 Summary Information
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Location: 17q11.2-q12
Aliases: HER2, NEU
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| Gene Database Entries for ERBB2
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OMIM
GeneCard (Weizmann Institute)
Tumor Gene Database
Swiss-Prot
Locus Link
UniGene
GenAtlas
GDB
Nomenclature (search for ERBB2)
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| Other Related Resources
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Roche HER2 Website (Hoffmann-La Roche Ltd) an educational site about the HER2 gene with separate areas for patients and medical professionals (requires free registration); includes info about testing, prognosis, educational resources. Roche market a HER2 targeted drug.
- Search Medline for related articles (PubMed)
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- Medline Search: cancer AND gene AND (ERBB2[TI] OR HER2[TI] OR NEU[TI]) (PubMed)
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| ERBB2 and Breast Cancer
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Xie D, et al. Population-Based, Case-Control Study of HER2 Genetic Polymorphism and Breast Cancer Risk. J Natl Cancer Inst. 2000 Mar 1;92(5):412-417. Related articles
Menard S, et al. Role of HER2 gene overexpression in breast carcinoma. [Review] J Cell Physiol 2000; 182(2):150-62 Related articles (PubMed)
Scorilas A, et al. Determination of c-myc amplification and overexpression in breast cancer patients: evaluation of its prognostic value against c-erbB-2, cathepsin-D and clinicopathological characteristics using univariate and multivariate analysis. Br J Cancer 1999;81(8):1385-91 Related articles (PubMed)
Medline Search: breast cancer AND (erbb2 OR her2 OR neu) (PubMed)
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 Breast Cancer Genetics
Breast Cancer : Clinical and Epidemiological Information
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| anti-HER2 Monoclonal Antibody in Breast Cancer Treatment
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Cobleigh MA, et al. Multinational Study of the Efficacy and Safety of Humanized Anti-HER2 Monoclonal Antibody in Women Who Have HER2-Overexpressing Metastatic Breast Cancer That Has Progressed After Chemotherapy for Metastatic Disease. J Clin Oncol. 1999; 17(9):2639 Related articles (PubMed)
Shak S. Overview of the trastuzumab (Herceptin) anti-HER2 monoclonal antibody clinical program in HER2-overexpressing metastatic breast cancer. Herceptin Multinational Investigator Study Group. Semin Oncol. 1999; 26(4 Suppl 12):71-7. [Review] Related articles (PubMed)
Baselga J, et al. Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer. J Clin Oncol 1996;14(3):737-44 Related articles (PubMed)
Baselga J, et al. Phase II study of weekly intravenous trastuzumab (Herceptin) in patients with HER2/neu-overexpressing metastatic breast cancer Semin Oncol. 1999;26(4 Suppl 12):78-83 Related articles (PubMed)
Pegram MD, et al. Phase II study of receptor-enhanced chemosensitivity using recombinant humanized HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment. J Clin Oncol. 1998; 16(8):2659-71 Related articles (PubMed)
Medline Search: HER2 AND monoclonal antibody AND breast cancer (PubMed)
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Breast Cancer Genetics
Breast Cancer : Clinical and Epidemiological Information
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| ERBB2 and Benign Breast Lesions
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Stark A, et al. HER-2/neu Amplification in Benign Breast Disease and the Risk of Subsequent Breast Cancer J Clin Oncol, 2000; 18:267-74
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Breast Cancer Genetics
Breast Cancer : Clinical and Epidemiological Information
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| ERBB2 and Mammary Paget's disease
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Schelfhout VR, et al. Pathogenesis of Paget's disease: epidermal heregulin-alpha, motility factor, and the HER receptor family. J Natl Cancer Inst 2000 Apr 19;92(8):622-8 Related articles (PubMed)
Medline Search: mammary Paget's disease AND (erbb2 OR her2 OR neu) (PubMed)
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Breast Cancer Genetics
Breast Cancer : Clinical and Epidemiological Information
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| ERBB2 and Childhood Medulloblastoma
