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  Chromosome 19

Genes Linked with Cancer (109)

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 19; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
EXT3 19p EXT2-Multiple Hereditary Exostoses
FSTL3 19p13 FLRG, FSRPSomatic-Brain Tumours, Childhood
-Medulloblastoma
-Breast Cancer
PIN1 19p13 DOD, UBL5-Breast Cancer
-Stomach Cancer
CDKN2D 19p13 p19, INK4D, p19-INK4D-Bladder Cancer
-Osteosarcoma
-Ovarian Cancer
-Testicular Cancer
CD70 19p13 CD27L, CD27LG, TNFSF7-Kidney Cancer
-Melanoma
-von Hippel-Lindau Disease
NR2F6 19p13.1 EAR2, EAR-2, ERBAL2
ELL 19p13.1 MEN, ELL1, PPP1R68, C19orf17Somatic-Acute Lymphocytic Leukaemia (ALL)
-Acute Myeloid Leukaemia
-Leukaemia
RAB8A 19p13.1 MEL, RAB8-Pancreatic Cancer
BRD4 19p13.1 CAP, MCAP, HUNK1, HUNKISomatic-Acute Myeloid Leukaemia
-Breast Cancer
-Lung Cancer
TPM4 19p13.1 HEL-S-108Somatic-Breast Cancer
-Esophageal Cancer
-Haematological Malignancies
JAK3 19p13.1 JAKL, LJAK, JAK-3, L-JAK, JAK3_HUMANSomatic-Stomach Cancer
CRTC1 19p13.11 MECT1, TORC1, TORC-1, WAMTP1Somatic-Cervical Cancer
-Lung Cancer
-Salivary Gland Cancer
SLC5A5 19p13.11 NIS, TDH1-Testicular Cancer
-Thyroid Cancer
GDF15 19p13.11 PDF, MIC1, PLAB, MIC-1, NAG-1, PTGFB, GDF-15-Breast Cancer
-Colorectal Cancer
-Eye Cancer
-Liver Cancer
-Melanoma
-Prostate Cancer
-Skin Cancer
KEAP1 19p13.2 INrf2, KLHL19-Breast Cancer
-Lung Cancer, Non-Small Cell
DNMT1 19p13.2 AIM, DNMT, MCMT, CXXC9, HSN1E, ADCADN-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Small Cell Lung Cancer
VAV1 19p13.2 VAV-Leukaemia
-Pancreatic Cancer
JUND 19p13.2 AP-1-Breast Cancer
-Lung Cancer
-Prostate Cancer
-Skin Cancer
JUNB 19p13.2 AP-1-Breast Cancer
-Cervical Cancer
-Chronic Myelogenous Leukemia
-Liver Cancer
PGLS 19p13.2 6PGL-Adrenocortical Cancer
-Head and Neck Cancers
-Lung Cancer
-Pheochromocytoma and Paraganglioma
SMARCA4 19p13.2 BRG1, SNF2, SWI2, MRD16, RTPS2, BAF190, SNF2L4, SNF2LB, hSNF2b, BAF190ASomatic-Bladder Cancer
-Lung Cancer
-Ovarian Cancer
-Rhabdoid Tumours
-Wilms Tumour
ELAVL1 19p13.2 HUR, Hua, MelG, ELAV1-Breast Cancer
-Colorectal Cancer
DNM2 19p13.2 DYN2, CMT2M, DYNII, LCCS5, CMTDI1, CMTDIB, DI-CMTBSomatic-Acute Myeloid Leukaemia
-Ovarian Cancer
TYK2 19p13.2 JTK1, IMD35-Acute Lymphocytic Leukaemia (ALL)
-Bladder Cancer
-Myeloproliferative Disorders
-Stomach Cancer
NOTCH3 19p13.2-p13.1 IMF2, CASIL, CADASIL-Breast Cancer
-Lung Cancer
-Ovarian Cancer
MUC16 19p13.2 CA125-Breast Cancer
-Cancer Screening
-Ovarian Cancer
-Pancreatic Cancer
LYL1 19p13.2 bHLHa18Somatic
Translocation
-Acute Lymphocytic Leukaemia (ALL)
LDLR 19p13.2 FH, FHC, LDLCQ2-Bladder Cancer
-Breast Cancer
-Liver Cancer
-Prostate Cancer
CARM1 19p13.2 PRMT4-Breast Cancer
-Prostate Cancer
ZBTB7A 19p13.3 LRF, FBI1, FBI-1, ZBTB7, ZNF857A, pokemon-Breast Cancer
-Cervical Cancer
-Liver Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Prostate Cancer
DOT1L 19p13.3 DOT1, KMT4-Acute Myeloid Leukaemia
