[TI] OR EWSR2[TI] OR SIC-1[TI]) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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The t(11;22)(q24;q12) translocation is present in over 90% of Ewing's sarcoma cases. The resulting EWS-FLI1 fusion gene has been demonstrated to have oncogenic potential. Many alternative forms of the translocation exist, corresponding to variations in the locations of the EWS and FLI1 breakpoints. The most common form, "Type 1", accounts for approximately 60% of cases and consists of the first seven exons of EWS joined to exons 6-9 of FLI1. "Type 2", accounts for approximately 25% of cases and also includes FLI1 exon 5. The type of translocation has been related to prognosis.

Medline Search: Ewing's sarcoma AND chromosome 11 AND cheomosome 22 (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

Related Resources
Ewing's Sarcoma Genetics
Ewing's Sarcoma : Clinical and Epidemiological Information

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Delattre O. et al. The Ewing family of tumors--a subgroup of small-round-cell tumors defined by specific chimeric transcripts. N Engl J Med 1994; 331:294-9    Related articles (PubMed)

Medline Search: Ewing's sarcoma AND chromosome 11 AND cheomosome 22 (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

Related Resources
Ewing's Sarcoma Genetics
Ewing's Sarcoma : Clinical and Epidemiological Information

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Delattre O. et al. The Ewing family of tumors--a subgroup of small-round-cell tumors defined by specific chimeric transcripts. N Engl J Med 1994; 331:294-9    Related articles (PubMed)

Medline Search: Ewing's sarcoma AND polymerase chain reaction (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

Related Resources
Ewing's Sarcoma Genetics
Ewing's Sarcoma : Clinical and Epidemiological Information

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Lin PP, et al. Differential transactivation by alternative EWS-FLI1 fusion proteins correlates with clinical heterogeneity in Ewing's sarcoma. Cancer Res. 1999 Apr 1;59(7):1428-32    Related articles (PubMed)

de Alava E. et al. EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma. J Clin Oncol 1998; 16:1248-55    Related articles (PubMed)

Zoubek A. et al. Does expression of different EWS chimeric transcripts define clinically distinct risk groups of Ewing tumor patients? J Clin Oncol 1996; 14:1245-51    Related articles (PubMed)

Medline Search: Ewing's sarcoma AND (EWS-FLI1 OR 11;22) AND (transcript OR type) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

Related Resources
Ewing's Sarcoma Genetics
Ewing's Sarcoma : Clinical and Epidemiological Information

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