 Summary Information
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Location: 10q25.3-q26.1
Candidate region. Allelic loss on 10q is common in glioblastoma multiforme and other brain tumours.
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| Gene Database Entries for DMBT1
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OMIM
Locus Link
UniGene
GDB (search for DMBT1)
Nomenclature (search for DMBT1)
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| Other Related Resources
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- Search Medline for related articles (PubMed)
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- Medline Search: cancer AND gene AND DMBT1[TI] (PubMed)
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| DMBT1 and CNS Tumours
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Chromosome 10q losses are frequently seen in CNS tumours, particularly in glioblastoma multiforme. Mollenhauer (1997) identidied a novel candidate gene, DMBT1, deleted at 10q25.3-26.1 in a medulloblastoma cell line. They cloned the gene and identified
intragenic homozygous deletions were detected in 2/20 medulloblastomas and in 9/39 glioblastomas multiformes.
Mollenhauer J, et al. DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours. Nat Genet. 1997; 17(1):32-9. Related articles (PubMed)
Medline Search: DMBT1 AND brain tumor (PubMed)
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- Related Resources
 Brain and CNS Tumours : Clinical and Epidemiological Information
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| DMBT1 and Lung Cancer
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Takeshita H, et al. Expression of the DMBT1 gene is frequently suppressed in human lung cancer. Jpn J Cancer Res. 1999; 90(9):903-8. Related articles (PubMed)
Wu W, et al. Expression of DMBT1, a candidate tumor suppressor gene, is frequently lost in lung cancer Cancer Res. 1999 Apr 15;59(8):1846-51 Related articles (PubMed)
Medline Search: lung cancer AND DMBT1 (PubMed)
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Lung Cancer Genetics
Lung Cancer : Clinical and Epidemiological Information
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| DMBT1 and Other Cancers
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Mori M, et al. Lack of DMBT1 expression in oesophageal, gastric and colon cancers. Br J Cancer 1999; 79(2):211-3 Related articles (PubMed)
Medline Search: DMBT1 and cancer (PubMed)
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[Home] This page created: 09/10/1999 Last revised: 29/04/2003 © Copyright 1999-
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