-Leukaemia
ANGPTL4 19p13.3 NL2, ARP4, FIAF, HARP, PGAR, HFARP, TGQTL, UNQ171, pp1158, ANGPTL2-Breast Cancer
-Colorectal Cancer
PRTN3 19p13.3 MBN, MBT, NP4, P29, PR3, ACPA, AGP7, NP-4, PR-3, CANCA, C-ANCA-Acute Myeloid Leukaemia
-Chronic Myelogenous Leukemia
-Leukaemia
KISS1R 19p13.3 HH8, CPPB1, GPR54, AXOR12, KISS-1R, HOT7T175-Bladder Cancer
-Breast Cancer
-Kidney Cancer
-Lung Cancer
-Ovarian Cancer
-Transitional Cell Cancer of the Renal Pelvis and Ureter
UHRF1 19p13.3 Np95, hNP95, ICBP90, RNF106, hUHRF1, huNp95-Breast Cancer
-Prostate Cancer
MUM1 19p13.3 MUM-1, EXPAND1, HSPC211-Multiple Myeloma
-Testicular Cancer
EPOR 19p13.3-p13.2 EPO-R-Breast Cancer
-Cervical Cancer
-von Hippel-Lindau Disease
GADD45B 19p13.3 MYD118, GADD45BETA-Breast Cancer
-Liver Cancer
-Pancreatic Cancer
-Prostate Cancer
MAP2K2 19p13.3 CFC4, MEK2, MKK2, MAPKK2, PRKMK2-Breast Cancer
-Melanoma
ICAM1 19p13.3-p13.2 BB2, CD54, P3.58-Bladder Cancer
-Melanoma
-Skin Cancer
-Soft Tissue Sarcoma
-Stomach Cancer
INSR 19p13.3-p13.2 HHF5, CD220-Breast Cancer
-Colorectal Cancer
CAPS 19p13.3 CAPS1-Prostate Cancer
SH3GL1 19p13.3 EEN, CNSA1, SH3P8, SH3D2BSomatic-Acute Myeloid Leukaemia
-Leukaemia
GNA11 19p13.3 FBH, FBH2, FHH2, HHC2, GNA-11, HYPOC2Somatic-Eye Cancer
-Melanoma
-Skin Cancer
MLLT1 19p13.3 ENL, LTG19, YEATS1Somatic
Translocation
-Acute Lymphocytic Leukaemia (ALL)
-Acute Myeloid Leukaemia
-Leukaemia
TCF3 19p13.3 E2A, E47, ITF1, VDIR, TCF-3, bHLHb21Somatic
Translocation
-Acute Lymphocytic Leukaemia (ALL)
-Acute Lymphocytic Leukemia (ALL), child
-Breast Cancer
-Colorectal Cancer
-Liver Cancer
STK11 19p13.3 PJS, LKB1, hLKB1Germline & Somatic-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Pancreatic Cancer
CCNE1 19q12 CCNESomatic-Breast Cancer
-Liver Cancer
-Osteosarcoma
TFPT 19q13 FB1, amida, INO80FSomatic-Acute Lymphocytic Leukaemia (ALL)
PLAUR 19q13 CD87, UPAR, URKR, U-PAR-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Prostate Cancer
KLK10 19q13 NES1, PRSSL1-Breast Cancer
-Head and Neck Cancers
-Lung Cancer, Non-Small Cell
-Ovarian Cancer
-Prostate Cancer
SUPT5H 19q13 SPT5, SPT5H, Tat-CT1
ACTN4 19q13 FSGS, FSGS1, ACTININ-4-Lung Cancer
AXL 19q13.1 ARK, UFO, JTK11, Tyro7-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Thyroid Cancer
AKT2 19q13.1-q13.2 PKBB, PRKBB, HIHGHH, PKBBETA, RAC-BETASomatic-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Ovarian Cancer
-Thymoma and Thymic Carcinoma
-Thyroid Cancer
BCL3 19q13.1-q13.2 BCL4, D19S37Somatic-Breast Cancer
-Chronic Lymphocytic Leukemia
-Hodgkin Lymphoma
ZFP36 19q13.1 TTP, G0S24, GOS24, TIS11, NUP475, zfp-36, RNF162A-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Uterine Sarcoma
CD22 19q13.1 SIGLEC2, SIGLEC-2-Acute Lymphocytic Leukaemia (ALL)
-Chronic Lymphocytic Leukemia
SPINT2 19q13.1 PB, Kop, HAI2, DIAR3, HAI-2-Cervical Cancer
-Kidney Cancer
-Liver Cancer
-Ovarian Cancer
-Uterine Sarcoma
