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  Chromosome 19

Genes Linked with Cancer

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 19; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
EXT3 19p EXT2
CDKN2D 19p13 p19, INK4D, p19-INK4D
FSTL3 19p13 FLRG, FSRPSomatic
BRD4 19p13.1 CAP, MCAP, HUNK1, HUNKISomatic
NR2F6 19p13.1 EAR2, EAR-2, ERBAL2
TPM4 19p13.1 HEL-S-108Somatic
RAB8A 19p13.1 MEL, RAB8
ELL 19p13.1 MEN, ELL1, PPP1R68, C19orf17Somatic
JAK3 19p13.1 JAKL, LJAK, JAK-3, L-JAK, JAK3_HUMANSomatic
SLC5A5 19p13.11 NIS, TDH1
CRTC1 19p13.11 MECT1, TORC1, TORC-1, WAMTP1Somatic
VAV1 19p13.2 VAV-Leukaemia
-Pancreatic Cancer
JUNB 19p13.2 AP-1
LYL1 19p13.2 bHLHa18Somatic
Translocation
-Acute Lymphocytic Leukaemia (ALL) - adult
JUND 19p13.2 AP-1
DNM2 19p13.2 DYN2, CMT2M, DYNII, LCCS5, CMTDI1, CMTDIB, DI-CMTBSomatic
NOTCH3 19p13.2-p13.1 IMF2, CASIL, CADASIL
SMARCA4 19p13.2 BRG1, SNF2, SWI2, MRD16, RTPS2, BAF190, SNF2L4, SNF2LB, hSNF2b, BAF190ASomatic
TCF3 19p13.3 E2A, E47, ITF1, VDIR, TCF-3, bHLHb21Somatic
Translocation
-Acute Lymphocytic Leukemia (ALL), child
STK11 19p13.3 PJS, LKB1, hLKB1Germline & Somatic
SH3GL1 19p13.3 EEN, CNSA1, SH3P8, SH3D2BSomatic
MLLT1 19p13.3 ENL, LTG19, YEATS1Somatic
Translocation
-Leukaemia
GNA11 19p13.3 FBH, FBH2, FHH2, HHC2, GNA-11, HYPOC2Somatic
CCNE1 19q12 CCNESomatic-Breast Cancer
-Liver Cancer
-Osteosarcoma
TFPT 19q13 FB1, amida, INO80FSomatic
SUPT5H 19q13 SPT5, SPT5H, Tat-CT1
CEACAM5 19q13.1-q13.2 CEA, CD66e
TGFB1 19q13.1 CED, LAP, DPD1, TGFB, TGFbeta
BCL3 19q13.1-q13.2 BCL4, D19S37Somatic
CEBPA 19q13.1 CEBP, C/EBP-alphaSomatic
AXL 19q13.1 UFO, JTK11
AKT2 19q13.1-q13.2 PKBB, PRKBB, HIHGHH, PKBBETA, RAC-BETASomatic-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Ovarian Cancer
-Thymoma and Thymic Carcinoma
-Thyroid Cancer
PDCD5 19q13.11 TFAR19
MIA 19q13.2 CD-RAP
CBLC 19q13.2 CBL-3, RNF57, CBL-SLSomatic
CD79A 19q13.2 IGA, MB-1Somatic
CIC 19q13.2 Somatic
CYP2B6 19q13.2 CPB6, EFVM, IIB1, P450, CYP2B, CYP2B7, CYP2B7P, CYPIIB6
CYP2A6 19q13.2 CPA6, CYP2A, CYP2A3, P450PB, CYPIIA6, P450C2A
CEACAM8 19q13.2 CD67, CGM6, CD66b, NCA-95
CEACAM1 19q13.2 BGP, BGP1, BGPI
CEACAM3 19q13.2 CEA, CGM1, W264, W282, CD66D
CEACAM4 19q13.2 NCA, CGM7, CGM7_HUMAN
CEACAM6 19q13.2 NCA, CEAL, CD66c
CEACAM7 19q13.2 CEA, CGM2
POLD1 19q13.3 CDC2, MDPL, POLD, CRCS10
ERCC2 19q13.3 EM9, TTD, XPD, COFS2Germline
CD33 19q13.3 p67, SIGLEC3, SIGLEC-3
BAX 19q13.3-q13.4 BCL2L4
FOSB 19q13.32 AP-1, G0S3, GOS3, GOSB
FTL 19q13.33 LFTD, NBIA3
KLK3 19q13.41 APS, PSA, hK3, KLK2A1Overexpression-Breast Cancer
-Ovarian Cancer
-Prostate Cancer
PPP2R1A 19q13.41 PR65A, PP2AAALPHA, PP2A-AalphaSomatic
KLK2 19q13.41 hK2, hGK-1, KLK2A2Somatic
ZNF331 19q13.42 RITA, ZNF361, ZNF463Somatic

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 19:

Abnormality Type Gene(s)
LOH 19q in Familial Wilms' Tumour (FWT2 19q13.3-q13.4)LOH
t(7;19)(q35;p13) in T-cell Acute Lymphoblastic LeukemiaTranslocationLYL1 (19p13.2)TRB (7q34)
t(11;19)(q23;p13) in LeukaemiaTranslocationMLLT1 (19p13.3)KMT2A (11q23)
t(1;19)(q23;p13.3) in pre-B-cell ALLTranslocationTCF3 (19p13.3)PBX1 (1q23)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


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