Chromosome 19

Genes Linked with Cancer

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 19; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
EXT3 19p EXT2-Multiple Hereditary Exostoses
CDKN2D 19p13 p19, INK4D, p19-INK4D-Bladder Cancer
-Ovarian Cancer
-Testicular Cancer
FSTL3 19p13 FLRG, FSRPSomatic
NR2F6 19p13.1 EAR2, EAR-2, ERBAL2
TPM4 19p13.1 HEL-S-108Somatic
BRD4 19p13.1 CAP, MCAP, HUNK1, HUNKISomatic
RAB8A 19p13.1 MEL, RAB8
ELL 19p13.1 MEN, ELL1, PPP1R68, C19orf17Somatic-Acute Lymphocytic Leukaemia (ALL) - adult
-Acute Myeloid Leukaemia
JAK3 19p13.1 JAKL, LJAK, JAK-3, L-JAK, JAK3_HUMANSomatic
CRTC1 19p13.11 MECT1, TORC1, TORC-1, WAMTP1Somatic
SLC5A5 19p13.11 NIS, TDH1-Testicular Cancer
-Thyroid Cancer
JUNB 19p13.2 AP-1-Breast Cancer
-Cervical Cancer
-Chronic Myelogenous Leukemia
-Liver Cancer
SMARCA4 19p13.2 BRG1, SNF2, SWI2, MRD16, RTPS2, BAF190, SNF2L4, SNF2LB, hSNF2b, BAF190ASomatic
NOTCH3 19p13.2-p13.1 IMF2, CASIL, CADASIL
JUND 19p13.2 AP-1-Breast Cancer
-Lung Cancer
-Prostate Cancer
-Skin Cancer
VAV1 19p13.2 VAV-Leukaemia
-Pancreatic Cancer
LYL1 19p13.2 bHLHa18Somatic
-Acute Lymphocytic Leukaemia (ALL) - adult
TCF3 19p13.3 E2A, E47, ITF1, VDIR, TCF-3, bHLHb21Somatic
-Acute Lymphocytic Leukaemia (ALL) - adult
-Acute Lymphocytic Leukemia (ALL), child
-Bowel Cancer
-Breast Cancer
-Liver Cancer
STK11 19p13.3 PJS, LKB1, hLKB1Germline & Somatic-Breast Cancer
-Childhood Cancers
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Pancreatic Cancer
GNA11 19p13.3 FBH, FBH2, FHH2, HHC2, GNA-11, HYPOC2Somatic
MLLT1 19p13.3 ENL, LTG19, YEATS1Somatic
SH3GL1 19p13.3 EEN, CNSA1, SH3P8, SH3D2BSomatic
CCNE1 19q12 CCNESomatic-Breast Cancer
-Liver Cancer
SUPT5H 19q13 SPT5, SPT5H, Tat-CT1
TFPT 19q13 FB1, amida, INO80FSomatic
CEACAM5 19q13.1-q13.2 CEA, CD66e
AXL 19q13.1 UFO, JTK11
AKT2 19q13.1-q13.2 PKBB, PRKBB, HIHGHH, PKBBETA, RAC-BETASomatic-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Ovarian Cancer
-Thymoma and Thymic Carcinoma
-Thyroid Cancer
TGFB1 19q13.1 CED, LAP, DPD1, TGFB, TGFbeta
CEBPA 19q13.1 CEBP, C/EBP-alphaSomatic
BCL3 19q13.1-q13.2 BCL4, D19S37Somatic
PDCD5 19q13.11 TFAR19
MIA 19q13.2 CD-RAP
RPS19 19q13.2 DBA, S19, DBA1Germline & Somatic
CYP2B6 19q13.2 CPB6, EFVM, IIB1, P450, CYP2B, CYP2B7, CYP2B7P, CYPIIB6
CYP2A6 19q13.2 CPA6, CYP2A, CYP2A3, P450PB, CYPIIA6, P450C2A
CEACAM8 19q13.2 CD67, CGM6, CD66b, NCA-95
CEACAM7 19q13.2 CEA, CGM2
CD79A 19q13.2 IGA, MB-1Somatic
CIC 19q13.2 Somatic
CEACAM6 19q13.2 NCA, CEAL, CD66c
CBLC 19q13.2 CBL-3, RNF57, CBL-SLSomatic
CEACAM3 19q13.2 CEA, CGM1, W264, W282, CD66D
CD33 19q13.3 p67, SIGLEC3, SIGLEC-3
BAX 19q13.3-q13.4 BCL2L4
POLD1 19q13.3 CDC2, MDPL, POLD, CRCS10
ERCC2 19q13.3 EM9, TTD, XPD, COFS2Germline
FOSB 19q13.32 AP-1, G0S3, GOS3, GOSB
FTL 19q13.33 LFTD, NBIA3
KLK2 19q13.41 hK2, hGK-1, KLK2A2Somatic
KLK3 19q13.41 APS, PSA, hK3, KLK2A1Overexpression-Breast Cancer
-Ovarian Cancer
-Prostate Cancer
PPP2R1A 19q13.41 PR65A, PP2AAALPHA, PP2A-AalphaSomatic
ZNF331 19q13.42 RITA, ZNF361, ZNF463Somatic

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 19:

Abnormality Type Gene(s)
LOH 19q in Familial Wilms' Tumour (FWT2 19q13.3-q13.4)LOH
t(7;19)(q35;p13) in T-cell Acute Lymphoblastic LeukemiaTranslocationLYL1 (19p13.2)TRB (7q34)
t(11;19)(q23;p13.1) MLL-ELL translocation in acute leukaemiaTranslocationELL (19p13.1)KMT2A (11q23)
t(11;19)(q23;p13) in LeukaemiaTranslocationMLLT1 (19p13.3)KMT2A (11q23)
t(1;19)(q23;p13.3) TCF3-PBX1 fusion in pre-B-cell ALLTranslocationTCF3 (19p13.3)PBX1 (1q23)
t(17;19)(q22;p13) TCF3-HLF fusion in Acute Lymphoblastic LeukemiaTranslocationTCF3 (19p13.3)HLF (17q22)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.

Further Resources (2 links)


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