TGFB1 19q13.1 CED, LAP, DPD1, TGFB, TGFbeta-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Prostate Cancer
CEACAM5 19q13.1-q13.2 CEA, CD66e-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Pancreatic Cancer
CEBPA 19q13.1 CEBP, C/EBP-alphaSomatic-Acute Myeloid Leukaemia
-Leukaemia
-Myelodysplastic Syndromes
PDCD5 19q13.11 TFAR19-Chronic Myelogenous Leukemia
-Leukaemia
-Liver Cancer
-Multiple Myeloma
-Stomach Cancer
ARHGEF1 19q13.13 LSC, GEF1, LBCL2, SUB1.5, P115-RHOGEF-Breast Cancer
-Colorectal Cancer
-Stomach Cancer
-Wilms Tumour
CBLC 19q13.2 CBL-3, RNF57, CBL-SLSomatic-Chronic Myelogenous Leukemia
-Lung Cancer
-Lung Cancer, Non-Small Cell
APOE 19q13.2 AD2, LPG, APO-E, LDLCQ5-Brain Tumours, Childhood
-Breast Cancer
-Colorectal Cancer
-Kaposi Sarcoma
-Liver Cancer
PAK4 19q13.2 -Liver Cancer
-Ovarian Cancer
-Pancreatic Cancer
-Prostate Cancer
-Stomach Cancer
PPP1R15A 19q13.2 GADD34-Melanoma
-Skin Cancer
CIC 19q13.2 Somatic-Brain and CNS Tumours
-Brain Tumours, Childhood
-Breast Cancer
-Head and Neck Cancers
-Multiple Myeloma
CYP2A13 19q13.2 CPAD, CYP2A, CYPIIA13-Bladder Cancer
-Head and Neck Cancers
-Lung Cancer
-Uterine Sarcoma
CD79A 19q13.2 IGA, MB-1Somatic-Acute Lymphocytic Leukaemia (ALL)
-Chronic Lymphocytic Leukemia
-Hodgkin Lymphoma
CEACAM8 19q13.2 CD67, CGM6, CD66b, NCA-95
CEACAM4 19q13.2 NCA, CGM7, CGM7_HUMAN
MIA 19q13.2 CD-RAP-Melanoma
CEACAM6 19q13.2 NCA, CEAL, CD66c-Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Pancreatic Cancer
RPS19 19q13.2 DBA, S19, DBA1Germline & Somatic
CEACAM3 19q13.2 CEA, CGM1, W264, W282, CD66D-Acute Lymphocytic Leukaemia (ALL)
-Chronic Myelogenous Leukemia
-Lung Cancer
CYP2A6 19q13.2 CPA6, CYP2A, CYP2A3, P450PB, CYPIIA6, P450C2A-Colorectal Cancer
-Esophageal Cancer
-Lung Cancer
CEACAM1 19q13.2 BGP, BGP1, BGPI-Bladder Cancer
-Colorectal Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Prostate Cancer
CYP2B6 19q13.2 CPB6, EFVM, IIB1, P450, CYP2B, CYP2B7, CYP2B7P, CYPIIB6-Breast Cancer
-Liver Cancer
XRCC1 19q13.2 RCC-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Prostate Cancer
CEACAM7 19q13.2 CEA, CGM2-Colorectal Cancer
POLD1 19q13.3 CDC2, MDPL, POLD, CRCS10-Adenomatous Polyposis Coli
-Breast Cancer
-Colorectal Cancer
-Endometrial Cancer
GLTSCR2 19q13.3 PICT1, PICT-1-Astrocytoma, Childhood
-Brain and CNS Tumours
-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
BAX 19q13.3-q13.4 BCL2L4-Breast Cancer
-Liver Cancer
-Oral Cavity Cancer
-Osteosarcoma
-Stomach Cancer
KLK6 19q13.3 hK6, Bssp, Klk7, SP59, PRSS9, PRSS18-Bladder Cancer
-Brain Tumours, Childhood
-Breast Cancer
-Colorectal Cancer
-Ovarian Cancer
-Prostate Cancer
-Uterine Sarcoma
BCL2L12 19q13.3 -Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Nasopharyngeal Cancer
-Stomach Cancer
IRF3 19q13.3-q13.4 -Cervical Cancer
-Ovarian Cancer
-Prostate Cancer
-Skin Cancer
ERCC2 19q13.3 EM9, TTD, XPD, COFS2, TFIIHGermline-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
IL11 19q13.3-q13.4 AGIF, IL-11-Bone Cancer (primary)
