Mandard AM, et al. Genetic steps in the development of squamous cell carcinoma of the esophagus. [Review] Mutat Res 2000 Apr;462(2-3):335-42 Related articles (PubMed)
Lam AK. Molecular biology of esophageal squamous cell carcinoma. [Review] Crit Rev Oncol Hematol. 2000;33(2):71-90. Related articles (PubMed)
Nishiwaki T, et al. Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor suppressor locus in 9q32. Genes Chromosomes Cancer 2000;27(2):169-76 Related articles (PubMed)
Xing EP, et al. Mechanisms of inactivation of p14ARF, p15INK4b, and p16INK4a genes in human esophageal squamous cell carcinoma. Clin Cancer Res 1999 Oct;5(10):2704-13 Related articles (PubMed)
Shimada Y, et al. Prognostic factors of oesophageal squamous cell carcinoma from the perspective of molecular biology. Br J Cancer 1999 Jun;80(8):1281-8 Related articles (PubMed)
Medline Search: esophageal cancer AND genetics (PubMed)
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 Esophageal Cancer Genetics
Esophageal Cancer : Clinical and Epidemiological Information
 Hereditary Tylosis and Increased Risk of Esophageal Cancer
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An increased risk of esophageal cancer has been associated with tylosis (a rare skin condition also known as focal non-epidermolytic palmoplantar keratoderma) in 3 large kindreds in the UK, the American Midwest and Germany. Genomic mapping of this
familial disease has identified candidate genes implicated in sporadic esophageal cancer. In particular, LOH 17q is frequent feature of sporadic esophageal cancer and linkage and haplotype analyses of the UK and US families with tylosis and oesophageal
cancer implicate the TOC gene locus located at 17q25.
Risk JM, et al. The tylosis esophageal cancer (TOC) locus: more than just a familial cancer gene. Dis Esophagus. 1999;12(3):173-6 Related articles (PubMed)
Ellis A, et al. Tylosis associated with carcinoma of the oesophagus and oral leukoplakia in a large Liverpool family--a review of six generations. Eur J Cancer 1994;30B(2):102-12 Related articles (PubMed)
Medline Search: tylosis AND esophageal cancer (PubMed)
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- Related Resources
- TOC locus - 17q
- FTOCS - Familial Tylosis and Oesophageal Cancer Study (Molecular Genetics and Oncology Group, University of Liverpool, UK) A study into a rare form of oesophageal cancer, associated with an inherited skin condition called ‘tylosis’. The site includes information for patients, doctors and scientists.
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