Carcinoembryonic antigen (CEA) is one of the most frequently used serum tumour markers for carcinoma, particularly in colorectal cancer. It is useful in the diagnosis and monitoring of cancer, however, specificity for CEA assays is not absolute. Therefore,
it is often used in conjunction with tests for other markers. There are are infact a number of genes and pseudogenes composing a CEA family which are subdivided into CEACAM and PSG (pregnancy-specific glycoprotein) genes.
Beauchemin, N et al. Redefined Nomenclature for Members of the Carcinoembryonic Antigen Family Exp Cell Res, 1999; 252(2): 243-249
Sanders DS, Kerr MA Lewis blood group and CEA related antigens; coexpressed cell-cell adhesion molecules with roles in the biological progression and dissemination of tumours. [Review] Mol Pathol 1999;52(4):174-8 Related articles (PubMed)
Mayer A, et al. Taking engineered anti-CEA antibodies to the clinic. J Immunol Methods 1999 Dec 10;231(1-2):261-73 Related articles (PubMed)
Hammarstrom S The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Semin Cancer Biol 1999;9(2):67-81 Related articles (PubMed)
Mitchell EP Role of carcinoembryonic antigen in the management of advanced colorectal cancer. Semin Oncol 1998;25(5 Suppl 11):12-20 Related articles (PubMed)
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- Related Resources
- The CEA Family Home Page (Germany) This English language site is hosted by the Institute of Molecular Medicine and Cell Research, Freiburg University. It contains detailed information on the Carcinoembryonic Antigen Family, CEA splice variants, publications etc.
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CEACAM5; Carcinoembryonic antigen-related cell adhesion molecule 5 (19q13.2)
