 Summary Information
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Location: Xpter-p22.32
Alias: CD99
The gene product is overexpressed in Ewing's sarcoma.
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| Gene Database Entries for MIC2
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OMIM
GeneCard (Weizmann Institute)
Genbank
Swiss-Prot
Locus Link (search for MIC2)
UniGene
GenAtlas
GDB
Nomenclature (search for MIC2)
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| Other Related Resources
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- Search Medline for related articles (PubMed)
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- Medline Search: cancer AND gene AND (MIC2[TI] OR CD99[TI]) (PubMed)
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| MIC2 in the Diagnosis of Ewing's Sarcoma
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Unlike most other small blue cell tumors of childhood, Ewing's sarcoma and pPNET strongly express the MIC2(CD99) antigen. Therefore MIC2 analysis can be a useful part of the panel of tests used in the differential diagnosis of Ewing's sarcoma / pPNET.
Perlman EJ, et al. Ewing's sarcoma--routine diagnostic utilization of MIC2 analysis: a Pediatric Oncology Group/Children's Cancer Group Intergroup Study Hum Pathol. 1994;25(3):304-7 Related articles (PubMed)
Devaney K, et al. MIC2 detection in tumors of bone and adjacent soft tissues Clin Orthop. 1995; (310):176-87 Related articles (PubMed)
Ambros IM, et al. MIC2 is a specific marker for Ewing's sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of Ewing's sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberration. Cancer 1991; 67(7):1886-93 Related articles (PubMed)
Medline Search: Ewing's sarcoma AND (mic2[TI] OR cd99[TI]) (PubMed)
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- Related Resources
 Ewing's Sarcoma Genetics
Ewing's Sarcoma : Clinical and Epidemiological Information
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| MIC2 Expression in Sex Cord-Stromal Tumours
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Baker RJ, et al. Inhibin and CD99 (MIC2) expression in uterine stromal neoplasms with sex-cord-like elements. um Pathol 1999;30(6):671-9 Related articles (PubMed)
Gordon MD, et al. CD99, keratin, and vimentin staining of sex cord-stromal tumors, normal ovary, and testis. Mod Pathol 1998;11(8):769-73 Related articles (PubMed)
Matias-Guiu X, et al. Mullerian inhibiting substance, alpha-inhibin, and CD99 expression in sex cord-stromal tumors and endometrioid ovarian carcinomas resembling sex cord-stromal tumors. um Pathol 1998;29(8):840-5 Related articles (PubMed)
Medline Search: sex cord stromal tumor AND (mic2[TI] OR cd99[TI]) (PubMed)
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| MIC2 and Hodgkin's Disease
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Kim SH, et al. Viral latent membrane protein 1 (LMP-1)-induced CD99 down-regulation in B cells leads to the generation of cells with Hodgkin's and Reed-Sternberg phenotype. Blood 2000 Jan 1;95(1):294-300 Related articles (PubMed)
Kim SH, et al. Generation of cells with Hodgkin's and Reed-Sternberg phenotype through downregulation of CD99 (Mic2). Blood 1998 Dec 1;92(11):4287-95 Related articles (PubMed)
Medline Search: Hodgkin's disease AND (mic2[TI] OR cd99[TI]) (PubMed)
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- Related Resources
Hodgkin's Disease Genetics
Hodgkin's Disease : Clinical and Epidemiological Information
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[Home] This page created: 24/11/1999 Last revised: 29/04/2003 © Copyright 1999-
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