-Breast Cancer
-Prostate Cancer
-Stomach Cancer
-Thyroid Cancer
-Uterine Sarcoma
CD33 19q13.3 p67, SIGLEC3, SIGLEC-3-Acute Myeloid Leukaemia
-Chronic Myelogenous Leukemia
-Leukaemia
-Skin Cancer
BBC3 19q13.3-q13.4 JFY1, PUMA, JFY-1-Breast Cancer
-Chronic Lymphocytic Leukemia
RELB 19q13.32 IREL, I-REL, REL-B-Breast Cancer
-Prostate Cancer
PPP1R13L 19q13.32 RAI, RAI4, IASPP, NKIP1-Bladder Cancer
-Cervical Cancer
-Lung Cancer
-Testicular Cancer
ERCC1 19q13.32 UV20, COFS4, RAD10-Bladder Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Ovarian Cancer
-Stomach Cancer
FOSB 19q13.32 AP-1, G0S3, GOS3, GOSB-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Ovarian Cancer
FTL 19q13.33 LFTD, NBIA3-Bone Cancer (primary)
-Brain Tumours, Childhood
-Esophageal Cancer
-Liver Cancer
-Uterine Sarcoma
KLK5 19q13.33 SCTE, KLKL2, KLK-L2-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Ovarian Cancer
-Prostate Cancer
HAS1 19q13.4 HAS-Bladder Cancer
-Colorectal Cancer
-Multiple Myeloma
-Ovarian Cancer
-Waldenstrom's Macroglobulinemia
PEG3 19q13.4 PW1, ZNF904, ZSCAN24, ZKSCAN22-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Ovarian Cancer
PTPRH 19q13.4 SAP1, R-PTP-H-Breast Cancer
-Colorectal Cancer
-Thyroid Cancer
PPP2R1A 19q13.41 PR65A, PP2AAALPHA, PP2A-AalphaSomatic-Breast Cancer
-Endometrial Cancer
-Melanoma
-Ovarian Cancer
-Uterine Sarcoma
-Wilms Tumour
KLK4 19q13.41 ARM1, EMSP, PSTS, AI2A1, EMSP1, KLK-L1, PRSS17, kallikrein-Breast Cancer
-Ovarian Cancer
-Prostate Cancer
KLK2 19q13.41 hK2, hGK-1, KLK2A2Somatic-Ovarian Cancer
-Prostate Cancer
-Uterine Sarcoma
ZNF350 19q13.41 ZFQR, ZBRK1-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Ovarian Cancer
KLK3 19q13.41 APS, PSA, hK3, KLK2A1Overexpression-Breast Cancer
-Ovarian Cancer
-Prostate Cancer
OSCAR 19q13.42 PIGR3, PIgR-3-Breast Cancer
-Kidney Cancer
-Ovarian Cancer
-Soft Tissue Sarcoma
NLRP7 19q13.42 HYDM, PAN7, NALP7, NOD12, PYPAF3, CLR19.4
ZNF331 19q13.42 RITA, ZNF361, ZNF463Somatic-Breast Cancer
-Multiple Myeloma
-Thyroid Cancer

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 19:

Abnormality Type Gene(s)
LOH 19q in Familial Wilms' Tumour (FWT2 19q13.3-q13.4)LOH
t(7;19)(q35;p13) in T-cell Acute Lymphoblastic LeukemiaTranslocationLYL1 (19p13.2)TRB (7q34)
t(11;19)(q23;p13.1) MLL-ELL translocation in acute leukaemiaTranslocationELL (19p13.1)KMT2A (11q23)
t(11;19)(q23;p13) in LeukaemiaTranslocationMLLT1 (19p13.3)KMT2A (11q23)
t(1;19)(q23;p13.3) TCF3-PBX1 fusion in pre-B-cell ALLTranslocationTCF3 (19p13.3)PBX1 (1q23)
t(17;19)(q22;p13) TCF3-HLF fusion in Acute Lymphoblastic LeukemiaTranslocationTCF3 (19p13.3)HLF (17q22)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


Further Resources (2 links)

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Cite this page: Cotterill SJ. Chromosome 19, Cancer Genetics Web: http://www.cancerindex.org/geneweb/clinkc19.htm Accessed: date

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