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Gilbertson RJ, et al. Prognostic significance of HER2 and HER4 coexpression in childhood medulloblastoma Cancer Res 1997; 57(15):3272-80 Related articles (PubMed)
Gilbertson RJ, et al. Expression of the ErbB-neuregulin signaling network during human cerebellar development: implications for the biology of medulloblastoma. Cancer Res 1998; 58(17):3932-41 Related articles (PubMed)
Herms JW, et al. Potential prognostic value of C-erbB-2 expression in medulloblastomas in very young children J Pediatr Hematol Oncol 1997; 19(6):510-5 Related articles (PubMed)
Medline Search: medulloblastoma AND (erbb2 OR her2 OR neu) (PubMed)
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- NGR1 gene (ERBB2 activating ligand)
- ERBB4 gene
Childhood Brain Tumours Genetics
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| ERBB2 and Ovarian Cancer
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Meden H, et al. Overexpression of the oncogene c-erbB-2 (HER2/neu) and response to Int J Gynecol Pathol. 1998; 17(1):61-5 Related articles (PubMed)
Medline Search: ovarian cancer AND (erbb2 OR her2 OR neu) (PubMed)
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Ovarian Ca. Genetics
Ovarian Ca. : Clinical and Epidemiological Information
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| ERBB2 and Lung Cancer
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Graziano SL, et al. Analysis of neuroendocrine markers, HER2 and CEA before and after chemotherapy in patients with stage IIIA non-small cell lung cancer: a Cancer and Leukemia Group B study. Lung Cancer 1998; 21(3):203-11 Related articles (PubMed)
Medline Search: lung cancer AND (erbb2 OR her2 OR neu) (PubMed)
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Lung Cancer Genetics
Lung Cancer : Clinical and Epidemiological Information
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| ERBB2 and Prostate Cancer
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Mark HF, et al. Fluorescence in situ hybridization study of HER-2/neu oncogene amplification in prostate cancer. Exp Mol Pathol. 1999; 66(2):170-8 Related articles (PubMed)
Craft N, et al. A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase Nat Med. 1999; 5(3):280-5 Related articles (PubMed)
Yeh S, et al. From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells. Proc Natl Acad Sci USA. 1999; 96(10):5458-63 Related articles (PubMed)
Medline Search: prostate cancer AND (erbb2 OR her2 OR neu) (PubMed)
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Prostate Cancer Genetics
Prostate Cancer : Clinical and Epidemiological Information
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| ERBB2 and Osteosarcoma
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A retrospective, single centre study of 53 patients (Gorlick, 1999) implicated ERBB2 in osteosarcoma. Higher levels of ERBB2 expression were seen in 43% of 47 initial biopsy samples analysed. Higher expression of ERBB2 correlated with metastatic disease,
histological response, and event free survival. Larger prospective studies are needed to further clarify the role of ERBB2 in osteosarcoma.
Gorlick R, et al. Expression of HER2/erbB-2 Correlates With Survival in Osteosarcoma. J Clin Oncol. 1999; 17(9):2781 Related articles (PubMed)
Medline Search: osteosarcoma AND (erbb2 OR her2 OR neu) (PubMed)
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Osteosarcoma Genetics
Osteosarcoma : Clinical and Epidemiological Information
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| ERBB2 and Carcinoma of Unknown Primary Site
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- Related Resources
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| ERBB2 and Fallopean Tube Cancer
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Chung TK, et al. Overexpression of p53 and HER-2/neu and c-myc in primary fallopian tube carcinoma. Gynecol Obstet Invest 2000;49(1):47-51 Related articles (PubMed)
Lacy MQ, et al. c-erbB-2 and p53 expression in fallopian tube carcinoma. Cancer 1995 Jun 15;75(12):2891-6 Related articles (PubMed)
Medline Search: fallopean tube cancer AND (erbb2 OR her2 OR neu) (PubMed)
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Fallopian Tube ca. : Clinical and Epidemiological Information
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[Home] This page created: 09/10/1999 Last revised: 29/04/2003 © Copyright 1999-
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